Vitamin A and Carotenoid Metabolism (Bos taurus)

From WikiPathways

Jump to: navigation, search
5, 10, 12BloodROL-binding proteinsNuclear receptorsRhodopsin formationRE + dietary lipidsRetinal pigment epithelium specific???RE + dietary lipidschylomicronNucleusRE + dietary lipidsCytochrome P450 family?DietEnterocyteROL=retinol; RAL=retinaldehyde, RA = retinoic acid, RE = retinyl ester, RPE = retinal pigment epithelium PPAR pathwaysRA-binding proteins?11-cis binding protein?Liver/other organsgap junction communicationRetinolVitamin ARDH5BCMO1RBP2CYP26A113,14 dehydroretinalLuteinAWAT2RARG4-oxo-Retinoic acidRXRASCARB1CanthaxanthinADH4NPC1L1ViolaxanthinCd36ALDH1A2beta 10' apocorotenalRBP7CYP2E1RetinalVitamin A aldehydeLRATRDH10BetacaroteneABCG5RetinolVitamin ADGAT1RETSAT11-cis-RetinalLycopeneRBP1BCO2All-trans-13,14-dihydroretinolRARAABCG8RDH8ALDH1A2all-transe 4-oxo RARetinyl esterVitamin D3RPE65ALDH1A1ZeaxanthinSCARB1LRATRetinyl ester11-cis-RetinolLPLCRABP1all-trans Retinoic acidVitamin A acidSULT1A1BetacaroteneRLBP1CRABP2DHRS3BetacaroteneSULT2B1Adh1BetacaroteneRDH12AstaxanthinRDH5BCMO1Beta-CryptoxanthinALDH1A3RXRGall-trans RetinalRDH12CYP26B19-cis-Retinoic acidRBP4all-trans RetinolVitamin AMAPK1Alpha-Carotene13,14 dehydro RARXRBRARBALDH1A1ALDH1A39-cis-Retinol9-cis-RetinalSDR16C5BCMO18, 93, 4, 6, 7, 14...1, 2, 11, 139, 15, 17


Description

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP716(79968) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.''; Am J Vet Res, 1986 PubMed
  2. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.''; Nutr Cancer, 1999 PubMed
  3. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.''; J Am Diet Assoc, 1996 PubMed
  4. Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.''; Nutrition, 1996 PubMed
  5. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D; ''Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.''; OMICS, 2009 PubMed
  6. Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.''; Gastroenterology, 2003 PubMed
  7. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.''; Am J Clin Nutr, 1994 PubMed
  8. Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.''; Ann N Y Acad Sci, 1992 PubMed
  9. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.''; Invest Ophthalmol Vis Sci, 1988 PubMed
  10. Bendich A, Olson JA; ''Biological actions of carotenoids.''; FASEB J, 1989 PubMed
  11. Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.''; J Bone Miner Res, 2001 PubMed
  12. Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.''; J Lipid Res, 2002 PubMed
  13. Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.''; J Investig Dermatol Symp Proc, 1996 PubMed
  14. Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.''; Neoplasma, 2003 PubMed
  15. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.''; Am J Clin Nutr, 1992 PubMed
  16. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.''; Eur J Pediatr, 1997 PubMed
  17. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.''; Anal Chem, 1992 PubMed

History

CompareRevisionActionTimeUserComment
86817view16:39, 11 July 2016EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-cis-RetinalMetaboliteHMDB02152 (HMDB)
11-cis-RetinolMetaboliteHMDB06216 (HMDB)
13,14 dehydro RAMetabolite
13,14 dehydroretinalMetabolite
4-oxo-Retinoic acidMetaboliteHMDB06285 (HMDB)
9-cis-RetinalMetaboliteHMDB06218 (HMDB)
9-cis-Retinoic acidMetaboliteHMDB02369 (HMDB)
9-cis-RetinolMetaboliteHMDB06217 (HMDB)
ABCG5GeneProductENSBTAG00000016365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
ABCG8GeneProductENSBTAG00000016366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
ADH4GeneProductENSBTAG00000034139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:127
ALDH1A1GeneProductENSBTAG00000008103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:216
ALDH1A2GeneProductENSBTAG00000010119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8854
ALDH1A3GeneProductENSBTAG00000009125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:220
AWAT2GeneProductENSBTAG00000012281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:158835
Adh1GeneProductENSBTAG00000034189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:124
All-trans-13,14-dihydroretinolMetaboliteHMDB11618 (HMDB)
Alpha-CaroteneMetaboliteHMDB03993 (HMDB)
AstaxanthinMetaboliteHMDB02204 (HMDB)
BCMO1GeneProductENSBTAG00000001026 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53630
BCO2GeneProductENSBTAG00000034193 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83875
Beta-CryptoxanthinMetaboliteHMDB02268 (HMDB)
BetacaroteneMetaboliteHMDB00561 (HMDB)
CRABP1GeneProductENSBTAG00000012909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1381
CRABP2GeneProductENSBTAG00000005716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1382
CYP26A1GeneProductENSBTAG00000021118 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1592
CYP26B1GeneProductENSBTAG00000012212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56603
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1571
CanthaxanthinMetaboliteHMDB03154 (HMDB)
Cd36GeneProductENSBTAG00000014220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:948
DGAT1ProteinENSBTAG00000026356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694
DHRS3GeneProductENSBTAG00000024493 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9249
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
LRATGeneProductENSBTAG00000017167 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121207
LuteinMetaboliteHMDB03233 (HMDB)
LycopeneMetaboliteHMDB03000 (HMDB)
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
NPC1L1GeneProductENSBTAG00000044146 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29881
RARAGeneProductENSBTAG00000012500 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5914
RARBGeneProductENSBTAG00000011518 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5915
RARGGeneProductENSBTAG00000007592 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5916
RBP1GeneProductENSBTAG00000020028 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5947
RBP2GeneProductENSBTAG00000015056 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5948
RBP4GeneProductENSBTAG00000000442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5950
RBP7GeneProductENSBTAG00000015574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116362
RDH10GeneProductENSBTAG00000020143 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:157506
RDH12GeneProductENSBTAG00000012838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:145226
RDH5GeneProductENSBTAG00000011927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5959
RDH8GeneProductENSBTAG00000010188 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50700
RETSATGeneProductENSBTAG00000021934 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54884
RLBP1GeneProductENSBTAG00000033721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6017
RPE65GeneProductENSBTAG00000020494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6121
RXRAGeneProductENSBTAG00000017851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
RXRBGeneProductENSBTAG00000000602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6257
RXRGGeneProductENSBTAG00000016801 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6258
Retinal Vitamin A aldehydeMetaboliteHMDB01358 (HMDB)
Retinol Vitamin AMetaboliteHMDB00305 (HMDB)
Retinyl esterMetaboliteHMDB03598 (HMDB)
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
SDR16C5GeneProductENSBTAG00000018570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:195814
SULT1A1GeneProductENSBTAG00000008635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6817
SULT2B1GeneProductENSBTAG00000045498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6820
ViolaxanthinMetaboliteHMDB03101 (HMDB)
Vitamin D3MetaboliteHMDB00876 (HMDB)
ZeaxanthinMetaboliteHMDB02789 (HMDB)
all-trans RetinalMetaboliteHMDB01358 (HMDB)
all-trans Retinoic acid Vitamin A acidMetaboliteHMDB01852 (HMDB)
all-trans Retinol Vitamin AMetaboliteHMDB00305 (HMDB)
all-transe 4-oxo RAMetabolite
beta 10' apocorotenalMetabolite

Annotated Interactions

No annotated interactions
Personal tools