Wnt Signaling in Kidney Disease (Mus musculus)

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1, 2Canonical TranscriptionNon-Canonical Cytoskeleton/planar cell PolarityRhoaCalciumbeta-cateninNphp3Nphp2 (Invs)Lrp5Lrp6Wnt1Wnt10aWnt10bWnt7aWnt16Wnt6Wnt5aWnt2bWnt11Wnt4Wnt3aWnt5bWnt9bWnt2Wnt3Wnt7bFzd1Fzd8Fzd4Fzd2Fzd7Fzd9Fzd5Fzd6Fzd3Fzd1Fzd8Fzd4Fzd2Fzd7Fzd9Fzd5Fzd6Fzd3Dvl2Dvl3Dvl1Mapk9Mapk10Mapk8Dvl2Dvl3Dvl1cytoplasmicdisheveledmembrane-bounddisheveled


This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects.

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Ontology Terms



  1. Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kränzlin B, Nürnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nürnberg P, Gretz N, Lo C, Lienkamp S, Schäfer T, Walz G, Benzing T, Zerres K, Omran H; ''Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.''; Am J Hum Genet, 2008 PubMed Europe PMC
  2. Bissler JJ, Siroky BJ, Yin H; ''Glomerulocystic kidney disease.''; Pediatr Nephrol, 2010 PubMed Europe PMC


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90797view17:25, 14 December 2016KhanspersModified title
90183view18:28, 21 October 2016Khanspersupdated lit ref
88437view21:20, 6 August 2016AlexanderPicoUpdated references
88436view21:19, 6 August 2016AlexanderPicoModified description
88435view21:11, 6 August 2016AlexanderPicoUpdated title, lit ref and label
88434view21:02, 6 August 2016AlexanderPicoOntology Term : 'signaling pathway' added !
88433view21:00, 6 August 2016AlexanderPicoAdded paralogs, Lrp5/6, cell compartments and Dvl labels
88380view01:21, 2 August 2016AAR&CoOntology Term : 'Wnt signaling, the planar cell polarity pathway' added !
88379view01:20, 2 August 2016AAR&CoOntology Term : 'kidney disease' added !
88217view00:37, 1 August 2016AAR&CoAdded Identifier
88216view00:35, 1 August 2016AAR&CoAdded Identifiers
87416view11:31, 22 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
87279view16:47, 20 July 2016AAR&CoIdentifiers Added
87277view16:43, 20 July 2016AAR&CoModified description
87268view16:08, 20 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
CalciumMetaboliteHMDB00464 (HMDB)
Dvl1GeneProduct13542 (Entrez Gene)
Dvl2GeneProduct13543 (Entrez Gene)
Dvl3GeneProduct13544 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Fzd3GeneProduct14365 (Entrez Gene)
Fzd4GeneProduct14366 (Entrez Gene)
Fzd5GeneProduct14367 (Entrez Gene)
Fzd6GeneProduct14368 (Entrez Gene)
Fzd7GeneProduct14369 (Entrez Gene)
Fzd8GeneProduct14370 (Entrez Gene)
Fzd9GeneProduct14371 (Entrez Gene)
Lrp5GeneProductENSMUSG00000024913 (Ensembl)
Lrp6GeneProductENSMUSG00000030201 (Ensembl)
Mapk10GeneProduct26414 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
Nphp2 (Invs)GeneProductENSMUSG00000028344 (Ensembl)
Nphp3GeneProductENSMUSG00000032558 (Ensembl)
RhoaGeneProductENSMUSG00000007815 (Ensembl)
Wnt10aGeneProduct22409 (Entrez Gene)
Wnt10bGeneProduct22410 (Entrez Gene)
Wnt11GeneProduct22411 (Entrez Gene)
Wnt1GeneProduct22408 (Entrez Gene)
Wnt16GeneProduct93735 (Entrez Gene)
Wnt2GeneProduct22413 (Entrez Gene)
Wnt2bGeneProduct22414 (Entrez Gene)
Wnt3GeneProduct22415 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt4GeneProduct22417 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Wnt5bGeneProduct22419 (Entrez Gene)
Wnt6GeneProduct22420 (Entrez Gene)
Wnt7aGeneProduct22421 (Entrez Gene)
Wnt7bGeneProduct22422 (Entrez Gene)
Wnt9bGeneProduct22412 (Entrez Gene)
beta-cateninGeneProductENSMUSG00000006932 (Ensembl)

Annotated Interactions

No annotated interactions

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