Development and heterogeneity of the ILC family (Homo sapiens)

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1CLPsCHILPILCpa4b7+NKpCHILP: Common helper innate lymphoid precursorCD127-CLP: Common lymphoid progenitorPeripheryBone marrow/Fetal liverILC: Innate Lymphoid CellROR-gammatnegativeNKILC1ILC1ILC2ILC3IL-25TOXIL18ID2NFIL3IL-7AREGPLZFT-betNFIL3IL1BEOMESIL23AIL-4IL6IL15TNFIFNGGFI1IL22TCF1IL13AHRBCL11BROR-gammatGATA3GATA3IL17ATNFIL12ANCR-NCR+CD4-CD4+exILC3IL15T-bet+ ILC1sGATA3+ ILC2sROR-gammat+ ILC3sIFNGIFNGID2TOXRORAIL-33TSLPIL-25IL-5IL-9CCR6+ T-bet+ILC3CCR6+LTi cellsID2NFIL3T-betT-betIL-7IL12BCD127+CD103+IFNGIL12AIL12BIFNGIL22IL17AIL23AIL1BILC: Innate lymphoid cell, ILCp: Innate lymphoid cell progenitorNCR: Natural cytotoxicity receptors NK: Natural killer, NKp: Natural killer progenitorLegend


Description

Development and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription factors and cytokines are involved in the development of the three groups of mature ILCs. All ILCs develop from CLPs, which can differentiate into NKps or CHILPs. CHILPs can further differentiate into LTi cells through α4β7+ populations or into other ILC populations through differentiation into ILCps. ILC1s express T-bet, are responsive to IL-12, and produce IFN-γ and/or TNF. ILC2s highly express GATA3, are responsive to IL-25, IL-33 and TSLP, and produce IL-4, IL-5, IL-9, IL-13 and amphiregulin. ILC3s express ROR-γt, are responsive to IL-1β and IL-23, and produce IL-17 and/or IL-22.

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Ontology Terms

 

Bibliography

  1. Lai DM, Shu Q, Fan J; ''The origin and role of innate lymphoid cells in the lung.''; Mil Med Res, 2016 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
89702view20:46, 26 September 2016Khanspersconnected interaction
89701view20:45, 26 September 2016Khanspers
89700view19:32, 26 September 2016Khansperstidy and legend
89321view15:48, 1 September 2016KhanspersOntology Term : 'common lymphoid progenitor' added !
89320view15:47, 1 September 2016KhanspersModified description
89315view15:42, 1 September 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AHRGeneProductENSG00000106546 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
BCL11BGeneProductENSG00000127152 (Ensembl)
EOMESGeneProductENSG00000163508 (Ensembl)
GATA3GeneProductENSG00000107485 (Ensembl)
GFI1GeneProductENSG00000162676 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IL-25GeneProductENSG00000166090 (Ensembl)
IL-33GeneProductENSG00000137033 (Ensembl)
IL-4GeneProductENSG00000113520 (Ensembl)
IL-5GeneProductENSG00000113525 (Ensembl)
IL-7GeneProductENSG00000104432 (Ensembl)
IL-9GeneProductENSG00000145839 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL13GeneProductENSG00000169194 (Ensembl)
IL15GeneProductENSG00000164136 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL23AGeneProductENSG00000110944 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
NFIL3GeneProductENSG00000165030 (Ensembl)
PLZFGeneProductENSG00000109906 (Ensembl)
ROR-gammatGeneProduct
RORAGeneProductENSG00000069667 (Ensembl)
T-betGeneProductENSG00000073861 (Ensembl)
TCF1GeneProductENSG00000135100 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TOXGeneProductENSG00000198846 (Ensembl)
TSLPGeneProductENSG00000145777 (Ensembl)

Annotated Interactions

No annotated interactions

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