HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)

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85247, 28, 30, 94, 97...11, 65, 125, 13814, 17, 11125, 38, 40, 49, 77...20, 14552, 62, 130, 1618, 9, 10914, 11132, 6712, 18, 29, 80, 81, 103...4, 12214, 23, 90, 111, 147...92, 108, 1603, 5, 33, 89, 104...11, 53, 59, 119, 155...68, 93, 95, 142, 16175, 12834, 51, 63, 88, 99...15670, 14021, 24, 55, 56, 131...618, 45, 80, 81, 103...13, 112, 1173210851, 35, 47, 72, 146...41, 61, 66, 69, 71...14, 11160, 61, 76, 106, 117...53, 65, 8615824, 26, 44, 93, 95...898520, 87, 1451607046, 98, 13270, 16213410, 39nucleoplasmcytosolMRE11A RAD50 p-MRNMRE11A p-S406-FAM175A RAD51AP1 cleaved Holliday structure EXO1 3' overhanging DNA at resected DSB ends XRCC3XRCC2 BLM p-S343-NBN DNA2 RAD9A RPS27A(1-76) KAT5 RPA3 PiH2ORFC4 p-S327,T847,T859-RBBP8 RFC5 HIST1H2BB RMI2 RMI1 PPP4R2 WRN BLM p-S343-NBN ADPHUS1 RPA3 p-S990,Ac-K1249-BRIP1 PALB2p-Y104-RAD52 ERCC1 RAD17:RFCRAD51B p-S988,S1387,S1423,S1524,S1547-BRCA1 RFC1 RAD50 KAT5 RFC4 WRN RAD1 RPA1 MRE11A ExtendedD-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexXRCC3 DNA2 RAD51BRMI2 CCNA1 RFC3 RFC5 SLX1A WRN PALB2 BRCA2p-T714,T734-BARD1 p-S1981,Ac-K3016-ATM POLE KAT5 EXO1,DNA2:BLM,WRNRAD51AP1 KAT5 p-T160-CDK2 BLM DNA2 NAMRAD52 heptamerDNA DSB with annealed 3' overhanging ssDNA and flaps HIST3H3 p-S988,S1387,S1423,S1524,S1547-BRCA1 RAD51C p-S1981,Ac-K3016-ATM UBC(1-76) RAD50 RAD9A MRE11A p-S990,Ac-K1249-BRIP1 EXO1 MRE11A EXO1 p-S317,S345-CHEK1RAD50 RFC2 HIST1H2BC BLM RPA1 MRE11A UBC(533-608) p-S327,T847,T859-RBBP8 EXO1 HIST3H3 DNA double-strand break ends p-5S-BRCA1:p-2T-BARD1H2BFS BABAM1 RAD1 RPA2 DNA2 RAD50 XRCC3 3' overhanging DNA at resected DSB ends HIST1H2BB TOP3A p-S988,S1387,S1423,S1524,S1547-BRCA1 KAT5WRN RAD51D KAT5 WRN HollidayJunction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexRAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1RAD51C XRCC2 KAT5 p-S327,T847,T859-RBBP8 RPA2 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complexRMI2 RPA2 Extended D-loop SPIDRCleavedHollidayJunction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexTOP3A RFC2 ATR TOP3A ERCC1:ERCC4RPA3 RAD17 TOPBP1 p-S343-NBN p-S327,T847,T859-RBBP8 RFC5 POLD2 Sister Chromatid Armwith CrossoverKAT5 ATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1RMI2 TOP3A TOP3A HIST1H2BN EME1 KAT5 p-T3387-BRCA2 3' short overhanging ssDNA-DSBs ADPDNA2 MUS81 RFC5 RAD51D UBB(1-76) UBB(77-152) Zn2+ HIST1H2BO RAD1 TOP3A RNF8 HIST1H2BO ATR XRCC3 KAT5 ATRIP RFC5 ATPRAD51CDNADSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5RMI1 RFC2 p-T309-RAD51 p-S990,Ac-K1249-BRIP1 UBE2N PiTOP3A p-S327,T847,T859-RBBP8 p-S327,T847,T859-RBBP8 ATR RAD9A CHEK1 p-S990,Ac-K1249-BRIP1 RAD9B KAT5 p-S327,T847,T859-RBBP8 EXO1 p-S33-RPA2 RPA3 p-T714,T734-BARD1 p-S343-NBN UBB(153-228) SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1RMI2 p-S1981,Ac-K3016-ATM BREMRE11A RMI2 p-S990,Ac-K1249-BRIP1 p-S327,T847,T859-RBBP8 XRCC3 EXO1 RAD51AP1p-S990,Ac-K1249-BRIP1 RAD51C RAD51C HUS1 TOP3A Sister ChromosomalArmRAD51B p-S1981,Ac-K3016-ATM RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1p-S1981,Ac-K3016-ATM p-S1981,Ac-K3016-ATM p-S990,Ac-K1249-BRIP1 p-S343-NBN SUMO2:UBE2Ip-S1981,Ac-K3016-ATM PALB2 p-S343-NBN p-S990,Ac-K1249-BRIP1 HIST1H2BC GEN1 p-T714,T734-BARD1 UBC(457-532) p-S343-NBN RAD51D KAT5 TIMELESS p-S988,S1387,S1423,S1524,S1547-BRCA1 ATPKAT5 KAT5 K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-NucleosomeK48PolyUb,SUMO2-K1840,p-5T-MDC1 p-S1981,Ac-K3016-ATM RAD51DMRE11A RAD50 RAD50 RAD51C p-T4827,SUMO1-HERC2 TOP3A KAT5 MRE11A XRCC2 3' overhanging DNA at resected DSB ends p-S33-RPA2 RNF4 homodimerp-S990,Ac-K1249-BRIP1 HUS1 p-S327,T847,T859-RBBP8 XRCC2 p-S1981,Ac-K3016-ATM RAD50 RAD50 3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1dsDNA with crossoverBRE BLM SLX4 p-T3387-BRCA2 MRE11A ss-gap-reannealedDNAEME1 Me2K21-HIST1H4 3' overhanging DNA at resected DSB ends SLX4 WRN RFC5 RAD50 HIST1H2BM UBB(77-152) RAD50 EME2 NonhomologousEnd-Joining (NHEJ)RAD51B p-T3387-BRCA2RMI1 p-S990,Ac-K1249-BRIP1 p-T916,S945-CLSPN UBA52(1-76) RAD9:HUS1:RAD1RNF8 p-S1981,Ac-K3016-ATM KAT5 WRN PCNA p-S990,Ac-K1249-BRIP1 p-S990,Ac-K1249-BRIP1 RMI2 RAD50 RAD1 WRN p-T3387-BRCA2 UBE2N PIAS4BLM CX3 complexp-S1981,Ac-K3016-ATM HIST1H2BD HIST1H2BB Me2K21-HIST1H4 RPA3 ATRIP DNA2 SUMO2-C93-UBE2I RAD51D p-S33-RPA2 EXO1 RAD9B RNF168 ATR RMI1 p-T3387-BRCA2 p-S343-NBN RAD51C UBC(457-532) XRCC2BLM RAD17 p-S327,T847,T859-RBBP8 homotetramerSUMO1:p-T4827-HERC2BCDX2 complexp-S988,S1387,S1423,S1524,S1547-BRCA1 HIST1H2BJ WRN BLM:TOP3A:RMI1:RMI2:SPIDRH2ORAD9:HUS1:RAD1RAD51C XRCC3 p-S988,S1387,S1423,S1524,S1547-BRCA1 TOP3A p-S990,Ac-K1249-BRIP1UBB(153-228) RHNO1 ADPDNA2 RPA1 p-S343-NBN DNA2 p-T714,T734-BARD1 H2BFS UIMC1RAD17 3' overhanging DNA at resected DSB ends p-S327,T847,T859-RBBP8 BRE p-S327,T847,T859-RBBP8 BCDX2 complexEME2 MRE11A WRN RFC5 WRN RAD50 RMI1 MRE11A ATR:ATRIP:p-RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1CX3 complexADPWRN RAD51C CCNA:p-T160-CDK2RFC5 RFC3 ATR:ATRIPRAD1 RAD51B RMI1 p-S343-NBN RAD50 p-T4827,SUMO1-HERC2 HIST1H2BA p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S990,Ac-K1249-BRIP1RFC2 RFC2 RAD50 UBC(609-684) ATPRAD51AP1 H2Op-S327,T847,T859-RBBP8 BLM p-S327,T847,T859-RBBP8 RAD51AP1HIST1H2BM p-S1981,Ac-K3016-ATM TOP3A BLM p-S1981,Ac-K3016-ATMp-S1981,Ac-K3016-ATM p-S1981,Ac-K3016-ATM p-S988,S1387,S1423,S1524,S1547-BRCA1 RAD50 p-S1981,Ac-K3016-ATM UbKAT5 EXO1 H2OEXO1 HIST1H2BL p-T309-RAD51 p-S343-NBN EME1,EME23'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2PiEXO1 HUS1 RPA1 RMI2 XRCC2 TOPBP1 RAD51B DNA double-strand break ends UBC(1-76) RAD9B p-S988,S1387,S1423,S1524,S1547-BRCA1 RFC2 WRN DNA2 ADPRAD9B EXO1,DNA2:BLM,WRNp-S988,S1387,S1423,S1524,S1547-BRCA1 PIAS4 TOP3A p-S988,S1387,S1423,S1524,S1547-BRCA1 MRE11A 3'shortoverhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1POLE4 MRE11A RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1HIST1H2BA RPA3 p-S1981,Ac-K3016-ATM RAD51AP1 RFC3 p-T309-RAD51DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexp-5T-MDC1 KAT5 UBC(609-684) HUS1 p-S327,T847,T859-RBBP8 p-T714,T734-BARD1 MRE11A p-Y104-RAD52 PCNA:POLD,POLE,POLH,POLK:RPA:RFCHolliday structure HIST1H2BH p-S990,Ac-K1249-BRIP1 p-T3387-BRCA2:p-T309-RAD51 complexRAD17 EXO1 RAD9B PALB2 RAD50 3'shortoverhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complexUBE2V2 KAT5BCDX2 complexDNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexUBC(305-380) p-S1981,Ac-K3016-ATM CHEK1HIST1H2BA EXO1 p-S988,S1387,S1423,S1524,S1547-BRCA1 MRE11A dNTPTOP3A BLM RPA1 BLM XRCC2 p-S1981,Ac-K3016-ATM p-S988,S1387,S1423,S1524,S1547-BRCA1 POLK RHNO1 RPA1 p-S990,Ac-K1249-BRIP1 DNA2 RPA1 RHNO1 UBC(381-456) RHNO1SUMO2-K1840,p-5T-MDC1 RAD51WRN WRN RFC4 ATR BLM p-S343-NBN p-S1981,Ac-K3016-ATM WRN ATRIP MUS81UBC(77-152) EXO1 HIST1H2BM KAT5 p-S990,Ac-K1249-BRIP1 p-S988,S1387,S1423,S1524,S1547-BRCA1 p-T714,T734-BARD1 Zn2+ p-Y104-RAD52heptamerp-T309-RAD51 p-T160-CDK2 HIST1H2BH MRE11A BLM EXO1 ATR CleavedD-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexp-T714,T734-BARD1 UBE2Ip-S343-NBN MDC1-SUMO2 HIST1H2BJ ATRIP UBE2I-G93-SUMO2 RNF168K63PolyUb-K14,K16,p-S140-H2AFX p-S1981,Ac-K3016-ATMKAT5 TOPBP1PIAS4 RMI2 RMI1 p-S1981,Ac-K3016-ATM TOP3A CCNA2 POLD3 RAD52EME2 EME1 RBBP8 ADPMUS81 p-S988,S1387,S1423,S1524,S1547-BRCA1 ADPRMI1 ATR RHNO1 p-S988,S1387,S1423,S1524,S1547-BRCA1 DNA2 HERC2-SUMO1 RFC2 RFC3 p-S25,S1778-TP53BP1p-T714,T734-BARD1 3' overhanging DNA at resected DSB ends p-S343-NBN RPA3 RMI1 UBE2V2 p-S343-NBN HIST2H2BE KAT5 HIST1H2BL RMI2 UBC(381-456) p-S25,S1778-TP53BP1 H2OHIST3H2BB TOP3A PALB2 D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complexMonoUb-K164-PCNA 3' overhanging DNA at resected DSB ends 3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complexRAD51D EXO1 RMI1 RMI1 BLM p-T714,T734-BARD1 DNA2 PPP4C BLM TOP3A p-S988,S1387,S1423,S1524,S1547-BRCA1 p-T3387-BRCA2 p-T309-RAD51 EXO1 BLM BRCC3DNA2 BRCC3 MRE11A EXO1 RMI2 Cleaved D-loop DNA2 p-T714,T734-BARD1 ATRIP RMI2 MDC1-SUMO2 RMI2 p-S343-NBN TOPBP1 RMI2 RAD50 BABAM1 RAD51B RAD9B p-S988,S1387,S1423,S1524,S1547-BRCA1 BLM UIMC1 HIST1H2BK KAT5 RAD50 MRE11A HIST1H2BL KAT5 p-Y104-RAD52 Ac-K432,K526,K604-RBBP8 HIST3H2BB HUS1 PALB2 PALB2RAD51AP1 RAD51D CCNA2 CCNA1 RPA3 p-T714,T734-BARD1 HIST1H2BN RAD9A ATRIP RMI1 RAD50 RAD51B p-S990,Ac-K1249-BRIP1 DNA double-strand break ends HIST1H2BD Heteroduplex DNA with D-loop structure with extended pairing between invading strand and complementary heteroduplex strand HIST2H2BE RMI1 p-S327,T847,T859-RBBP8 RFC3 p-S327,T847,T859-RBBP8 RFC3 BLM:TOP3A:RMI1:RMI2RAD50 p-MRNSLX1A DNA2 RAD51 SLX4 TOP3A Zn2+ TOP3A WRN XRCC2 RAD52 ATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1TOP3A p-T714,T734-BARD1 RAD9A KAT5 DNA double-strand break ends RAD17:RFCHIST1H2BD Heteroduplex DNA with D-loop structure with extended pairing between invading strand and complementary heteroduplex strand RPA2 p-S343-NBN RAD51C XRCC2 p-S102-WHSC1 RPA2 p-S990,Ac-K1249-BRIP1 RPA1 TOPBP1DNA double-strand break ends ATRIP p-T309-RAD51 DNA2 RFC3 RAD51C RNF8:Zn2+POLD4 MRE11A WRN UBE2N:UBE2V2ATR BRCC3 p-S1981,Ac-K3016-ATM RPS27A(1-76) p-S33-RPA2 ATPRNF8 POLE2 K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimerp-Y104-RAD52heptamerp-Y104-RAD52 p-T714,T734-BARD1 MRE11A ATPp-S988,S1387,S1423,S1524,S1547-BRCA1 p-S327,T847,T859-RBBP8 RPA1 p-S343-NBN KAT5 p-T714,T734-BARD1 UBC(153-228) p-S327,T847-RBBP8 ADPp-T714,T734-BARD1 p-S343-NBN p-S1981,Ac-K3016-ATM PPiDNA Double StrandBreak ResponseAc-K432,K526,K604-RBBP8 homotetramerRAD9B ATPRAD51C RAD51 ATR:ATRIP:p-RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1HIST2H2BE TOP3A BLM RMI1 p-S327,T847,T859-RBBP8 homotetramerHIST1H2BK RHNO1POLD1 HIST1H2BJ RAD51D p-T714,T734-BARD1 EXO1 RFC4 RMI2 p-S343-NBN RMI1 p-S1981,Ac-K3016-ATM TIPIN RFC5 UBB(1-76) p-T3387-BRCA2 p-S327,T847,T859-RBBP8 RAD50 HIST3H2BB HERC2-SUMO1 2'-O-acetyl-ADP-riboseRAD51AP1 SIRT6p-T714,T734-BARD1 RPA3 RFC4 RBBP8 homotetramerSPIDR p-T714,T734-BARD1 UBA52(1-76) p-S406-FAM175A p-RPA heterotrimerRAD17 HIST1H2BH RMI2 RMI1 MRE11A ERCC4 RPA1 FlapMRE11A UBC(153-228) p-S988,S1387,S1423,S1524,S1547-BRCA1 RNF168 p-S988,S1387,S1423,S1524,S1547-BRCA1 RMI1 ATPPALB2 RAD50 p-S1981,Ac-K3016-ATM DNA2 DNA2 RAD50 RPA3 UBC(229-304) p-T714,T734-BARD1 RFC3 RHNO1 RAD17 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8PALB23' overhanging DNA at resected DSB ends p-T714,T734-BARD1 DNADSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5RAD50 MRE11A p-T714,T734-BARD1 HUS1 RNF4 p-S343-NBN HUS1 BABAM1SLX1A:SLX4p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1RAD51C RHNO1 RBBP8 RPA1 dsDNA with inter-SSAdeletionMRE11A RTEL1RAD1 RAD50 p-T3387-BRCA2 BLM p-S25,S1778-TP53BP1 p-T309-RAD51 RMI2 TOP3A TOP3A RFC4 H2BFS UBE2N TIMELESS POLH RAD1 p-RPA heterotrimerp-S990,Ac-K1249-BRIP1TOPBP1 RAD51AP1p-T3387-BRCA2 RMI1 KAT5 p-S343-NBN RFC2 XRCC2 WRN p-S988,S1387,S1423,S1524,S1547-BRCA1 p-S406-FAM175Ap-T714,T734-BARD1 p-S343-NBN RPA3 KAT5 RFC4 RAD51D MUS81:EME1,(MUS81:EME2)UBC(229-304) p-T309-RAD51 UBC(77-152) RAD9A p-S343-NBN BLM TOP3A EXO1,DNA2:BLM,WRNHIST1H2BO p-S343-NBN XRCC2 p-S1981,Ac-K3016-ATM K63PolyUb-K14,K16,p-S140-H2AFX XRCC3 p-S988,S1387,S1423,S1524,S1547-BRCA1 RFC3 RMI2 CX3 complexWRN p-S33-RPA2 dsDNAp-S343-NBN p-S988,S1387,S1423,S1524,S1547-BRCA1 BLM UBC(305-380) UBC(533-608) XRCC3 HERC2-SUMO1 DNA double-strand break ends RMI2 p-S456-ABL13' overhanging DNA at resected DSB ends BLM RPA heterotrimerSister ChromosomalArmRAD51C RMI2 RAD51D RFC2 MRE11A RAD17 HIST3H3 RAD9A p-T714,T734-BARD1 ATPHIST1H2BC MUS81 EME1 p-S33-RPA2 HIST1H2BN RMI2 RMI2 XRCC3 RFC4 ATR SLX1A POLE3 RMI1 p-S988,S1387,S1423,S1524,S1547-BRCA1 RAD51B p-Y104-RAD52 EXO1 UBE2V2 ATRIP p-S102-WHSC1EME2 UIMC1 ATRIP RMI1 RPA1 p-T3387-BRCA2:p-T309-RAD51 complexWRN RAD9A p-T4827,SUMO1-HERC2 p-S343-NBN RAD51B DNA2 p-S327,T847,T859-RBBP8 K63PolyUb-K14,K16,p-S140-H2AFX p-T714,T734-BARD1 RAD17 p-S33-RPA2 p-S327,T847,T859-RBBP8 p-T714,T734-BARD1 RMI1 DNADSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5p-T916,S945-CLSPNMe2K21-HIST1H4 RAD50 MRE11A NAD+TOPBP1 ADPRAD51D TIPIN RFC4 PPP4C:PPP4R2dNTPp-S327,T847,T859-RBBP8 p-S102-WHSC1 3' overhanging DNA at resected DSB ends RMI1 RAD1 MRE11A ATPp-S990,Ac-K1249-BRIP1 SSB-dsDNA withinter-SSA deletionEXO1 TOPBP1 ATR:ATRIPRMI1 TIMELESS:TIPINdNTPRMI2 p-T3387-BRCA2 p-S343-NBN DNA double-strand break ends DNA2 DNA2 3' short overhanging ssDNA-DSBs RAD9B p-S1981,Ac-K3016-ATM p-T309-RAD51 HIST1H2BK p-S327,T847,T859-RBBP8 p-T309-RAD51 BLM EXO1 SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)p-S327,T847,T859-RBBP8 p-T309-RAD51 p-T3387-BRCA2 p-5S-BRCA1:p-2T-BARD1p-5S-BRCA1:p-2T-BARD1RPA3 RAD51B RAD50 70, 1621363714, 11115614, 1113770, 16214, 11114, 11112243, 911664867223223214, 1111665814, 1112, 15, 16, 19, 27...37328573, 74224873, 7413622221296711314, 111102