Canonical and Non-Canonical TGF-B signaling (Homo sapiens)

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This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Sethi A, Wordinger RJ, Clark AF; ''Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells.''; Exp Eye Res, 2013 PubMed Europe PMC Scholia


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106348view21:35, 21 August 2019KhanspersModified description
105549view06:10, 9 August 2019KhanspersModified description
89272view23:31, 28 August 2016Khanspersadded states, labels, interactions
89112view18:48, 22 August 2016AAR&CoModified description
89061view06:44, 19 August 2016FehrhartMinor cosmetic changes
88954view21:13, 17 August 2016AAR&CoOntology Term : 'Bone morphogenetic proteins signaling pathway' added !
88953view21:11, 17 August 2016AAR&CoOntology Term : 'primary angle-closure glaucoma' added !
88802view21:30, 14 August 2016AAR&CoModified description
88801view21:13, 14 August 2016AAR&CoLiterature Reference Added
88800view21:10, 14 August 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
BMPGeneProductENSG00000168487 (Ensembl)
BMPR1GeneProductENSG00000107779 (Ensembl)
BMPR2GeneProductENSG00000204217 (Ensembl)
GremGeneProductENSG00000166923 (Ensembl)
JNK1GeneProductENSG00000107643 (Ensembl)
JNK2GeneProductENSG00000050748 (Ensembl)
LOXGeneProductENSG00000113083 (Ensembl)
LOXL1GeneProductENSG00000129038 (Ensembl)
LOXL2GeneProductENSG00000134013 (Ensembl)
LOXL4GeneProductENSG00000138131 (Ensembl)
P38GeneProductENSG00000112062 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
TGF-BetaGeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)

Annotated Interactions

No annotated interactions

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