Hepatitis C and Hepatocellular Carcinoma (Homo sapiens)

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1Cell Growth and SurvivalCell MigrationMMP1CDKN1AJAK1CASP9CASP3CCND1TGFB1AngiogenesisCXCR1SOS1GRB2PODXLPTPN11CCND1ApoptosisFRZBBIRC5FASLGMAPK SignalingMIR744VEGFABRCA1LEF1MAPK3IL6HIF1ABIRC3MYOFTP53Cytoskeleton ActivationNFKB1 SignalingNFKB1VAV2RRM2MIR34ASMAD3MYCE2F2PI3K SignalingCell ProliferationVEGFAIL6RBCL2L1Cell Cycle ProgressionSTAT3CTTNWNT SignalingCell MigrationDNA RepairAKT1IL8COL4A2PTGS2MAPK14UCHL1CD44RAC1HNF1AMYCJUNCCND1MYCMAPK SignalingMYCCell ProliferationCell ProliferationAngiogenesisApoptosisCASP9CASP7MIR34AMIR155MIR34AMIR155MIR34AMIR155MIR24-1MIR24-2MIR92A1MIR92A2BIRC3BCL2L1ApoptosisNOS2AngiogenesisMIR34AMAPK SignalingMAPK8JUNCCND1IL8MMP1SMAD4CDKN1ATGFBR1MIR24-1MIR24-2MIR744MAPK SignalingApoptosisMIR155AngiogenesisTNFSS10Cell ProliferationCell Proliferation


Description

Pathway model based on hub miRNAs and their putative targets from network analysis.

- From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/).

- After topological analysis and network visualization in Cytoscape, the top hub genes were identified. - miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network.

Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, Ghavami S, Alavian SE, Rezaei Moghadam A, Amiri M; ''How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.''; Hepat Mon, 2016 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106591view19:33, 10 September 2019KhanspersModified description
105615view04:56, 10 August 2019KhanspersModified description
103011view15:22, 31 January 2019Mkutmonupdated outdated Ensembl identifier (MIR34A)
102150view18:57, 4 December 2018Khanspersupdated mirna identifiers
97632view10:53, 31 May 2018AMTanOntology Term : 'hepatocellular carcinoma' added !
88640view14:54, 12 August 2016JmeliusOntology Term : 'disease pathway' added !
85722view23:14, 6 June 2016KhanspersModified description
85720view20:53, 6 June 2016KhanspersAdded one final interaction
85719view20:49, 6 June 2016KhanspersModified description
85718view20:48, 6 June 2016KhanspersModified description
85714view20:39, 6 June 2016KhanspersModified description
85713view20:39, 6 June 2016KhanspersModified description
85700view18:34, 6 June 2016KhanspersOntology Term : 'hepatocyte' added !
85699view18:33, 6 June 2016KhanspersOntology Term : 'carcinoma' added !
85698view18:32, 6 June 2016KhanspersOntology Term : 'hepatitis' added !
85697view18:31, 6 June 2016KhanspersModified description
85696view18:28, 6 June 2016Khanspersupdate
85566view22:54, 31 May 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BIRC5GeneProductENSG00000089685 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
CTTNGeneProductENSG00000085733 (Ensembl)
CXCR1GeneProductENSG00000163464 (Ensembl)
Cell Cycle ProgressionPathwayWP45 (WikiPathways)
Cell MigrationPathway
Cell ProliferationPathway
Cytoskeleton ActivationPathway
DNA RepairPathwayWP707 (WikiPathways)
E2F2GeneProductENSG00000007968 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FRZBGeneProductENSG00000162998 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HNF1AGeneProductENSG00000135100 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
IL8GeneProductENSG00000169429 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MIR155GeneProductENSG00000283904 (Ensembl)
MIR24-1GeneProductENSG00000284459 (Ensembl)
MIR24-2GeneProductENSG00000284387 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIR744GeneProductENSG00000266297 (Ensembl)
MIR92A1GeneProductMIR92A1 (HGNC)
MIR92A2GeneProductENSG00000284538 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
NFKB1 SignalingPathway
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
PI3K SignalingPathway
PODXLGeneProductENSG00000128567 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RRM2GeneProductENSG00000171848 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TNFSS10GeneProductENSG00000117560 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCHL1GeneProductENSG00000154277 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
WNT SignalingPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions

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