Dysregulated miRNA Targeting in Insulin/PI3K-AKT Signaling (Mus musculus)

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1Eif4e2Ccnd2Socs1Crklmmu-miR-425-5pExoc7PI3K/AKT SignallingCol4a2AcacaCol3a1mmu-miR-16-5pmmu-miR-155-5pmmu-miR-29a-3pPrkar2aSos1PrkxBadCol1a2FasnBcl2l11Flot2Col5a3mmu-miR-29b-3pPik3r1MtorRhebCol1a1mmu-miR-503-5pCdkn1bRaf1Mapk3Bcl2mmu-miR-15a-5pPik3r3Insulin Signaling


Description

This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.

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Ontology Terms

 

Bibliography

  1. Kwon DN, Chang BS, Kim JH; ''MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.''; Biomed Res Int, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
89747view23:54, 29 September 2016KhanspersModified title
89746view23:53, 29 September 2016KhanspersModified title
89644view23:42, 22 September 2016Khansperscorrected direction of miRNA-target interactions
88610view23:00, 11 August 2016AAR&CoAdded Data Node
88609view22:58, 11 August 2016AAR&CoAdded DataNode
87414view11:31, 22 July 2016MkutmonOntology Term : 'regulatory pathway' added !
87257view14:22, 20 July 2016AAR&CoOntology Term : 'type 2 diabetes mellitus' added !
87256view14:22, 20 July 2016AAR&CoOntology Term : 'glucose intolerance' added !
87255view14:21, 20 July 2016AAR&CoModified description
87254view14:09, 20 July 2016AAR&CoAdded Citation
87253view13:51, 20 July 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AcacaGeneProductENSMUSG00000020532 (Ensembl)
BadGeneProductENSMUSG00000024959 (Ensembl)
Bcl2GeneProductENSMUSG00000057329 (Ensembl)
Bcl2l11GeneProductENSMUSG00000027381 (Ensembl)
Ccnd2GeneProductENSMUSG00000000184 (Ensembl)
Cdkn1bGeneProductENSMUSG00000003031 (Ensembl)
Col1a1GeneProductENSMUSG00000001506 (Ensembl)
Col1a2GeneProductENSMUSG00000029661 (Ensembl)
Col3a1GeneProductENSMUSG00000026043 (Ensembl)
Col4a2GeneProductENSMUSG00000031503 (Ensembl)
Col5a3GeneProductENSMUSG00000004098 (Ensembl)
CrklGeneProductENSMUSG00000006134 (Ensembl)
Eif4e2GeneProductENSMUSG00000026254 (Ensembl)
Exoc7GeneProductENSMUSG00000020792 (Ensembl)
FasnGeneProductENSMUSG00000025153 (Ensembl)
Flot2GeneProductENSMUSG00000061981 (Ensembl)
Insulin SignalingPathwayWP65 (WikiPathways)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MtorGeneProductENSMUSG00000028991 (Ensembl)
PI3K/AKT SignallingPathwayWP3675 (WikiPathways)
Pik3r1GeneProductENSMUSG00000041417 (Ensembl)
Pik3r3GeneProductENSMUSG00000028698 (Ensembl)
Prkar2aGeneProductENSMUSG00000032601 (Ensembl)
PrkxGeneProductENSMUSG00000035725 (Ensembl)
Raf1GeneProductENSMUSG00000000441 (Ensembl)
RhebGeneProductENSMUSG00000028945 (Ensembl)
Socs1GeneProductENSMUSG00000038037 (Ensembl)
Sos1GeneProductENSMUSG00000024241 (Ensembl)
mmu-miR-155-5pRnaMI0000177 (miRBase Sequence)
mmu-miR-15a-5pRnaMIMAT0000526 (miRBase Sequence)
mmu-miR-16-5pRnaMIMAT0000527 (miRBase Sequence)
mmu-miR-29a-3pRnaMIMAT0000535 (miRBase Sequence)
mmu-miR-29b-3pRnaMIMAT0000127 (miRBase Sequence)
mmu-miR-425-5pRnaMIMAT0004750 (miRBase Sequence)
mmu-miR-503-5pRnaMIMAT0003188 (miRBase Sequence)

Annotated Interactions

No annotated interactions

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