Angiopoietin-like protein 8 regulatory pathway (Homo sapiens)

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5, 3422, 38, 4013395, 2619132821, 294, 628312, 20333328331318162426393011, 353332, 41, 42415, 431942059, 223171992632, 41, 4244, 433327185, 262, 431620434, 613LegendHepatocytep70 S6 KinasesInhibitionAmpk isoformsInsulin Receptor SubstratesPancreatic Beta-cell proliferationmTORC1Erk SignalTransduction PathwayActivationT3Glucose UptakePI 3-Kinase isoformsLXRInsulin Signaling Pathway CIP42PI(3,4,5)P3PIK3CAF-2,6-P2Triacylglyceride SynthesisChrebpPP2AInsulinG6PCLPLRAF1PIK3CDExo70GRB2CD45+ hematopoietic- derived cell proliferation SEST3PIK3R2INSRX-5-PRPS6KB2RictorSOS2SREBP1a-cglycogenPIK3C2AIRS1Glycolysis-GluconeogenesisGLUT1PIK3R1Protein synthesis and Translation RegulationPTPAutophagy SignalingPIK3CGIRS2GlycogenesisPEPCKTSC2SREBP2SOS1G-6-PFBPPPARalphamlst8amino acidsGSSIN1PI(4,5)P2GCKRHEBPIK3C2GPIK3CBPIK3R4IRS4 AMPKPathwaymTORmTORRPS6KB1PIK3C3RaptorGlucoseGLUT4Cell GrowthDifferentiationPIK3R3SREBP PathwayTSC1RAS13923DIO2RXRATHRATHRBSLC16A2SLCO1C1T3T4RXRAANGPTL8T3 and T4 intracelullar uptakeSHC2SHC3SHC1GSK3AGSK3BPDKPKB/Akt isoformsAKT1AKT2pT308pT308EIF4EEIF4EBP1mlst8mTORSIN1pRictormlst8mTORC2FOXO1AFOXO3AmTORC2INSRCAP1CBLFLOT1FLOT2CRKRAPGEF1RHOQTransport of GLUT4 Transporters toPlasma MembraneRictorRXRA8, 36ABCG8FASN3714ABCG5CYP3A43714CYP7A114CYP2B614LXR target genes31Drug and steroidmetabolismMulti-drugresistancelipogenesisSCDTranscriptionfactorsMEK/MAP Kinasesp90 Rsk KinasesMAP2K1MAP3K7MAPK14MAPK1MAP2K2RPS6KA5MAP3K2MAP3K6MAPK8MAP4K1MAP3K11MAP4K3MAPK10RPS6KA6MAP2K7MAP3K4MAP3K1MAP3K12MAPK4RPS6KA4MAPK11MAP4K5MAPK6MAP4K4MAPK3MAP3K14MAPK12MAP2K5MAP2K4MAPK13RPS6KA1RPS6KA2MAP3K5RPS6KA3MAPK9MAPK7MAP3K3MAP3K9MAP3K8MAP2K6MAP3K13MAP4K2MAP2K3MAP3K10MINK1PI(3,4,5)P3PKB/Akt isoformsAKT1AKT2pS473pT308pT308pS473CBLCCBLBFOXO1AFOXO3AInsulinINSRLXR target genes31CatalysisInsulin Signaling Pathway Undefined MechanismT4Activation from within the PathwayAMPKy3AMPKa1AMPKy2AMPKy1AMPKb2AMPKb1AMPKa2Ampk isoforms1111, 35


The hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated signaling events of insulin signaling in the liver. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



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  20. Rong Guo X, Li Wang X, Chen Y, Hong Yuan Y, Mei Chen Y, Ding Y, Fang J, Jiao Bian L, Sheng Li D; ''ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells.''; Exp Cell Res, 2016 PubMed Europe PMC Scholia
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123920view05:59, 31 August 2022Fehrhartremoved one "type your comment here"
123857view06:09, 19 August 2022EgonwRemoved the reference to a retracted article (pmid: 23623304)
123522view05:59, 1 August 2022EgonwMoved another KEGG pathway identifier to the comment as they are not reaction identifiers
123521view05:57, 1 August 2022EgonwMoved another KEGG pathway identifier to the comment as they are not reaction identifiers
123516view17:19, 31 July 2022EgonwMoved two KEGG pathway identifiers to the comment as they are not reaction identifiers
122574view11:00, 16 April 2022EgonwMade multiple pathways clickable (and fixed one data source)
120659view18:51, 22 December 2021EweitzOntology Term : 'PW:0000143' removed !
116786view09:55, 14 May 2021EweitzModified title
112155view17:57, 29 September 2020Khanspersremoved extraneous text from comments
110713view14:55, 28 May 2020Marvin M2changed unknown type to metabolite with chebi ID
106761view13:24, 17 September 2019MaintBotHMDB identifier normalization
106297view17:42, 20 August 2019KhanspersModified description
105529view06:01, 9 August 2019KhanspersModified description
94801view23:35, 5 October 2017AlexanderPicoConverted lines, removed nested groups and connected interactions
93137view15:19, 31 July 2017SiddiqaANGPTL8 role in CD45+ hematopoietic-derived cell proliferation
92444view06:37, 6 June 2017SiddiqaInteractions present exclusively in rat/mouse updated.
92359view08:00, 30 May 2017SusanLegend adapted
90629view14:45, 2 December 2016EgonwNo mim-conversion on gene-gene interactions.
90628view14:41, 2 December 2016EgonwRemoved type info from Entrez Gene ID.
90627view14:09, 2 December 2016EgonwUppercased c in KEGG identifier.
90610view22:11, 1 December 2016KhanspersModified description
90604view10:18, 1 December 2016Elisasolved unconnected lines
90499view14:52, 18 November 2016SusanOntology Term : 'insulin signaling pathway' added !
90498view14:51, 18 November 2016SusanModified description
90497view14:48, 18 November 2016SusanOntology Term : 'regulatory pathway' added !
90463view12:44, 17 November 2016SiddiqaModified title
90461view12:40, 17 November 2016SiddiqaAdded AUthor List
90460view11:58, 17 November 2016SiddiqaNew pathway

External references


View all...
NameTypeDatabase referenceComment
AMPK PathwayPathwayWP1403 (WikiPathways)
ABCG5GeneProductENSG00000138075 (Ensembl)
ABCG8GeneProductENSG00000143921 (Ensembl)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AMPKa1GeneProduct5562 (Entrez Gene)
AMPKa2GeneProduct5563 (Entrez Gene)
AMPKb1GeneProduct5564 (Entrez Gene)
AMPKb2GeneProduct5565 (Entrez Gene)
AMPKy1GeneProduct5571 (Entrez Gene)
AMPKy2GeneProduct51422 (Entrez Gene)
AMPKy3GeneProduct53632 (Entrez Gene)
ANGPTL8GeneProduct55908 (Entrez Gene) synonyms: RIFL; TD26; PRO1185; PVPA599; C19orf80
Autophagy SignalingPathway
CAP1GeneProduct10487 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CBLCGeneProduct23624 (Entrez Gene)
CD45+ hematopoietic-
  derived cell 
PathwayWP2849 (WikiPathways)
CIP42GeneProduct9322 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl) is not affected in human
Cell Growth DifferentiationPathwayWP2029 (WikiPathways)
ChrebpGeneProduct51085 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
Drug and steroid metabolismPathway
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
Exo70GeneProduct23265 (Entrez Gene)
F-2,6-P2MetaboliteC00665 (KEGG Compound)
FASNGeneProductENSG00000169710 (Ensembl)
FBPGeneProduct2203 (Entrez Gene)
FLOT1GeneProduct10211 (Entrez Gene)
FLOT2GeneProduct2319 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
G-6-PMetaboliteC00092 (KEGG Compound)
G6PCGeneProduct2538 (Entrez Gene)
GCKGeneProduct2645 (KEGG Genes)
GLUT1GeneProduct6513 (Entrez Gene)
GLUT4GeneProduct6517 (Entrez Gene)
GSGeneProduct2997 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GlucoseMetaboliteC00031 (KEGG Compound)
Glycolysis-GluconeogenesisPathwayWP534 (WikiPathways)
INSRGeneProduct3643 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
Insulin Signaling Pathway Pathway
Insulin Signaling Pathway PathwayWP1982 (WikiPathways)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
LPLGeneProduct4023 (Entrez Gene)
LXRGeneProduct10062 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K10GeneProduct4294 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP3K9GeneProduct4293 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K2GeneProduct5871 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAP4K5GeneProduct11183 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
Multi-drug resistancePathway
PDKGeneProduct5170 (Entrez Gene)
PEPCKGeneProduct5105 (Entrez Gene)
PI(3,4,5)P3MetaboliteC05981 (KEGG Compound) Phosphatidylinositol-3,4,5-trisphosphate(PIP3)
PI(4,5)P2MetaboliteC04637 (KEGG Compound)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PTPGeneProduct5770 (Entrez Gene) PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase
Protein synthesis and Translation RegulationPathway
RAF1GeneProduct5894 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASGeneProduct3265 (Entrez Gene)
RHEBGeneProduct6009 (Entrez Gene)
RHOQGeneProduct23433 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA4GeneProduct8986 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KA6GeneProduct27330 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRAGeneProductENSG00000186350 (Ensembl)
RaptorGeneProduct57521 (Entrez Gene)
RictorGeneProduct253260 (Entrez Gene)
SCDGeneProductENSG00000099194 (Ensembl)
SEST3GeneProduct143686 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene)
SIN1GeneProduct79109 (Entrez Gene)
SLC16A2GeneProduct6567 (Entrez Gene)
SLCO1C1GeneProduct53919 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SREBP PathwayPathwayWP1982 (WikiPathways)
SREBP1a-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
T3Metabolite5707 (Chemspider)
T4MetaboliteHMDB0000248 (HMDB)
THRAGeneProduct7067 (Entrez Gene)
THRBGeneProduct7068 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
Transcription factorsPathway
Triacylglyceride SynthesisPathwayWP325 (WikiPathways)
X-5-PMetaboliteC00231 (KEGG Compound)
amino acidsMetaboliteCHEBI:33709 (ChEBI)
glycogenMetaboliteC00369 (KEGG Compound)
mTOR GeneProduct2475 (Entrez Gene)
mTORGeneProduct2475 (Entrez Gene)
mlst8GeneProduct64223 (Entrez Gene)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
ArrowWP1982 (WikiPathways)
ArrowWP2882 (WikiPathways)
DIO2mim-catalysisR03734 (KEGG Reaction)
GlucoseArrowhsa04911 (KEGG Pathway)
mim-catalysisR04545 (KEGG Reaction)
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