Interleukin-20 family signaling (Homo sapiens)

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1, 14, 4029, 42, 4693, 2227, 324, 18, 49, 5129, 435, 263947, 5320, 24, 5010, 12, 34, 52510, 194223, 3225422542114230, 322142, 46, 4717, 425, 6, 1514, 42, 534214, 42, 464450232, 14, 33, 422942, 4629, 42, 4611, 3642, 5329, 46, 47416, 44, 4710, 12, 194216, 44, 475, 6, 15, 4571113, 30, 35232329, 43711, 365295, 15, 48cytosolnucleoplasmIL20RA ADPIL20RA ADPp-Y1022,Y1023-JAK1 IL22IL22 IFNL1 IL22 p-Y-251,p-Y301-IL22RA1 IL20RB 2 x p-STAT3IL24 IL26 IFNL2 IL20:IL22RA1:JAK1:IL20RBADPJAK1 IL22RA1 IL24 p-STAT4 IL24p-Y-251,p-Y301-IL22RA1 JAK1 p-Y1022,Y1023-JAK1 p-Y1022,Y1023-JAK1 p-JAK1 STAT3 IL20RA ATPIL20RA p-STAT1ADPp-Y705-STAT3 IL20RA STAT5 JAK1 IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3IL20RAp-Y1007,Y1008-JAK2 p-Y343-Y517-IFNLR1 IL22RA1:JAK1:IL20RBATPIL20RBIFNLR1:JAK1IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3STAT3 TYK2 p-STAT3 IL20RA p-JAK1 IL10RB JAK1 IL26:IL20RA:JAK1p-Y705-STAT3 IL22:IL22RA1:JAK1IL10RBIL19:IL20RA:JAK1:IL20RBp-STAT3 STAT3 IL24 p-JAK1 IL19 p-Y649-STAT5A, p-STAT5B IL10RB IL20RA IL22RA1 IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2IFNLR1 ATPIFNL1IL24:IL22RA1:p-JAK1:IL20RBADPIL20RB IL10RB IFNLR1 p-Y705-STAT3 p-STAT3 JAK1 ADPSTAT4 p-STAT3 JAK1 IL20RB IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5IL10RB IL26 p-Y705-STAT3 JAK1 STAT1 p-STAT1 IL10RB IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RBIFNLR1IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3IL20RB JAK1 IL19 IL20RA IL20RB IL20RA IL26 ADPIL10RB p-TYK2 p-TYK2 p-STAT1 p-JAK1 STAT3 JAK1 IL10RB IL20RB IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3IL20RB IL20RA IL20RA p-TYK2 STAT2 IL22RA1 p-TYK2 p-JAK1 JAK2 IL10RB IL26 IL20RA IL22 STAT2 STAT1 PTPN11 JAK1 p-JAK1 STAT3 JAK1 ADPJAK1 TYK2 IL26:IL20RA:JAK1:IL10RB:TYK2p-JAK1 IL20RA:JAK1:IL20RBIL20RB IL20RA p-STAT3p-STAT3 2 x p-STAT1IL20:IL20RA:JAK1:IL20RBATPp-TYK2 ADPSTAT1 p-STAT4 STAT3PTPN11 IL20RB IFNL1 IL20RB IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3p-Y1007,Y1008-JAK2 IL10RB IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2IFNL3 ATPSTAT3 IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT32 x p-STAT1p-STAT3 IL10RB IL10RB IL22RA1 p-TYK2 p-JAK1 IL22RA1JAK1p-STAT3 STAT4 TYK2 IL20RA p-TYK2 IL22 IL10RB TYK2IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3JAK1 PTPN11ATPIL10RB STAT3ATPIL19:IL20RA:p-JAK1:IL20RB:STAT3IL20RA p-STAT1, p-STAT3IL20JAK3 STAT1 IL20 STAT3 STAT3 SOCS3 geneTYK2 STAT1, STAT3IL20RB IL24:IL22RA1:JAK1:IL20RBIL22 p-JAK1 ADPIL20RA p-Y343-Y517-IFNLR1 STAT1 p-JAK1 STAT1, STAT3ATPIL22:IL22RA1:JAK1:IL10RB:TYK2p-Y343-Y517-IFNLR1 IL20RA IL20 IFNL1 IFNL3 p-JAK1 IL26IL24 IFNL2 JAK1p-TYK2 IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1,p-STAT3IL20RB IL20 IL20RB ADPp-STAT3 IL24:IL20RA:JAK1:IL20RBADPTYK2 IL22 ATPJAK1 p-STAT1 STAT1, STAT2, STAT3,STAT4, STAT5IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2IL26 p-TYK2 IL19p-Y-251,p-Y301-IL22RA1 p-JAK3 p-JAK3 JAK1 IL24 p-Y-STAT2 p-Y705-STAT3 dimerIL24 IL22RA2:IL22IL10RB IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3IL19 IL20RB p-Y-251,p-Y301-IL22RA1 IL19:IL20RA:p-JAK1:IL20RBp-TYK2 IL20IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:p-STAT3p-Y1022,Y1023-JAK1 p-Y1022,Y1023-JAK1 IL20RA IL20RB JAK1 p-STAT1 IL24IL20RA:JAK1IL10RB IL22RA1 IL10RB:TYK2IL10RB IL22RA1 ADPIL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2p-TYK2 IL20RB IL24:IL22RA1:p-JAK1:IL20RB:p-STAT3IL20RB IL20RB IL20 IL20RA IL22RA2 p-Y649-STAT5A, p-STAT5B TYK2 p-JAK1 IFNLR1 ATPSTAT5 JAK1 p-JAK3 STAT1 IL22RA1:JAK1IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2IL20RA ATPJAK2, JAK3p-JAK1 p-STAT3 JAK1IL22RA1 ATPp-Y1007,Y1008-JAK2 IL19 IL22RA1 ATPIL10RB:TYK2IL22 p-Y705-STAT3IL24:IL22RA1:p-JAK1:IL20RB:STAT3JAK3 IFNL1 IL22 IL10RB IL24 PTPN11 JAK1 IL10RB IFNLR1 p-JAK1 IL22RA2ADPATPSTAT3 ADPp-JAK1 SOCS3 mRNAIL24 IL20RB p-STAT1 IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2IL22RA1 p-STAT1, p-Y-STAT2,p-STAT3,p-STAT4,p-STAT5IL22RA1 JAK1 IL20RB IL20 ATPIFNL2,IFNL32xp-STAT3IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3IFNL1:IFNLR1:JAK1:IL10RB:TYK2p-Y1022,Y1023-JAK1 p-STAT1 IL20 p-Y-STAT2 p-TYK2 ATPIL26:IL10RB:p-TYK2:IL20RA:p-JAK1STAT3p-STAT1 p-Y705-STAT3 dimerIFNL1 JAK2 STAT3 ADPp-JAK1 729878, 38268, 38328, 3874141328, 388, 38378, 382928328, 388, 38378, 388, 38268, 388, 38283129288, 387298, 38298502950328, 388, 38


Description

The interleukin 20 (IL20) subfamily comprises IL19, IL20, IL22, IL24 and IL26. They are members of the larger IL10 family, but have been grouped together based on their usage of common receptor subunits and similarities in their target cell profiles and biological functions. Members of the IL20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. Much of the understanding of this group of cytokines is based on IL22, which is the most studied member (Rutz et al. 2014, Akdis M et al. 2016, Longsdon et al. 2012). View original pathway at:Reactome.

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Pathway is converted from Reactome ID: 8854691
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Reactome version: 66
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Reactome Author: Jupe, Steve

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Bibliography

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  1. Rutz S, Wang X, Ouyang W.; ''The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.''; PubMed Europe PMC
  2. Gallagher G, Dickensheets H, Eskdale J, Izotova LS, Mirochnitchenko OV, Peat JD, Vazquez N, Pestka S, Donnelly RP, Kotenko SV.; ''Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10).''; PubMed Europe PMC
  3. Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S.; ''Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity.''; PubMed Europe PMC
  4. Li J, Tomkinson KN, Tan XY, Wu P, Yan G, Spaulding V, Deng B, Annis-Freeman B, Heveron K, Zollner R, De Zutter G, Wright JF, Crawford TK, Liu W, Jacobs KA, Wolfman NM, Ling V, Pittman DD, Veldman GM, Fouser LA.; ''Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2.''; PubMed Europe PMC
  5. Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A, Donnelly RP, Kotenko SV.; ''Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.''; PubMed Europe PMC
  6. Yoon SI, Logsdon NJ, Sheikh F, Donnelly RP, Walter MR.; ''Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.''; PubMed Europe PMC
  7. Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C.; ''Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.''; PubMed Europe PMC
  8. Vignali DA, Kuchroo VK.; ''IL-12 family cytokines: immunological playmakers.''; PubMed Europe PMC
  9. Ferrao R, Lupardus PJ.; ''The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions.''; PubMed Europe PMC
  10. Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T.; ''Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.''; PubMed Europe PMC
  11. Tritsaris K, Myren M, Ditlev SB, Hübschmann MV, van der Blom I, Hansen AJ, Olsen UB, Cao R, Zhang J, Jia T, Wahlberg E, Dissing S, Cao Y.; ''IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs.''; PubMed Europe PMC
  12. Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T.; ''New microRNAs from mouse and human.''; PubMed Europe PMC
  13. Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR.; ''A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.''; PubMed Europe PMC
  14. Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR.; ''Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.''; PubMed Europe PMC
  15. Yoon SI, Jones BC, Logsdon NJ, Harris BD, Deshpande A, Radaeva S, Halloran BA, Gao B, Walter MR.; ''Structure and mechanism of receptor sharing by the IL-10R2 common chain.''; PubMed Europe PMC
  16. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV.; ''The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.''; PubMed Europe PMC
  17. Wehinger J, Gouilleux F, Groner B, Finke J, Mertelsmann R, Weber-Nordt RM.; ''IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes.''; PubMed Europe PMC
  18. Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL.; ''Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.''; PubMed Europe PMC
  19. Liu L, McBride KM, Reich NC.; ''STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.''; PubMed Europe PMC
  20. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T, Kishimoto T.; ''Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.''; PubMed Europe PMC
  21. Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa JJ, Renauld JC.; ''Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.''; PubMed Europe PMC
  22. Dumoutier L, Lejeune D, Colau D, Renauld JC.; ''Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22.''; PubMed Europe PMC
  23. Novak AJ, Grote DM, Ziesmer SC, Rajkumar V, Doyle SE, Ansell SM.; ''A role for IFN-lambda1 in multiple myeloma B cell growth.''; PubMed Europe PMC
  24. Haan C, Kreis S, Margue C, Behrmann I.; ''Jaks and cytokine receptors--an intimate relationship.''; PubMed Europe PMC
  25. Sestito R, Madonna S, Scarponi C, Cianfarani F, Failla CM, Cavani A, Girolomoni G, Albanesi C.; ''STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation.''; PubMed Europe PMC
  26. Walter MR.; ''The molecular basis of IL-10 function: from receptor structure to the onset of signaling.''; PubMed Europe PMC
  27. Gad HH, Dellgren C, Hamming OJ, Vends S, Paludan SR, Hartmann R.; ''Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family.''; PubMed Europe PMC
  28. Johnston JA, Bacon CM, Finbloom DS, Rees RC, Kaplan D, Shibuya K, Ortaldo JR, Gupta S, Chen YQ, Giri JD.; ''Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.''; PubMed Europe PMC
  29. Andoh A, Shioya M, Nishida A, Bamba S, Tsujikawa T, Kim-Mitsuyama S, Fujiyama Y.; ''Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease.''; PubMed Europe PMC
  30. Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM.; ''IL-28, IL-29 and their class II cytokine receptor IL-28R.''; PubMed Europe PMC
  31. Donnelly RP, Sheikh F, Dickensheets H, Savan R, Young HA, Walter MR.; ''Interleukin-26: an IL-10-related cytokine produced by Th17 cells.''; PubMed Europe PMC
  32. Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, Renauld JC.; ''Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.''; PubMed Europe PMC
  33. Pletnev S, Magracheva E, Kozlov S, Tobin G, Kotenko SV, Wlodawer A, Zdanov A.; ''Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.''; PubMed Europe PMC
  34. Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE.; ''Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.''; PubMed Europe PMC
  35. Vandenbroeck K, Alvarez J, Swaminathan B, Alloza I, Matesanz F, Urcelay E, Comabella M, Alcina A, Fedetz M, Ortiz MA, Izquierdo G, Fernandez O, Rodriguez-Ezpeleta N, Matute C, Caillier S, Arroyo R, Montalban X, Oksenberg JR, Antigüedad A, Aransay A.; ''A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis.''; PubMed Europe PMC
  36. Lee SJ, Lee EJ, Kim SK, Jeong P, Cho YH, Yun SJ, Kim S, Kim GY, Choi YH, Cha EJ, Kim WJ, Moon SK.; ''Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A.''; PubMed Europe PMC
  37. Doyle SE, Schreckhise H, Khuu-Duong K, Henderson K, Rosler R, Storey H, Yao L, Liu H, Barahmand-pour F, Sivakumar P, Chan C, Birks C, Foster D, Clegg CH, Wietzke-Braun P, Mihm S, Klucher KM.; ''Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes.''; PubMed Europe PMC
  38. Floss DM, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, Hermanns H, Scheller J.; ''Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases.''; PubMed Europe PMC
  39. You W, Tang Q, Zhang C, Wu J, Gu C, Wu Z, Li X.; ''IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation.''; PubMed Europe PMC
  40. Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA.; ''Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases.''; PubMed Europe PMC
  41. Naeger LK, McKinney J, Salvekar A, Hoey T.; ''Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.''; PubMed Europe PMC
  42. Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, Brandt C, Jelinek L, Madden K, McKernan PA, Foster DC, Jaspers S, Chandrasekher YA.; ''Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.''; PubMed Europe PMC
  43. Sainz-Perez A, Gary-Gouy H, Gaudin F, Maarof G, Marfaing-Koka A, de Revel T, Dalloul A.; ''IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression.''; PubMed Europe PMC
  44. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV.; ''Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia.''; PubMed Europe PMC
  45. Finbloom DS, Winestock KD.; ''IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.''; PubMed Europe PMC
  46. Wang M, Tan Z, Zhang R, Kotenko SV, Liang P.; ''Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.''; PubMed Europe PMC
  47. Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC.; ''Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.''; PubMed Europe PMC
  48. Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H.; ''The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.''; PubMed Europe PMC
  49. Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, Schlutsmeyer S, Yao L, Whitmore TE, Chandrasekher Y, Grant FJ, Maurer M, Jelinek L, Storey H, Brender T, Hammond A, Topouzis S, Clegg CH, Foster DC.; ''A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist.''; PubMed Europe PMC
  50. Ferrao R, Wallweber HJ, Ho H, Tam C, Franke Y, Quinn J, Lupardus PJ.; ''The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.''; PubMed Europe PMC
  51. Jones BC, Logsdon NJ, Walter MR.; ''Structure of IL-22 bound to its high-affinity IL-22R1 chain.''; PubMed Europe PMC
  52. Braunstein J, Brutsaert S, Olson R, Schindler C.; ''STATs dimerize in the absence of phosphorylation.''; PubMed Europe PMC
  53. Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA.; ''Interleukin 20: discovery, receptor identification, and role in epidermal function.'';