Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism (Homo sapiens)

From WikiPathways

Jump to: navigation, search
36, 41, 6433486538, 62414, 6129, 5430506, 214413248, 26, 32, 555, 15, 19, 25273317, 422216, 52, 5667, 70931, 437, 484, 8, 26, 32, 55391, 2, 68, 6914, 61286035, 5710, 401847446, 4945514311, 23, 5834374, 4136, 41, 6471125953, 63, 6620peroxisomal matrixmitochondrial matrixmitochondrial matrixcytosolmitochondrial intermembrane spaceL-KYNMeOH3HKYNTAT dimerPYRL-AlaASRGL1 heterodimerTDP APDBAPiALDH7A1 CCBL2 dimerGTPPXLP-AADAT H2OIDO1PXLP-KYAT1 dimerH2OASRGL1(1-167) FAH HPPYRAAADAT dimerAM-SHDH2OGPHYKPL tetramerAnserineH2OL-PheO2I3LACT GL-CoASLC7A5:SLC3A2L-LysL-Glu5SH2OALDH4A1 HDC dimer2AMAI3LACT, I3PROPAL-Met CRYMH2Olipo-aKGDHL-GluFAD H2OHAAOL-Tyr FADH2I3PROPA PXLP-AADAT HistADPTDO2 tetramerCO2CARNMT1H2O3HAANAD+HNMTPRODH2H+NicotinatemetabolismFADL-GluNAD+Fe2+ SLC25A21L-Leu Lipo-K110-DLST PXLP-CCBL2 SLC7A5 L-TrpH2OL-Trp NAD+BH44aOH-BH4NAD+L-Met QDPR dimerIDO2KYNU dimerNAD+PCBD1 tetramerCO2aspartameAdoMetL-Asp2AMPCBD1 NAD+L-PheUCAL-Ile L-Val HAAO GCDH tetramerPAH tetramerASRGL1(168-308) 5HLYSO2ACMSD dimerheme NH4+ligands of SLC7A5P6CPXLP-KYAT1 dimerPXLP H2O2L-AlaAADAT dimerO2AMDHD1H2O2OGKYNAaKADAFUMAO2KYNAAdoHcyNADP+FAD O2L-His PXLP-TAT AP-DOBuACSL-HisH2ONADPHNADHL-ProO2H+HGD hexamerQDPR O2SLC36A4HYKKALDH4A1 dimerNAD+ HALH2Oligands of SLC7A5H2OPYRL-AlaHPD ALDH7A1 tetramer1PYR-5COOH4I-5PROAL-Tyr ACMSD FADCO2NADHIDO2 GCDH H2OUROC1:NAD+L-Ile FAH dimerLIPAM L-KYN2AMASL-Val L-Pheb-AlaHPROPRODH(1-?)HGD NADPHheme PIPOXGDPL-GluL-TrpHGTANADP+HDC H+KMOCARNS1PPCA2OGL-Phe H+ACAH2OFITHFL-GluL-GluGSTZ1 dimerkPPVIL4I1 H+CO2UROC1 CARNH2OAASS THFIDO1 L-GluAFMIDPXLP-KYAT1 2OGFe2+ FTCD crotonyl-CoAATPPXLP L-Trp NFKH+H2OFAD FADH2L-TyrH+HCOOHAdoHcy2OGAASS tetramerH2O2NF-GluH+SLC3A2 PiNADP+SACNNH3PAH GSTZ1 NADH5PHLH+H+O24FAAFe2+ NADHPXLP-KYAT1 L-Leu MeHistNADHP2CCO2FTCD octamerNADPHNH3PXLP-KYNU HPD dimerqDHBNADH3IN-PYRAFe2+ 2AMA4MAAL-Phe 2OGTDO2 L-His aKADAIL4I1:FADOGDH PHYKPL GSH DLD AdoMetCoA-SHheme 12358, 26, 321, 68202126, 322324011, 2336, 4165106038174936, 411438, 26, 3236, 4136, 4126, 3238, 6270


Description

The catabolic pathways of histidine, lysine, phenylalanine, tyrosine, proline and tryptophan are described in this section (Berg et al. 2002). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 6788656
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Jassal, Bijay

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Reed LJ, Hackert ML.; ''Structure-function relationships in dihydrolipoamide acyltransferases.''; PubMed
  2. Brautigam CA, Chuang JL, Tomchick DR, Machius M, Chuang DT.; ''Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.''; PubMed
  3. Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S.; ''Enzymology of NAD+ homeostasis in man.''; PubMed
  4. MILLER IL, TSUCHIDA M, ADELBERG EA.; ''The transamination of kynurenine.''; PubMed
  5. Cantor JR, Stone EM, Chantranupong L, Georgiou G.; ''The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.''; PubMed
  6. Fernández-Cañón JM, Granadino B, Beltrán-Valero de Bernabé D, Renedo M, Fernández-Ruiz E, Peñalva MA, Rodríguez de Córdoba S.; ''The molecular basis of alkaptonuria.''; PubMed
  7. Espinós C, Pineda M, Martínez-Rubio D, Lupo V, Ormazabal A, Vilaseca MA, Spaapen LJ, Palau F, Artuch R.; ''Mutations in the urocanase gene UROC1 are associated with urocanic aciduria.''; PubMed
  8. Baran H, Okuno E, Kido R, Schwarcz R.; ''Purification and characterization of kynurenine aminotransferase I from human brain.''; PubMed
  9. ICHIYAMA A, NAKAMURA S, KAWAI H, HONJO T, NISHIZUKA Y, HAYAISHI O, SENOH S.; ''STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID.''; PubMed
  10. Keyser B, Mühlhausen C, Dickmanns A, Christensen E, Muschol N, Ullrich K, Braulke T.; ''Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH).''; PubMed
  11. Ficner R, Sauer UH, Stier G, Suck D.; ''Three-dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1.''; PubMed
  12. Toma S, Nakamura M, Toné S, Okuno E, Kido R, Breton J, Avanzi N, Cozzi L, Speciale C, Mostardini M, Gatti S, Benatti L.; ''Cloning and recombinant expression of rat and human kynureninase.''; PubMed
  13. Pillai SM, Meredith D.; ''SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.''; PubMed
  14. Markovitz PJ, Chuang DT, Cox RP.; ''Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.''; PubMed
  15. Nomme J, Su Y, Konrad M, Lavie A.; ''Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.''; PubMed
  16. Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X.; ''Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.''; PubMed
  17. Pineda M, Fernández E, Torrents D, Estévez R, López C, Camps M, Lloberas J, Zorzano A, Palacín M.; ''Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.''; PubMed
  18. Mamune-Sato R, Yamauchi K, Tanno Y, Ohkawara Y, Ohtsu H, Katayose D, Maeyama K, Watanabe T, Shibahara S, Takishima T.; ''Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells.''; PubMed
  19. Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, Zhang Y.; ''Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.''; PubMed
  20. Malherbe P, Köhler C, Da Prada M, Lang G, Kiefer V, Schwarcz R, Lahm HW, Cesura AM.; ''Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase.''; PubMed
  21. Titus GP, Mueller HA, Burgner J, Rodríguez De Córdoba S, Peñalva MA, Timm DE.; ''Crystal structure of human homogentisate dioxygenase.''; PubMed
  22. Fiermonte G, Dolce V, Palmieri L, Ventura M, Runswick MJ, Palmieri F, Walker JE.; ''Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location.''; PubMed
  23. Hauer CR, Rebrin I, Thöny B, Neuheiser F, Curtius HC, Hunziker P, Blau N, Ghisla S, Heizmann CW.; ''Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence.''; PubMed
  24. Summitt CB, Johnson LC, Jönsson TJ, Parsonage D, Holmes RP, Lowther WT.; ''Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.''; PubMed
  25. Nomme J, Su Y, Lavie A.; ''Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis.''; PubMed
  26. Rossi F, Han Q, Li J, Li J, Rizzi M.; ''Crystal structure of human kynurenine aminotransferase I.''; PubMed
  27. Pabarcus MK, Casida JE.; ''Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad.''; PubMed
  28. Yu P, Li Z, Zhang L, Tagle DA, Cai T.; ''Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family.''; PubMed
  29. Hallen A, Cooper AJ, Jamie JF, Karuso P.; ''Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.''; PubMed
  30. Comings DE, Muhleman D, Dietz G, Sherman M, Forest GL.; ''Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat.''; PubMed
  31. Dodt G, Kim DG, Reimann SA, Reuber BE, McCabe K, Gould SJ, Mihalik SJ.; ''L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.''; PubMed
  32. Han Q, Robinson H, Cai T, Tagle DA, Li J.; ''Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.''; PubMed
  33. Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E.; ''Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.''; PubMed
  34. Drozak J, Piecuch M, Poleszak O, Kozlowski P, Chrobok L, Baelde HJ, de Heer E.; ''UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase.''; PubMed
  35. Wong JW, Chan CL, Tang WK, Cheng CH, Fong WP.; ''Is antiquitin a mitochondrial Enzyme?''; PubMed
  36. Rossi F, Garavaglia S, Montalbano V, Walsh MA, Rizzi M.; ''Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia.''; PubMed
  37. Boulland ML, Marquet J, Molinier-Frenkel V, Möller P, Guiter C, Lasoudris F, Copie-Bergman C, Baia M, Gaulard P, Leroy K, Castellano F.; ''Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.''; PubMed
  38. Su Y, Varughese KI, Xuong NH, Bray TL, Roche DJ, Whiteley JM.; ''The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.''; PubMed
  39. Kawai Y, Moriyama A, Asai K, Coleman-Campbell CM, Sumi S, Morishita H, Suchi M.; ''Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene.''; PubMed
  40. Fu Z, Wang M, Paschke R, Rao KS, Frerman FE, Kim JJ.; ''Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions.''; PubMed
  41. Han Q, Robinson H, Li J.; ''Crystal structure of human kynurenine aminotransferase II.''; PubMed
  42. Prasad PD, Wang H, Huang W, Kekuda R, Rajan DP, Leibach FH, Ganapathy V.; ''Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function.''; PubMed
  43. Hallen A, Jamie JF, Cooper AJ.; ''Lysine metabolism in mammalian brain: an update on the importance of recent discoveries.''; PubMed
  44. Rüetschi U, Cerone R, Pérez-Cerda C, Schiaffino MC, Standing S, Ugarte M, Holme E.; ''Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III.''; PubMed
  45. Labelle Y, Phaneuf D, Leclerc B, Tanguay RM.; ''Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity.''; PubMed
  46. Geraghty MT, Vaughn D, Nicholson AJ, Lin WW, Jimenez-Sanchez G, Obie C, Flynn MP, Valle D, Hu CA.; ''Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia.''; PubMed
  47. Fukuoka S, Ishiguro K, Yanagihara K, Tanabe A, Egashira Y, Sanada H, Shibata K.; ''Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".''; PubMed
  48. Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A.; ''Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.''; PubMed
  49. Forte-McRobbie CM, Pietruszko R.; ''Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase.''; PubMed
  50. Bender HU, Almashanu S, Steel G, Hu CA, Lin WW, Willis A, Pulver A, Valle D.; ''Functional consequences of PRODH missense mutations.''; PubMed
  51. Breton J, Avanzi N, Magagnin S, Covini N, Magistrelli G, Cozzi L, Isacchi A.; ''Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.''; PubMed
  52. Yamauchi K, Sekizawa K, Suzuki H, Nakazawa H, Ohkawara Y, Katayose D, Ohtsu H, Tamura G, Shibahara S, Takemura M.; ''Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.''; PubMed
  53. Murley LL, Mejia NR, MacKenzie RE.; ''The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli.''; PubMed
  54. Cheng Z, Sun L, He J, Gong W.; ''Crystal structure of human micro-crystallin complexed with NADPH.''; PubMed
  55. Perry S, Harries H, Scholfield C, Lock T, King L, Gibson G, Goldfarb P.; ''Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase.''; PubMed
  56. Rutherford K, Parson WW, Daggett V.; ''The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics.''; PubMed
  57. Mills PB, Struys E, Jakobs C, Plecko B, Baxter P, Baumgartner M, Willemsen MA, Omran H, Tacke U, Uhlenberg B, Weschke B, Clayton PT.; ''Mutations in antiquitin in individuals with pyridoxine-dependent seizures.''; PubMed
  58. Citron BA, Kaufman S, Milstien S, Naylor EW, Greene CL, Davis MD.; ''Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism.''; PubMed
  59. Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E.; ''Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1).''; PubMed
  60. Polekhina G, Board PG, Blackburn AC, Parker MW.; ''Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.''; PubMed
  61. Sacksteder KA, Biery BJ, Morrell JC, Goodman BK, Geisbrecht BV, Cox RP, Gould SJ, Geraghty MT.; ''Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia.''; PubMed
  62. Lockyer J, Cook RG, Milstien S, Kaufman S, Woo SL, Ledley FD.; ''Structure and expression of human dihydropteridine reductase.''; PubMed
  63. Solans A, Estivill X, de la Luna S.; ''Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency.''; PubMed
  64. Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.; ''Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).''; PubMed
  65. Sugimoto H, Oda S, Otsuki T, Hino T, Yoshida T, Shiro Y.; ''Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.''; PubMed
  66. Hilton JF, Christensen KE, Watkins D, Raby BA, Renaud Y, de la Luna S, Estivill X, MacKenzie RE, Hudson TJ, Rosenblatt DS.; ''The molecular basis of glutamate formiminotransferase deficiency.''; PubMed
  67. Guldberg P, Mallmann R, Henriksen KF, Güttler F.; ''Phenylalanine hydroxylase deficiency in a population in Germany: mutational profile and nine novel mutations.''; PubMed
  68. McCartney RG, Rice JE, Sanderson SJ, Bunik V, Lindsay H, Lindsay JG.; ''Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components.''; PubMed
  69. Zhou ZH, McCarthy DB, O'Connor CM, Reed LJ, Stoops JK.; ''The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.''; PubMed
  70. Fusetti F, Erlandsen H, Flatmark T, Stevens RC.; ''Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria.''; PubMed
  71. Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC.; ''Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan.''; PubMed

History

View all...
CompareRevisionActionTimeUserComment
101379view11:26, 1 November 2018ReactomeTeamreactome version 66
100917view21:01, 31 October 2018ReactomeTeamreactome version 65
100458view19:36, 31 October 2018ReactomeTeamreactome version 64
100005view16:20, 31 October 2018ReactomeTeamreactome version 63
99558view14:54, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99187view12:42, 31 October 2018ReactomeTeamreactome version 62
93949view13:47, 16 August 2017ReactomeTeamreactome version 61
93542view11:26, 9 August 2017ReactomeTeamreactome version 61
87466view14:13, 22 July 2016MkutmonOntology Term : 'amino acid metabolic pathway' added !
86643view09:22, 11 July 2016ReactomeTeamreactome version 56
83463view12:29, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1PYR-5COOHMetaboliteCHEBI:17388 (ChEBI)
2AMAMetaboliteCHEBI:15745 (ChEBI)
2AMAMetaboliteCHEBI:17082 (ChEBI)
2AMASMetaboliteCHEBI:17917 (ChEBI)
2AMMetaboliteCHEBI:16886 (ChEBI)
2OGMetaboliteCHEBI:30915 (ChEBI)
3HAAMetaboliteCHEBI:15793 (ChEBI)
3HKYNMetaboliteCHEBI:17380 (ChEBI)
3IN-PYRAMetaboliteCHEBI:29750 (ChEBI)
4FAAMetaboliteCHEBI:18034 (ChEBI)
4I-5PROAMetaboliteCHEBI:27384 (ChEBI)
4MAAMetaboliteCHEBI:17105 (ChEBI)
4aOH-BH4MetaboliteCHEBI:15374 (ChEBI)
5HLYSMetaboliteCHEBI:60175 (ChEBI)
5PHLMetaboliteCHEBI:16752 (ChEBI)
AADAT dimerComplexR-HSA-508545 (Reactome)
AASS ProteinQ9UDR5 (Uniprot-TrEMBL)
AASS tetramerComplexR-HSA-70925 (Reactome)
ACAMetaboliteCHEBI:13705 (ChEBI)
ACMSD ProteinQ8TDX5 (Uniprot-TrEMBL)
ACMSD dimerComplexR-HSA-71221 (Reactome)
ACSMetaboliteCHEBI:29044 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AFMIDProteinQ63HM1 (Uniprot-TrEMBL)
ALDH4A1 ProteinP30038 (Uniprot-TrEMBL)
ALDH4A1 dimerComplexR-HSA-70674 (Reactome)
ALDH7A1 ProteinP49419 (Uniprot-TrEMBL)
ALDH7A1 tetramerComplexR-HSA-508564 (Reactome)
AM-SHDHR-HSA-71237 (Reactome)
AMDHD1ProteinQ96NU7 (Uniprot-TrEMBL)
AP-DOBuMetaboliteCHEBI:17442 (ChEBI)
APDBAMetaboliteCHEBI:17442 (ChEBI)
ASRGL1 heterodimerComplexR-HSA-5696373 (Reactome)
ASRGL1(1-167) ProteinQ7L266 (Uniprot-TrEMBL)
ASRGL1(168-308) ProteinQ7L266 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AdoHcyMetaboliteCHEBI:16680 (ChEBI)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
AnserineMetaboliteCHEBI:18323 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
CARNMetaboliteCHEBI:15727 (ChEBI)
CARNMT1ProteinQ8N4J0 (Uniprot-TrEMBL)
CARNS1ProteinA5YM72 (Uniprot-TrEMBL)
CCBL2 dimerComplexR-HSA-901094 (Reactome)
CO2MetaboliteCHEBI:16526 (ChEBI)
CRYMProteinQ14894 (Uniprot-TrEMBL)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
DLD ProteinP09622 (Uniprot-TrEMBL)
FAD MetaboliteCHEBI:16238 (ChEBI)
FADMetaboliteCHEBI:16238 (ChEBI)
FADH2MetaboliteCHEBI:17877 (ChEBI)
FAH ProteinP16930 (Uniprot-TrEMBL)
FAH dimerComplexR-HSA-71175 (Reactome)
FITHFMetaboliteCHEBI:15639 (ChEBI)
FTCD ProteinO95954 (Uniprot-TrEMBL)
FTCD octamerComplexR-HSA-70908 (Reactome)
FUMAMetaboliteCHEBI:37154 (ChEBI)
Fe2+ MetaboliteCHEBI:18248 (ChEBI)
GCDH ProteinQ92947 (Uniprot-TrEMBL)
GCDH tetramerComplexR-HSA-71040 (Reactome)
GDPMetaboliteCHEBI:17552 (ChEBI)
GL-CoAMetaboliteCHEBI:15524 (ChEBI)
GSH MetaboliteCHEBI:16856 (ChEBI)
GSTZ1 ProteinO43708 (Uniprot-TrEMBL)
GSTZ1 dimerComplexR-HSA-71166 (Reactome)
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HAAO ProteinP46952 (Uniprot-TrEMBL)
HAAOComplexR-HSA-71086 (Reactome)
HALProteinP42357 (Uniprot-TrEMBL)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
HDC ProteinP19113 (Uniprot-TrEMBL)
HDC dimerComplexR-HSA-977300 (Reactome)
HGD ProteinQ93099 (Uniprot-TrEMBL)
HGD hexamerComplexR-HSA-71076 (Reactome)
HGTAMetaboliteCHEBI:16169 (ChEBI)
HNMTProteinP50135 (Uniprot-TrEMBL)
HPD ProteinP32754 (Uniprot-TrEMBL)
HPD dimerComplexR-HSA-71161 (Reactome)
HPPYRAMetaboliteCHEBI:15999 (ChEBI)
HPROMetaboliteCHEBI:18240 (ChEBI)
HYKKProteinA2RU49 (Uniprot-TrEMBL)
HistMetaboliteCHEBI:18295 (ChEBI)
I3LACT MetaboliteCHEBI:55528 (ChEBI)
I3LACT, I3PROPAComplexR-ALL-8939576 (Reactome)
I3PROPA MetaboliteCHEBI:43580 (ChEBI)
IDO1 ProteinP14902 (Uniprot-TrEMBL)
IDO1ComplexR-HSA-198580 (Reactome)
IDO2 ProteinQ6ZQW0 (Uniprot-TrEMBL)
IDO2ComplexR-HSA-888612 (Reactome)
IL4I1 ProteinQ96RQ9 (Uniprot-TrEMBL)
IL4I1:FADComplexR-HSA-2160485 (Reactome)
KMOProteinO15229 (Uniprot-TrEMBL)
KYNAMetaboliteCHEBI:18344 (ChEBI)
KYNU dimerComplexR-HSA-71202 (Reactome)
L-AlaMetaboliteCHEBI:57972 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-Glu5SMetaboliteCHEBI:17232 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
L-His MetaboliteCHEBI:32513 (ChEBI)
L-HisMetaboliteCHEBI:32513 (ChEBI)
L-Ile MetaboliteCHEBI:58045 (ChEBI)
L-KYNMetaboliteCHEBI:16946 (ChEBI)
L-Leu MetaboliteCHEBI:57427 (ChEBI)
L-LysMetaboliteCHEBI:32551 (ChEBI)
L-Met MetaboliteCHEBI:57844 (ChEBI)
L-Phe MetaboliteCHEBI:58095 (ChEBI)
L-PheMetaboliteCHEBI:58095 (ChEBI)
L-ProMetaboliteCHEBI:60039 (ChEBI)
L-Trp MetaboliteCHEBI:57912 (ChEBI)
L-TrpMetaboliteCHEBI:57912 (ChEBI)
L-Tyr MetaboliteCHEBI:58315 (ChEBI)
L-TyrMetaboliteCHEBI:58315 (ChEBI)
L-Val MetaboliteCHEBI:57762 (ChEBI)
LIPAM MetaboliteCHEBI:17460 (ChEBI)
Lipo-K110-DLST ProteinP36957 (Uniprot-TrEMBL)
MeHistMetaboliteCHEBI:2