PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (Homo sapiens)

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1AKT inhibitorsPI3K inhibitorsAllosteric mTOR inhibitorsATP site mTOR inhibitorsATG13BADPTENGRB10TFEBFIP200p27AKTTSC2RICTORRAPTORFOXO3PDK1MTORPIP3FOXO1ULK1RHEBMTORReceptor TyrosineKinaseseNOSS6K1FOXO4GSK3BPIP24EBP1PIK3CAPIK3CBPIK3R1PIK3R2PIK3R3PIK3CGG Protein-coupled ReceptorsHRASNRASKRAS


Description

This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell's ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success.

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Ontology Terms

 

Bibliography

  1. Merritt P Edlind, Andrew C Hsieh; ''PI3K-AKT-mTOR singaling in prostate cancer progression and androgen deprivation therapy resistance''; NIH, 2014 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106751view13:23, 17 September 2019MaintBotHMDB identifier normalization
106550view00:12, 6 September 2019KhanspersModified description
105495view05:49, 8 August 2019KhanspersModified description
89952view14:17, 6 October 2016MkutmonModified description
89754view18:10, 30 September 2016Khanspersupdated some interactions
89740view23:39, 29 September 2016KhanspersModified title
88432view20:17, 6 August 2016AlexanderPicoOntology Term : 'signaling pathway' added !
88431view20:14, 6 August 2016AlexanderPicoUpdated complex, metabolites and interactions
88430view19:34, 6 August 2016AlexanderPicoUpdated PMID
88369view21:15, 1 August 2016AAR&CoModified description
88367view21:13, 1 August 2016AAR&CoBolded Labels
88325view15:44, 1 August 2016FehrhartOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
88323view15:43, 1 August 2016FehrhartOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
88213view17:36, 31 July 2016AAR&CoModify Datanode
88206view13:59, 31 July 2016AAR&CoPeriodical save, work in progress
88205view13:46, 31 July 2016AAR&CoModify Datanode
88200view12:55, 31 July 2016AAR&CoModify Datanode
88195view12:34, 31 July 2016AAR&CoClose excess space
87101view17:17, 18 July 2016AAR&CoFixed Unconnected Lines
86821view23:23, 11 July 2016AAR&CoModified description
86820view23:22, 11 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4EBP1 GeneProductENSG00000187840 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
FOXO4GeneProductENSG00000184481 (Ensembl)
G Protein-coupled ReceptorsGeneProduct
GRB10GeneProductENSG00000106070 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP2MetaboliteHMDB10035 (HMDB)
PIP3MetaboliteHMDB10147 (HMDB)
PTENGeneProductENSG00000171862 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
Receptor Tyrosine KinasesGeneProduct
S6K1GeneProductENSG00000082701 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
eNOSGeneProductENSG00000164867 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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