MAPK Signaling Pathway (Rattus norvegicus)

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Scaffold1-7, 9, 10811LegendCalcium channelsActivating mutationCalcium channelsHeteromeric G-proteinProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTraf6Mef2cPSrfRps6ka3PMap2k3PElk4PRap1aPCrkIl1aPdgfbAkt3EcsitMap3k13Rasgrp4LOC100910771PMapk9PGrb2Mknk1PDusp1Stmn1PElk1PPPEgfrPpp3cbPpp3ccMap4k1Nfatc1PArrb2MaptPRasgrp1Rap1bPCd14IkbkgBdnfDaxxMapk10PLOC103694380MosStk4Mapk14PIkbkbPPArrb1Lrrk2Casp3FlnaPRKACAMapkapk2PTnfrsf1aMap3k14Hspb1PMap3k20Gna12Tgfb1LOC100912399PMap3k2PMaxPDusp10RASGRF2Map4k4PdgfrbTab1Map3k4Gadd45aWnt signaling pathwayMap2k5Cdc25bPIl1r1Rac2PrkcdPpp5cMap2k1PPRac1Ptpn7Il1r2Tab2Tgfbr1Mapk1PPPtprrPtpn5Pla2g4dPBrafNtrk1Atf2PMap2k4PLPSFosPrkcgMycSos2Tgfb2Elk1PLOC100912585PDusp4Cacng3ApoptosisHspa8Mapk12PMapk8ip1IP3Ppm1aCa2+Il1bElk4PTraf2Mapk13PTaok1Map2k6PDusp8Akt2Mapkapk5PRasa2Dusp7Ppp3r2Fgfr1Tgfb3Ppp3caEgfDdit3PMap3k6Map3k8NgfLOC100911248Taok2cAMPMapk3PPMapk8PNr4a1PCell cyclePrkcaAtf4PNtf4PdgfaAtf4PNtrk2FaslgPdgfrbPpm1bFgfr2Cdc42Fgfr3Lamtor3Fgfr4JunPPJundSos1PHrasRrasPPRps6ka5PMap3k12Tp53PRras2PNfkb1Gng12Pla2g4cPNf1Rasgrp2Akt1p53 signaling pathwayRasgrp3Rasgrp4Rasa1Rasgrf1HSPA6Ca2+Ntf3Rapgef2Phosphatidylinositolsignaling systemPrkacbHspa1aPrkacaStk3Dusp3Map4k3ChukPTgfbr2Nfkb2Map4k2RelaMap2k7PRelbPPP3R1Dusp9NlkPDusp2DAGDusp16FasMknk2PPla2g4aPNfatc3PMap3k5Map3k11PPTaok3Dusp6Map2k2PPPPP5D1Mapk11PRps6ka4PMapkapk3PRac3Mapk8ip2Mapk8ip3FlnbFlncHspa1aHspa1lHspa2MrasPNrasPKrasPRaf1PPla2g4fPPla2g4bPPla2g4ePCacng2Cacng5Cacng4Cacna2d3Cacng8Cacng7Cacng6Cacna1aCacna1bCacna1cCacna1dCacna1eCacna1fCacna1sCacna2d1Cacnb1Cacnb2Cacnb3Cacnb4Cacng1CACNA1ICacna1hCacna1gCacna2d2Cacna2d4Fgf4Fgf1Fgf2Fgf3Fgf4Fgf5Fgf6Fgf7Fgf8Fgf9Fgf10Fgf11Fgf12Fgf13Fgf14Fgf20Fgf21Fgf22Fgf23Fgf18Fgf17Fgf16Fgf19Fibroblast growth factorsFibroblast growthfactorsPak2Pak1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  2. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  3. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  4. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  5. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  6. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  7. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  8. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  9. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  10. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  11. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106982view13:44, 17 September 2019MaintBotHMDB identifier normalization
105688view20:58, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96398view10:11, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95780view14:33, 19 January 2018MkutmonHomology conversion update
95213view12:05, 24 November 2017Mkutmonadded homology converter comment source
83027view01:58, 18 November 2015MkutmonFix outdated identifiers
69374view18:55, 8 July 2013MaintBotUpdated to 2013 gpml schema
67442view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
47771view05:31, 6 April 2012Khanspersupdated xref
41688view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
35661view22:13, 12 February 2010KhanspersAdded Description and LIt Refs
34074view19:11, 9 December 2009MaintBotAutomatic update of empty xrefs
32409view17:04, 15 August 2009MaintBotFixed text labels
32065view13:35, 14 August 2009MaintBotFixed group labels
31440view21:05, 13 August 2009MaintBotFixed text labels
30944view00:41, 30 July 2009MaintBotConverted from Homo sapiens
21429view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:MAPK signaling pathway KEGG]] moved to [[Pathway:WP358]]: Moved to stable identifier
8252view13:46, 7 January 2008MaintBot[[Pathway:Rat:MAPK signaling pathway KEGG]] moved to [[Pathway:Rattus norvegicus:MAPK signaling pathway KEGG]]: Renaming species
7746view16:15, 18 December 2007MaintBotfixed category names
7279view12:41, 4 November 2007MaintBotAdded categories to GPML
6574view22:20, 22 May 2007S.Burelgpml file for [[Rat:MAPK_signaling_pathway_ KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProductENSRNOG00000028629 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:207
Akt2GeneProductENSRNOG00000018677 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:208
Akt3GeneProductENSRNOG00000021497 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10000
ApoptosisPathwayWP254 (WikiPathways)
Arrb1GeneProductENSRNOG00000030404 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:408
Arrb2GeneProductENSRNOG00000019308 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:409
Atf2GeneProductENSRNOG00000001597 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Atf4GeneProductENSRNOG00000017801 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:468
BdnfGeneProductENSRNOG00000047466 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:627
BrafGeneProductENSRNOG00000010957 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:673
CACNA1IGeneProductNo homologues found for original id En:ENSG00000100346
Ca2+MetaboliteHMDB0000464 (HMDB)
Cacna1aGeneProductENSRNOG00000052707 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000141837
Cacna1bGeneProductENSRNOG00000004560 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000148408
Cacna1cGeneProductENSRNOG00000007090 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000151067
Cacna1dGeneProductENSRNOG00000013147 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000157388
Cacna1eGeneProductENSRNOG00000002863 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000198216
Cacna1fGeneProductENSRNOG00000010348 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102001
Cacna1gGeneProductENSRNOG00000060528 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000006283
Cacna1hGeneProductENSRNOG00000033893 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196557
Cacna1sGeneProductENSRNOG00000046231 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000081248
Cacna2d1GeneProductENSRNOG00000033531 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000153956
Cacna2d2GeneProductENSRNOG00000015835 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000007402
Cacna2d3GeneProductENSRNOG00000031287 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000157445
Cacna2d4GeneProductENSRNOG00000008031 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000151062
Cacnb1GeneProductENSRNOG00000004518 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000067191
Cacnb2GeneProductENSRNOG00000018378 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000165995
Cacnb3GeneProductENSRNOG00000054274 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000167535
Cacnb4GeneProductENSRNOG00000007666 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000182389
Cacng1GeneProductENSRNOG00000003245 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000108878
Cacng2GeneProductENSRNOG00000006226 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000166862
Cacng3GeneProductENSRNOG00000012362 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = H:CACNG3
Cacng4GeneProductENSRNOG00000003262 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075461
Cacng5GeneProductENSRNOG00000003288 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075429
Cacng6GeneProductENSRNOG00000057852 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000130433
Cacng7GeneProductENSRNOG00000056257 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105605
Cacng8GeneProductENSRNOG00000057848 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000142408
Casp3GeneProductENSRNOG00000010475 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:836
Cd14GeneProductENSRNOG00000017819 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:929
Cdc25bGeneProductENSRNOG00000021248 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:994
Cdc42GeneProductENSRNOG00000013536 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998
Cell cyclePathwayWP179 (WikiPathways)
ChukGeneProductENSRNOG00000022485 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000213341
CrkGeneProductENSRNOG00000025792 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1398
DAGMetaboliteCHEBI:18035 (ChEBI)
DaxxGeneProductENSRNOG00000000477 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1616
Ddit3GeneProductENSRNOG00000006789 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1649
Dusp10GeneProductENSRNOG00000004003 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11221
Dusp16GeneProductENSRNOG00000006628 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000111266
Dusp1GeneProductENSRNOG00000003977 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1843
Dusp2GeneProductENSRNOG00000013862 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158050
Dusp3GeneProductENSRNOG00000036798 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000108861
Dusp4GeneProductENSRNOG00000011921 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1846
Dusp6GeneProductENSRNOG00000023896 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1848
Dusp7GeneProductENSRNOG00000010789 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1849
Dusp8GeneProductENSRNOG00000029394 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000184545
Dusp9GeneProductENSRNOG00000055185 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000130829
EcsitGeneProductENSRNOG00000014128 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51295
EgfGeneProductENSRNOG00000053979 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1950
EgfrGeneProductENSRNOG00000004332 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1956
Elk1GeneProductENSRNOG00000010171 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2002
Elk4GeneProductENSRNOG00000007887 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158711
FasGeneProductENSRNOG00000019142 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:355
FaslgGeneProductENSRNOG00000002978 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:356
Fgf10GeneProductENSRNOG00000012278 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000070193
Fgf11GeneProductENSRNOG00000014882 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000161958
Fgf12GeneProductENSRNOG00000001931 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000114279
Fgf13GeneProductENSRNOG00000042753 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000129682
Fgf14GeneProductENSRNOG00000009288 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102466
Fgf16GeneProductENSRNOG00000061530 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196468
Fgf17GeneProductENSRNOG00000012912 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158815
Fgf18GeneProductENSRNOG00000048389 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000156427
Fgf19GeneProductENSRNOG00000020899 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000162344
Fgf1GeneProductENSRNOG00000013867 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000113578
Fgf20GeneProductENSRNOG00000000109 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000078579
Fgf21GeneProductENSRNOG00000020990 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105550
Fgf22GeneProductENSRNOG00000008960 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000070388
Fgf23GeneProductENSRNOG00000052205 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000118972
Fgf2GeneProductENSRNOG00000017392 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000138685
Fgf3GeneProductENSRNOG00000020888 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000186895
Fgf4GeneProductENSRNOG00000020890 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075388
Fgf5GeneProductENSRNOG00000022631 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000138675
Fgf6GeneProductENSRNOG00000053662 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000111241
Fgf7GeneProductENSRNOG00000009425 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000140285
Fgf8GeneProductENSRNOG00000017524 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000107831
Fgf9GeneProductENSRNOG00000011471 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102678
Fgfr1GeneProductENSRNOG00000016050 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2260
Fgfr2GeneProductENSRNOG00000016374 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000066468
Fgfr3GeneProductENSRNOG00000016818 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000068078
Fgfr4GeneProductENSRNOG00000016763 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000160867
FlnaGeneProductENSRNOG00000054890 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2316
FlnbGeneProductENSRNOG00000009470 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000136068
FlncGeneProductENSRNOG00000007281 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000128591
FosGeneProductENSRNOG00000008015 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2353
Gadd45aGeneProductENSRNOG00000005615 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1647
Gna12GeneProductENSRNOG00000001235 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2768
Gng12GeneProductENSRNOG00000050231 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000172380
Grb2GeneProductENSRNOG00000003990 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2885
HSPA6GeneProductNo homologues found for original id En:ENSG00000173110
HrasGeneProductENSRNOG00000016611 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000174775
Hspa1aGeneProductENSRNOG00000045654 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000204388
Hspa1lGeneProductENSRNOG00000047966 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000204390
Hspa2GeneProductENSRNOG00000006472 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000126803
Hspa8GeneProductENSRNOG00000032585 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3312
Hspb1GeneProductENSRNOG00000023546 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3315
IP3MetaboliteCHEBI:16595 (ChEBI)
IkbkbGeneProductENSRNOG00000019073 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3551
IkbkgGeneProductENSRNOG00000060936 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8517
Il1aGeneProductENSRNOG00000004575 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3552
Il1bGeneProductENSRNOG00000004649 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3553
Il1r1GeneProductENSRNOG00000014504 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3554
Il1r2GeneProductENSRNOG00000014378 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7850
JunGeneProductENSRNOG00000026293 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3725
JundGeneProductENSRNOG00000019568 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3727
KrasGeneProductENSRNOG00000009338 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3845
LOC100910771GeneProductENSRNOG00000005724 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6885
LOC100911248GeneProductENSRNOG00000001868 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1399
LOC100912399GeneProductENSRNOG00000013177 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4214
LOC100912585GeneProductENSRNOG00000002412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5598
LOC103694380GeneProductENSRNOG00000000837 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7124
LPSMetaboliteCHEBI:16412 (ChEBI)
Lamtor3GeneProductENSRNOG00000010552 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8649
Lrrk2GeneProductENSRNOG00000004048 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000188906
Map2k1GeneProductENSRNOG00000010176 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5604
Map2k2GeneProductENSRNOG00000020005 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5605
Map2k3GeneProductENSRNOG00000049132 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5606
Map2k4GeneProductENSRNOG00000003834 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6416
Map2k5GeneProductENSRNOG00000007926 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5607
Map2k6GeneProductENSRNOG00000004437 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5608
Map2k7GeneProductENSRNOG00000001047 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5609
Map3k11GeneProductENSRNOG00000020773 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4296
Map3k12GeneProductENSRNOG00000015134 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7786
Map3k13GeneProductENSRNOG00000025423 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9175
Map3k14GeneProductENSRNOG00000003278 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000006062
Map3k20GeneProductENSRNOG00000001515 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51776
Map3k2GeneProductENSRNOG00000014089 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10746
Map3k4GeneProductENSRNOG00000017419 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4216
Map3k5GeneProductENSRNOG00000031700 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4217
Map3k6GeneProductENSRNOG00000008936 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9064
Map3k8GeneProductENSRNOG00000016378 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1326
Map4k1GeneProductENSRNOG00000020505 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11184
Map4k2GeneProductENSRNOG00000021061 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000168067
Map4k3GeneProductENSRNOG00000007172 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8491
Map4k4GeneProductENSRNOG00000014013 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9448
Mapk10GeneProductENSRNOG00000002079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5602
Mapk11GeneProductENSRNOG00000006984 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000185386
Mapk12GeneProductENSRNOG00000031233 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6300
Mapk13GeneProductENSRNOG00000000515 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5603
Mapk14GeneProductENSRNOG00000000513 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1432
Mapk1GeneProductENSRNOG00000001849 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5594
Mapk3GeneProductENSRNOG00000053583 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5595
Mapk8GeneProductENSRNOG00000020155 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5599
Mapk8ip1GeneProductENSRNOG00000058478 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000121653
Mapk8ip2GeneProductENSRNOG00000032828 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000008735
Mapk8ip3GeneProductENSRNOG00000033568 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000138834
Mapk9GeneProductENSRNOG00000002823 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5601
Mapkapk2GeneProductENSRNOG00000004726 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9261
Mapkapk3GeneProductENSRNOG00000014832 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000114738
Mapkapk5GeneProductENSRNOG00000001345 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8550
MaptGeneProductENSRNOG00000005133 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4137
MaxGeneProductENSRNOG00000008049 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4149
Mef2cGeneProductENSRNOG00000033134 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4208
Mknk1GeneProductENSRNOG00000010381 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8569
Mknk2GeneProductENSRNOG00000029028 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000099875
MosGeneProductENSRNOG00000008567 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4342
MrasGeneProductENSRNOG00000014060 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22808
MycGeneProductENSRNOG00000004500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Nf1GeneProductENSRNOG00000013780 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196712
Nfatc1GeneProductENSRNOG00000017146 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4772
Nfatc3GeneProductENSRNOG00000054264 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000072736
Nfkb1GeneProductENSRNOG00000023258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4790
Nfkb2GeneProductENSRNOG00000019311 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000077150
NgfGeneProductENSRNOG00000016571 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000134259
NlkGeneProductENSRNOG00000008704 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51701
Nr4a1GeneProductENSRNOG00000007607 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3164
NrasGeneProductENSRNOG00000023079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4893
Ntf3GeneProductENSRNOG00000019716 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000185652
Ntf4GeneProductENSRNOG00000020783 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000225950
Ntrk1GeneProductENSRNOG00000013953 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4914
Ntrk2GeneProductENSRNOG00000018839 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000148053
PPP3R1GeneProductNo homologues found for original id L:5534
PPP5D1GeneProductNo homologues found for original id En:ENSG00000230510
PRKACAGeneProductNo homologues found for original id L:5566
Pak1GeneProductENSRNOG00000029784 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5058
Pak2GeneProductENSRNOG00000001747 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5062
PdgfaGeneProductENSRNOG00000001312 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000197461
PdgfbGeneProductENSRNOG00000017197 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5155
PdgfrbGeneProductENSRNOG00000018461 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000113721
Phosphatidylinositol signaling systemPathway
Pla2g4aGeneProductENSRNOG00000002657 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000116711
Pla2g4bGeneProductENSRNOG00000007447 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000243708
Pla2g4cGeneProductENSRNOG00000026764 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105499
Pla2g4dGeneProductENSRNOG00000037231 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000159337
Pla2g4eGeneProductENSRNOG00000024904 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000188089
Pla2g4fGeneProductENSRNOG00000008135 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000168907
Ppm1aGeneProductENSRNOG00000005916 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5494
Ppm1bGeneProductENSRNOG00000030667 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5495
Ppp3caGeneProductENSRNOG00000009882 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5530
Ppp3cbGeneProductENSRNOG00000054782 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5532
Ppp3ccGeneProductENSRNOG00000009745 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5533
Ppp3r2GeneProductENSRNOG00000005368 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5535
Ppp5cGeneProductENSRNOG00000016907 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5536
PrkacaGeneProductENSRNOG00000005257 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000165059
PrkacbGeneProductENSRNOG00000004978 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000142875
PrkcaGeneProductENSRNOG00000003491 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000154229
PrkcdGeneProductENSRNOG00000016346 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5580
PrkcgGeneProductENSRNOG00000054371 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5582
Ptpn5GeneProductENSRNOG00000013981 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84867
Ptpn7GeneProductENSRNOG00000005807 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5778
PtprrGeneProductENSRNOG00000004483 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5801
RASGRF2GeneProductENSRNOG00000056151 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5924
Rac1GeneProductENSRNOG00000001068 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5879
Rac2GeneProductENSRNOG00000007350 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5880
Rac3GeneProductENSRNOG00000048172 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000169750
Raf1GeneProductENSRNOG00000010153 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5894
Rap1aGeneProductENSRNOG00000032463 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5906
Rap1bGeneProductENSRNOG00000007048 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5908
Rapgef2GeneProductENSRNOG00000021581 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000109756
Rasa1GeneProductENSRNOG00000029185 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5921
Rasa2GeneProductENSRNOG00000011909 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5922
Rasgrf1GeneProductENSRNOG00000014025 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000058335
Rasgrp1GeneProductENSRNOG00000005404 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10125
Rasgrp2GeneProductENSRNOG00000021098 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000068831
Rasgrp3GeneProductENSRNOG00000032703 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000152689
Rasgrp4GeneProductENSRNOG00000033744 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000171777
RelaGeneProductENSRNOG00000030888 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000173039
RelbGeneProductENSRNOG00000033235 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000104856
Rps6ka3GeneProductENSRNOG00000006632 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6197
Rps6ka4GeneProductENSRNOG00000021117 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000162302
Rps6ka5GeneProductENSRNOG00000004362 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9252
Rras2GeneProductENSRNOG00000012258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000133818
RrasGeneProductENSRNOG00000037247 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000126458
Sos1GeneProductENSRNOG00000007106 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000115904
Sos2GeneProductENSRNOG00000004826 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6655
SrfGeneProductENSRNOG00000018232 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6722
Stk3GeneProductENSRNOG00000011278 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6788
Stk4GeneProductENSRNOG00000013529 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000101109
Stmn1GeneProductENSRNOG00000016810 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3925
Tab1GeneProductENSRNOG00000017285 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10454
Tab2GeneProductENSRNOG00000016054 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23118
Taok1GeneProductENSRNOG00000015692 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57551
Taok2GeneProductENSRNOG00000019964 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9344
Taok3GeneProductENSRNOG00000001138 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000135090
Tgfb1GeneProductENSRNOG00000020652 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7040
Tgfb2GeneProductENSRNOG00000002418 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7042
Tgfb3GeneProductENSRNOG00000009867 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7043
Tgfbr1GeneProductENSRNOG00000007036 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7046
Tgfbr2GeneProductENSRNOG00000013265 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7048
Tnfrsf1aGeneProductENSRNOG00000031312 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000067182
Tp53GeneProductENSRNOG00000010756 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157
Traf2GeneProductENSRNOG00000006238 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7186
Traf6GeneProductENSRNOG00000004639 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7189
Wnt signaling pathwayPathwayWP428 (WikiPathways)
cAMPMetaboliteHMDB0000058 (HMDB)
p53 signaling pathwayPathway

Annotated Interactions

No annotated interactions
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