BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation (Homo sapiens)

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1SMAD-mediated signalingFOXO1 TargetsSFRPsBCL2L11SSTWNT4cAMPSMAD1DKKsFOXO1B-CateninSMAD5BMP2DCNSMAD8LEFTY2Differentiation of Human Endometrial Stromal Cells


Description

This pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO1 function through B-Catenin which indirectly stimulates HPESC differentiation. DKKs and SFRPs are activated by BMP2 inhibit WNT4 and stop downstream signaling.

Quality Tags

Ontology Terms

 

Bibliography

  1. Li Q, Kannan A, Das A, Demayo FJ, Hornsby PJ, Young SL, Taylor RN, Bagchi MK, Bagchi IC; ''WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal celldifferentiation.''; Endocrinology, 2013 PubMed

History

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CompareRevisionActionTimeUserComment
94744view15:12, 5 October 2017Mkutmonfix unconnected line
90122view04:37, 14 October 2016Khanspersfixed unconnected
89273view05:11, 29 August 2016Khanspersupdated layout, added nodes
89060view06:40, 19 August 2016Fehrhartconnected line
88814view22:41, 14 August 2016AAR&CoOntology Term : 'Wnt signaling pathway' added !
88813view22:41, 14 August 2016AAR&CoOntology Term : 'stromal cell' added !
88812view22:39, 14 August 2016AAR&CoModified description
88811view22:31, 14 August 2016AAR&CoModified title
88810view22:31, 14 August 2016AAR&CoModified description
88809view22:30, 14 August 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
B-CateninProteinB4DGU4 (Uniprot-TrEMBL)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
DCNGeneProductENSG00000011465 (Ensembl)
DKKsGeneProductO94907 (Uniprot-TrEMBL) Protein Family
Differentiation of Human Endometrial Stromal CellsPathwayWP2848 (WikiPathways)
FOXO1GeneProductENSG00000150907 (Ensembl)
LEFTY2GeneProductENSG00000143768 (Ensembl)
SFRPsGeneProductENSG00000104332 (Ensembl) Protein Family
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
SMAD8GeneProductENSG00000120693 (Ensembl)
SSTGeneProductENSG00000157005 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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