Metabolism of polyamines (Homo sapiens)

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22, 41, 4845, 503159525, 677, 171, 46, 551323, 561524, 434, 5326, 3615, 32, 47, 64426, 28, 2937, 49589, 11, 12592118656560, 61, 6621, 4116548, 19, 39, 44, 5741, 5063327, 6833-35, 5114, 20, 3825, 30peroxisomal matrixmitochondrial matrixcytosolPSMB7 ATPAPIP:Zn++CoA-SHPSMD1 SLC6A8-like proteinsCK octamersL-ArgZn2+ O2PSMA6 PSMA5 MTRIBUPPutrescineL-OrnAc-CoAAcireductoneFe2+ SLC25A2 NASPNAGML-OrnE1:Mg++PSMD4 PXLP-ODC1 ADPPSMC4 OAZ2 HCOOHGlyPSMA1 PSMD5 PSMD10 PSMA4 PSMB3 CKMT2 Ac-CoAUreaODC:OAZ complexPSMD13 ADCNa+H+GAACRETPSMD14 MTAP PiH2OCKB AZIN1 OAZ2,3-DMPPPSMD2 SPNSRMH2OGAAASL tetramerPXLP-ODC1PSMC5 FAD ASS1 H2OSMOX-3PiPAOX OTC trimerPSMD3 CO2GOT1 OAZ1 PAOX:FADGAMTCRETSLC25A15 CKM PSMC1 SLC6A12 PSMA8 PSMD12 ADPPXLP OAZ3 CKMT1A SPNNASPMNQO1 L-amino acidL-CitARG1 trimerGATM NMRAL1 CO2Mg2+ Na+ARG1 OAZ1 PSMB1 GOT1 dimer3APALPSMB2 PSME4 OAZ2 26S proteasome4MTOBUTAL-ArgCKB, CKML-OrnSLC6A7 ARG2 trimerNASPNAMPH2OCRETPSMA3 dc-AdoMetGATM dimerPiARD:Fe++L-AspFUMAO2PSMD11 HCO3-NAGS(19-534)PXLP-ODC1 H2O2NADPH PSMA7 L-OrnASL OAZ3 AdoHcyNASPMNAcGluATPCO2SLC6A11 PSMD6 SHFM1 MitochondrialornithinetransportersPPiSMSCREATUreaMTAP trimerMTADL-MetPSMB8 SPM3AAPNALAdeENOPH1 MTRIBPPSME3 PSMC3 SAT1OAZ3 PSMB5 PSME1 ARSUAAMD1(1-67)ATPCAPL-ArgGluAZIN1 bound OAZ:ODCcomplexASS1 tetramer:NMRAL1dimer:NADPHPSMB4 NH4+H2OPcrARG2 AZIN1NQO1PXLP PSMC6 ODC:NQO1 complexOTC PSMB9 Mn2+ PSMD7 CPS1H2Odc-AdoMetPiPXLP CoA-SHPiPSMC2 OAZ2 PSMB11 PTCNSPMPSMD9 PSMB6 PSMF1 PSME2 AdoMetOAZ1 PXLP-ODC1 APIP ADI1 L-CitH+H2OSLC6A8 PSMA2 L-ArgPSMB10 Mn2+ O22-OxoacidMRI1AGMAT(1-?)PSMD8 2, 62244623395360291110624037


Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure: View original pathway at:Reactome.


Pathway is converted from Reactome ID: 351202
Reactome version: 61
Reactome Author 
Reactome Author: Gopinathrao, G

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101578view11:44, 1 November 2018ReactomeTeamreactome version 66
101114view21:28, 31 October 2018ReactomeTeamreactome version 65
100642view20:02, 31 October 2018ReactomeTeamreactome version 64
100192view16:47, 31 October 2018ReactomeTeamreactome version 63
99742view15:13, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99308view12:46, 31 October 2018ReactomeTeamreactome version 62
93775view13:35, 16 August 2017ReactomeTeamreactome version 61
93302view11:19, 9 August 2017ReactomeTeamreactome version 61
87888view12:26, 25 July 2016RyanmillerOntology Term : 'polyamine metabolic pathway' added !
87887view12:25, 25 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86386view09:16, 11 July 2016ReactomeTeamreactome version 56
83445view12:25, 18 November 2015ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
2,3-DMPPMetaboliteCHEBI:58828 (ChEBI)
2-OxoacidMetaboliteCHEBI:35179 (ChEBI)
26S proteasomeComplexR-HSA-68819 (Reactome)
3AAPNALMetaboliteCHEBI:30322 (ChEBI)
3APALMetaboliteCHEBI:18090 (ChEBI)
4MTOBUTAMetaboliteCHEBI:16723 (ChEBI)
ADCProteinQ96A70 (Uniprot-TrEMBL)
ADI1 ProteinQ9BV57 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AGMAT(1-?)ProteinQ9BSE5 (Uniprot-TrEMBL)
AGMMetaboliteCHEBI:17431 (ChEBI)
AMD1(1-67)ProteinP17707 (Uniprot-TrEMBL)
AMPMetaboliteCHEBI:16027 (ChEBI)
APIP ProteinQ96GX9 (Uniprot-TrEMBL)
APIP:Zn++ComplexR-HSA-1237083 (Reactome)
ARD:Fe++ComplexR-HSA-1237173 (Reactome)
ARG1 ProteinP05089 (Uniprot-TrEMBL)
ARG1 trimerComplexR-HSA-70567 (Reactome)
ARG2 ProteinP78540 (Uniprot-TrEMBL)
ARG2 trimerComplexR-HSA-452013 (Reactome)
ARSUAMetaboliteCHEBI:15682 (ChEBI)
ASL ProteinP04424 (Uniprot-TrEMBL)
ASL tetramerComplexR-HSA-70571 (Reactome)
ASS1 ProteinP00966 (Uniprot-TrEMBL)
ASS1 tetramer:NMRAL1 dimer:NADPHComplexR-HSA-6810875 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
AZIN1 ProteinO14977 (Uniprot-TrEMBL)
AZIN1 bound OAZ:ODC complexComplexR-HSA-353105 (Reactome)
AZIN1ProteinO14977 (Uniprot-TrEMBL)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
AcireductoneMetaboliteCHEBI:58795 (ChEBI)
AdeMetaboliteCHEBI:16708 (ChEBI)
AdoHcyMetaboliteCHEBI:16680 (ChEBI)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
CAPMetaboliteCHEBI:17672 (ChEBI)
CK octamersComplexR-HSA-200373 (Reactome)
CKB ProteinP12277 (Uniprot-TrEMBL)
CKB, CKMComplexR-HSA-200343 (Reactome)
CKM ProteinP06732 (Uniprot-TrEMBL)
CKMT1A ProteinP12532 (Uniprot-TrEMBL)
CKMT2 ProteinP17540 (Uniprot-TrEMBL)
CO2MetaboliteCHEBI:16526 (ChEBI)
CPS1ProteinP31327 (Uniprot-TrEMBL)
CREATMetaboliteCHEBI:16737 (ChEBI)
CRETMetaboliteCHEBI:16919 (ChEBI)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
E1:Mg++ComplexR-HSA-1237166 (Reactome)
ENOPH1 ProteinQ9UHY7 (Uniprot-TrEMBL)
FAD MetaboliteCHEBI:16238 (ChEBI)
FUMAMetaboliteCHEBI:37154 (ChEBI)
Fe2+ MetaboliteCHEBI:18248 (ChEBI)
GAAMetaboliteCHEBI:16344 (ChEBI)
GAMTProteinQ14353 (Uniprot-TrEMBL)
GATM ProteinP50440 (Uniprot-TrEMBL)
GATM dimerComplexR-HSA-71268 (Reactome)
GOT1 ProteinP17174 (Uniprot-TrEMBL)
GOT1 dimerComplexR-HSA-70579 (Reactome)
GluMetaboliteCHEBI:29985 (ChEBI)
GlyMetaboliteCHEBI:57305 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCO3-MetaboliteCHEBI:17544 (ChEBI)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
L-ArgMetaboliteCHEBI:32682 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-CitMetaboliteCHEBI:16349 (ChEBI)
L-MetMetaboliteCHEBI:57844 (ChEBI)
L-OrnMetaboliteCHEBI:15729 (ChEBI)
L-amino acidMetaboliteCHEBI:59869 (ChEBI)
MRI1ProteinQ9BV20 (Uniprot-TrEMBL)
MTADMetaboliteCHEBI:17509 (ChEBI)
MTAP ProteinQ13126 (Uniprot-TrEMBL)
MTAP trimerComplexR-HSA-1237147 (Reactome)
MTRIBPMetaboliteCHEBI:58533 (ChEBI)
MTRIBUPMetaboliteCHEBI:58548 (ChEBI)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)


ComplexR-HSA-374018 (Reactome)
Mn2+ MetaboliteCHEBI:29035 (ChEBI)
NADPH MetaboliteCHEBI:16474 (ChEBI)
NAGS(19-534)ProteinQ8N159 (Uniprot-TrEMBL)
NASPMMetaboliteCHEBI:17927 (ChEBI)
NASPNMetaboliteCHEBI:17312 (ChEBI)
NAcGluMetaboliteCHEBI:17533 (ChEBI)
NH4+MetaboliteCHEBI:28938 (ChEBI)
NMRAL1 ProteinQ9HBL8 (Uniprot-TrEMBL)
NQO1 ProteinP15559 (Uniprot-TrEMBL)
NQO1ProteinP15559 (Uniprot-TrEMBL)
Na+MetaboliteCHEBI:29101 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
OAZ1 ProteinP54368 (Uniprot-TrEMBL)
OAZ2 ProteinO95190 (Uniprot-TrEMBL)
OAZ3 ProteinQ9UMX2 (Uniprot-TrEMBL)
OAZComplexR-HSA-350592 (Reactome)
ODC:NQO1 complexComplexR-HSA-353103 (Reactome)
ODC:OAZ complexComplexR-HSA-353118 (Reactome)
OTC ProteinP00480 (Uniprot-TrEMBL)
OTC trimerComplexR-HSA-70558 (Reactome)
PAOX ProteinQ6QHF9 (Uniprot-TrEMBL)
PAOX:FADComplexR-HSA-141346 (Reactome)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
PTCNMetaboliteCHEBI:17148 (ChEBI)
PXLP MetaboliteCHEBI:18405 (ChEBI)
PXLP-ODC1 ProteinP11926 (Uniprot-TrEMBL)
PXLP-ODC1ProteinP11926 (Uniprot-TrEMBL)
PcrMetaboliteCHEBI:17287 (ChEBI)
PiMetaboliteCHEBI:18367 (ChEBI)
PutrescineMetaboliteCHEBI:17148 (ChEBI)
SAT1ProteinP21673 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SLC25A15 ProteinQ9Y619 (Uniprot-TrEMBL)
SLC25A2 ProteinQ9BXI2 (Uniprot-TrEMBL)
SLC6A11 ProteinP48066 (Uniprot-TrEMBL)
SLC6A12 ProteinP48065 (Uniprot-TrEMBL)
SLC6A7 ProteinQ99884 (Uniprot-TrEMBL)
SLC6A8 ProteinP48029 (Uniprot-TrEMBL)
SLC6A8-like proteinsComplexR-HSA-3902491 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
SMOX-3ProteinQ9NWM0-3 (Uniprot-TrEMBL)
SMSProteinP52788 (Uniprot-TrEMBL)
SPMMetaboliteCHEBI:16610 (ChEBI)
SPNMetaboliteCHEBI:15746 (ChEBI)
SRMProteinP19623 (Uniprot-TrEMBL)
UreaMetaboliteCHEBI:16199 (ChEBI)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
dc-AdoMetMetaboliteCHEBI:15625 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
2,3-DMPPArrowR-HSA-1237140 (Reactome)
2,3-DMPPR-HSA-1237129 (Reactome)
2-OxoacidArrowR-HSA-1237102 (Reactome)
26S proteasomemim-catalysisR-HSA-353125 (Reactome)
3AAPNALArrowR-HSA-141348 (Reactome)
3AAPNALArrowR-HSA-141351 (Reactome)
3APALArrowR-HSA-141341 (Reactome)
4MTOBUTAArrowR-HSA-1237119 (Reactome)
4MTOBUTAR-HSA-1237102 (Reactome)
ADCmim-catalysisR-HSA-350598 (Reactome)
ADPArrowR-HSA-200318 (Reactome)
ADPArrowR-HSA-200326 (Reactome)
ADPArrowR-HSA-70555 (Reactome)
AGMAT(1-?)mim-catalysisR-HSA-350604 (Reactome)
AGMArrowR-HSA-350598 (Reactome)
AGMR-HSA-350604 (Reactome)
AMD1(1-67)mim-catalysisR-HSA-351222 (Reactome)
AMPArrowR-HSA-70577 (Reactome)
APIP:Zn++mim-catalysisR-HSA-1237140 (Reactome)
ARD:Fe++mim-catalysisR-HSA-1237119 (Reactome)
ARG1 trimermim-catalysisR-HSA-70569 (Reactome)
ARG2 trimermim-catalysisR-HSA-452036 (Reactome)
ARSUAArrowR-HSA-70577 (Reactome)
ARSUAR-HSA-70573 (Reactome)
ASL tetramermim-catalysisR-HSA-70573 (Reactome)
ASS1 tetramer:NMRAL1 dimer:NADPHmim-catalysisR-HSA-70577 (Reactome)
ATPR-HSA-200318 (Reactome)
ATPR-HSA-200326 (Reactome)
ATPR-HSA-70555 (Reactome)
ATPR-HSA-70577 (Reactome)
AZIN1 bound OAZ:ODC complexArrowR-HSA-350600 (Reactome)
AZIN1R-HSA-350600 (Reactome)
Ac-CoAR-HSA-351207 (Reactome)
Ac-CoAR-HSA-351208 (Reactome)
Ac-CoAR-HSA-70542 (Reactome)
AcireductoneArrowR-HSA-1237129 (Reactome)
AcireductoneR-HSA-1237119 (Reactome)
AdeArrowR-HSA-1237160 (Reactome)
AdoHcyArrowR-HSA-71286 (Reactome)
AdoMetR-HSA-351222 (Reactome)
AdoMetR-HSA-71286 (Reactome)
CAPArrowR-HSA-70555 (Reactome)
CAPR-HSA-70560 (Reactome)
CK octamersmim-catalysisR-HSA-200326 (Reactome)
CKB, CKMmim-catalysisR-HSA-200318 (Reactome)
CO2ArrowR-HSA-350598 (Reactome)
CO2ArrowR-HSA-351222 (Reactome)
CO2ArrowR-HSA-70692 (Reactome)
CPS1mim-catalysisR-HSA-70555 (Reactome)
CREATArrowR-HSA-71287 (Reactome)
CRETArrowR-HSA-200396 (Reactome)
CRETArrowR-HSA-71286 (Reactome)
CRETR-HSA-200318 (Reactome)
CRETR-HSA-200326 (Reactome)
CRETR-HSA-200396 (Reactome)
CoA-SHArrowR-HSA-351207 (Reactome)
CoA-SHArrowR-HSA-351208 (Reactome)
CoA-SHArrowR-HSA-70542 (Reactome)
E1:Mg++mim-catalysisR-HSA-1237129 (Reactome)
FUMAArrowR-HSA-70573 (Reactome)
GAAArrowR-HSA-71275 (Reactome)
GAAR-HSA-71286 (Reactome)
GAMTmim-catalysisR-HSA-71286 (Reactome)
GATM dimermim-catalysisR-HSA-71275 (Reactome)
GOT1 dimermim-catalysisR-HSA-1237102 (Reactome)
GluR-HSA-70542 (Reactome)
GlyR-HSA-71275 (Reactome)
H+ArrowR-HSA-1237129 (Reactome)
H+ArrowR-HSA-71286 (Reactome)
H2O2ArrowR-HSA-141341 (Reactome)
H2O2ArrowR-HSA-141348 (Reactome)
H2O2ArrowR-HSA-141351 (Reactome)
H2OArrowR-HSA-1237140 (Reactome)
H2OR-HSA-1237129 (Reactome)
H2OR-HSA-141341 (Reactome)
H2OR-HSA-141348 (Reactome)
H2OR-HSA-141351 (Reactome)
H2OR-HSA-350604 (Reactome)
H2OR-HSA-452036 (Reactome)
H2OR-HSA-70569 (Reactome)
H2OR-HSA-71287 (Reactome)
HCO3-R-HSA-70555 (Reactome)
HCOOHArrowR-HSA-1237119 (Reactome)
L-ArgArrowR-HSA-70542 (Reactome)
L-ArgArrowR-HSA-70573 (Reactome)
L-ArgR-HSA-350598 (Reactome)
L-ArgR-HSA-452036 (Reactome)
L-ArgR-HSA-70569 (Reactome)
L-ArgR-HSA-71275 (Reactome)
L-AspR-HSA-70577 (Reactome)
L-CitArrowR-HSA-70560 (Reactome)
L-CitArrowR-HSA-70634 (Reactome)
L-CitR-HSA-70577 (Reactome)
L-CitR-HSA-70634 (Reactome)
L-MetArrowR-HSA-1237102 (Reactome)
L-OrnArrowR-HSA-452036 (Reactome)
L-OrnArrowR-HSA-70569 (Reactome)
L-OrnArrowR-HSA-70634 (Reactome)
L-OrnArrowR-HSA-71275 (Reactome)
L-OrnR-HSA-70560 (Reactome)
L-OrnR-HSA-70634 (Reactome)
L-OrnR-HSA-70692 (Reactome)
L-amino acidR-HSA-1237102 (Reactome)
MRI1mim-catalysisR-HSA-1237096 (Reactome)
MRI1mim-catalysisR-HSA-1299507 (Reactome)
MTADArrowR-HSA-351210 (Reactome)
MTADArrowR-HSA-351215 (Reactome)
MTADR-HSA-1237160 (Reactome)
MTAP trimermim-catalysisR-HSA-1237160 (Reactome)
MTRIBPArrowR-HSA-1237160 (Reactome)
MTRIBPArrowR-HSA-1299507 (Reactome)
MTRIBPR-HSA-1237096 (Reactome)
MTRIBUPArrowR-HSA-1237096 (Reactome)
MTRIBUPR-HSA-1237140 (Reactome)
MTRIBUPR-HSA-1299507 (Reactome)


mim-catalysisR-HSA-70634 (Reactome)
NAGS(19-534)mim-catalysisR-HSA-70542 (Reactome)
NASPMArrowR-HSA-351201 (Reactome)
NASPMArrowR-HSA-351208 (Reactome)
NASPMR-HSA-141348 (Reactome)
NASPMR-HSA-351201 (Reactome)
NASPNArrowR-HSA-351207 (Reactome)
NASPNArrowR-HSA-351229 (Reactome)
NASPNR-HSA-141351 (Reactome)
NASPNR-HSA-351229 (Reactome)
NAcGluArrowR-HSA-70542 (Reactome)
NAcGluArrowR-HSA-70555 (Reactome)
NH4+R-HSA-70555 (Reactome)
NQO1R-HSA-350578 (Reactome)
Na+ArrowR-HSA-200396 (Reactome)
Na+R-HSA-200396 (Reactome)
O2R-HSA-1237119 (Reactome)
O2R-HSA-141341 (Reactome)
O2R-HSA-141348 (Reactome)
O2R-HSA-141351 (Reactome)
OAZArrowR-HSA-353125 (Reactome)
OAZR-HSA-350567 (Reactome)
ODC:NQO1 complexArrowR-HSA-350578 (Reactome)
ODC:OAZ complexArrowR-HSA-350567 (Reactome)
ODC:OAZ complexR-HSA-350600 (Reactome)
ODC:OAZ complexR-HSA-353125 (Reactome)
OTC trimermim-catalysisR-HSA-70560 (Reactome)
PAOX:FADmim-catalysisR-HSA-141348 (Reactome)
PAOX:FADmim-catalysisR-HSA-141351 (Reactome)
PPiArrowR-HSA-70577 (Reactome)
PTCNArrowR-HSA-141348 (Reactome)
PXLP-ODC1R-HSA-350567 (Reactome)
PXLP-ODC1R-HSA-350578 (Reactome)
PXLP-ODC1mim-catalysisR-HSA-70692 (Reactome)
PcrArrowR-HSA-200318 (Reactome)
PcrArrowR-HSA-200326 (Reactome)
PcrR-HSA-71287 (Reactome)
PiArrowR-HSA-1237129 (Reactome)
PiArrowR-HSA-70555 (Reactome)
PiArrowR-HSA-70560 (Reactome)
PiArrowR-HSA-71287 (Reactome)
PiR-HSA-1237160 (Reactome)
PutrescineArrowR-HSA-350604 (Reactome)
PutrescineArrowR-HSA-70692 (Reactome)
PutrescineR-HSA-351215 (Reactome)
R-HSA-1237096 (Reactome) Equilibrium between 5'-methylthio ribose-1-phosphate and 5'-methylthio ribulose-1-phosphate is catalyzed by 5'-methylthio ribose-1-phosphate isomerase. (Kabuyama et al, 2009)
R-HSA-1237102 (Reactome) In the last step MOB gets transaminated to methionine. The reaction was confirmed in yeast, where several transaminases catalyze it, which appears to be also the case in rat. At the moment, the human enzymes involved are unknown but due to homology to the respective enzyme in the parasite Crithidia fasciculata we feel supported to state that human GOT is probably one of the involved transaminases. (Berger et al, 2001)