Novel intracellular components of RIG-I-like receptor (RLR) pathway (Homo sapiens)

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1Type I inteferonDDX3YMAPK11MAPK14TMEM173Ub-mediated proteolysisDDX17ApoptosisMAPK8MAPK13short dsRNACYLDCXCL8MAPK12DDX58ISG15TRIM25ATG5ATG12NLRX1MAVSDHX58RNF125IFIH1DAKOTUD5TRAF3TRADDTANKAZI2TBKBP1FADDRIPK1SIKE1IKBKETBK1IKBKGCASP8CASP10DDX3XPIN1IRF3IRF7IKBKGCHUKIKBKBNFKBIANFKBIBNFKB1RELAMAPK10MAPK9MAP3K7MAP3K1TRAF2TRAF6IRF3IRF7NFKB1RELAIFNGIFNA1IFNB1IFNEIFNKTNFACXCL12CXCL10Inflammatory cytokinesNucleus5'ppp-RNAlong dsRNAViral pathogensUb-mediated proteolysisMAPK signalingISG15SNW1viral RNAviral RNA


Description

Viral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initiate signaling pathways, triggering the innate antiviral response via production of type I interferons and inflammatory cytokines. RLR pathway genes are characterized by rapid evolution, viral protein interactions, limited sets of protein domains, specific TF regulation, and densely connected interaction networks. The study by van der Lee et al. (2015) identfied novel components, DDX17 and SNW1, for the RIG-I pathway.

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Ontology Terms

 

Bibliography

  1. van der Lee R, Feng Q, Langereis MA, Ter Horst R, Szklarczyk R, Netea MG, Andeweg AC, van Kuppeveld FJ, Huynen MA; ''Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.''; PLoS Comput Biol, 2015 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106524view23:45, 5 September 2019KhanspersModified description
105798view22:48, 15 August 2019KhanspersModified description
104869view19:51, 21 June 2019AlexanderPicoModified description
104868view19:48, 21 June 2019AlexanderPicoModified title
104581view12:47, 2 June 2019YtModified title
88186view00:44, 30 July 2016AlexanderPicoAdded newly discovered viral RNA-host RLR components
88185view00:39, 30 July 2016AlexanderPicoOntology Term : 'viral infectious disease' added !
88184view00:38, 30 July 2016AlexanderPicoOntology Term : 'signaling pathway in the innate immune response' added !
88183view00:38, 30 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
88182view00:38, 30 July 2016AlexanderPicoModified description
88181view00:23, 30 July 2016AlexanderPicoAdded literature reference
88180view00:22, 30 July 2016AlexanderPicofixed complex position
88179view00:21, 30 July 2016AlexanderPicoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
5'ppp-RNARna
ATG12GeneProductENSG00000145782 (Ensembl)
ATG5GeneProductENSG00000057663 (Ensembl)
AZI2GeneProductENSG00000163512 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
CASP10GeneProductENSG00000003400 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CYLDGeneProductENSG00000083799 (Ensembl)
DAKGeneProductENSG00000149476 (Ensembl)
DDX17GeneProductENSG00000100201 (Ensembl)
DDX3XGeneProductENSG00000215301 (Ensembl)
DDX3YGeneProductENSG00000067048 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl)
DHX58GeneProductENSG00000108771 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
IFIH1GeneProductENSG00000115267 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IFNEGeneProductENSG00000184995 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNKGeneProductENSG00000147896 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAVSGeneProductENSG00000088888 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIBGeneProductENSG00000104825 (Ensembl)
NLRX1GeneProductENSG00000160703 (Ensembl)
OTUD5GeneProductENSG00000068308 (Ensembl)
PIN1GeneProductENSG00000127445 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RIPK1GeneProductENSG00000137275 (Ensembl)
RNF125GeneProductENSG00000101695 (Ensembl)
SIKE1GeneProductENSG00000052723 (Ensembl)
SNW1GeneProductENSG00000100603 (Ensembl)
TANKGeneProductENSG00000136560 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TBKBP1GeneProductENSG00000198933 (Ensembl)
TMEM173GeneProductENSG00000184584 (Ensembl)
TNFAProteinENSG00000232810 (Ensembl)
TRADDGeneProductENSG00000102871 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRIM25GeneProductENSG00000121060 (Ensembl)
Ub-mediated proteolysisPathwayWP183 (WikiPathways)
long dsRNARna
short dsRNARna
viral RNARna

Annotated Interactions

No annotated interactions

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