Robo4 and VEGF Signaling Pathways Crosstalk (Mus musculus)

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1PermeabilityAngiogenesisSrcRobo4VegfaVEGFR2Rac1Slit2


Description

This pathway is based on Figure 2 of "Robo4: a guidance receptor that regulates angiogenesis." (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637482/). The gene Robo4 plays a role in regulating vascular stability in mice. Robo4 inhibits the gene Notch1, which regulates tip cell formation, in order to create more tip cells. Robo4 also inhibits cell migration, decreasing vessel complexity. The combination of Slit2 and Robo4 inhibits the activation of Src by VEGF-165 and VEGFR2. This inhibition reduces vascular leakage of Evans Blue from retinal blood vessels. More experimentation is necessary to determine whether Robo4 will inhibit other members of the Src family.

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Ontology Terms

 

Bibliography

  1. Weitzman M, Bayley EB, Naik UP; ''Robo4: a guidance receptor that regulates angiogenesis.''; Cell Adh Migr, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
90820view18:45, 14 December 2016KhanspersModified description
89750view23:59, 29 September 2016KhanspersModified title
89749view23:57, 29 September 2016Khanspersupdated lit ref
89630view22:38, 21 September 2016KhanspersModified description
89629view22:37, 21 September 2016KhanspersModified description
89628view22:35, 21 September 2016Khanspersadded cell shape and adjusted inhibitory interaction
88768view19:29, 14 August 2016AAR&CoOntology Term : 'Notch signaling pathway' added !
88767view19:28, 14 August 2016AAR&CoEdited Datanodes and Interactions
88765view19:18, 14 August 2016AAR&CoFix excess space
87425view11:34, 22 July 2016MkutmonOntology Term : 'regulatory pathway' added !
87333view15:16, 21 July 2016AAR&CoWork in progress
87332view15:07, 21 July 2016AAR&CoModified description
87331view15:05, 21 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Rac1GeneProductENSMUSG00000001847 (Ensembl)
Robo4GeneProductENSMUSG00000032125 (Ensembl)
Slit2GeneProductENSMUSG00000031558 (Ensembl)
SrcGeneProductENSMUSG00000027646 (Ensembl)
VEGFR2GeneProductENSMUSG00000062960 (Ensembl)
VegfaGeneProductENSMUSG00000023951 (Ensembl)

Annotated Interactions

No annotated interactions

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