Striated Muscle Contraction Pathway (Homo sapiens)

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Troponin-CTropomyosinMyosin Light ChainActinActinCaContraction by Ca++Myosin HeadMyosin Binding Site(Covered)M DiskTroponin-TRegulatory ProteinsA Model of Triggering of Striated MuscleMyosin BindingOther StructuralZ DiskCaMyosin Heavy ChainTroponin-IZ DiskACTN2TPM4MYH3TNNC2NEBACTCMYBPC2TNNT1MYL2TNNI1DESVIMMYH6TNNI3TPM3MYOM1TNNT3MYBPC1MYL9ACTA2MYL3MYH8TTNACTG1TPM1ACTN4DMDTNNC1TPM2MYL1MYL4MYBPC3TMOD1TNNI2ACTA1ACTN3TNNT2TCAP


Muscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In case of voluntary action the nervous signals are initiated from the brain by so called action potentials. With reflexes these potentials are coming directly from the spinal cord. Striated muscles are a group of muscles also called skeletal and cardiac muscle tissue. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms



  1. Zhu S, Si ML, Wu H, Mo YY; ''MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).''; J Biol Chem, 2007 PubMed Europe PMC Scholia


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105826view23:04, 15 August 2019KhanspersModified description
105825view23:04, 15 August 2019KhanspersModified description
102323view08:23, 20 December 2018FehrhartChanged title due to overlap with other pathway
94665view13:20, 4 October 2017Marvin M2Connected unconnected lines and changed some lines into graphical lines
87840view11:47, 25 July 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
80200view18:52, 22 May 2015Khanspersremoved mir-21 targeting of TPM1
80147view18:06, 14 May 2015KhanspersAddednlit ref for mir-21 target
80144view17:44, 14 May 2015KhanspersAdded mir21
68970view17:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
56581view12:55, 9 January 2013AndraModified description
45112view23:02, 6 October 2011KhanspersOntology Term : 'striated muscle cell' added !
41139view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38847view17:48, 24 September 2010Khanspers
32666view15:30, 27 August 2009KhanspersPeriodical save, work in progress
32415view17:07, 15 August 2009MaintBotFixed text labels
32072view13:36, 14 August 2009MaintBotFixed group labels
21484view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Striated muscle contraction]] moved to [[Pathway:WP383]]: Moved to stable identifier
14078view10:25, 21 May 2008MartijnVanIerselall linked up
8414view13:46, 7 January 2008MaintBot[[Pathway:Human:Striated muscle contraction]] moved to [[Pathway:Homo sapiens:Striated muscle contraction]]: Renaming species
7824view16:20, 18 December 2007MaintBotfixed category names
7491view12:42, 4 November 2007MaintBotAdded categories to GPML
19547view22:18, 22 May 2007J.Fonggpml file for [[Human:Striated_muscle_contraction]]
6394view22:18, 22 May 2007Nsalomonisgpml file for [[Human:Striated_muscle_contraction]]

External references


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NameTypeDatabase referenceComment
ACTA1GeneProduct58 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
ACTCGeneProduct70 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
ACTN2GeneProduct88 (Entrez Gene) AAC2 MOUSE
ACTN3GeneProduct89 (Entrez Gene) AAC3 MOUSE
ACTN4GeneProduct81 (Entrez Gene)
DESGeneProduct1674 (Entrez Gene)
DMDGeneProduct1756 (Entrez Gene)
MYBPC1GeneProduct4604 (Entrez Gene)
MYBPC2GeneProduct4606 (Entrez Gene)
MYBPC3GeneProduct4607 (Entrez Gene)
MYH3GeneProduct4621 (Entrez Gene)
MYH6GeneProduct4624 (Entrez Gene)
MYH8GeneProduct4626 (Entrez Gene)
MYL1GeneProduct4632 (Entrez Gene)
MYL2GeneProduct4633 (Entrez Gene)
MYL3GeneProduct4634 (Entrez Gene) MLEV HUMAN
MYL4GeneProduct4635 (Entrez Gene)
MYL9GeneProduct10398 (Entrez Gene)
MYOM1GeneProduct8736 (Entrez Gene)
NEBGeneProduct4703 (Entrez Gene)
TCAPGeneProduct8557 (Entrez Gene)
TMOD1GeneProduct7111 (Entrez Gene)
TNNC1GeneProduct7134 (Entrez Gene)
TNNC2GeneProduct7125 (Entrez Gene)
TNNI1GeneProduct7135 (Entrez Gene)
TNNI2GeneProduct7136 (Entrez Gene)
TNNI3GeneProduct7137 (Entrez Gene)
TNNT1GeneProduct7138 (Entrez Gene)
TNNT2GeneProduct7139 (Entrez Gene)
TNNT3GeneProduct7140 (Entrez Gene)
TPM1GeneProduct7168 (Entrez Gene) p10469
TPM2GeneProduct7169 (Entrez Gene)
TPM3GeneProduct7170 (Entrez Gene)
TPM4GeneProduct7171 (Entrez Gene)
TTNGeneProduct7273 (Entrez Gene) similiar to hs: Q10465
VIMGeneProduct7431 (Entrez Gene)

Annotated Interactions

No annotated interactions

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