EDA Signalling in Hair Follicle Development (Homo sapiens)

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1Induction/PatterningWNT3SOSTDC1Nf-kBp50p65DKK1EDARADDDKK4EDARCell DifferentiationPTCH1BMP1RELBEDAGLI1Cell GrowthEDALTBSHH


Description

EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "EDA Signalling in Hair Follicle Development", WP3652 revision 89222, with a 82.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D; ''Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.''; Proc Natl Acad Sci U S A, 2006 PubMed

History

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CompareRevisionActionTimeUserComment
90751view23:41, 13 December 2016Khanspersupdated source pathway information
90746view23:36, 13 December 2016KhanspersOntology Term : 'hair follicle cell' added !
90745view23:36, 13 December 2016KhanspersOntology Term : 'signaling pathway' added !
90744view23:35, 13 December 2016KhanspersOntology Term : 'altered nuclear factor kappa B signaling pathway' added !
90743view23:35, 13 December 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BMP1GeneProductENSG00000168487 (Ensembl)
  • BMP Not Specified
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022098
Cell DifferentiationPathwayWP2082 (WikiPathways)
Cell GrowthPathwayN/A (WikiPathways) Identifier Not Found
DKK1GeneProductENSG00000107984 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024868
DKK4GeneProductENSG00000104371 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031535
EDAProteinENSG00000158813 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1L2D9
EDARADDGeneProductENSG00000186197 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000095105
EDARGeneProductENSG00000135960 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003227
GLI1GeneProductENSG00000111087 (Ensembl)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025407
LTBGeneProductENSG00000227507 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024399
Nf-kBGeneProduct
PTCH1GeneProductENSG00000185920 (Ensembl)
  • Ptc Not Specified
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021466
RELBGeneProductENSG00000104856 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002983
SHHGeneProductENSG00000164690 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002633
SOSTDC1GeneProductENSG00000171243 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036169
WNT3ProteinENSG00000108379 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A2A649
p50GeneProduct
p65GeneProduct

Annotated Interactions

No annotated interactions
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