Microglia Pathogen Phagocytosis Pathway (Homo sapiens)

From WikiPathways

Revision as of 21:18, 25 August 2017 by DeSl (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
1VesiclePathogenMicrogliaOxidative burstPik3Actin reorganizationSYKTYROBPSIGLEC7IgGPIP2HCKPIK3R1Pik3C1QATREM1FCGR1AOxygenFCER1GITGAMPPPTREM2PPPTrem3ITGB2LYNPTPN6PLCG2LATPRAC1RAC2RAC3VAV1VAV2VAV3NCKAP1LARPC1BNCF4NCF2NCF1CYBBCYBANCF1PNCF4PPNCF2RAC1RAC2RAC3CYBBCYBAPhagocytosis migrationC1QBC1QCPIP3PIK3CGPIK3CAPIK3CDPIK3CBPIK3R2PIK3C3PIK3C2APIK3R6PIK3R3


Description

Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. This pathway was converted from the original human pathway to mouse.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Microglia Pathogen Phagocytosis Pathway", WP3626 revision 87399, with a 94.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V; ''Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.''; Cell, 2013 PubMed

History

View all...
CompareRevisionActionTimeUserComment
94208view21:18, 25 August 2017DeSlAdded ID for PIP2
90777view01:24, 14 December 2016KhanspersOntology Term : 'innate immune response pathway' added !
90776view01:24, 14 December 2016KhanspersOntology Term : 'Alzheimer disease pathway' added !
90775view01:23, 14 December 2016KhanspersOntology Term : 'microglial cell' added !
90774view01:23, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARPC1BGeneProductENSG00000130429 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029622
C1QAGeneProductENSG00000173372 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036887
C1QBGeneProductENSG00000173369 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036905
C1QCGeneProductENSG00000159189 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896
CYBAGeneProductENSG00000051523 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519
CYBBGeneProductENSG00000165168 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340
FCER1GGeneProductENSG00000158869 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000058715
FCGR1AGeneProductENSG00000150337 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015947
HCKGeneProductENSG00000101336 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003283
ITGAMGeneProductENSG00000169896 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786
ITGB2GeneProductENSG00000160255 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290
IgGGeneProduct
LATGeneProductENSG00000213658 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030742
LYNGeneProductENSG00000254087 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042228
NCF1GeneProductENSG00000158517 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950
NCF2GeneProductENSG00000116701 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480
NCF4GeneProductENSG00000100365 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715
NCKAP1LGeneProductENSG00000123338 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488
OxygenMetaboliteHMDB01377 (HMDB)
PIK3C2AGeneProductENSG00000011405 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030660
PIK3C3GeneProductENSG00000078142 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033628
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027665
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032462
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039936
PIK3CGGeneProductENSG00000105851 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041417
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031834
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698
PIK3R6GeneProductENSG00000276231 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046207
PIP2MetaboliteQ27088398 (Wikidata)
PIP3MetaboliteHMDB04249 (HMDB)
PLCG2GeneProductENSG00000197943 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034330
PTPN6GeneProductENSG00000111679 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004266
Pik3GeneProduct
RAC1GeneProductENSG00000136238 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847
RAC2GeneProductENSG00000128340 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220
RAC3GeneProductENSG00000169750 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012
SIGLEC7GeneProductENSG00000168995 (Ensembl)
  • Siglece interacts with Ptpn6 according to BioGRID
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030474
SYKGeneProductENSG00000165025 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021457
TREM1GeneProductENSG00000124731 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042265
TREM2GeneProductENSG00000095970 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023992
TYROBPGeneProductENSG00000011600 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579
Trem3GeneProductNo homologues found for original id En:ENSMUSG00000041754
VAV1GeneProductENSG00000141968 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034116
VAV2GeneProductENSG00000160293 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000009621
VAV3GeneProductENSG00000134215 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033721

Annotated Interactions

No annotated interactions
Personal tools