Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism (Homo sapiens)

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36, 41, 6433486538, 62414, 6129, 5430506, 214413248, 26, 32, 555, 15, 19, 25273317, 422216, 52, 5667, 70931, 437, 484, 8, 26, 32, 55391, 2, 68, 6914, 61286035, 5710, 401847446, 4945514311, 23, 5834374, 4136, 41, 6471125953, 63, 6620peroxisomal matrixmitochondrial matrixmitochondrial matrixcytosolmitochondrial intermembrane spaceL-KYNMeOH3HKYNTAT dimerPYRL-AlaASRGL1 heterodimerTDP APDBAPiALDH7A1 CCBL2 dimerGTPPXLP-AADAT H2OIDO1PXLP-KYAT1 dimerH2OASRGL1(1-167) FAH HPPYRAAADAT dimerAM-SHDH2OGPHYKPL tetramerAnserineH2OL-PheO2I3LACT GL-CoASLC7A5:SLC3A2L-LysL-Glu5SH2OALDH4A1 HDC dimer2AMAI3LACT, I3PROPAL-Met CRYMH2Olipo-aKGDHL-GluFAD H2OHAAOL-Tyr FADH2I3PROPA PXLP-AADAT HistADPTDO2 tetramerCO2CARNMT1H2O3HAANAD+HNMTPRODH2H+NicotinatemetabolismFADL-GluNAD+Fe2+ SLC25A21L-Leu Lipo-K110-DLST PXLP-CCBL2 SLC7A5 L-TrpH2OL-Trp NAD+BH44aOH-BH4NAD+L-Met QDPR dimerIDO2KYNU dimerNAD+PCBD1 tetramerCO2aspartameAdoMetL-Asp2AMPCBD1 NAD+L-PheUCAL-Ile L-Val HAAO GCDH tetramerPAH tetramerASRGL1(168-308) 5HLYSO2ACMSD dimerheme NH4+ligands of SLC7A5P6CPXLP-KYAT1 dimerPXLP H2O2L-AlaAADAT dimerO2AMDHD1H2O2OGKYNAaKADAFUMAO2KYNAAdoHcyNADP+FAD O2L-His PXLP-TAT AP-DOBuACSL-HisH2ONADPHNADHL-ProO2H+HGD hexamerQDPR O2SLC36A4HYKKALDH4A1 dimerNAD+ HALH2Oligands of SLC7A5H2OPYRL-AlaHPD ALDH7A1 tetramer1PYR-5COOH4I-5PROAL-Tyr ACMSD FADCO2NADHIDO2 GCDH H2OUROC1:NAD+L-Ile FAH dimerLIPAM L-KYN2AMASL-Val L-Pheb-AlaHPROPRODH(1-?)HGD NADPHheme PIPOXGDPL-GluL-TrpHGTANADP+HDC H+KMOCARNS1PPCA2OGL-Phe H+ACAH2OFITHFL-GluL-GluGSTZ1 dimerkPPVIL4I1 H+CO2UROC1 CARNH2OAASS THFIDO1 L-GluAFMIDPXLP-KYAT1 2OGFe2+ FTCD crotonyl-CoAATPPXLP L-Trp NFKH+H2OFAD FADH2L-TyrH+HCOOHAdoHcy2OGAASS tetramerH2O2NF-GluH+SLC3A2 PiNADP+SACNNH3PAH GSTZ1 NADH5PHLH+H+O24FAAFe2+ NADHPXLP-KYAT1 L-Leu MeHistNADHP2CCO2FTCD octamerNADPHNH3PXLP-KYNU HPD dimerqDHBNADH3IN-PYRAFe2+ 2AMA4MAAL-Phe 2OGTDO2 L-His aKADAIL4I1:FADOGDH PHYKPL GSH DLD AdoMetCoA-SHheme 12358, 26, 321, 68202126, 322324011, 2336, 4165106038174936, 411438, 26, 3236, 4136, 4126, 3238, 6270


Description

The catabolic pathways of histidine, lysine, phenylalanine, tyrosine, proline and tryptophan are described in this section (Berg et al. 2002). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 6788656
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Jassal, Bijay

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
101379view11:26, 1 November 2018ReactomeTeamreactome version 66
100917view21:01, 31 October 2018ReactomeTeamreactome version 65
100458view19:36, 31 October 2018ReactomeTeamreactome version 64
100005view16:20, 31 October 2018ReactomeTeamreactome version 63
99558view14:54, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99187view12:42, 31 October 2018ReactomeTeamreactome version 62
93949view13:47, 16 August 2017ReactomeTeamreactome version 61
93542view11:26, 9 August 2017ReactomeTeamreactome version 61
87466view14:13, 22 July 2016MkutmonOntology Term : 'amino acid metabolic pathway' added !
86643view09:22, 11 July 2016ReactomeTeamreactome version 56
83463view12:29, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1PYR-5COOHMetaboliteCHEBI:17388 (ChEBI)
2AMAMetaboliteCHEBI:15745 (ChEBI)
2AMAMetaboliteCHEBI:17082 (ChEBI)
2AMASMetaboliteCHEBI:17917 (ChEBI)
2AMMetaboliteCHEBI:16886 (ChEBI)
2OGMetaboliteCHEBI:30915 (ChEBI)
3HAAMetaboliteCHEBI:15793 (ChEBI)
3HKYNMetaboliteCHEBI:17380 (ChEBI)
3IN-PYRAMetaboliteCHEBI:29750 (ChEBI)
4FAAMetaboliteCHEBI:18034 (ChEBI)
4I-5PROAMetaboliteCHEBI:27384 (ChEBI)
4MAAMetaboliteCHEBI:17105 (ChEBI)
4aOH-BH4MetaboliteCHEBI:15374 (ChEBI)
5HLYSMetaboliteCHEBI:60175 (ChEBI)
5PHLMetaboliteCHEBI:16752 (ChEBI)
AADAT dimerComplexR-HSA-508545 (Reactome)
AASS ProteinQ9UDR5 (Uniprot-TrEMBL)
AASS tetramerComplexR-HSA-70925 (Reactome)
ACAMetaboliteCHEBI:13705 (ChEBI)
ACMSD ProteinQ8TDX5 (Uniprot-TrEMBL)
ACMSD dimerComplexR-HSA-71221 (Reactome)
ACSMetaboliteCHEBI:29044 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AFMIDProteinQ63HM1 (Uniprot-TrEMBL)
ALDH4A1 ProteinP30038 (Uniprot-TrEMBL)
ALDH4A1 dimerComplexR-HSA-70674 (Reactome)
ALDH7A1 ProteinP49419 (Uniprot-TrEMBL)
ALDH7A1 tetramerComplexR-HSA-508564 (Reactome)
AM-SHDHR-HSA-71237 (Reactome)
AMDHD1ProteinQ96NU7 (Uniprot-TrEMBL)
AP-DOBuMetaboliteCHEBI:17442 (ChEBI)
APDBAMetaboliteCHEBI:17442 (ChEBI)
ASRGL1 heterodimerComplexR-HSA-5696373 (Reactome)
ASRGL1(1-167) ProteinQ7L266 (Uniprot-TrEMBL)
ASRGL1(168-308) ProteinQ7L266 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AdoHcyMetaboliteCHEBI:16680 (ChEBI)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
AnserineMetaboliteCHEBI:18323 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
CARNMetaboliteCHEBI:15727 (ChEBI)
CARNMT1ProteinQ8N4J0 (Uniprot-TrEMBL)
CARNS1ProteinA5YM72 (Uniprot-TrEMBL)
CCBL2 dimerComplexR-HSA-901094 (Reactome)
CO2MetaboliteCHEBI:16526 (ChEBI)
CRYMProteinQ14894 (Uniprot-TrEMBL)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
DLD ProteinP09622 (Uniprot-TrEMBL)
FAD MetaboliteCHEBI:16238 (ChEBI)
FADMetaboliteCHEBI:16238 (ChEBI)
FADH2MetaboliteCHEBI:17877 (ChEBI)
FAH ProteinP16930 (Uniprot-TrEMBL)
FAH dimerComplexR-HSA-71175 (Reactome)
FITHFMetaboliteCHEBI:15639 (ChEBI)
FTCD ProteinO95954 (Uniprot-TrEMBL)
FTCD octamerComplexR-HSA-70908 (Reactome)
FUMAMetaboliteCHEBI:37154 (ChEBI)
Fe2+ MetaboliteCHEBI:18248 (ChEBI)
GCDH ProteinQ92947 (Uniprot-TrEMBL)
GCDH tetramerComplexR-HSA-71040 (Reactome)
GDPMetaboliteCHEBI:17552 (ChEBI)
GL-CoAMetaboliteCHEBI:15524 (ChEBI)
GSH MetaboliteCHEBI:16856 (ChEBI)
GSTZ1 ProteinO43708 (Uniprot-TrEMBL)
GSTZ1 dimerComplexR-HSA-71166 (Reactome)
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HAAO ProteinP46952 (Uniprot-TrEMBL)
HAAOComplexR-HSA-71086 (Reactome)
HALProteinP42357 (Uniprot-TrEMBL)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
HDC ProteinP19113 (Uniprot-TrEMBL)
HDC dimerComplexR-HSA-977300 (Reactome)
HGD ProteinQ93099 (Uniprot-TrEMBL)
HGD hexamerComplexR-HSA-71076 (Reactome)
HGTAMetaboliteCHEBI:16169 (ChEBI)
HNMTProteinP50135 (Uniprot-TrEMBL)
HPD ProteinP32754 (Uniprot-TrEMBL)
HPD dimerComplexR-HSA-71161 (Reactome)
HPPYRAMetaboliteCHEBI:15999 (ChEBI)
HPROMetaboliteCHEBI:18240 (ChEBI)
HYKKProteinA2RU49 (Uniprot-TrEMBL)
HistMetaboliteCHEBI:18295 (ChEBI)
I3LACT MetaboliteCHEBI:55528 (ChEBI)
I3LACT, I3PROPAComplexR-ALL-8939576 (Reactome)
I3PROPA MetaboliteCHEBI:43580 (ChEBI)
IDO1 ProteinP14902 (Uniprot-TrEMBL)
IDO1ComplexR-HSA-198580 (Reactome)
IDO2 ProteinQ6ZQW0 (Uniprot-TrEMBL)
IDO2ComplexR-HSA-888612 (Reactome)
IL4I1 ProteinQ96RQ9 (Uniprot-TrEMBL)
IL4I1:FADComplexR-HSA-2160485 (Reactome)
KMOProteinO15229 (Uniprot-TrEMBL)
KYNAMetaboliteCHEBI:18344 (ChEBI)
KYNU dimerComplexR-HSA-71202 (Reactome)
L-AlaMetaboliteCHEBI:57972 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-Glu5SMetaboliteCHEBI:17232 (ChEBI)
L-GluMetabolite