Photodynamic therapy-induced unfolded protein response (Homo sapiens)

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Photodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, and ATF4.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed Europe PMC Scholia
  2. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed Europe PMC Scholia


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106539view00:07, 6 September 2019KhanspersModified description
105786view19:46, 15 August 2019KhanspersModified description
89330view09:58, 4 September 2016Mkutmonfix unconnected lines
88318view15:37, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
86061view23:29, 28 June 2016KhanspersOntology Term : 'cancer' added !
85990view19:27, 22 June 2016KhanspersModified title
84544view19:08, 1 March 2016MaintBotConnected interactions and created groups
84532view20:04, 29 February 2016RuudweijerAdded reference.
84499view07:36, 26 February 2016RuudweijerModified description
84498view07:35, 26 February 2016RuudweijerModified title
84459view18:12, 25 February 2016RuudweijerNew pathway

External references


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NameTypeDatabase referenceComment
ASNSGeneProduct440 (Entrez Gene)
ATF3GeneProduct467 (Entrez Gene)
ATF4GeneProduct468 (Entrez Gene)
ATF6GeneProduct22926 (Entrez Gene)
BBC3GeneProduct27113 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
CALRGeneProduct811 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
DNAJB11GeneProduct51726 (Entrez Gene)
DNAJB9GeneProduct4189 (Entrez Gene)
DNAJC3GeneProduct5611 (Entrez Gene)
EDEM1GeneProduct9695 (Entrez Gene)
EIF2AGeneProduct83939 (Entrez Gene)
EIF2AK3GeneProduct9451 (Entrez Gene)
ERN1GeneProduct2081 (Entrez Gene)
ERP27GeneProduct121506 (Entrez Gene)
HSP90B1GeneProduct7184 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
NARSGeneProduct4677 (Entrez Gene)
NFE2L2GeneProduct4780 (Entrez Gene)
PDIA6GeneProduct10130 (Entrez Gene)
PPP1R15AGeneProduct23645 (Entrez Gene)
SULT1E1GeneProduct6783 (Entrez Gene)
TRIB3GeneProduct57761 (Entrez Gene)
UBE2E1GeneProduct7324 (Entrez Gene)
WARSGeneProduct7453 (Entrez Gene)
XBP1GeneProduct7494 (Entrez Gene)

Annotated Interactions

No annotated interactions

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