TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition (Homo sapiens)

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1Late Response TFSMAD PathwayMesenchymal MarkersEpithelial MarkersEMT Transcription FactorsSMAD4MAPKTGF-BTNCE-CADSMAD3N-CADERKCDH16AKTCDH6ID1SMAD2RUNX2SNAI1SNAI2PI3KVIMFN1PPPPPPPNon-SMAD PathwayEarly Response TF


This pathway is based on the Figure 7 of "Cadherin 6 Is a New RUNX2 Target in TGF-β Signalling Pathway" (see bibliography). TGF-B is a target gene in thyroid cells in the causation of cancer. When TGF-B is activated, the pathway can take 2 directions, through a SMAD pathway or a Non-Smad pathway. Through the SMAD pathway, SMAD separates into SMAD2/3, SMAD4, and involves phosphates into the nuclear signalling. Through the Non-SMAD pathway, the activation of MAPK and Pi3k causes the activation of ERK, AKT and phosphates, and then into the nuclear signalling. Within the nuclear signalling, EMT-TF has two responses, early and late. With the early response, EMT-TF signals to Id1 and RUNX2, and with the late response, EMT-TF signals to Snai1 and Snai2. Depending on the response also dictates the type of marker that will follow. If early, N-CAD,FN1,VIM,TNC, and CDH6 all cause the activation of the Mesenchymal markers. If late, E-CAD, and CDH16 cause the inhibition of the Epithelial Markers.

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Ontology Terms



  1. Sancisi V, Gandolfi G, Ragazzi M, Nicoli D, Tamagnini I, Piana S, Ciarrocchi A; ''Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway.''; PLoS One, 2013 PubMed Europe PMC


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90120view00:17, 14 October 2016Khanspersupdated layout and interactions
89942view13:56, 6 October 2016EgonwModified description
88619view02:02, 12 August 2016AAR&CoAdded Data Nodes
88618view02:01, 12 August 2016AAR&CoPeriodical save, work in progress
87420view11:32, 22 July 2016MkutmonOntology Term : 'signaling pathway' added !
87310view21:17, 20 July 2016AAR&CoModified description
87306view20:51, 20 July 2016AAR&CoOntology Term : 'thyroid cancer' added !
87305view20:48, 20 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
AKTGeneProductENSG00000142208 (Ensembl) AKT Not Specified
CDH16GeneProductENSG00000166589 (Ensembl)
CDH6GeneProductENSG00000113361 (Ensembl)
E-CADGeneProductP12830 (Uniprot-TrEMBL)
ERKGeneProductP27361 (Uniprot-TrEMBL) ERK Not Specified
FN1GeneProductENSG00000115414 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
MAPKGeneProductENSG00000100030 (Ensembl) MAPK Not Specified
N-CADProteinA0A024RC42 (Uniprot-TrEMBL)
PI3KGeneProductP91634 (Uniprot-TrEMBL)
RUNX2GeneProductENSG00000124813 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
TGF-BGeneProductP01137 (Uniprot-TrEMBL)
TNCGeneProductENSG00000041982 (Ensembl)
VIMGeneProductENSG00000026025 (Ensembl)

Annotated Interactions

No annotated interactions

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