Caffeine and Theobromine metabolism (Homo sapiens)

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Metabolism pathway of two compounds commonly found in human samples: caffeine and theobromine.

Quality Tags

Ontology Terms



  1. Denis M. Grant, Bing K. Tang, Werner Kalow; ''Variability in caffeine metabolism''; Clinical Pharmacology and Therapeutics, 1983


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85154view12:02, 21 April 2016MaintBotOntology Term : 'caffeine metabolic pathway' added !
85153view11:55, 21 April 2016MaintBotOntology Term : 'xenobiotic metabolic pathway' added !
85116view10:46, 17 April 2016EgonwAdded an XMetDB interaction ID.
85115view10:38, 17 April 2016EgonwModified description
85114view10:37, 17 April 2016EgonwAdded a reference.
85113view10:18, 17 April 2016EgonwNew pathway

External references


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NameTypeDatabase referenceComment
1,7-dimethyluric acidMetaboliteHMDB11103 (HMDB)
1-methyluric acidMetaboliteHMDB03099 (HMDB)
1-methylxanthineMetaboliteHMDB10738 (HMDB)
3,7-dimethyluric acidMetaboliteHMDB01982 (HMDB)
7-methyluric acidMetaboliteHMDB11107 (HMDB)
7-methylxanthineMetaboliteHMDB01991 (HMDB)
AFMUMetaboliteCHEBI:32643 (ChEBI)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
NAT2GeneProductENSG00000156006 (Ensembl)
Purine metabolismPathway
XDHGeneProductENSG00000158125 (Ensembl)
XanthineMetaboliteHMDB00292 (HMDB)
caffeineMetaboliteHMDB01847 (HMDB)
paraxanthineMetaboliteHMDB01860 (HMDB)
theobromineMetaboliteHMDB02825 (HMDB)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
caffeineparaxanthinemim-conversionXMETDB64 (XMetDB)
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