Simplified Depiction of MYD88 Distinct Input-Output Pathway (Homo sapiens)

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1MyD88 dimerizationReactive oxygen species NFKBTLR9IL-1TRAF6IRAK1TLR4MYD88TLR2TLR7AP-1TLR11UBC13CRETLR10TLR1TLR6TIFATLR5UEV1ATLR8UbPUbMYD88UbPMYD88MYD88MYD88MYD88TRAF6TIFAUBC13UEV1AIRAK1PPTRAF6/IRAK1 ubiquitination


Description

This pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 through canonical IKK phosphorylation. This complex also induces the production of reactive oxygen species.

Quality Tags

Ontology Terms

 

Bibliography

  1. Li F, Thiele I, Jamshidi N, Palsson BØ; ''Identification of potential pathway mediation targets in Toll-like receptor signaling.''; PLoS Comput Biol, 2009 PubMed

History

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CompareRevisionActionTimeUserComment
89291view18:53, 30 August 2016Khanspers
89129view19:54, 22 August 2016Khansperslayout, reformat of complexes, addded recycling/degradation of MyD88 dimer
89128view19:35, 22 August 2016KhanspersOntology Term : 'Toll-like receptor signaling pathway' added !
89059view06:37, 19 August 2016FehrhartConnected line
88823view23:46, 14 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88822view23:45, 14 August 2016AAR&CoModified description
88821view23:35, 14 August 2016AAR&CoModified title
88820view23:35, 14 August 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AP-1ProteinP05412 (Uniprot-TrEMBL)
CREGeneProductIdentifier Not Found
IL-1GeneProductENSG00000115008 (Ensembl) Interleukin Not Specified
IRAK1GeneProductENSG00000184216 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFKBGeneProductENSG00000109320 (Ensembl) NFKB NOt Specified
Reactive oxygen species Metabolite784 (PubChem-compound)
TIFAGeneProductENSG00000145365 (Ensembl)
TLR10GeneProductENSG00000174123 (Ensembl)
TLR11GeneProductIdentifier Not Found
TLR1GeneProductENSG00000174125 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR5GeneProductENSG00000187554 (Ensembl)
TLR6GeneProductENSG00000174130 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
UBC13GeneProductENSG00000177889 (Ensembl)
UEV1AGeneProductENSG00000244687 (Ensembl)

Annotated Interactions

No annotated interactions

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