Gene Silencing by RNA (Homo sapiens)

From WikiPathways

Revision as of 11:40, 1 November 2018 by ReactomeTeam (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
2, 12, 20, 31, 60...9, 10, 14, 27, 32...9, 10, 14, 27, 30...359916, 27, 47, 61, 63...49, 88, 92, 10940, 44, 8940, 44, 899, 11, 16, 27, 41...16, 47, 61, 63, 67...16, 47, 61, 63, 67...21, 39, 54, 62, 10021, 28, 39, 58, 62...2817, 25, 29, 39, 45...5, 11, 15, 19, 22...3, 9, 14, 27, 42...18, 26, 97, 103, 1071, 5, 7, 24, 28...51, 53, 65, 95, 1104, 9, 14, 27, 42...819, 22, 50, 755, 19, 22, 34, 36...13, 23, 87nucleoplasmcytosolTARBP2,PRKRARLC:duplex miRNAEIF2C3 TNRC6A Nup45 TARBP2,PRKRA:DICER1:Pre-RISC (siRNA)TDRD9 TNRC6A6xMeR-PIWIL2:TDRD1:TDRD12:DDX4:ASZ:MOV10L1TDRKH EIF2C4 EIF2C1 RAN HIST1H2BK HIST1H2BH DDX4 H2BFS miRNA 6xMeR-PIWIL2 4xMeR-PIWIL1:TDRD6:TDRKHTARBP2 POLR2A AdoHcyNUP98-3 MeR-PIWIL4:TDRD9:MAEL:TDRKHpiRNA miRNA HIST1H2AJ duplex siRNA NUP155 HIST2H2AC HIST1H2BL RNA Polymerase IIholoenzyme complex(unphosphorylated)POLR2J POLR2D NUP35 TDRD12 6xMeR-PIWIL2:TDRD1:TDRD12:DDX4:ASZ:MOV10L1pre-piRNAH2AFX SEH1L-2 NUP85 DDX4 pre-piRNA HIST1H2BM 2'-O-methyl-piRNA TNRC6:RISC:TargetRNA (inexact match)XPO5 miRNA 2'-O-methyl-piRNA RISCEIF2C3 DDX4 POLR2I MAEL FKBP6 AGO2:siRNATNRC6B MeR-PIWIL4 HIST1H2AB EIF2C3 miRNA geneHIST3H2BB Cleaved transposon RNA POLR2E TNRC6:Nonendonucleolytic RISC:Target RNA (exact match)EIF2C2 Endonucleolytic RISCTARBP2 HIST2H2AC EIF2C4 HIST1H4 POLR2I HIST1H2BN ASZ1 POLR2L primary piRNAtranscriptHIST1H3A NUP98-5 AdoMetNUP188 DICER1 EIF2C4 POLR2K TARBP2,PRKRA RLCEIF2C3 AGO2:miRNAEIF2C4 POLR2A 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH4xMeR-PIWIL1 pri-microRNADNA siRNA HIST1H2BC MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKHGDP TARBP2,PRKRA:DICER1:RISC (miRNA)pre-microRNAAGO2 PRKRA pre-microRNA with 3' overhang H2AFZ TNRC6C XPO5 POLR2D MOV10L1 HIST1H2BO TNRC6A:AGO2:miRNAHIST2H3A ASZ1 ASZ1 miRNA DDX4 TNRC6A:AGO2:miRNAEIF2C3 TDRD12 Double-stranded RNAHIST1H2BO MOV10L1 NUP107 EIF2C1 AGO2:duplex siRNAHENMT1TDRD12 miRNA DICER1 TDRD6 RNA (exact match)HIST1H2BJ PRKRA HIST1H2BD AGO2 TDRKH TARBP2 IPO8:RAN:GTPRAN 6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1AGO2 EIF2C2 EIF2C1 TNRC6A MAEL siRNA GTP TPR GTP NUPL2 TDRD6 ASZ1 AGO2 RNA (inexact match) NDC1 TDRKHPOLR2D ChromatinMYBL1MeR-PIWIL4 H3F3A POLR2G NUP160 RNA (exact match) TARBP2,PRKRA:DICER1:RISC (siRNA)POLR2A 6xMeR-PIWIL2:2'-O-methyl-piRNA:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1AdoMet2'-O-methyl-piRNA POLR2I MeR-PIWIL4 TNRC6B DDX4 HENMT1piRNA AGO2 HIST1H2BA GTP AGO2 EIF2C3 TDRKH EIF2C2 TDRD1 Nonendonucleolytic RISC 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1MAELHIST2H2AA3 HIST2H2BE NUP50 H2AFB1 primary piRNAtranscriptBCDIN3Ddimethyl-5'-phospho-pre-miR-145 miRNA POLR2B piRNA POLR2C 4xMeR-PIWIL1 DICER1 POLR2K HENMT1duplex miRNA HIST1H2BB H2AFV IPO8TDRD9 duplex siRNA with cleaved passenger strand HIST1H2AD POLR2F Cleaved RNA with 5'Phosphate and 3'HydroxylsiRNA PRKRA DDX4 PiH2AFX POM121 RAN:GDP:Exportin-5POLR2J TDRKH TDRD9H2AFZ AGO1,2:miRNANUPL1-2 AGO2 RNA (inexact match)EIF2C3 HIST1H2BK HIST1H2BM TDRD1 AGO2 NUP88 EIF2C2 siRNA POLR2C EIF2C4 6xMeR-PIWIL2 AdoHcyEIF2C1 miRNA POLR2J pre-miR-145,23bHIST1H2BB TDRD1 PLD6 dimer6xMeR-PIWIL2 Transposon RNADDX4 Endonucleolytic RISC POLR2B HIST1H2BN RANBP2 6xMeR-PIWIL2 POLR2F AGO2:miRNAH2AFJ TSN TDRD1 POLR2H POLR2L TARBP2,PRKRA:DICER1:Pre-RISC (miRNA)TNRC6C duplex siRNA TNRC6A EIF2C1 HIST1H2AD DICER1 RNA Polymerase IIholoenzyme complex(generic)TDRKH HIST3H2BB POLR2A POLR2E AGO2 TNRC6A HIST1H2BH HIST2H2BE AdoMetPOLR2C 6xMeR-PIWIL2 EIF2C1 MeR-PIWIL4 4xMeR-PIWIL1 XPO5 dimethyl-5'-phospho-pre-miR-23b pre-miR-145 TDRD1 PRKRA EIF2C1 TDRD6 TNRC6C AGO2 miRNA FKBP6:HSP90AA1Cleaved transposon RNA TDRD9 TDRKH HIST2H3A TDRD12 EIF2C1 TDRD12 TNRC6A PLD6 DICER1 IPO8:AGO2:miRNAduplex siRNA POM121C MAEL POLR2D HIST1H2BD POLR2H POLR2C HSP90AA1 POLR2K AGO2 TDRD6 MicroProcessorComplexMeR-PIWIL4:cleavedtransposonRNA:TDRD9:MAEL:TDRKHH3F3A POLR2L POLR2I TDRD12 Endonucleolytic RISC miRNA NUP210 EIF2C3 TARBP2 TDRKH EIF2C1 PRKRA POLR2L POLR2H H2AFB1 NUP93 TARBP2,PRKRARLC:duplex siRNAIPO8 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH4xMeR-PIWIL1 MOV10L1 POLR2B POLR2G POLR2K HIST1H2AB duplex miRNA NUP133 EIF2C1 POLR2B RAN HIST1H3A HIST1H2BC MAEL pre-piRNA DICER1 TDRKH HIST1H2AC DNA POLR2G TSNAX dimethyl-5'-phospho-pre-miR-145,23bGTP NUP214 H2AFV MeR-PIWIL4:2'-O-methyl-piRNATNRC6 (GW182)MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH2'-O-methyl-piRNA Nuclear Pore Complex(NPC)6xMeR-PIWIL2:cleavedtransposonRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1POLR2E RAN NUP62 HIST2H2AA3 TARBP2 pre-miRNA:RAN:GTP:Exportin-5HIST1H2AC POLR2G PRKRA 6xMeR-PIWIL2 piRNA locus (DNA)AdoHcyPOLR2E TDRD12 H2BFS MOV10L1 pre-microRNA with 3'overhangAGO2:cleaved duplexsiRNAEIF2C3 AGO2 AGO1,2:miRNA:chromatin:RNA pol IIASZ1 HIST1H2BA HIST1H2AJ RNA Polymerase IIholoenzyme complex(generic)6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1TDRD9 MeR-PIWIL4 NUP205 POLR2F EIF2C4 NUP54 AGO2 RAN DROSHA HIST1H2BJ Cleaved transposon RNA NUP43 pre-miR-23b NonendonucleolyticRISCPOLR2J EIF2C4 RAN:GTPDICER1 HIST1H2BL AGO2 NUP98-4 EIF2C4 NUP37 AdoHcyTNRC6B AAAS MOV10L1 H2AFJ EIF2C1 C3POTARBP2 TDRD1 HIST1H4 MOV10L1 miRNA 4xMeR-PIWIL1:2'-O-methyl-piRNA:TDRD6:TDRKHsiRNA 6xMeR-PIWIL2 TARBP2 IPO8 Ran:GTP:Exportin-52'-O-methyl-piRNA POLR2F NUP153 RAE1 EIF2C4 AdoMetPOLR2H ASZ1 miRNA DGCR8 Nonendonucleolytic RISC ASZ1 MOV10L1 TDRD1 PRKRA 77108999624, 73108108741086, 37, 85, 1069955, 592110896108108282899


Description

In this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 211000
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Gopinathrao, G

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Eulalio A, Helms S, Fritzsch C, Fauser M, Izaurralde E.; ''A C-terminal silencing domain in GW182 is essential for miRNA function.''; PubMed Europe PMC
  2. Peters L, Meister G.; ''Argonaute proteins: mediators of RNA silencing.''; PubMed Europe PMC
  3. Dueck A, Ziegler C, Eichner A, Berezikov E, Meister G.; ''microRNAs associated with the different human Argonaute proteins.''; PubMed Europe PMC
  4. Sakurai K, Amarzguioui M, Kim DH, Alluin J, Heale B, Song MS, Gatignol A, Behlke MA, Rossi JJ.; ''A role for human Dicer in pre-RISC loading of siRNAs.''; PubMed Europe PMC
  5. Landthaler M, Gaidatzis D, Rothballer A, Chen PY, Soll SJ, Dinic L, Ojo T, Hafner M, Zavolan M, Tuschl T.; ''Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs.''; PubMed Europe PMC
  6. Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMed Europe PMC
  7. Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ.; ''The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.''; PubMed Europe PMC
  8. Zeng L, Zhang Q, Yan K, Zhou MM.; ''Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.''; PubMed Europe PMC
  9. Maniataki E, Mourelatos Z.; ''A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.''; PubMed Europe PMC
  10. Koscianska E, Starega-Roslan J, Krzyzosiak WJ.; ''The role of Dicer protein partners in the processing of microRNA precursors.''; PubMed Europe PMC
  11. La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB.; ''In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.''; PubMed Europe PMC
  12. Kim VN, Han J, Siomi MC.; ''Biogenesis of small RNAs in animals.''; PubMed Europe PMC
  13. Zhang F, Wang J, Xu J, Zhang Z, Koppetsch BS, Schultz N, Vreven T, Meignin C, Davis I, Zamore PD, Weng Z, Theurkauf WE.; ''UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.''; PubMed Europe PMC
  14. Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhattar R.; ''TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.''; PubMed Europe PMC
  15. Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G.; ''Structural features of Argonaute-GW182 protein interactions.''; PubMed Europe PMC
  16. Wei JX, Yang J, Sun JF, Jia LT, Zhang Y, Zhang HZ, Li X, Meng YL, Yao LB, Yang AG.; ''Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells.''; PubMed Europe PMC
  17. Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S, Enokida H, Dahiya R.; ''Small dsRNAs induce transcriptional activation in human cells.''; PubMed Europe PMC
  18. Borchert GM, Lanier W, Davidson BL.; ''RNA polymerase III transcribes human microRNAs.''; PubMed Europe PMC
  19. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T.; ''Identification of novel argonaute-associated proteins.''; PubMed Europe PMC
  20. Ipsaro JJ, Joshua-Tor L.; ''From guide to target: molecular insights into eukaryotic RNA-interference machinery.''; PubMed Europe PMC
  21. Weinmann L, Höck J, Ivacevic T, Ohrt T, Mütze J, Schwille P, Kremmer E, Benes V, Urlaub H, Meister G.; ''Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.''; PubMed Europe PMC
  22. Ameres SL, Martinez J, Schroeder R.; ''Molecular basis for target RNA recognition and cleavage by human RISC.''; PubMed Europe PMC
  23. Handler D, Meixner K, Pizka M, Lauss K, Schmied C, Gruber FS, Brennecke J.; ''The genetic makeup of the Drosophila piRNA pathway.''; PubMed Europe PMC
  24. Lazzaretti D, Tournier I, Izaurralde E.; ''The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.''; PubMed Europe PMC
  25. Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, Chen ZX, Riggs AD, Rossi JJ, Morris KV.; ''The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells.''; PubMed Europe PMC
  26. Lin SL, Miller JD, Ying SY.; ''Intronic microRNA (miRNA).''; PubMed Europe PMC
  27. Stalder L, Heusermann W, Sokol L, Trojer D, Wirz J, Hean J, Fritzsche A, Aeschimann F, Pfanzagl V, Basselet P, Weiler J, Hintersteiner M, Morrissey DV, Meisner-Kober NC.; ''The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.''; PubMed Europe PMC
  28. Nishi K, Nishi A, Nagasawa T, Ui-Tei K.; ''Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus.''; PubMed Europe PMC
  29. Younger ST, Corey DR.; ''Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.''; PubMed Europe PMC
  30. Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD.; ''A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.''; PubMed Europe PMC
  31. Verdel A, Vavasseur A, Le Gorrec M, Touat-Todeschini L.; ''Common themes in siRNA-mediated epigenetic silencing pathways.''; PubMed Europe PMC
  32. Bernstein E, Caudy AA, Hammond SM, Hannon GJ.; ''Role for a bidentate ribonuclease in the initiation step of RNA interference.''; PubMed Europe PMC
  33. Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO.; ''Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance.''; PubMed Europe PMC
  34. Jo MH, Shin S, Jung SR, Kim E, Song JJ, Hohng S.; ''Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs.''; PubMed Europe PMC
  35. Bortvin A.; ''PIWI-interacting RNAs (piRNAs) - a mouse testis perspective.''; PubMed Europe PMC
  36. Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L.; ''Purified Argonaute2 and an siRNA form recombinant human RISC.''; PubMed Europe PMC
  37. Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMed Europe PMC
  38. Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN.; ''The role of PACT in the RNA silencing pathway.''; PubMed Europe PMC
  39. Gagnon KT, Li L, Chu Y, Janowski BA, Corey DR.; ''RNAi factors are present and active in human cell nuclei.''; PubMed Europe PMC
  40. Lund E, Güttinger S, Calado A, Dahlberg JE, Kutay U.; ''Nuclear export of microRNA precursors.''; PubMed Europe PMC
  41. Noland CL, Doudna JA.; ''Multiple sensors ensure guide strand selection in human RNAi pathways.''; PubMed Europe PMC
  42. Noland CL, Ma E, Doudna JA.; ''siRNA repositioning for guide strand selection by human Dicer complexes.''; PubMed Europe PMC
  43. Gredell JA, Dittmer MJ, Wu M, Chan C, Walton SP.; ''Recognition of siRNA asymmetry by TAR RNA binding protein.''; PubMed Europe PMC
  44. Bohnsack MT, Czaplinski K, Gorlich D.; ''Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs.''; PubMed Europe PMC
  45. Younger ST, Corey DR.; ''Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini.''; PubMed Europe PMC
  46. MacRae IJ, Ma E, Zhou M, Robinson CV, Doudna JA.; ''In vitro reconstitution of the human RISC-loading complex.''; PubMed Europe PMC
  47. Robb GB, Rana TM.; ''RNA helicase A interacts with RISC in human cells and functions in RISC loading.''; PubMed Europe PMC
  48. Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R.; ''MicroRNA-373 induces expression of genes with complementary promoter sequences.''; PubMed Europe PMC
  49. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R.; ''The Microprocessor complex mediates the genesis of microRNAs.''; PubMed Europe PMC
  50. Liu J, Rivas FV, Wohlschlegel J, Yates JR, Parker R, Hannon GJ.; ''A role for the P-body component GW182 in microRNA function.''; PubMed Europe PMC
  51. Gould DW, Lukic S, Chen KC.; ''Selective constraint on copy number variation in human piwi-interacting RNA Loci.''; PubMed Europe PMC
  52. Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T.; ''Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.''; PubMed Europe PMC
  53. Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, Toth KF, Bestor T, Hannon GJ.; ''A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.''; PubMed Europe PMC
  54. Kim DH, Saetrom P, Snøve O, Rossi JJ.; ''MicroRNA-directed transcriptional gene silencing in mammalian cells.''; PubMed Europe PMC
  55. Kim DH, Villeneuve LM, Morris KV, Rossi JJ.; ''Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.''; PubMed Europe PMC
  56. Alló M, Agirre E, Bessonov S, Bertucci P, Gómez Acuña L, Buggiano V, Bellora N, Singh B, Petrillo E, Blaustein M, Miñana B, Dujardin G, Pozzi B, Pelisch F, Bechara E, Agafonov DE, Srebrow A, Lührmann R, Valcárcel J, Eyras E, Kornblihtt AR.; ''Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells.''; PubMed Europe PMC
  57. Schirle NT, Sheu-Gruttadauria J, MacRae IJ.; ''Structural basis for microRNA targeting.''; PubMed Europe PMC
  58. Doyle M, Badertscher L, Jaskiewicz L, Güttinger S, Jurado S, Hugenschmidt T, Kutay U, Filipowicz W.; ''The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal.''; PubMed Europe PMC
  59. Huang V, Zheng J, Qi Z, Wang J, Place RF, Yu J, Li H, Li LC.; ''Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells.''; PubMed Europe PMC
  60. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R.; ''Control of translation and mRNA degradation by miRNAs and siRNAs.''; PubMed Europe PMC
  61. Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, Urlaub H, Meister G.; ''Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.''; PubMed Europe PMC
  62. Ahlenstiel CL, Lim HG, Cooper DA, Ishida T, Kelleher AD, Suzuki K.; ''Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells.''; PubMed Europe PMC
  63. Yoda M, Kawamata T, Paroo Z, Ye X, Iwasaki S, Liu Q, Tomari Y.; ''ATP-dependent human RISC assembly pathways.''; PubMed Europe PMC
  64. Takahashi T, Miyakawa T, Zenno S, Nishi K, Tanokura M, Ui-Tei K.; ''Distinguishable in vitro binding mode of monomeric TRBP and dimeric PACT with siRNA.''; PubMed Europe PMC
  65. Rosenkranz D, Zischler H.; ''proTRAC--a software for probabilistic piRNA cluster detection, visualization and analysis.''; PubMed Europe PMC
  66. Haase AD, Jaskiewicz L, Zhang H, Lainé S, Sack R, Gatignol A, Filipowicz W.; ''TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.''; PubMed Europe PMC
  67. Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S.; ''Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection.''; PubMed Europe PMC
  68. Ohrt T, Mütze J, Staroske W, Weinmann L, Höck J, Crell K, Meister G, Schwille P.; ''Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells.''; PubMed Europe PMC
  69. Tomari Y, Zamore PD.; ''Perspective: machines for RNAi.''; PubMed Europe PMC
  70. Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ.; ''Argonaute2 is the catalytic engine of mammalian RNAi.''; PubMed Europe PMC
  71. Fukunaga R, Han BW, Hung JH, Xu J, Weng Z, Zamore PD.; ''Dicer partner proteins tune the length of mature miRNAs in flies and mammals.''; PubMed Europe PMC
  72. Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, Mione M, Carninci P, d'Adda di Fagagna F.; ''Site-specific DICER and DROSHA RNA products control the DNA-damage response.''; PubMed Europe PMC
  73. Baillat D, Shiekhattar R.; ''Functional dissection of the human TNRC6 (GW182-related) family of proteins.''; PubMed Europe PMC
  74. Fontoura BM, Blobel G, Matunis MJ.; ''A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.''; PubMed Europe PMC
  75. Maroney PA, Yu Y, Fisher J, Nilsen TW.; ''Evidence that microRNAs are associated with translating messenger RNAs in human cells.''; PubMed Europe PMC
  76. Betancur JG, Tomari Y.; ''Dicer is dispensable for asymmetric RISC loading in mammals.''; PubMed Europe PMC
  77. Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H.; ''Structure of C3PO and mechanism of human RISC activation.''; PubMed Europe PMC
  78. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA, Wang HW.; ''Substrate-specific structural rearrangements of human Dicer.''; PubMed Europe PMC
  79. Robb GB, Brown KM, Khurana J, Rana TM.; ''Specific and potent RNAi in the nucleus of human cells.''; PubMed Europe PMC
  80. Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD.; ''Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.''; PubMed Europe PMC
  81. Provost P, Dishart D, Doucet J, Frendewey D, Samuelsson B, Rådmark O.; ''Ribonuclease activity and RNA binding of recombinant human Dicer.''; PubMed Europe PMC
  82. Doench JG, Sharp PA.; ''Specificity of microRNA target selection in translational repression.''; PubMed Europe PMC
  83. Shin C.; ''Cleavage of the star strand facilitates assembly of some microRNAs into Ago2-containing silencing complexes in mammals.''; PubMed Europe PMC
  84. Zhang H, Kolb FA, Brondani V, Billy E, Filipowicz W.; ''Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP.''; PubMed Europe PMC
  85. Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMed Europe PMC
  86. Hutvágner G, Zamore PD.; ''A microRNA in a multiple-turnover RNAi enzyme complex.''; PubMed Europe PMC
  87. Muerdter F, Guzzardo PM, Gillis J, Luo Y, Yu Y, Chen C, Fekete R, Hannon GJ.; ''A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.''; PubMed Europe PMC
  88. Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN.; ''The Drosha-DGCR8 complex in primary microRNA processing.''; PubMed Europe PMC
  89. Yi R, Qin Y, Macara IG, Cullen BR.; ''Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.''; PubMed Europe PMC
  90. Bernard MA, Wang L, Tachado SD.; ''DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes.''; PubMed Europe PMC
  91. Kok KH, Ng MH, Ching YP, Jin DY.; ''Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.''; PubMed Europe PMC
  92. Seong Y, Lim DH, Kim A, Seo JH, Lee YS, Song H, Kwon YS.; ''Global identification of target recognition and cleavage by the Microprocessor in human ES cells.''; PubMed Europe PMC
  93. Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt C, Batsché E, Harel-Bellan A.; ''Argonaute proteins couple chromatin silencing to alternative splicing.''; PubMed Europe PMC
  94. Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E.; ''A novel class of RanGTP binding proteins.'';