Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling (Homo sapiens)

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1, 2ROSMultidrug resistanceGene transcriptionHMOX1ABCC3GCLMGSTP1ABCG2ABCC6ABCC4JUNABCC2FOSGCLCKEAP1OHOHMAPK12MAPK13MAPK11NFE2L2MAPK14MAPK8KEAP1NFE2L2NFE2L2Antioxidant synthesis/recyclingNeutralization of toxinsEPHX1CES1NQO2SRXN1NQO1


Photodynamic therapy may induce an antioxidant response mediated by NFE2L2.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed Europe PMC Scholia
  2. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed Europe PMC Scholia


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106540view00:07, 6 September 2019KhanspersModified description
105785view19:45, 15 August 2019KhanspersModified description
95149view03:39, 17 November 2017AlexanderPicoupdated interactions
88317view15:37, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
87392view11:05, 22 July 2016MaintBotadded missing graphids
86064view23:30, 28 June 2016KhanspersOntology Term : 'cancer' added !
85989view19:27, 22 June 2016KhanspersModified title
84549view19:22, 1 March 2016MaintBotAdded OH states
84543view19:06, 1 March 2016MaintBotConnected interactions
84531view20:03, 29 February 2016RuudweijerAdded reference
84501view07:37, 26 February 2016RuudweijerModified description
84500view07:37, 26 February 2016RuudweijerModified title
84458view18:11, 25 February 2016RuudweijerNew pathway

External references


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NameTypeDatabase referenceComment
ABCC2GeneProduct1244 (Entrez Gene)
ABCC3GeneProduct8714 (Entrez Gene)
ABCC4GeneProduct10257 (Entrez Gene)
ABCC6GeneProduct368 (Entrez Gene)
ABCG2GeneProduct9429 (Entrez Gene)
CES1GeneProduct1066 (Entrez Gene)
EPHX1GeneProduct2052 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GSTP1GeneProduct2950 (Entrez Gene)
HMOX1GeneProduct3162 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KEAP1GeneProduct9817 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
NFE2L2GeneProduct4780 (Entrez Gene)
NQO1GeneProduct1728 (Entrez Gene)
NQO2GeneProduct4835 (Entrez Gene)
SRXN1GeneProduct140809 (Entrez Gene)

Annotated Interactions

No annotated interactions

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