Angiotensin II signaling (acute) in thick ascending limbs (Rattus norvegicus)

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3, 93, 130, 144825, 12, 5114, 38, 64, 152101, 148cGMP SignalingNOItpr1cAMPMas1PIP2PKCaSuperoxideItpr2PKAPI3KPLC g2AT1aItpr3IP3G alfa-QAT2RCa2+DAG94, 131, 132, 14337AT1b61, 73, 120, 147, 167120AT1R APB-Arrestin 2Dynamin 1 Dynamin 2G alfa-11PLC g1Ca2+PIP2PIP3PTENAkt2 / PKBAkt1 / PKBAkt3 / PKB124NOS3Calmodulin 1Calmodulin 2Calmodulin 3NOX4Rac129, 153, 1757DECREASEDTransport Rates24, 78, 111INCREASEDTransport RatesPKCaPKCgINCREASEDTransport RatesAMPPDE 2a86, 164Uncoupled NOSs100PDPK1DECREASEDTransport RatesPLA2AA20-HETEcit-P450


The thick ascending limb of the loop pf Henle reabsorbs 25 to 30 % of the NaCl filtered through the glomerulus. Abnormally elevated Na reabsorption by this segment is link to salt-sensitive hypertension. Ang II is an important regulator of transport in the thick ascending limb, in part due to its modulatory effects on the balance between nitric oxide and superoxide. This pathway features the acute effects of Ang II in NO and O2- production in thick ascending limb. The information presented here is based on both genomic and physiological data.

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107039view14:00, 17 September 2019MaintBotHMDB identifier normalization
107038view13:51, 17 September 2019Mkutmonfix special character in literature reference
106986view13:44, 17 September 2019MaintBotHMDB identifier normalization
97920view05:51, 24 June 2018EgonwFixed the non-existing ChEBI ID, assuming AA is short for arachidonic acid.
96438view07:55, 15 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
95224view18:28, 26 November 2017DeSlAdded unconnected line.
95169view20:11, 20 November 2017SusanAnnotated protein
95162view17:55, 17 November 2017AgustinGVModified title
95161view17:53, 17 November 2017AgustinGVAdding 20-HETE pw
94514view19:11, 16 September 2017AlexanderPicoRemoved "undefined" xref values
94478view18:45, 12 September 2017AgustinGV
94477view18:43, 12 September 2017AgustinGV
94476view18:35, 12 September 2017AgustinGVQuick edit to datanode annotation or property
92339view12:32, 25 May 2017AgustinGV
92338view12:30, 25 May 2017AgustinGVcorrect alignment
91518view20:55, 8 March 2017Khanspersadded ids for some metabolites
91331view18:19, 2 February 2017Khanspersconnected interactions
90426view19:54, 15 November 2016AgustinGV
89600view16:04, 19 September 2016AgustinGV
89588view15:45, 19 September 2016AgustinGVOntology Term : 'kidney loop of henle thick ascending limb epithelial cell' added !
89587view15:45, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89576view15:31, 19 September 2016AgustinGVModified description
89568view07:52, 17 September 2016EgonwReplaced an secondary HMDB id with the main ID.
89402view19:49, 10 September 2016AlexanderPicoOntology Term : 'signaling pathway' added !
89401view19:49, 10 September 2016AlexanderPicoOntology Term : 'angiotensin signaling pathway' added !
89248view17:49, 25 August 2016AgustinGVSpecify description
89239view21:35, 24 August 2016AgustinGVModified description
89214view14:05, 23 August 2016AgustinGVSpecify description
89213view14:03, 23 August 2016AgustinGVNew pathway

External references


View all...
NameTypeDatabase referenceComment
20-HETEMetaboliteHMDB0005998 (HMDB)
AAMetaboliteCHEBI:15843 (ChEBI)
AMPMetaboliteHMDB03540 (HMDB)
AT1R APGeneProduct298646 (Entrez Gene)
AT1aGeneProduct24180 (Entrez Gene)
AT1bGeneProduct81638 (Entrez Gene)
AT2RGeneProduct24182 (Entrez Gene)
Akt1 / PKBProtein24185 (Entrez Gene)
Akt2 / PKBProtein25233 (Entrez Gene)
Akt3 / PKBProtein29414 (Entrez Gene)
B-Arrestin 2GeneProduct25388 (Entrez Gene)
Ca2+MetaboliteHMDB00464 (HMDB)
Calmodulin 1GeneProduct24242 (Entrez Gene)
Calmodulin 2GeneProduct50663 (Entrez Gene)
Calmodulin 3GeneProduct24244 (Entrez Gene)
DAGMetaboliteCHEBI:18035 (ChEBI)
Dynamin 1 GeneProduct140694 (Entrez Gene)
Dynamin 2GeneProduct25751 (Entrez Gene)
G alfa-11GeneProduct81662 (Entrez Gene)
G alfa-QGeneProduct81666 (Entrez Gene)
IP3MetaboliteHMDB01498 (HMDB)
Itpr1GeneProduct25262 (Entrez Gene)
Itpr2GeneProduct81678 (Entrez Gene)
Itpr3GeneProduct25679 (Entrez Gene)
Mas1Protein25153 (Entrez Gene)
NOMetaboliteHMDB03378 (HMDB)
NOS3GeneProduct24600 (Entrez Gene)
NOX4GeneProduct85431 (Entrez Gene)
PDE 2aGeneProduct81743 (Entrez Gene)
PDPK1GeneProduct81745 (Entrez Gene)
PIP2Metabolite21169207 (Chemspider)
PIP3MetaboliteQ3078767 (Wikidata)
PKAProtein3389 (RGD)
PKCaGeneProduct24680 (Entrez Gene)
PKCgGeneProduct24681 (Entrez Gene)
PLC g1GeneProduct25738 (Entrez Gene)
PLC g2GeneProduct29337 (Entrez Gene)
PTENProtein50557 (Entrez Gene)
Rac1GeneProduct85431 (Entrez Gene)
SuperoxideMetaboliteHMDB02168 (HMDB)
Uncoupled NOSsGeneProduct24600 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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