Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway (Homo sapiens)

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1RTK/MAPK PathwayTGFB PathwayOxidativeStressesLegendOS pathwayECSITNQO1LOXL4CDC37NFE2L2SIRT1SUV39H1NRF1TGFB1COL2A1BMP2EXOC6PKD1FN1ANXA5FGF7DDR1IGFBP7Direct physical interactionTranscriptional activation by OS pathwayImpact by OS pathway via phosphorylation, activity or nuclear-cytoplasmic distribution of Nrf1/2 proteinsDirect interaction, with repression


This pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAPK and TGFB pathways. These pathways along with oxidative stress promotes NRF1/2 activation of theoxidative stress pathway. This pathway promotes the transcription of NQO1, ECSIT, EXOC6, and SIRT1. SIRT1 then activates SUV39H1. LOXL2 also activates some of these proteins downstream in the pathway (SUV39H1, EXOC6, ECSIT). This pathway has been modeled after figure 7 in Deng et al.

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  1. Deng H, Lv L, Li Y, Zhang C, Meng F, Pu Y, Xiao J, Qian L, Zhao W, Liu Q, Zhang D, Wang Y, Zhang H, He Y, Zhu J; ''miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway.''; Mol Cancer, 2014 PubMed Europe PMC


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90107view18:28, 13 October 2016KhanspersModified title
90106view18:27, 13 October 2016Khanspersadded legend
90105view18:22, 13 October 2016Khansperscleanup and xrefs
88614view01:16, 12 August 2016AAR&CoEdited Data Node
88613view01:15, 12 August 2016AAR&CoEdited Pathways
87046view22:47, 17 July 2016AlexanderPicoModified description
87045view22:46, 17 July 2016AlexanderPicoOntology Term : 'disease pathway' added !
87044view22:45, 17 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
87043view22:45, 17 July 2016AlexanderPicoOntology Term : 'oxidative stress response pathway' added !
87042view22:44, 17 July 2016AlexanderPicoOntology Term : 'bladder cancer pathway' added !
87041view22:41, 17 July 2016AlexanderPicoReduced white space
87040view22:39, 17 July 2016AlexanderPicoFixed interactions and updated OS
87039view22:32, 17 July 2016AlexanderPicoAdded pathway identifiers
86014view11:10, 25 June 2016AAR&CoModified description
86013view10:56, 25 June 2016AAR&CoAdd Citation
86012view10:54, 25 June 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
ANXA5GeneProductENSG00000164111 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
CDC37GeneProductENSG00000105401 (Ensembl)
COL2A1GeneProductENSG00000139219 (Ensembl)
DDR1GeneProductENSG00000204580 (Ensembl)
ECSITGeneProductENSG00000130159 (Ensembl)
EXOC6GeneProductENSG00000138190 (Ensembl)
FGF7GeneProductENSG00000140285 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
IGFBP7GeneProductENSG00000163453 (Ensembl)
LOXL4GeneProductENSG00000138131 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
NRF1GeneProductENSG00000106459 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SUV39H1GeneProductENSG00000101945 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)

Annotated Interactions

No annotated interactions

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