IL-3 Signaling Pathway (Mus musculus)

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AutophosphorylationGlycosylationAcetylationDMACY->PMControlMA(Protein-protein interaction)Golgi apparatusDTranslocationDMTPalmitoylationReceptorCytoplasmProteolytic cleavageMAEREndosomeCY->NUDEnzyme complexDCY->PMDInhibitionDDActivationDemethylationSumoylationCYENPMUbiquitinationDephosphorylationMAAccession Number: NetPath 15DDGONucleusMolecule in the pathwayDRecruitmentProteins in a complex interactionMALigandNUDeubiquitinationDMADesumoylationDCY->NUMitochondrionDPlasma membraneMT->CYPhosphorylationDDMolecular AssociationDEndoplasmic reticulumDECMethylationCY->PMDDeacetylationReaction through unknown mechanisms/moleculesExtracellularMapk9Map2k1Mapk14SykBadFesLynBcl2l11Slc2a1Nfkb1Shc1CishBirc5Gm2423Bcl2l1PrkcaHspb1KrasTecStat3PrkacaId1Vav1Mapk3CrkRac2Il3raMrasIl3raMapkapk2RaraPxnPik3cdSos1HckSelpGene SymbolATF1Chek1Tyk2FynMmp2PILRBMmp9Akt1Rac1CblJak1Sfpi1Gsk3bIL3Stat5aPik3r1BaxRps6kb2CDC42Mapk8Ptpn6Pik3r2Stat6Slc2a1YwhabGata1CrklInpp5dGnb2l1Rapgef1Socs3LckRaf1Rap1aStat5bPtpn11Gab1BadPik3caYwhazIL3Creb1PrkcbGata2Gab2Mapk3Dnm1Mapk7Stat1MatkGsk3aKcnip3Nfkb1Shc1SrcFcer2aHras1Tnfrsf1bPpp2caVclMapk1PrkcaPtk2Atf2Grb2CSF2RBIL3CSF2RBJak2SOCS2Foxo1IL3Pak1BmxRxraBcl2


Description

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP286(r21281) with a 90% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69196view18:23, 8 July 2013MaintBotUpdated to 2013 gpml schema
67376view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-3 signaling pathway' added !
41387view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
35789view06:40, 13 February 2010MaintBotAdded description
35788view06:38, 13 February 2010MaintBotAdded description
35787view06:34, 13 February 2010MaintBotAdded description
34426view23:21, 9 December 2009MaintBotAutomatic update of empty xrefs
31442view21:06, 13 August 2009MaintBotFixed text labels
30867view00:13, 30 July 2009MaintBotConverted from Homo sapiens
21463view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-3 NetPath 15]] moved to [[Pathway:WP373]]: Moved to stable identifier
8172view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-3 NetPath 15]] moved to [[Pathway:Mus musculus:IL-3 NetPath 15]]: Renaming species
7706view16:11, 18 December 2007MaintBotfixed category names
7245view12:41, 4 November 2007MaintBotAdded categories to GPML
6460view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-3_NetPath_15]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF1GeneProduct11908 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Atf2GeneProduct11909 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
BaxGeneProduct12028 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
Bcl2l11GeneProduct12125 (Entrez Gene)
Bcl2l1GeneProduct12048 (Entrez Gene)
Birc5GeneProduct11799 (Entrez Gene)
BmxGeneProduct12169 (Entrez Gene)
CDC42GeneProduct12540 (Entrez Gene)
CSF2RBGeneProduct12983 (Entrez Gene)
CblGeneProduct12402 (Entrez Gene)
Chek1GeneProduct12649 (Entrez Gene)
CishGeneProduct12700 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
CrklGeneProduct12929 (Entrez Gene)
Dnm1GeneProduct13429 (Entrez Gene)
Fcer2aGeneProduct14128 (Entrez Gene)
FesGeneProduct14159 (Entrez Gene)
Foxo1GeneProduct56458 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Gab2GeneProduct14389 (Entrez Gene)
Gata1GeneProduct14460 (Entrez Gene)
Gata2GeneProduct14461 (Entrez Gene)
Gene SymbolGeneProduct
Gm2423GeneProduct100039786 (Entrez Gene)
Gnb2l1GeneProduct14694 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gsk3aGeneProduct606496 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
HckGeneProduct15162 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
Hspb1GeneProduct15507 (Entrez Gene)
IL3GeneProduct16187 (Entrez Gene)
Id1GeneProduct15901 (Entrez Gene)
Il3raGeneProduct16188 (Entrez Gene)
Inpp5dGeneProduct16331 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
Kcnip3GeneProduct56461 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
LckGeneProduct16818 (Entrez Gene)
LynGeneProduct17096 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
Mapkapk2GeneProduct17164 (Entrez Gene)
MatkGeneProduct17179 (Entrez Gene)
Mmp2GeneProduct17390 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
MrasGeneProduct17532 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
PILRBGeneProduct
Pak1GeneProduct18479 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Ppp2caGeneProduct19052 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Ptpn6GeneProduct15170 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rac2GeneProduct19354 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Rap1aGeneProduct109905 (Entrez Gene)
Rapgef1GeneProduct107746 (Entrez Gene)
RaraGeneProduct19401 (Entrez Gene)
Rps6kb2GeneProduct58988 (Entrez Gene)
RxraGeneProduct20181 (Entrez Gene)
SOCS2GeneProduct216233 (Entrez Gene)
SelpGeneProduct20344 (Entrez Gene)
Sfpi1GeneProduct20375 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Slc2a1GeneProduct20525 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
Stat6GeneProduct20852 (Entrez Gene)
SykGeneProduct20963 (Entrez Gene)
TecGeneProduct21682 (Entrez Gene)
Tnfrsf1bGeneProduct21938 (Entrez Gene)
Tyk2GeneProduct54721 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)
VclGeneProduct22330 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene)

Annotated Interactions

No annotated interactions
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