DNA Double Strand Break Response (Homo sapiens)

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10065, 8813, 80, 94, 114, 119407, 18, 57, 709528, 29, 35, 54, 77...112, 114, 11946, 74, 79, 9758, 7438, 85, 105, 108, 1124140, 95107112, 11410, 875, 49, 9150, 71, 10776, 82, 111829, 16, 19, 34, 52...953, 5, 24, 33, 37...10, 12, 62, 67, 10222, 28, 35, 77, 9931, 33, 67, 681201168, 30, 11251, 72, 814, 5, 148, 20, 26, 45, 1215711911, 59, 85, 11521119, 12373, 9614, 37, 103, 1184013, 38, 80, 94, 108...11671, 10739, 11940, 60nucleoplasmcytosolHIST1H2BL HIST1H2BN UIMC1 DNA double-strand break ends KDM4B p-S140-H2AFX HIST1H2BN p-S343-NBN MRE11A PIAS4 RAD50:MRE11AMRE11A HIST1H2BH HIST1H2BL DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1p-T4827,SUMO1-HERC2 HIST1H2BM HIST1H2BL HIST3H3 Zn2+ HIST1H2BC HIST1H2BJ HIST1H2BB KAT5 NBNp-S102-WHSC1 p-S25,S1778-TP53BP1 p-5T-MDC1 HIST1H2BB HIST2H2BE HIST2H2BE HIST1H2BL NBN KDM4B MRE11A UBE2N DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1p-S343-NBN HIST1H2BM ADPPip-S1387,S1423,S1524,S1547-BRCA1 p-5T-MDC1 HIST1H2BH HIST1H2BD UbHIST1H2BO HIST1H2BH HIST3H3 p-S1981,Ac-K3016-ATM p-S1981,Ac-K3016-ATM KDM4B HIST2H2BE DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complexp-S343-NBN HIST1H2BK HIST1H2BN p-S140-H2AFX HIST1H2BJ HIST1H2BC p-S1981,Ac-K3016-ATM PIAS4 RAD50 KAT5 HIST1H2BM EYA1-4RAD50 HERC2-SUMO1 KDM4A HIST2H2BE HIST3H2BB HIST1H2BJ Me2K21-HIST1H4 Zn2+ DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4HIST1H2BM p-S,3T-CHEK2ROS RAD50 DNA double-strand break ends MRE11A HIST1H2BO UBE2V2 p-S343-NBN HIST1H2BD Zn2+ HIST2H2BE HIST2H2BE p-S140,Y143-H2AFX HIST3H2BB Me2K21-HIST1H4 ADPHIST1H2BL HIST1H2BD KDM4A,BTP53 TetramerMRE11A HIST1H2BH H2BFS HIST1H2BM APBB1 MRE11A HIST2H2BE ATPHIST2H2BE p-5T-MDC1 HIST1H2BB HIST3H2BB HIST1H2BJ HIST1H2BN p-S343-NBN HIST1H2BK EYA4 p-S140-H2AFX HIST3H2BB DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complexDNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4UBC(153-228) HIST1H2BO Me2K21-HIST1H4 Zn2+ p-S140-H2AFX p-S343-NBN RNF168 HIST1H2BM HIST1H2BB HIST1H2BM MRE11A p-Y143-H2AFX BRCC3 HIST1H2BC HIST1H2BK HIST3H3 UIMC1 HIST1H2BO ATPp-T4827,SUMO1-HERC2 HIST3H3 HIST1H2BJ HIST3H3 HIST2H2BE HIST1H2BJ p-T4827,SUMO1-HERC2 H2BFS p-S343-NBN MRE11A HIST1H2BM HIST1H2BA HIST1H2BM HIST2H2BE HIST1H2BA HIST2H2BE H2BFS ADPKAT5 RNF8 RNF168 p-5T-MDC1 p-5T-MDC1 H2BFS WHSC1 HIST1H2BL HIST1H2BM DNA double-strand break ends p-S343-NBN RNF8 HIST1H2BL H2BFS UBC(77-152) HIST1H2BN H2BFS MDC1 p-S1387,S1423,S1524,S1547-BRCA1 p-T4827,SUMO1-HERC2 HIST1H2BB BRCC3 DNA double-strand break ends DNA double-strand break ends HIST1H2BH HIST1H2BD HIST3H2BB KAT5 MRE11A HIST2H2BE p-S343-NBN p-S343-NBN HIST2H2BE RNF168 HIST1H2BN NBN:KPNA2HIST1H2BA Me2K21-HIST1H4 HIST1H2BH MRE11A RAD50 p-S406-FAM175A AdoMetHIST1H2BO HIST1H2BB UBE2V2 PIAS4 HIST1H2BN UBE2N HIST2H2BE HIST2H2BE Me2K21-HIST1H4 HIST3H2BB K48PolyUb-KDM4A HIST1H2BK NBN DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+RAD50 EYA3 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8UBE2N HIST1H2BN RAD50 HIST1H2BM MRE11A MRE11A RNF8 ATPHIST1H2BK p-S25,S1778-TP53BP1 p-S140-H2AFX p-S343-NBN HIST2H2BE HIST1H2BJ PIAS4WICHBABAM1HIST1H2BO WHSC1X-ray ATPHIST1H2BL p-5T-MDC1 p-S15-TP53 HIST1H2BC RAD50 KDM4A NonhomologousEnd-Joining (NHEJ)HIST1H2BM p-5T-MDC1 p-S1981,Ac-K3016-ATM BRE ADPHIST1H2BB Zn2+ HIST1H2BH DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4DNA double-strand break ends ATPKAT5 RNF168H2BFS HIST1H2BA HIST1H2BK HIST1H2BB p-S406-FAM175A p-5T-MDC1 HIST1H4 KDM4A HIST1H2BA RAD50 DNA double-strand break ends p-S1981,Ac-K3016-ATM HIST3H3 HIST3H2BB HIST1H2BH MRE11A HIST1H2BM HIST1H2BC KAT5 KAT5 KPNA2HIST1H2BC HIST2H2BE H2BFS DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1HIST1H2BB p-S1981,Ac-K3016-ATM RNF8 ATPATPHIST1H2BK DNA double-strand break ends HIST1H2BC HIST1H2BA HIST1H2BL DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1HIST1H2BC HIST1H2BB HIST1H2BC HIST1H2BD Zn2+ H2BFS K63PolyUb-K14,K16,p-S140-H2AFX p-S343-NBN RNF8 DNA double-strand break ends HIST1H2BD HIST1H2BJ Me2K21-HIST1H4 p-S102-WHSC1 Zn2+ HIST1H2BJ DNA double-strand break ends DNADSBs:MRN:Ac-K3016-ATM dimer:KAT5HIST3H2BB HIST1H2BN KAT5 p-S1981,Ac-K3016-ATM KAT5 p-S140-H2AFX p-S102-WHSC1 HIST1H4 p-S140-H2AFX HIST1H2BK HIST3H3 p-T714,T734-BARD1 KAT5 HIST1H2BB DNADSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5Me2K21-HIST1H4 BARD1 DNADSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5HERC2 ADPHIST1H2BD PIAS4 MRE11A HIST3H3 DNA double-strand break ends p-S1981,Ac-K3016-ATM K48PolyUb-KDM4A,BUBA52(1-76) ATM DNA double-strand break ends p-T714,T734-BARD1 p-S343-NBN ADPp-S140-H2AFX HIST1H2BA KAT5 KAT5 p-S140-H2AFX H2BFS p-S1981,Ac-K3016-ATM RNF8 HIST1H2BL HIST1H2BJ HIST3H3 MRE11A p-Y142-H2AFX-NucleosomeHIST1H2BD PIAS4 HIST1H2BH HIST3H3 RNF8 HIST1H2BN p-S140-H2AFX CHEK2 ATPHIST1H2BK HIST1H2BC HIST1H2BJ ADPMRE11A p-5T-MDC1 p-S343-NBN HIST1H2BA Zn2+ p-EYA2 p-S102-WHSC1 p-S1981,Ac-K3016-ATM HIST1H2BM PIAS4 SUMO1-C93-UBE2I RAD50 HIST1H2BH DNA double-strandbreak endsRNF8 p-S140-H2AFX HIST1H2BK HERC2-SUMO1 MRE11A UBC(305-380) HIST3H2BB beta-particle p-5T-MDC1 HIST1H2BH HIST1H2BH HIST1H2BA KAT5 MRE11A RNF168 p-S102-WHSC1 UBE2I-G97-SUMO1 DNA double-strand break ends HIST3H2BB RAD50 EYA1 HERC2-SUMO1 p-S140-H2AFX Me2K21-HIST1H4 p-5T-MDC1 HIST1H2BA HIST1H2BC MRE11Ap-T68-CHEK2RAD50 HIST1H2BA HIST3H2BB BABAM1 HIST3H2BB HIST1H2BA HIST1H2BD HERC2Me2K21-HIST1H4 ADPHIST1H2BB RAD50 H2AFX HIST1H2BA p-EYA1-4HIST1H2BL p-S102-WHSC1 PPP5CCHEK2HIST3H2BB HIST1H2BM RAD50 ATM HIST1H2BN HIST1H2BO p-5T-MDC1 UBE2V2 HIST1H2BC p-S406-FAM175A HIST1H2BC HIST1H2BK MRE11A DNA DSBs:MRN:ATMdimer:KAT5HIST1H2BJ BABAM1 p-S25,S1778-TP53BP1 RNF168 HIST3H3 RNF8 p-S1981,Ac-K3016-ATM H2BFS NBN Ac-CoAHIST2H2BE HIST1H2BN HIST3H2BB p-T,Y-MAPK8HIST1H2BB HIST1H2BM KDM4B UBC(1-76) p-T4827,SUMO1-HERC2 HIST1H2BJ p-S102-WHSC1 p-S102-WHSC1 KDM4A p-T4827,SUMO1-HERC2 UBE2V2 HIST1H2BK DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1p-S102-WHSC1 DNA DSBs:MRNKAT5 HIST1H2BL p-S988,S1387,S1423,S1524,S1547-BRCA1 Zn2+ HIST1H2BB Me2K21-HIST1H4 H2BFS RAD50 DNA double-strand break ends MRE11A HIST3H3 HIST1H4 KAT5 HIST3H2BB H2BFS HIST1H2BD RPS27A(1-76) HERC2-SUMO1 HIST1H2BL PIAS4 H2BFS HIST1H2BL DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2HIST1H2BJ UBE2N p-T714,T734-BARD1 HIST1H2BB RAD50 BRCA1 HIST1H2BJ H2BFS Me2K21-HIST1H4 HIST1H2BC HIST1H2BH p-T4827,SUMO1-HERC2 BRCA1:BARD1HIST1H2BA HIST1H2BL HIST1H2BM NBN HIST1H2BO UBE2V2 HIST1H2BN H2BFS PIAS4 DNA double-strand break ends HIST1H2BD p-S25,S1778-TP53BP1 HIST1H2BD p-S343-NBN KDM4A HIST3H3 DNA double-strand break ends HIST3H3 BARD1HIST3H3 HIST1H2BL HERC2-SUMO1 gamma-ray ATPp-T,Y-MAPK8 HIST1H2BM BRCC3RAD50 HIST1H2BB RAD50 p-S1981,Ac-K3016-ATM KAT5 H2Op-S406-FAM175A HIST1H2BH HIST1H2BH DNA double-strand break ends RAD50 Me2K21-HIST1H4 HIST1H2BO HERC2-SUMO1 H2BFS K63PolyUb-K14,K16,p-S140-H2AFX DNADSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-NucleosomeHIST1H4 K63PolyUb-K14,K16,p-S140-H2AFX p-S1981,Ac-K3016-ATM HIST1H2BA HIST1H2BL PIAS4 KDM4A HIST1H2BD RNF8 p-5T-MDC1 NBNp-S102-WHSC1 K63PolyUb-K14,K16,p-S140-H2AFX p-T68-CHEK2 UBE2V2 Zn2+ BRCA1p-Y143-H2AFX DNA double-strand break ends DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4HDR throughHomologousRecombination (HR)or Single StrandAnnealing (SSA)UBE2N H2BFS HIST3H3 MRE11A p-S102-WHSC1 BAZ1B HIST1H2BJ RNF8 UBC(609-684) HIST1H2BO UBE2N HIST1H2BD NBN HIST1H2BO HERC2-SUMO1 HIST1H2BA BAP1:BARD1HIST1H2BD BRE DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-NucleosomePIAS4 HIST3H2BB p-5T-MDC1 HIST3H3 HIST3H2BB APBB1p-S343-NBN UBE2N:UBE2V2ADPHIST1H2BN p-S406-FAM175A DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1PIAS4 UBE2V2 H2BFS HIST1H2BJ PIAS4 p-EYA1 HIST3H2BB MRE11A ATPBRE KAT5 p-S1981,Ac-K3016-ATM UBE2V2 HIST1H2BL DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4ATPp-S343-NBN HIST1H2BC KAT5 HIST3H2BB UIMC1 HIST1H2BN p-S102-WHSC1 UBC(457-532) UBE2N ABL1HIST1H2BC RNF168 RNF168 KDM4B HIST1H2BJ MRE11A HIST1H2BL ADPMRE11A p-5T-MDC1 p-5T-MDC1 HERC2-SUMO1 HIST1H2BN PIAS4 p-S1981,Ac-K3016-ATM Ac-K3016-ATM UBB(1-76) Zn2+ p-T4827,SUMO1-HERC2 p-S25,S1778-TP53BP1 HIST1H2BJ ATPKAT5 p-S1981,Ac-K3016-ATM p-T68-CHEK2 dimerRNF8 HIST1H2BH HIST3H3 HIST1H2BO KAT5 HERC2-SUMO1 KAT5 HIST2H2BE DNA double-strand break ends RAD50 Me2K21-HIST1H4 MDC1UBE2N H2BFS p-T4827,SUMO1-HERC2 p-S1981,Ac-K3016-ATM HIST1H2BA Zn2+ p-S343-NBN HIST1H2BN HIST1H2BM H2OHIST1H2BC BRE K48PolyUb-KDM4B HIST1H2BL KPNA2HIST1H4 HIST1H2BK KAT5 BREUBE2N ATM dimer:KAT5p-S102-WHSC1 RAD50 HIST1H2BB p-S140-H2AFX HIST1H2BN NBN HIST3H3 RNF168 HIST1H2BC HIST1H2BK HIST1H2BA HERC2-SUMO1 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4UBE2V2 BABAM1 RNF168 DNA double-strand break ends HIST1H2BB HIST1H2BN HIST1H2BA Me2K21-HIST1H4 H2BFS HIST1H2BC Zn2+ HIST1H2BM KAT5 ADPK63PolyUb-K14,K16,p-S140-H2AFX Zn2+ HIST1H2BO K63PolyUb-K14,K16,p-S140-H2AFX HIST1H2BJ p-S1981,Ac-K3016-ATM RAD50 HIST1H2BC MRNHIST1H2BB HIST1H2BH HIST1H2BH HIST1H2BD HIST1H2BK HIST1H2BC TP53BP1HIST1H2BJ BRCC3 p-S343-NBN p-S1981,Ac-K3016-ATM ATPp-S406-FAM175AHIST1H2BA DNA double-strand break ends HIST1H2BM KDM4B RAD50 HERC2-SUMO1 HIST1H2BK HIST1H2BB proton HIST1H2BN Me2K21-HIST1H4 p-T4827,SUMO1-HERC2 HIST1H2BL UBC(533-608) HIST1H2BN HIST1H2BA HIST1H2BH HIST1H2BO MRE11A RNF8 KDM4A p-5T-MDC1 HIST3H3 MRE11A p-S1981,Ac-K3016-ATM H2BFS p-S343-NBN HIST3H3 HIST1H2BD MRE11A p-S102-WHSC1 HIST1H2BD HIST1H2BK RAD50 RAD50 HIST3H3 HIST1H2BK RAD50 HIST1H2BK H2AFX-NucleosomeHIST3H3 UBE2N p-S102-WHSC1 SUMO1:C93-UBE2IHIST1H2BM CoA-SHH2BFS HIST1H2BD Me2K21-HIST1H4 DNA double-strand break ends Me2K21-HIST1H4 H2BFS HIST1H2BB HIST1H2BL RAD50 ADPHIST1H2BJ HIST1H2BK H2BFS HIST2H2BE RNF8:Zn2+DNA double-strand break ends HIST1H2BH p-S1981,Ac-K3016-ATM HIST2H2BE HIST1H2BA HIST3H2BB HIST1H2BK UBB(77-152) KAT5 HIST1H4 HIST1H2BA RNF8 p-S1981,Ac-K3016-ATM HIST1H2BB Zn2+ DNA double-strand break ends K63PolyUb-K14,K16,p-S140-H2AFX ADPHIST1H2BH HIST1H2BM DNA double-strand break ends SMARCA5 HIST1H2BA KDM4B HIST1H2BL KAT5 p-S343-NBN HIST1H2BN HIST1H2BA p-S25,S1778-TP53BP1 p-S343-NBN TP53BP1 p-S1981,Ac-K3016-ATM HIST1H2BK DNA double-strand break ends DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4HIST1H2BB HIST1H2BN HIST1H2BD HIST1H2BO HIST1H2BO HIST1H2BM KAT5 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175AHIST1H2BH p-S456-ABL1HIST1H2BO UBC(229-304) HIST2H2BE HIST1H2BC UBE2V2 HIST3H2BB p-5T-MDC1 HIST1H2BO UBC(381-456) HIST1H2BB MRE11A HIST1H2BH HIST1H2BL H2BFS p-5T-MDC1 HIST3H2BB UBE2N HIST1H2BH HIST3H2BB BARD1 dsDNAHIST3H2BB p-S343-NBN MDC1 HIST1H2BK KAT5 ADPRAD50 HIST3H3 KAT5 HIST1H4 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1HIST1H2BL UBE2IBRCC3 HIST1H2BJ RAD50p-S102-WHSC1 HIST1H2BN p-S15-TP53 TetramerHIST1H2BJ HIST1H2BO HIST1H2BC ATPHIST1H4 HIST1H2BO H2BFS HIST3H2BB DNA double-strand break ends p-S343-NBN DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-NucleosomeK63PolyUb-K14,K16,p-S140-H2AFX UIMC1HIST2H2BE HIST1H2BO HDR through MMEJ(alt-NHEJ)HIST1H2BN p-T4827-HERC2 BAP1 HIST1H2BO HIST1H2BH HIST1H2BJ HIST1H2BC HIST1H2BD KDM4A ADPMRE11A HIST1H2BC MRE11A p-S1981,Ac-K3016-ATM p-S1981,Ac-K3016-ATM MRE11A HIST1H2BO HIST1H2BD RNF8 KAT5 alpha-particle HIST1H2BM UBE2N KDM4A HERC2-SUMO1 p-S102-WHSC1 K63PolyUb-K14,K16,p-S140-H2AFX HIST1H2BL DNA double-strand break ends p-EYA3 UBB(153-228) UIMC1 BABAM1 HIST1H4 DNA double-strand break ends p-S1981,Ac-K3016-ATMp-5T-MDC1 HIST1H2BM p-S343-NBN HIST3H2BB HIST1H2BO DNA double-strand break ends p-S1981,Ac-K3016-ATM p-S140,Y143-H2AFX HIST1H2BN p-T4827,SUMO1-HERC2 HIST1H2BK HIST1H2BB HIST2H2BE p-S1981,Ac-K3016-ATM BRCA1 PIAS4 HIST2H2BE ATPHIST1H2BK DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexHIST1H2BO PiHIST1H2BO HIST1H2BO HIST1H2BJ AdoHcyHIST1H2BD HIST1H2BD HIST2H2BE DSB inducing agentsKAT5 BARD1 p-S343-NBN HIST3H3 UBE2V2 HIST1H2BL KPNA2 HIST1H2BA HIST1H2BC HIST1H2BH HIST1H2BJ RAD50 HIST1H2BC HIST3H3 HIST3H3 HIST1H2BH HIST1H2BK HIST1H2BD HIST1H2BK MRE11A HIST1H2BN RAD50 HIST1H4 RNF8 UIMC1 RAD50 RAD50 HIST3H2BB TP53 HIST1H2BD RAD50 HIST2H2BE Zn2+ p-S102-WHSC1 EYA2 p-EYA4 HIST1H2BD HIST1H2BB KDM4B p-T4827,SUMO1-HERC2 HIST1H2BB KDM4B RNF168 HIST1H2BA HIST1H2BM UBE2V2 2, 25, 36, 42, 44...901485951073939112393939393910, 87394010040348540, 9539403939398539824, 51, 5, 6, 10, 15...116391124840, 9585395