HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)

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1225, 10512217, 4117019, 56, 59, 89, 113...77, 80, 14588, 101, 103, 110, 132...372814, 30, 97, 121, 14363, 10826, 35, 102, 104, 111...133, 13910417, 32, 41, 51, 112...9, 45, 58, 91, 95...58, 91, 135, 142, 146...21, 55, 61, 99, 119...63, 9611017, 41, 15411, 30, 50, 13042, 136, 14817, 411066315, 25, 36, 66, 73...33, 40, 11818, 25, 36, 73, 140...1261, 46, 7653, 62, 92, 1002, 4, 6, 30, 97...24, 47, 9240, 11812, 52, 93, 128, 157...20, 288014113, 43, 68, 72, 85...83, 91, 12522, 3747, 53, 54, 74, 107...122cytosolnucleoplasmEXO1 MRE11A XRCC3 K63PolyUb-K14,K16,p-S140-H2AFX CCNA1 DNA2 TOPBP1TOPBP1 RMI1 PIAS4 RAD51D BRE p-S343-NBN TIPIN RMI2 RPA3 UBB(153-228) RAD51D BLM H2BFS RFC2 BCDX2 complexBRCC3 ADPATPEME1 UBC(305-380) p-S327,T847,T859-RBBP8 RMI1 p-T916,S945-CLSPNp-S343-NBN ATR BLM HIST1H2BB RFC2 HIST1H2BB TOP3A p-S327,T847,T859-RBBP8 RAD51AP1p-S456-ABL1DNA2 TOP3A RAD51AP1 RPA3 RMI2 ATPRMI1 ATRIP ExtendedD-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexRAD50 MRE11A p-S33-RPA2 TOP3A WRN DNA double-strand break ends POLD2 p-T3387-BRCA2:p-T309-RAD51 complexp-T160-CDK2 RPA3 HERC2-SUMO1 3' short overhanging ssDNA-DSBs MonoUb-K164-PCNA XRCC3 PALB2RFC3 RMI1 RNF168 RAD50 WRN p-S327,T847,T859-RBBP8 XRCC3 PALB2 p-S102-WHSC1p-S990,Ac-K1249-BRIP1 EXO1,DNA2:BLM,WRNDNA2 HIST1H2BA EXO1 H2OATR p-S990,Ac-K1249-BRIP1MRE11A ATRIP UBC(457-532) RAD51C TOP3A RAD1 p-S343-NBN HIST1H2BL NAD+KAT5 TOP3A XRCC3 BRCC3 p-S327,T847,T859-RBBP8 TOP3A p-T4827,SUMO1-HERC2 CHEK1SLX1A ATR EXO1 BRCA2p-S1981,Ac-K3016-ATM p-T309-RAD51MUS81 MRE11A p-S1981,Ac-K3016-ATM ADPRPA1 HIST3H3 PCNA p-S343-NBN ATPRFC4 p-S1981,Ac-K3016-ATM p-S988,S1387,S1423,S1524,S1547-BRCA1 EXO1 RFC2 ATRIP UBE2I-G93-SUMO2 EME2 XRCC3HIST2H2BE p-S1981,Ac-K3016-ATM p-T714,T734-BARD1 WRN DNA double-strand break ends p-S1981,Ac-K3016-ATM HUS1 dsDNAp-5S-BRCA1:p-2T-BARD1H2BFS p-Y104-RAD52heptamerUBC(457-532) DNADSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5RAD50 CCNA2 DNA2 RPA1 ATPp-S990,Ac-K1249-BRIP1 RAD9A p-RPA heterotrimerRHNO1 MRE11A p-S990,Ac-K1249-BRIP1 RAD51D RAD50 RNF8 ATR:ATRIPMRE11A p-S327,T847,T859-RBBP8 p-S988,S1387,S1423,S1524,S1547-BRCA1 HIST1H2BK RFC3 p-S988,S1387,S1423,S1524,S1547-BRCA1 TOP3A p-T714,T734-BARD1 p-Y104-RAD52 BLM p-S343-NBN 3' overhanging DNA at resected DSB ends UBC(229-304) UIMC1 p-T714,T734-BARD1 p-S327,T847,T859-RBBP8 RAD51CKAT5 KAT5 RMI1 3' overhanging DNA at resected DSB ends RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1RMI1 TOP3A ADPUBC(609-684) HIST1H2BM K48PolyUb,SUMO2-K1840,p-5T-MDC1 MRE11A RFC3 p-Y104-RAD52 KAT5 p-T916,S945-CLSPN RAD17 RMI2 PIAS4 p-T3387-BRCA2 p-S343-NBN EXO1 RMI2 RPA3 HIST1H2BC RPA3 cleaved Holliday structure RAD51C RFC2 p-S343-NBN RAD9B ATRIP PALB2 RFC4 RPA1 BLM HIST1H2BH RMI1 WRN p-S343-NBN p-S1981,Ac-K3016-ATM RAD17 RAD1 TOP3A RAD51B H2ORFC5 RAD17 RAD50 EXO1 DNA2 SLX4 p-T714,T734-BARD1 DNA double-strand break ends HUS1 TOPBP1 EXO1 p-S102-WHSC1 DNA2 p-Y104-RAD52 p-S1981,Ac-K3016-ATM KAT5 KAT5 UBC(609-684) RAD51C CCNA:p-T160-CDK2HIST1H2BH SPIDR XRCC2 HIST1H2BM NonhomologousEnd-Joining (NHEJ)RHNO1PPP4R2 p-S988,S1387,S1423,S1524,S1547-BRCA1 3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complexBLM p-S990,Ac-K1249-BRIP1 EME1 RMI1 HIST1H2BM ATPHIST1H2BD p-S343-NBN p-T3387-BRCA2 RFC5 WRN UBB(1-76) UIMC1UBB(1-76) WRN HIST2H2BE CCNA2 RPA1 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexTOP3A RAD50 D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1KAT5 ATR:ATRIP:p-RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1Me2K21-HIST1H4 p-S990,Ac-K1249-BRIP1 RAD9B p-S343-NBN p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S327,T847-RBBP8 p-S343-NBN p-S327,T847,T859-RBBP8 RMI2 POLD1 Me2K21-HIST1H4 KAT5SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1RFC2 dNTPp-S1981,Ac-K3016-ATM RFC3 XRCC2 CleavedD-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexp-S343-NBN RNF168 ERCC1 p-S1981,Ac-K3016-ATM RFC5 MRE11A p-S102-WHSC1 ADPATPRAD9B RMI1 p-T714,T734-BARD1 p-S990,Ac-K1249-BRIP1 p-S343-NBN XRCC2 RAD51C RAD9A DNA double-strand break ends MRE11A p-S1981,Ac-K3016-ATM DNA2 TOP3A POLE TOP3A p-S343-NBN ATRIP 3' overhanging DNA at resected DSB ends p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S343-NBN KAT5 CHEK1 KAT5 RFC4 KAT5 RAD9:HUS1:RAD1MRE11A p-S1981,Ac-K3016-ATM p-S327,T847,T859-RBBP8 p-S343-NBN RMI2 XRCC2 DNADSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5MRE11A p-S988,S1387,S1423,S1524,S1547-BRCA1 EXO1 p-T309-RAD51 H2BFS RPA3 DNA2 p-S25,S1778-TP53BP1 p-Y104-RAD52heptamerMRE11A p-T3387-BRCA2 RFC2 RMI2 RPA3 ADP3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1UBC(381-456) POLH ATR BLM:TOP3A:RMI1:RMI2:SPIDRRAD9A RNF8:Zn2+UBE2N BLM RAD17 p-S327,T847,T859-RBBP8 RAD50 RAD51B p-T714,T734-BARD1 UBB(77-152) DNA2 RFC5 SIRT6BLM 3' overhanging DNA at resected DSB ends RAD51AP1 XRCC2 RAD50 RPA2 HIST2H2BE HIST1H2BD RAD51RAD9B RFC3 POLK RMI2 p-Y104-RAD52 p-S990,Ac-K1249-BRIP1 p-T714,T734-BARD1 RPA3 RMI2 p-S343-NBN ATR RAD50 p-T714,T734-BARD1 TOP3A EXO1 dsDNA with crossoverBLM RAD51DMRE11A XRCC2 RPS27A(1-76) XRCC2 HIST1H2BN Zn2+ BABAM1 TOP3A HIST1H2BN RHNO1 p-T714,T734-BARD1 RFC4 PPP4C RFC2 CX3 complexRFC3 EME2 XRCC2p-S343-NBN WRN UBA52(1-76) RAD9A p-S1981,Ac-K3016-ATMRMI2 MRE11A DNA Double StrandBreak ResponseHIST1H2BJ DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8p-T714,T734-BARD1 WRN HUS1 RMI2 RFC3 MRE11A Heteroduplex DNA with D-loop structure with extended pairing between invading strand and complementary heteroduplex strand RFC4 RAD51AP1 RHNO1 RAD17 HIST1H2BO Heteroduplex DNA with D-loop structure with extended pairing between invading strand and complementary heteroduplex strand BLM Cleaved D-loop RAD50 p-S990,Ac-K1249-BRIP1 HIST1H2BA p-S988,S1387,S1423,S1524,S1547-BRCA1 EXO1 HUS1 DNA2 p-S33-RPA2 ATRIP DNA2 p-T714,T734-BARD1 DNA2 UBC(77-152) p-T309-RAD51 UBC(305-380) MRE11A RPA1 RAD1 RMI1 XRCC2 UBC(153-228) BLM RAD51B p-S1981,Ac-K3016-ATM HollidayJunction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexDNA2 BCDX2 complexWRN p-T309-RAD51 WRN EXO1 SLX1A p-S988,S1387,S1423,S1524,S1547-BRCA1 MDC1-SUMO2 p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S343-NBN RAD51D p-S327,T847,T859-RBBP8 BRE HIST1H2BN KAT5 p-S990,Ac-K1249-BRIP1 p-T3387-BRCA2 RAD51C p-S988,S1387,S1423,S1524,S1547-BRCA1 PALB2p-T309-RAD51 TOPBP1 PALB2 p-S1981,Ac-K3016-ATM WRN p-T714,T734-BARD1 EME1 TOPBP1 Extended D-loop p-T309-RAD51 ATR:ATRIP:p-RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1POLD3 WRN RAD1 ADPXRCC3 p-S1981,Ac-K3016-ATM RPA2 RMI2 KAT5 RMI2 PALB2 dNTPRMI1 PALB2p-T714,T734-BARD1 3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2Holliday structure UBC(77-152) POLD4 XRCC3 TIMELESS RMI1 p-S327,T847,T859-RBBP8 RAD50 p-T3387-BRCA2 p-T714,T734-BARD1 RAD50 p-5S-BRCA1:p-2T-BARD1RAD51D RPA1 MUS81p-S33-RPA2 p-S988,S1387,S1423,S1524,S1547-BRCA1 RHNO1UBC(1-76) Piss-gap-reannealedDNAEME1 POLE4 RAD51D ADPK63PolyUb-K14,K16,p-S140-H2AFX SLX1A EXO1 p-S343-NBN p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S327,T847,T859-RBBP8 homotetramerp-S990,Ac-K1249-BRIP1 RNF8 p-S327,T847,T859-RBBP8 RAD51B UBE2N RAD51D Sister ChromosomalArmRAD51C RMI1 PCNA:POLD,POLE,POLH,POLK:RPA:RFCATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1UBC(153-228) p-T3387-BRCA2 p-T714,T734-BARD1 p-S25,S1778-TP53BP1 p-S343-NBN p-T4827,SUMO1-HERC2 WRN p-S1981,Ac-K3016-ATM XRCC3 dNTPp-T3387-BRCA2:p-T309-RAD51 complexp-S327,T847,T859-RBBP8 KAT5 BLM RFC5 p-T160-CDK2 ADP3'shortoverhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1p-S988,S1387,S1423,S1524,S1547-BRCA1 RAD51AP1 MUS81:EME1,(MUS81:EME2)EXO1 RAD9A Zn2+ RAD9B TOP3A NAMUBA52(1-76) RMI2 p-S327,T847,T859-RBBP8 Flap3' overhanging DNA at resected DSB ends RAD51C RMI1 RAD9B RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1RAD17 p-T714,T734-BARD1 p-T3387-BRCA2 RMI2 MDC1-SUMO2 BLM RMI1 SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)RMI2 K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-NucleosomeRAD51 MRE11A RAD51D TOPBP1RBBP8 HIST3H2BB MRE11A CCNA1 HIST1H2BC Sister Chromatid Armwith Crossoverp-S406-FAM175Ap-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1KAT5UBC(533-608) ATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1WRN p-S1981,Ac-K3016-ATM PIAS4BLM GEN1 p-5S-BRCA1:p-2T-BARD1p-S327,T847,T859-RBBP8 MUS81 KAT5 p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S406-FAM175A RAD50 TOP3A UBC(1-76) EME2 RAD9B UBE2V2 RPS27A(1-76) RAD50 K63PolyUb-K14,K16,p-S140-H2AFX HIST1H2BH p-S988,S1387,S1423,S1524,S1547-BRCA1 RAD9A p-S327,T847,T859-RBBP8 KAT5 WRN KAT5 RMI2 RPA1 KAT5 RAD51B MRE11A RAD51B BLM p-S327,T847,T859-RBBP8 homotetramerRAD1 PPiRMI2 HUS1 UBE2N RAD51 p-S1981,Ac-K3016-ATM p-T309-RAD51 HIST1H2BB RAD51C EXO1 p-T309-RAD51 2'-O-acetyl-ADP-riboseWRN SSB-dsDNA withinter-SSA deletionRHNO1 p-S1981,Ac-K3016-ATM ATR p-S327,T847,T859-RBBP8 MRE11A BLM RAD51D RAD50 p-S1981,Ac-K3016-ATMKAT5 EXO1 RMI1 RFC5 RAD51C XRCC2 PALB2 RMI1 RNF4 homodimerHIST1H2BD p-Y104-RAD52 p-S1981,Ac-K3016-ATM D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexRAD50 ATPTOP3A p-S990,Ac-K1249-BRIP1 RAD50 RPA heterotrimerRAD51AP1 p-S988,S1387,S1423,S1524,S1547-BRCA1 HIST1H2BJ RAD50 p-T714,T734-BARD1 3'shortoverhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complexRAD51C HIST1H2BO BLM RAD50 ATRIP ATPTOP3A UBB(153-228) p-T309-RAD51 RFC1 UBE2N:UBE2V2RAD51Bp-S343-NBN RAD9A p-S1981,Ac-K3016-ATM RPA1 RAD51AP1 3' overhanging DNA at resected DSB ends DNA2 HIST1H2BK TOP3A XRCC3 TOP3A 3' overhanging DNA at resected DSB ends p-T309-RAD51 RTEL1BREPiRMI1 RAD9A RAD50 H2Op-T714,T734-BARD1 p-S343-NBN UBB(77-152) SUMO2-C93-UBE2I RPA2 PPP4C:PPP4R2ATRIP RAD51C p-S327,T847,T859-RBBP8 DNA double-strand break ends RMI1 POLE3 RAD51B RAD9B p-S990,Ac-K1249-BRIP1 DNA DSB with annealed 3' overhanging ssDNA and flaps ATPp-S406-FAM175A RPA1 EME1,EME2EXO1,DNA2:BLM,WRNRPA3 BLM HIST1H2BC DNA2 RAD50 RAD1 p-S1981,Ac-K3016-ATM RAD50 UBC(533-608) RPA2 RFC3 EXO1 p-S990,Ac-K1249-BRIP1 HERC2-SUMO1 SUMO2:UBE2IRAD50 WRN UbATRIP RPA1 p-T714,T734-BARD1 KAT5 WRN HIST1H2BL HIST1H2BA HIST1H2BL RAD52 heptamerHIST3H2BB BCDX2 complexRFC4 p-S988,S1387,S1423,S1524,S1547-BRCA1 p-T3387-BRCA2 RPA3 RAD17:RFCRMI2 p-T4827,SUMO1-HERC2 p-T309-RAD51 MRE11A RMI1 SUMO1:p-T4827-HERC2KAT5 p-S343-NBN HERC2-SUMO1 KAT5 MRE11A p-MRN3' overhanging DNA at resected DSB ends p-T714,T734-BARD1 RMI1 p-S33-RPA2 RAD50 ATR:ATRIPMRE11A RAD51B Me2K21-HIST1H4 EXO1 DNA2 DNA double-strand break ends p-S990,Ac-K1249-BRIP1 p-T714,T734-BARD1 HUS1 BLM RFC5 MRE11A RNF8 TIPIN p-T714,T734-BARD1 Sister ChromosomalArmDNA2 Ac-K432,K526,K604-RBBP8 RPA3 BABAM1DNADSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5p-S327,T847,T859-RBBP8 BLM DNA2 RAD52CX3 complexp-S327,T847,T859-RBBP8 RBBP8 RAD50 ERCC1:ERCC4KAT5 HUS1 HUS1 p-S988,S1387,S1423,S1524,S1547-BRCA1 PALB2 RAD51C Ac-K432,K526,K604-RBBP8 homotetramerPOLE2 DNA2 BLM RHNO1 HIST1H2BO RMI1 HIST1H2BK p-S327,T847,T859-RBBP8 EXO1,DNA2:BLM,WRNp-S990,Ac-K1249-BRIP1p-S990,Ac-K1249-BRIP1 RPA3 RAD51AP1p-S343-NBN p-S988,S1387,S1423,S1524,S1547-BRCA1 UBE2IDNA2 p-T714,T734-BARD1 UBE2V2 RFC4 BLM p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S327,T847,T859-RBBP8 WRN DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex3' overhanging DNA at resected DSB ends RAD1 RAD51B MUS81 BLM:TOP3A:RMI1:RMI2p-T3387-BRCA2RAD51D RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1p-S1981,Ac-K3016-ATM TOP3A CleavedHollidayJunction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexp-S990,Ac-K1249-BRIP1 RMI2 p-S25,S1778-TP53BP1p-S1981,Ac-K3016-ATM RAD52 p-S1981,Ac-K3016-ATM SUMO2-K1840,p-5T-MDC1 RPA2 EXO1 RNF4 RFC5 RMI2 RPA1 dsDNA with inter-SSAdeletionRAD1 RFC4 BLM ATR RAD17:RFCTOP3A RBBP8 homotetramerp-5T-MDC1 H2OBABAM1 XRCC2 TIMELESS:TIPINTOPBP1 EXO1 p-S343-NBN KAT5 EXO1 RAD51AP1p-S1981,Ac-K3016-ATM RAD50 p-S988,S1387,S1423,S1524,S1547-BRCA1 RAD51B UBC(381-456) RPA1 p-T3387-BRCA2 ERCC4 RFC5 RAD9:HUS1:RAD1EME2 WRN TOPBP1 UBE2V2 p-T714,T734-BARD1 DNA2 RHNO1 RAD50 KAT5 RFC2 p-S1981,Ac-K3016-ATM Zn2+ CX3 complexMRE11A DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complexSPIDRp-S988,S1387,S1423,S1524,S1547-BRCA1 MRE11A 3' short overhanging ssDNA-DSBs RFC3 SLX4 RNF168p-S327,T847,T859-RBBP8 p-S990,Ac-K1249-BRIP1 p-S317,S345-CHEK1p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S33-RPA2 p-S990,Ac-K1249-BRIP1p-MRNRAD51C MRE11A p-S33-RPA2 Pip-S988,S1387,S1423,S1524,S1547-BRCA1 UIMC1 p-S990,Ac-K1249-BRIP1 RMI2 RFC2 RAD17 H2OKAT5 3' overhanging DNA at resected DSB ends p-S33-RPA2 TOP3A HIST3H2BB BRCC3DNA double-strand break ends K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimerRAD50 p-S343-NBN HIST1H2BJ UBC(229-304) HIST3H3 p-T3387-BRCA2 SLX4 KAT5 RAD17 RMI1 p-RPA heterotrimerEXO1 HIST3H3 BLM SLX1A:SLX4ADPp-T714,T734-BARD1 WRN ATR TIMELESS RMI2 RFC4 MRE11A ATR p-S343-NBN 12234, 137876911637282010161206017, 411063, 10816010660104917, 413, 7, 8, 16, 23...8713317, 4116134, 137115, 12017, 41104916863, 10817, 41282817, 414917, 41116