Transcription factor regulation in adipogenesis (Homo sapiens)

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Nucleus713, 87118753835383, 8372, 43672777833, 87GlucocorticoidsLipids/FA oxidationERAdipocyte Secretory ProductsROSLipidsGenes involved in:Mitochondrial uncouplingFA Beta-oxidationOxidative phosphorylationTCA cycleGlycolysisMitochondriaINSR7RXRA2, 4LPIN16PCK22, 4CEBPA3, 8GLUT45PPARG2-4, 8CREB13CEBPBCEBPDNR3C13NRIP15IRS1IRS27ADIPOQLEP8JNK7FOXO1A3TWIST11PPARGC1A1TNFIL61NRIP1557


The transcription factors involved in adipogenesis are shown in the current pathway. Adipogensis is the biological proces of cell differentation in which preadipocytes are converted into adipocytes.

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Ontology Terms



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  1. Dobrian AD; ''A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue.''; Front Endocrinol (Lausanne), 2012 PubMed
  2. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM; ''PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.''; Mol Cell Biol, 1995 PubMed
  3. Siersbæk R, Nielsen R, Mandrup S; ''Transcriptional networks and chromatin remodeling controlling adipogenesis.''; Trends Endocrinol Metab, 2012 PubMed
  4. Beale EG, Forest C, Hammer RE; ''Regulation of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes.''; Biochimie, 2003 PubMed
  5. Rosell M, Jones MC, Parker MG; ''Role of nuclear receptor corepressor RIP140 in metabolic syndrome.''; Biochim Biophys Acta, 2011 PubMed
  6. Miranda M, Escoté X, Alcaide MJ, Solano E, Ceperuelo-Mallafré V, Hernández P, Wabitsch M, Vendrell J; ''Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolyticgenes.''; Am J Physiol Endocrinol Metab, 2010 PubMed
  7. Hotamisligil GS; ''Inflammation and metabolic disorders.''; Nature, 2006 PubMed
  8. Lowe CE, O'Rahilly S, Rochford JJ; ''Adipogenesis at a glance.''; J Cell Sci, 2011 PubMed


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88581view19:16, 11 August 2016Mkutmonfix unconnected lines
85185view14:36, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
84770view09:29, 18 March 2016EgonwGave Glucocorticoids an identifier (semantic meaning).
84378view06:02, 18 February 2016EgonwOntology Term : 'fat cell' added !
84377view05:52, 18 February 2016EgonwOntology Term : 'signaling pathway pertinent to development' added !
84365view19:45, 16 February 2016KhanspersConnected interactions
84133view15:53, 18 January 2016Mkutmonupdated layout
84023view10:07, 11 January 2016SusanConnect lines
84022view10:04, 11 January 2016SusanModified description
83984view19:19, 7 January 2016Ingrid.felicidadeModified title
83983view19:17, 7 January 2016Ingrid.felicidadeNew pathway

External references


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NameTypeDatabase referenceComment
ADIPOQGeneProductENSG00000181092 (Ensembl)
CEBPAGeneProductENSG00000245848 (Ensembl)
CEBPBGeneProductENSG00000172216 (Ensembl)
CEBPDGeneProductENSG00000221869 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
FOXO1AGeneProductENSG00000150907 (Ensembl)
GLUT4GeneProductENSG00000181856 (Ensembl)
GlucocorticoidsMetaboliteCHEBI:24261 (ChEBI)
IL6GeneProductENSG00000136244 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
LEPGeneProductENSG00000174697 (Ensembl)
LPIN1GeneProductENSG00000134324 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
PCK2GeneProductENSG00000100889 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)

Annotated Interactions

No annotated interactions

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