EDA Signalling in Hair Follicle Development (Mus musculus)

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1Induction/PatterningEDA-A5 isoformShhRelbProtein Wntp65Cell DifferentiationEdaraddNfkb2Nfkb1PtcDkk4Cell GrowthRelbRelEDA-A1 isoformDkk1RelaLtbEdarGli1p50Sostdc1Bmp


EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

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Ontology Terms



  1. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D; ''Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia


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97556view15:07, 24 May 2018Mkutmonchanged "Ensembl Mouse" to "Ensembl"
97555view15:06, 24 May 2018Mkutmoncreated complex for nfkb
89222view21:43, 23 August 2016KhanspersOntology Term : 'CL:0000477' removed !
89221view21:43, 23 August 2016KhanspersOntology Term : 'hair follicle cell' added !
89220view21:42, 23 August 2016KhanspersOntology Term : 'follicle cell' added !
88463view22:55, 9 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88462view22:54, 9 August 2016AAR&CoEdited Labels and Interactions
87955view13:08, 25 July 2016SusanOntology Term : 'nuclear factor kappa B signaling pathway' added !
85916view18:06, 21 June 2016AAR&CoModified description
85773view18:58, 12 June 2016AAR&CoModified description
85770view18:53, 12 June 2016AAR&CoEdited interaction
85769view18:52, 12 June 2016AAR&CoAdded new interactions
85768view18:37, 12 June 2016AAR&CoQuick edit to datanode annotation or property
85767view18:34, 12 June 2016AAR&CoAdded Intermediate Protein
85766view18:14, 12 June 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
BmpGeneProductENSMUSG00000022098 (Ensembl)
Cell DifferentiationPathwayWP2082 (WikiPathways)
Cell GrowthPathway
Dkk1GeneProductENSMUSG00000024868 (Ensembl)
Dkk4GeneProductENSMUSG00000031535 (Ensembl)
EDA-A1 isoformProteinQ3UV69 (Uniprot-TrEMBL)
EDA-A5 isoformProteinQ1L2D9 (Uniprot-TrEMBL)
EdarGeneProductENSMUSG00000003227 (Ensembl)
EdaraddGeneProductENSMUSG00000095105 (Ensembl)
Gli1GeneProductENSMUSG00000025407 (Ensembl)
LtbGeneProductENSMUSG00000024399 (Ensembl)
Nfkb1GeneProductENSMUSG00000028163 (Ensembl)
Nfkb2GeneProductENSMUSG00000025225 (Ensembl)
Protein WntProteinA2A649 (Uniprot-TrEMBL)
PtcGeneProductENSMUSG00000021466 (Ensembl)
RelGeneProductENSMUSG00000020275 (Ensembl)
RelaGeneProductENSMUSG00000024927 (Ensembl)
RelbGeneProductENSMUSG00000002983 (Ensembl)
ShhGeneProductENSMUSG00000002633 (Ensembl)
Sostdc1GeneProductENSMUSG00000036169 (Ensembl)
p50GeneProductENSMUSG00000044475 (Ensembl)
p65GeneProductENSMUSG00000024927 (Ensembl)

Annotated Interactions

No annotated interactions

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