Canonical and Non-Canonical TGF-B signaling (Homo sapiens)

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1NucleusTrabecular Meshwork CellTGFBR1TGFBR2LOXLOXL4BMPGremSMAD2SMAD4JNK2BMPR2TGF-BetaLOXL2BMPR1LOXL1JNK1SMAD3P38PPPPPLOXL4LOXL2LOXL1LOXLOXLOXL1LOXLOXL1LOXL1LOXL4LOXL1LOXL4


Description

This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors.

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Ontology Terms

 

Bibliography

  1. Sethi A, Wordinger RJ, Clark AF; ''Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells.''; Exp Eye Res, 2013 PubMed

History

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CompareRevisionActionTimeUserComment
89272view23:31, 28 August 2016Khanspersadded states, labels, interactions
89112view18:48, 22 August 2016AAR&CoModified description
89061view06:44, 19 August 2016FehrhartMinor cosmetic changes
88954view21:13, 17 August 2016AAR&CoOntology Term : 'Bone morphogenetic proteins signaling pathway' added !
88953view21:11, 17 August 2016AAR&CoOntology Term : 'primary angle-closure glaucoma' added !
88802view21:30, 14 August 2016AAR&CoModified description
88801view21:13, 14 August 2016AAR&CoLiterature Reference Added
88800view21:10, 14 August 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BMPGeneProductENSG00000168487 (Ensembl)
BMPR1GeneProductENSG00000107779 (Ensembl)
BMPR2GeneProductENSG00000204217 (Ensembl)
GremGeneProductENSG00000166923 (Ensembl)
JNK1GeneProductENSG00000107643 (Ensembl)
JNK2GeneProductENSG00000050748 (Ensembl)
LOXGeneProductENSG00000113083 (Ensembl)
LOXL1GeneProductENSG00000129038 (Ensembl)
LOXL2GeneProductENSG00000134013 (Ensembl)
LOXL4GeneProductENSG00000138131 (Ensembl)
P38GeneProductENSG00000112062 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
TGF-BetaGeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)

Annotated Interactions

No annotated interactions

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