Hfe effect on hepcidin production (Homo sapiens)

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1ALabelHAMPHFESMAD7BMP6TMPRSS6HFE2ID1HFEHFEBC


Description

Hfe, the mouse equivalent of the human hemochromatosis gene, is known to promote expression of hepcidin, a gene product that inhibits iron absorption, but it is not fully clear how it does this, or at which point Hfe interacts with the cycle(Hfe could be acting on the interaction at points A,B, or C). Hfe, as well as Tmprss6, another gene product, are used in the regulation of systemic iron homeostasis. Evidence obtained from gene testing on mice seems to indicate that Hfe inhibits Tmprss6, which is known to be an inhibitor of Hjv, a gene product that augments BMP/SMAD signaling for the production of hepcidin. Alternatively, Hfe may promote Bmp/Smad signaling by HJV, or by promoting signaling at a point past where Tmprss6 inhibits HJV.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Hfe effect on hepcidin production", WP3673 revision 87409, with a 88.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Karin E. Finberg, Rebecca L. Wittlesey, Nancy C. Andrews; ''Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice''; NIH, 2011 PubMed

History

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CompareRevisionActionTimeUserComment
96137view21:12, 20 February 2018AlexanderPicoModified title
90736view23:24, 13 December 2016Khanspersupdated link to source pathway
90728view22:30, 13 December 2016KhanspersOntology Term : 'regulatory pathway' added !
90727view22:30, 13 December 2016KhanspersOntology Term : 'iron homeostasis pathway' added !
90726view22:28, 13 December 2016KhanspersModified description
90721view22:19, 13 December 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BMP6GeneProductENSG00000153162 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039004
HAMPGeneProductENSG00000105697 (Ensembl)
  • Hepcidin. Inhibits iron absorbtion
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050440
HFE2GeneProductENSG00000168509 (Ensembl)
HFEGeneProductENSG00000010704 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006611
ID1GeneProductENSG00000125968 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042745
SMAD7GeneProductENSG00000101665 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025880
TMPRSS6GeneProductENSG00000187045 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000016942

Annotated Interactions

No annotated interactions
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