Beta-catenin independent WNT signaling (Homo sapiens)

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11, 46, 50, 71, 72, 946817, 251, 6, 78, 86, 99...22, 38, 56, 63, 73...4, 8, 14, 15, 19...59, 77, 83, 87, 8968929150, 52, 892, 43, 44, 63, 1255450, 52, 895, 42, 69, 71, 90...11126, 49, 96, 10855, 9516, 64, 69, 112, 1198920, 57, 101, 11720, 80, 8823, 299, 15, 39, 79, 86...915, 34, 41, 76, 9720, 36, 88, 10659, 12061, 11184, 114, 11612, 59, 6898, 11117, 25, 65, 10911124, 6647, 11131, 75, 8137, 40, 67, 10537, 40, 67, 88, 105...7, 28, 48, 70, 74...20, 80, 8810, 20, 36, 76, 82...84, 11430, 55, 10413, 59, 89, 9284841, 45, 8611784, 11463cytosolendoplasmic reticulum lumennucleoplasmclathrin-coated endocytic vesiclePSMB8 AXIN2 gene PSMD13 N4GlycoAsn-PalmS WNT5B PDE6Fe3+ MOV10 GNG12 FZD4ppDVL:RAC:GTPADPAP2B1 N4GlycoAsn-PalmS WNT5A(36-380) GNG10 GNAT2 Fe3+ p-DVL2 GNG11 PSME4 GNG2 MYC gene PRKCB SMURF1 SHFM1 PARD6A:pp-DVL2:SMURFp-DVL3 N4GlycoAsn-PalmS WNT5A(36-380) GNAT2:GTPRHOA TCF7 GNB5 AP2A1 PSMD14 ITPR1 ROR2 CLTB cGMPG-protein beta-gammacomplexHeterotrimericG-protein (o/t2)(inactive)PSMD12 unknown kinaseGNB1 ITPR1 pT201,T212-TCF7L2 PSMD3 ATPGNG11 Ca2+ PLCB3 GNG13 Ca2+GNB4 DAGGNAT2 PSMB3 ATPPSMA2 GNG7 PSMA4 PRKG homodimer:cGMPPSMB11 GNGT1 ITPR3 GNB3 ROR1 ADPCTNNB1 N4GlycoAsn-PalmSWNT5A:ROR2:VANGL2GNB4 WNT5A/WNT11Calcineurin:Calmodulin (CaN:CaM)N4GlycoAsn-PalmS WNT1 UBC(229-304) FZD4 PPP3CA UBC(305-380) p-DVL2 MYC mRNA N4GlycoAsn-PalmS WNT5A(36-380) CALM1 FZD3 FZD3 G-protein alpha(o/t2)FZD5 Mg2+ 'canonical' WNTtarget genesRAC1 N4GlycoAsn-PalmS WNT5B GNAT2 Activated Proteinkinase C (alpha,beta, gammaisoforms)N4GlycoAsn-PalmS WNT5A(36-380) N4GlycoAsn-PalmSWNT5A:ROR2:p-VANGL2PARD6A PARD6A FZD6 WNT5A:FZDs/RORp-DVL2 GNG12 AP2S1 PRKCA GNG11 N4GlycoAsn-PalmS WNT11 EIF2C1 N4GlycoAsn-PalmS WNT1 GNB4 p-S-DVL1 RAC2 GNB5 FZD3 PSMA7 GNG7 GNGT1 PPP3CA ATPPRKG2 PCP pathway WNTsp-T286,T305,T306-CAMK2A N4GlycoAsn-PalmS WNT5A(36-380) UbN4GlycoAsn-PalmS WNT1 GNG12 N4GlycoAsn-PalmS WNT11 ATPFZD6 miR-92b Ca2+ FZD5 NLK mRNAGNG11 EIF2C4 UBC(533-608) WNT:FZDFZD7 UBC(153-228) GNG10 Ca2+ pp-DVL2 GNG2 p-T187-MAP3K7CLTB GNG5 ROR2 AP2S1 ITPR:I(1,4,5)P3tetramerPSMF1 Ca2+PLCB3 GTP ADPPRKG2 CLTB FZD4 GNGT2 FZD2 Zn2+ PSMB10 RPS27A(1-76) FZD5 PSMD10 ub-PRICKLE1FZD1 PRKG1 GNG13 DVL2'canonical'WNTtargetgenes:TCF/LEF:CTNNB1DAG miR-92b GNG4 PiVANGL2GNAT2 RAC:GTPPSMC2 N4GlycoAsn-PalmS-WNT5A:RYK:VANGL2AP2A2(1-939) RAC3 ATPclathrin:AP-2GTP 'canonical' WNTtarget genetranscriptsUBB(77-152) MAP3K7GTP Ca2+ GTP PSMA3 GNG10 GNB2 p-12S-NFATC1GNG8 GNG7 GNB2 UBC(1-76) pp-DVL2 CLTC AP2B1 TCF7L2 GDP PDE6A GNB1 p-T286,T305,T306-CAMK2AN4GlycoAsn-PalmS WNT5A(36-380) ROR1 PLCB1 CAMK2A PSMD4 GNAO1 GNG12 GTP SCRIB PDE6B unknown kinaseMAP3K7 ATPRYK DAG GNB3 GNB2 FZD5 GNGT1 FZD5 PSMA1 PARD6A:pp-DVL2PDE6A PSMA6 GNB3 N4GlycoAsn-PalmS WNT5A(36-380) pp-DVL3 IP3 receptorhomotetramerN4GlycoAsn-PalmS WNT5A(36-380) guanosine5'-monophosphatep-T286,T305,T306-CAMK2A PLCB2 PSMB9 pT298-NLK dimerCa2+ N4GlycoAsn-PalmS WNT11 GNG3 GNG13 UBB(1-76) UBC(77-152) GNAO1 GNG8 G-proteinbeta-gamma:PLC beta1/2/3GNG7 p-T286-CAMK2A pp-DVL1 FZD6 pp-DVL1 FZD7 pT497,T638,S657-PRKCA FZD6 N4GlycoAsn-PalmS WNT5A(36-380) p-TCF/LEF:CTNNB1N4GlycoAsn-PalmS WNT5A(36-380) GNG13 GNGT2 AP2M1 PPP3CA CTNNB1 VANGL2 PSMC1 N4GlycoAsn-PalmS WNT4 WNT5A/11:FZD:G-protein (alpha o/t2) inactiveADPFZD4 GDP PDE6G LEF1 SCRIBpp-DVL3 WNT:FZD:pDVLFZD1 Zn2+ GNG13 GNG8 CALM1:4xCa2+pp-DVL2 GNB4 Calcineurin (CaN)CALM1 FZD4 SMURFpp-DVL2 PPP3R1 AXIN2 gene p-DVL2 VANGL2 CLTC N4GlycoAsn-PalmS WNT4 CALM1 GNG8 AP2M1 FZD1 TNRC6A PLCB2 ADPp-S257-NFATC1 AGO2 GNB5 TNRC6C GNAT2 VANGL2:SCRIBDAAM1 PCP pathway FZDsFZD3GTP PRKG1 SMURF2 p-S257-NFATC1 TNRC6B GNB3 N4GlycoAsn-PalmS WNT5B GNB3 ARRB2 ppDVL:DAAM1:PFN1FZD1 PSMB7 GNGT1 GNG10 GTPGNG11 TCF7 FZD6 CAMK2:CaMN4GlycoAsn-PalmSWNT5A(36-380)PSMB6 GNG5 RAC3 PI(4,5)P2GNG4 WNT/Ca2+ FZDsFZD3 PRKG dimerGNG4 ppDVL:DAAM1:RHOA:GTPUBC(381-456) ITPR2 GNAT2:PDE6GDPFZD2 p-DVL2 FZD7 ARRB2FZD3 N4GlycoAsn-PalmS WNT11 N4GlycoAsn-PalmS WNT5A(36-380) TCF7L2 TNRC6A FZD4 FZD6 LEF1 GNB2 WNT5A:FZD4:DVL2UBB(153-228) NLK mRNA CLTA PPP3CB FZD4 ATPAXIN2 mRNA PSMC6 activated PKC alphaEIF2C3 TCF/LEF:CTNNB1GNGT2 N4GlycoAsn-PalmS WNT5A(36-380) ROR2PSMB4 AP2A1 FZD2/FZD5/ROR2CTNNB1 PSME3 PLC-beta 1/2/3RHOA FZD2 Ca2+ unknown kinaseCAMK2A GNG3 CLTA 26S proteasomeVANGL2:SCRIB:FZD3N4GlycoAsn-PalmS WNT4 PSMC5 FZD2 PSMD1 FZD3 EIF2C4 GNGT1 GNG2 FZD3 FZD3 GNB2 PSMB5 PSMD11 WNT5A:FZD4:p-DVL2I(1,4,5)P3 PSMD2 GNG5 FZD2 I(1,4,5)P3p-DVL3 TNRC6B RYKRAC1 ATPROR1 FZD4 FZD1 GNG10 GNAO1 PS TCF/LEF:CTNNB1FZD2 PPP3CB pT155,S166-LEF1 WNT5A/11:FZD:G-protein (alpha o/t2) activeEIF2C3 N4GlycoAsn-PalmS WNT5A(36-380) PSMB2 AP2A1 PFN1 GNG3 TCF7L2 ROR2 N4GlycoAsn-PalmS WNT11 EIF2C1 Fe3+ PSME1 PSMD7 PSMD6 GNB1 CTNNB1 FZD7 PARD6A pp-DVL1 pp-DVL1 FZD5 CLTC GTP FZD4 ROR2 Fe3+ GNB5 PFN1pp-DVLCALM1 PSMA5 p-S-DVL1 MOV10 Mg2+ AP2A2(1-939) PPP3CB SMURF2 UBC(609-684) GNAT2 DAAM1 WNT5A/11:FZDN4GlycoAsn-PalmS WNT5A(36-380) GNG12 SMURF1 N4GlycoAsn-PalmS WNT11 Zn2+ PS PPP3R1 WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrinGNB1 ROR2 FZD6 CALM1 WNT5A:FZDPSMA8 WNT5A:FZD4:p-DVL2:AP-2:clathrinTNRC6C FZD2 ADPCa2+ H2OPRICKLE1PSMD9 p-T286 CAMK2:CaMNLKFZD2 p-T298-NLK H2ON4GlycoAsn-PalmS WNT5A(36-380) ADPpp-DVL1 GNGT2 MYC gene DAAM1CALM1 GNB1 pS5,S82,S84-VANGL2 PSMC3 FZD3 pT298-NLK dimerCAMK2AGNAO1 UBA52(1-76) ITPR2 N4GlycoAsn-PalmS WNT5A(36-380) TCF7L1 p-T286,305,306-CAMK2:MAP3K7N4GlycoAsn-PalmS WNT11 ATPpp-DVL3 NLK mRNA:miR-92bRISCPSMD8 ITPR3 unknown kinaseGNG8 GNB5 p-T497,T638,S657-PRKCATCF dependentsignaling inresponse to WNTFZD4 PDE6G AP2B1 AP2A2(1-939) FZD4 GNG2 PSGNG5 NFATC1:CaN:CaMDAAM1 GNG5 PARD6A:p-DVL2VANGL2 RHOA:GTP:Mg2+N4GlycoAsn-PalmS WNT5A(36-380) UBC(457-532) PPP3CB PSMB1 GNG2 PSME2 FZD8 GNB4 PSMC4 FZD8 CLTA miR-92b RISCZn2+ PLCB1 ADPFZD2 pp-DVL2 FZD7 N4GlycoAsn-PalmS WNT5A(36-380) Ca2+ FZD5 SCRIB FZD5 TCF7L1 AP2S1 FZD5 cGMP p-DVL2 GNG3 GNGT2 FZD4 p-DVLPPP3R1 GNG4 pp-DVL3 FZD3 PRKCG PDE6B ppDVL:DAAM1pp-DVL3 AGO2 WNT5A:FZDs/RORp-T298-NLK pp-DVL2 DVL2 WNT5A-binding FZDsPSMD5 GNG3 GNG4 ADPRAC2 NFATC1:CaN:CaMVANGL2 AP2M1 N4GlycoAsn-PalmS-WNT5A:FZD4PPP3CA LEF1 PPP3R1 GNG7 pp-DVL2 33, 5850, 85, 10727, 124583, 18, 35, 51, 62...3227, 124