Association Between Physico-Chemical Features and Toxicity Associated Pathways (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Adhesion migrationActin polymerisationPancreatic cancerAmyotrophic lateral sclerosis (ALS)ErbB singaling pathwayReceptor ubiquiltylationLong-term depressionDegradationCell cycleDNARegulation of Actin cytoskeletonDisturbance of mitochondrial respirationFocal adhesionScaffoldCellular targetsWnt signaling pathwayO2CBLCa2+PeroxynitriteNOFZD1FZD2FZD3FZD4FZD5FZD6FZD7FZD8FZD9FZD10ACTA1PLCGCAMKARP3ARP2GRB2STAT5SOS1ArginineDVL1ELKJUNMLCPCTNNB1PP2AAPCROCK2Shc1MYCWNT16NEFHNEFMNEFLPKB/AKTAXIN1RafRasPAKPI3KMEKSOD1FAKGSK3BFN1DAAM1JNKNCKRHOAGluRp21p27GPX1NOS1GlutamateMLCMAPK/ERKJNKKTGFAWNT11PFN1PFN2PFN3PFN4TMSB4Cell CycleSrcMLCKNOS1SOD1SOD1NOROSOHH20Ca2+ErbB-1ErbB-2ErbB-4Name: Association Between Physico-Chemical Features and Toxicity Associated PathwaysOrganism: Homo sapiens


Description

This pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated with toxicity. The pathways associated with chemical hits (Wnt signaling, long-term depression, and ErbB signaling pathways) and the pathways associated with toxicity (focal adhesion, ALS, and pancreatic Cancer respectively) have been shown to have possible links through shared genes between the two pathways. The mechanisms of action presented by these links were only implied by the toxicity pathways.

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Ontology Terms

 

Bibliography

  1. Antczak P, Ortega F, Chipman JK, Falciani F; ''Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.''; PLoS One, 2010 PubMed

History

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90113view21:26, 13 October 2016Khanspersoverhaul
90112view20:38, 13 October 2016KhanspersModified title
88751view18:36, 14 August 2016AAR&CoFixed Unonnected Line
88750view18:34, 14 August 2016AAR&CoOntology Term : 'pancreatic cancer' added !
88749view18:33, 14 August 2016AAR&CoOntology Term : 'amyotrophic lateral sclerosis disease pathway' added !
88748view18:32, 14 August 2016AAR&CoModified title
88535view00:46, 11 August 2016AAR&CoOntology Term : 'signaling pathway' added !
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86139view13:23, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA1GeneProductENSG00000143632 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ARP2GeneProductENSG00000138071 (Ensembl)
ARP3GeneProductENSG00000115091 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
ArginineMetaboliteHMDB00517 (HMDB)
CAMK GeneProductENSG00000134072 (Ensembl)
CBLGeneProductENSG00000110395 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Ca2+MetaboliteCHEBI:48760 (ChEBI)
Cell CyclePathwayWP179 (WikiPathways)
DAAM1GeneProductENSG00000100592 (Ensembl) assists in formation of Dvl-Rho complex
DVL1GeneProductENSG00000107404 (Ensembl)
ELKGeneProductENSG00000126767 (Ensembl)
ErbB-1GeneProductENSG00000146648 (Ensembl)
ErbB-2GeneProductENSG00000141736 (Ensembl)
ErbB-4GeneProductENSG00000178568 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
  • PRK2
  • Focal adhesion kinase
FN1GeneProductENSG00000115414 (Ensembl)
FZD10GeneProductENSG00000111432 (Ensembl)
FZD1GeneProductENSG00000157240 (Ensembl)
FZD2GeneProductENSG00000180340 (Ensembl)
FZD3GeneProductENSG00000104290 (Ensembl)
FZD4GeneProductENSG00000174804 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD6GeneProductENSG00000164930 (Ensembl)
FZD7GeneProductENSG00000155760 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
FZD9GeneProductENSG00000188763 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
GluRGeneProductP42261 (Uniprot-TrEMBL) General glutamate receptor
Glutamate MetaboliteHMDB60475 (HMDB)
H20MetaboliteCHEBI:15377 (ChEBI)
JNKGeneProductENSG00000107643 (Ensembl)
JNKKGeneProductENSG00000065559 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MAPK/ERKGeneProductENSG00000100030 (Ensembl)
MEK GeneProductENSG00000169032 (Ensembl)
MLCGeneProductENSG00000168530 (Ensembl)
MLCKGeneProductENSG00000065534 (Ensembl) myosin light chain kinase
MLCPGeneProductENSG00000228868 (Ensembl) myosin-light chain phosphatase
MYCGeneProductENSG00000136997 (Ensembl)
NCKGeneProductENSG00000158092 (Ensembl)
NEFHGeneProductENSG00000100285 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NOS1GeneProductENSG00000089250 (Ensembl)
O2MetaboliteCHEBI:15379 (ChEBI)
OHMetaboliteCHEBI:44641 (ChEBI)
PAKGeneProductENSG00000149269 (Ensembl)
PFN1GeneProductENSG00000108518 (Ensembl)
PFN2GeneProductENSG00000070087 (Ensembl)
PFN3GeneProductENSG00000196570 (Ensembl)
PFN4GeneProductENSG00000176732 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl)
PKB/AKTGeneProductENSG00000142208 (Ensembl)
PLCGGeneProductENSG00000124181 (Ensembl)
PP2AGeneProductENSG00000113575 (Ensembl)
PeroxynitriteMetaboliteHMDB02179 (HMDB)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK2GeneProductENSG00000134318 (Ensembl)
ROSMetaboliteHMDB03125 (HMDB)
RafGeneProductENSG00000132155 (Ensembl)
RasGeneProductENSG00000132155 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT5GeneProductENSG00000126561 (Ensembl)
Shc1 GeneProductENSG00000160691 (Ensembl)
Src GeneProductENSG00000197122 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TMSB4GeneProductP62328 (Uniprot-TrEMBL)
WNT11GeneProductENSG00000085741 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
p21GeneProductENSG00000124762 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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