Insulin signalling in human adipocytes (diabetic condition) (Homo sapiens)

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1IRS1307S6IRiIRipAS160IRS1p307S6pPKBXpmTORC2mTORC1PKB308p473pS6KpGLUT4mGLUT4IRpPKB308pIRIRS1pPKB473pmTORC2aS6KmTORC1aXIRinsIRS1AS160p


Description

The paper describes insulin signalling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signalling under diabetic condition. Insulin signalling under normal condition is represented in WP3634. The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000449 from the BioModels Database directly. The layout has been improved manually.

Quality Tags

Ontology Terms

 

Bibliography

  1. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand EM, Cedersund G, Strålfors P; ''Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.''; J Biol Chem, 2013 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
102468view06:00, 24 December 2018EgonwFixed data sources.
97677view13:11, 1 June 2018AMTanOntology Term : 'fat cell' added !
86059view23:20, 28 June 2016KhanspersOntology Term : 'insulin signaling pathway' added !
86058view23:19, 28 June 2016KhanspersOntology Term : 'diabetes mellitus' added !
85137view01:57, 19 April 2016AnweshaModified description
85135view01:55, 19 April 2016AnweshaModified description
85132view01:48, 19 April 2016AnweshaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AS160ProteinO60343 (Uniprot-TrEMBL)
AS160pGeneProductPATO:0002220 (pato)
GLUT4ProteinP14672 (Uniprot-TrEMBL)
GLUT4mProteinP14672 (Uniprot-TrEMBL)
IRProteinP06213 (Uniprot-TrEMBL)
IRS1307ProteinP35568 (Uniprot-TrEMBL)
IRS1ProteinP35568 (Uniprot-TrEMBL)
IRS1p307ProteinP35568 (Uniprot-TrEMBL)
IRS1pProteinP35568 (Uniprot-TrEMBL)
IRiProteinP06213 (Uniprot-TrEMBL)
IRinsProteinP06213 (Uniprot-TrEMBL)
IRipProteinP06213 (Uniprot-TrEMBL)
IRpProteinP06213 (Uniprot-TrEMBL)
PKB308p473pProteinP31751 (Uniprot-TrEMBL)
PKB308pProteinP31751 (Uniprot-TrEMBL)
PKB473pProteinP31751 (Uniprot-TrEMBL)
PKBProteinP31751 (Uniprot-TrEMBL)
S6KProteinP23443 (Uniprot-TrEMBL)
S6KpProteinP23443 (Uniprot-TrEMBL)
S6ProteinP62753 (Uniprot-TrEMBL)
S6pProteinP62753 (Uniprot-TrEMBL)
XMetaboliteCHEBI:36080 (ChEBI)
XpMetaboliteC00562 (KEGG Compound)
mTORC1ProteinP42345 (Uniprot-TrEMBL)
mTORC1aProteinP42345 (Uniprot-TrEMBL)
mTORC2ProteinP42345 (Uniprot-TrEMBL)
mTORC2aProteinP42345 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
AS160O60343 (Uniprot-TrEMBL)
AS160SBGN-CatalysisO60343 (Uniprot-TrEMBL)
AS160SBGN-ProductionO60343 (Uniprot-TrEMBL)
AS160pPATO:0002220 (pato)
AS160pSBGN-CatalysisPATO:0002220 (pato)
AS160pSBGN-InhibitionPATO:0002220 (pato)
AS160pSBGN-ProductionPATO:0002220 (pato)
GLUT4P14672 (Uniprot-TrEMBL)
GLUT4SBGN-CatalysisP14672 (Uniprot-TrEMBL)
GLUT4SBGN-ProductionP14672 (Uniprot-TrEMBL)
GLUT4mP14672 (Uniprot-TrEMBL)
GLUT4mSBGN-CatalysisP14672 (Uniprot-TrEMBL)
GLUT4mSBGN-ProductionP14672 (Uniprot-TrEMBL)
IRP06213 (Uniprot-TrEMBL)
IRS1307P35568 (Uniprot-TrEMBL)
IRS1307SBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1307SBGN-ProductionP35568 (Uniprot-TrEMBL)
IRS1P35568 (Uniprot-TrEMBL)
IRS1SBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1SBGN-ProductionP35568 (Uniprot-TrEMBL)
IRS1p307P35568 (Uniprot-TrEMBL)
IRS1p307SBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1p307SBGN-ProductionP35568 (Uniprot-TrEMBL)
IRS1pP35568 (Uniprot-TrEMBL)
IRS1pSBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1pSBGN-ProductionP35568 (Uniprot-TrEMBL)
IRSBGN-CatalysisP06213 (Uniprot-TrEMBL)
IRSBGN-ProductionP06213 (Uniprot-TrEMBL)
IRiP06213 (Uniprot-TrEMBL)
IRiSBGN-CatalysisP06213 (Uniprot-TrEMBL)
IRinsP06213 (Uniprot-TrEMBL)
IRinsSBGN-CatalysisP06213 (Uniprot-TrEMBL)
IRinsSBGN-ProductionP06213 (Uniprot-TrEMBL)
IRipP06213 (Uniprot-TrEMBL)
IRipSBGN-CatalysisP06213 (Uniprot-TrEMBL)
IRpP06213 (Uniprot-TrEMBL)
IRpSBGN-CatalysisP06213 (Uniprot-TrEMBL)
IRpSBGN-ProductionP06213 (Uniprot-TrEMBL)
PKB308p473pP31751 (Uniprot-TrEMBL)
PKB308p473pSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKB308p473pSBGN-ProductionP31751 (Uniprot-TrEMBL)
PKB308pP31751 (Uniprot-TrEMBL)
PKB308pSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKB308pSBGN-ProductionP31751 (Uniprot-TrEMBL)
PKB473pP31751 (Uniprot-TrEMBL)
PKB473pSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKB473pSBGN-ProductionP31751 (Uniprot-TrEMBL)
PKBP31751 (Uniprot-TrEMBL)
PKBSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKBSBGN-ProductionP31751 (Uniprot-TrEMBL)
S6KP23443 (Uniprot-TrEMBL)
S6KSBGN-CatalysisP23443 (Uniprot-TrEMBL)
S6KSBGN-ProductionP23443 (Uniprot-TrEMBL)
S6KpP23443 (Uniprot-TrEMBL)
S6KpSBGN-CatalysisP23443 (Uniprot-TrEMBL)
S6KpSBGN-ProductionP23443 (Uniprot-TrEMBL)
S6P62753 (Uniprot-TrEMBL)
S6SBGN-CatalysisP62753 (Uniprot-TrEMBL)
S6SBGN-ProductionP62753 (Uniprot-TrEMBL)
S6pP62753 (Uniprot-TrEMBL)
S6pSBGN-CatalysisP62753 (Uniprot-TrEMBL)
S6pSBGN-ProductionP62753 (Uniprot-TrEMBL)
SBGN-ProductionP06213 (Uniprot-TrEMBL)
XCHEBI:36080 (ChEBI)
XSBGN-CatalysisCHEBI:36080 (ChEBI)
XSBGN-ProductionCHEBI:36080 (ChEBI)
XpC00562 (kegg.compound)
XpSBGN-CatalysisC00562 (kegg.compound)
XpSBGN-ProductionC00562 (kegg.compound)
mTORC1P42345 (Uniprot-TrEMBL)
mTORC1SBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC1SBGN-ProductionP42345 (Uniprot-TrEMBL)
mTORC1aP42345 (Uniprot-TrEMBL)
mTORC1aSBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC1aSBGN-ProductionP42345 (Uniprot-TrEMBL)
mTORC2P42345 (Uniprot-TrEMBL)
mTORC2SBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC2SBGN-ProductionP42345 (Uniprot-TrEMBL)
mTORC2aP42345 (Uniprot-TrEMBL)
mTORC2aSBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC2aSBGN-ProductionP42345 (Uniprot-TrEMBL)
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