DNA Double Strand Break Response (Homo sapiens)

From WikiPathways

Jump to: navigation, search
659856, 116757517, 43, 73, 11213, 34, 84, 94, 11616, 3813, 26, 56, 94, 114...37, 98434827, 31, 35, 74, 81...100101, 11915, 16, 66, 1233319, 233, 642, 28, 681136, 10, 20, 36, 45...78, 86, 119, 120, 12298, 10027, 63, 885, 58, 78, 1081, 14, 1162771, 79, 1061009818, 2331, 35, 44, 74, 9623, 26, 56, 114, 12127, 882349, 10929, 106, 11067, 71, 80, 871, 59, 90, 91, 9323, 56, 1168, 34, 42, 1075, 41, 47, 69, 76...44, 53, 62cytosolnucleoplasmMRE11A DNA double-strand break ends HIST1H2BN HIST1H2BN HIST1H2BJ p-S1981,Ac-K3016-ATM p-T,Y-MAPK8p-5T-MDC1 HIST1H2BJ HIST1H2BJ HIST1H2BL DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4APBB1p-S102-WHSC1 HERC2-SUMO1 PPP5CUbNBN:KPNA2PIAS4RAD50 p-S25,S1778-TP53BP1 MRE11A K63PolyUb-K14,K16,p-S140-H2AFX KAT5 p-T714,T734-BARD1 H2BFS UBE2V2 HIST1H2BL DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1HIST1H2BK RNF8 p-5T-MDC1 BRE Me2K21-HIST1H4 RAD50 Me2K21-HIST1H4 ATPRAD50 HIST1H2BK HIST1H2BB MRE11A HIST3H3 HIST1H2BK HIST1H2BA MRE11A HIST1H2BH ATPp-5T-MDC1 HIST1H2BO ATPHIST3H2BB HIST1H2BL p-5T-MDC1 PIAS4 Ac-K3016-ATM RNF8 UBE2N UIMC1 KAT5 p-S343-NBN MRE11A HIST1H2BO KDM4A p-S343-NBN HIST1H2BK HIST3H3 HIST1H2BA ATM MRE11A RNF168 PIAS4 HIST2H2BE HIST1H2BN DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexHIST1H2BL HIST2H2BE p-S102-WHSC1 HIST1H2BH H2BFS RAD50 RNF8 p-S343-NBN KPNA2K63PolyUb-K14,K16,p-S140-H2AFX Zn2+ HIST1H2BH HIST1H2BM DNADSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-NucleosomeHIST3H3 PIAS4 RPS27A(1-76) HIST1H2BM HIST1H4 p-S343-NBN RAD50 HIST1H2BK UBE2N p-S1981,Ac-K3016-ATM HIST3H3 HIST1H2BM p-S25,S1778-TP53BP1 PIAS4 KAT5 AdoMetHIST3H3 p-5T-MDC1 MRE11A HIST1H2BA p-S1981,Ac-K3016-ATM HIST3H3 HIST2H2BE HIST1H2BL K63PolyUb-K14,K16,p-S140-H2AFX HIST3H2BB NBN HERC2-SUMO1 Me2K21-HIST1H4 p-5T-MDC1 H2BFS KDM4A,BHIST1H2BJ HERC2-SUMO1 HIST1H2BM HERC2-SUMO1 HIST1H2BL HIST2H2BE HIST1H2BD HIST1H2BK HIST1H2BL RAD50 K63PolyUb-K14,K16,p-S140-H2AFX KDM4B p-S25,S1778-TP53BP1 HIST3H3 HIST1H2BJ p-S1981,Ac-K3016-ATM HIST1H2BA DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1HIST1H2BA p-S406-FAM175A Zn2+ UBE2V2 HIST1H2BL NonhomologousEnd-Joining (NHEJ)H2BFS NBN HIST1H2BA p-S102-WHSC1 HIST1H2BB HIST1H2BH HIST3H3 HIST1H2BM DNA double-strand break ends K63PolyUb-K14,K16,p-S140-H2AFX BRCC3DNA double-strand break ends HIST1H2BD MRE11A HIST1H2BO BARD1 H2BFS HIST1H2BB HIST1H2BO KDM4B KDM4B HIST3H2BB RAD50 p-S1981,Ac-K3016-ATM UBC(229-304) ADPKAT5 HIST3H3 HIST1H2BM HIST1H2BN p-5T-MDC1 HIST1H2BO WHSC1 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4ATM dimer:KAT5p-S102-WHSC1 HIST2H2BE p-S102-WHSC1 UBE2N RNF8:Zn2+p-S1981,Ac-K3016-ATM HIST1H2BJ p-S102-WHSC1 HIST1H2BM HIST1H2BM HIST1H2BA BRCC3 HIST2H2BE Me2K21-HIST1H4 p-S140-H2AFX HIST1H2BM HIST1H2BA HIST1H2BD HIST1H4 UBE2N UBE2V2 HIST1H2BD p-S15-TP53 TetramerHIST1H2BC p-S343-NBN p-S140-H2AFX HIST1H2BH HIST1H2BN NBN HIST3H3 MRE11A HIST1H2BO p-S1981,Ac-K3016-ATM p-5T-MDC1 p-T4827,SUMO1-HERC2 HIST1H2BB HIST1H2BD BRCC3 MRE11A p-S406-FAM175A HIST3H3 HIST1H2BH HIST3H2BB BABAM1 HIST1H2BH UBE2V2 UBC(77-152) DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4ATPHIST1H2BD KDM4A HIST3H2BB RNF8 HIST1H2BL UBC(533-608) HIST2H2BE HIST1H2BO p-S406-FAM175AMRE11A HIST1H4 HIST3H2BB HIST1H2BB HIST1H2BJ HIST1H2BN HIST1H2BH p-S988,S1387,S1423,S1524,S1547-BRCA1 HIST1H2BJ HIST1H2BA HIST2H2BE HIST1H2BL HIST1H2BB ATPHIST1H2BM HIST1H2BK HIST1H2BH DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1H2BFS HIST1H2BH HIST1H2BD KDM4B H2BFS DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1HIST3H3 HIST2H2BE UBE2N p-S140-H2AFX p-S343-NBN UBE2V2 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4HIST3H2BB ATPPIAS4 HIST1H2BC HIST1H2BD HIST2H2BE HIST1H2BA p-T4827,SUMO1-HERC2 HIST1H4 RAD50 p-T4827,SUMO1-HERC2 PIAS4 RAD50 HIST1H2BL DNA double-strand break ends HIST1H2BO RAD50 Me2K21-HIST1H4 UBE2N MRE11A p-5T-MDC1 HIST1H2BN Zn2+ p-S1981,Ac-K3016-ATM BABAM1UBE2V2 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2HIST3H2BB EYA3 UBE2N RNF168 DNA double-strand break ends DNADSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5HIST1H2BK HIST1H2BO beta-particle DNA double-strand break ends HIST1H2BK p-S343-NBN p-T4827,SUMO1-HERC2 p-S343-NBN HERC2-SUMO1 HIST1H2BN HIST1H2BA HIST1H2BB ROS p-S140-H2AFX AdoHcyHIST1H2BJ MRE11A KAT5 KDM4B KAT5 RAD50UIMC1 HIST1H2BO HIST1H2BB KDM4A HIST3H2BB HIST1H2BC HIST3H2BB HIST1H2BH HIST1H2BO HIST3H3 HIST2H2BE CoA-SHH2AFX-NucleosomeRAD50 UBE2V2 DNA double-strand break ends HIST1H2BM HIST1H2BN HIST1H2BA RNF8 H2BFS HIST1H2BK HIST1H2BB HIST1H2BN HIST2H2BE HIST1H2BC HIST1H2BA HIST1H2BJ p-T4827,SUMO1-HERC2 UBC(609-684) HIST1H2BM Me2K21-HIST1H4 HIST1H2BL PIAS4 ATPTP53BP1HIST1H2BB EYA4 H2BFS HIST1H2BO UBE2N Zn2+ HIST1H2BC BRCC3 HIST1H2BA RNF8 p-S25,S1778-TP53BP1 HIST1H2BN SMARCA5 p-S140,Y143-H2AFX DNA double-strand break ends p-T714,T734-BARD1 KAT5 HIST3H3 HIST3H3 Me2K21-HIST1H4 HIST3H2BB KAT5 p-S25,S1778-TP53BP1 HIST1H2BH p-S343-NBN HIST3H2BB HIST1H2BM SUMO1:C93-UBE2IHIST1H2BM p-T4827,SUMO1-HERC2 H2BFS HIST1H2BM p-S1981,Ac-K3016-ATM p-S406-FAM175A BABAM1 p-S140,Y143-H2AFX HIST1H2BH HIST2H2BE p-5T-MDC1 UBB(153-228) HIST2H2BE HIST1H2BJ HIST2H2BE DNA double-strand break ends DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4RNF168 HIST1H2BB ATPHIST1H2BC HIST1H2BN HIST3H2BB HIST1H2BA HIST1H2BL H2BFS RAD50 BARD1 p-S102-WHSC1 Me2K21-HIST1H4 HIST1H2BB MRE11A HIST1H2BA HIST1H2BA HIST1H2BD p-S1387,S1423,S1524,S1547-BRCA1 KDM4B MDC1KDM4B HIST1H2BK HIST3H2BB HIST1H2BN NBNCHEK2HIST3H3 HIST1H2BN HERC2HIST1H2BL UBE2N:UBE2V2PIAS4 HIST1H2BN p-Y142-H2AFX-Nucleosomep-5T-MDC1 p-EYA3 MRE11A HIST1H2BD HIST1H2BJ RNF168 UBE2V2 p-S1981,Ac-K3016-ATM HIST1H2BA RNF168 BRE HIST1H2BD MDC1 MRE11A HIST1H2BO p-S1981,Ac-K3016-ATMRNF8 HIST3H3 HIST3H2BB ADPHIST1H2BA p-S1981,Ac-K3016-ATM HIST1H2BL ATPHIST1H2BC p-5T-MDC1 KAT5 UBC(457-532) p-T68-CHEK2ATPHIST1H2BC HIST1H2BC RNF8 HIST1H2BD KAT5 HIST1H2BL HIST1H2BB HIST1H2BN HIST3H3 MRE11A ADPHIST1H2BH H2BFS DNA double-strand break ends WICHMRE11A RAD50 KAT5 PIAS4 HIST1H2BC RNF8 PIAS4 p-S,3T-CHEK2HIST1H2BO DNA double-strand break ends HIST1H2BC p-5T-MDC1 TP53BP1 RNF168 H2BFS p-T4827,SUMO1-HERC2 KAT5 DNA double-strand break ends p-S102-WHSC1 WHSC1DNA double-strand break ends KDM4A DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1p-S343-NBN HIST1H2BN p-5T-MDC1 HIST1H2BO HIST1H2BJ HIST1H2BB UBC(153-228) RNF8 HIST1H2BB HIST1H2BD p-S1981,Ac-K3016-ATM KPNA2RNF168 p-S343-NBN p-S15-TP53 KAT5 HIST2H2BE HIST3H2BB p-5T-MDC1 H2BFS MRNRAD50 RAD50 Zn2+ RNF8 HIST1H2BN HIST1H4 KAT5 HIST1H2BB HIST1H2BK HIST3H3 p-S102-WHSC1 HIST1H2BD UBC(381-456) HIST1H2BM HIST1H2BM HIST1H2BO ADPUBE2N KDM4B HIST3H2BB p-S1981,Ac-K3016-ATM HIST1H2BA RNF8 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8Me2K21-HIST1H4 HIST1H2BA HIST1H2BJ PIAS4 HIST1H2BK ADPDNA double-strand break ends HIST1H2BN HIST1H2BC HIST1H2BK p-S102-WHSC1 HIST1H2BB KDM4A UBC(1-76) p-S343-NBN HIST3H2BB EYA1-4p-5T-MDC1 KAT5 KAT5 p-S406-FAM175A ADPK48PolyUb-KDM4A,BHIST1H2BH CHEK2 HIST3H2BB UBC(305-380) H2BFS H2BFS HIST1H2BK alpha-particle MRE11A ADPHIST1H2BK HIST3H3 DNA double-strand break ends HIST1H2BH Me2K21-HIST1H4 UBB(1-76) HIST1H2BL UBE2I-G97-SUMO1 HIST1H2BD RAD50 DNA double-strand break ends HIST1H2BB X-ray EYA1 HIST1H2BC RAD50 HIST1H2BN DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complexp-S343-NBN HIST1H2BO HIST1H2BC APBB1 ADPMe2K21-HIST1H4 NBNKAT5 HIST1H2BK p-EYA2 H2BFS HIST1H2BO HIST1H2BM MRE11A HIST1H2BL HIST1H2BH MRE11A HIST1H2BK HIST1H2BJ H2BFS DNA DSBs:MRN:ATMdimer:KAT5Zn2+ HIST1H2BB p-S1981,Ac-K3016-ATM ADPHIST1H4 ADPHIST1H2BH DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-NucleosomeDNA double-strandbreak endsp-S102-WHSC1 p-S343-NBN MRE11A p-5T-MDC1 HIST1H2BC p-S102-WHSC1 p-S343-NBN HIST1H2BC RAD50 HIST1H2BH p-S343-NBN HIST1H4 HIST1H2BJ H2BFS RNF168RAD50 BRCA1 H2BFS p-S343-NBN DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complexPiHIST1H2BB Me2K21-HIST1H4 HIST1H2BC BAP1:BARD1KDM4A HIST1H2BJ HIST1H2BC DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1HIST1H2BK BRCA1K63PolyUb-K14,K16,p-S140-H2AFX RAD50 UBE2V2 HIST1H2BO HIST1H2BJ RNF168 HIST1H2BJ RAD50 RAD50 UBE2IHIST1H2BH HIST1H2BD MRE11A p-T714,T734-BARD1 UBE2N p-S140-H2AFX SUMO1-C93-UBE2I HIST1H2BL HIST1H2BC HIST1H2BK Zn2+ UIMC1 ADPKAT5 UIMC1 NBN RAD50 ATM HIST1H2BM K63PolyUb-K14,K16,p-S140-H2AFX RAD50 HIST2H2BE KAT5 p-S1981,Ac-K3016-ATM p-S1981,Ac-K3016-ATM KDM4A DNA double-strand break ends p-S25,S1778-TP53BP1 HERC2-SUMO1 p-S1981,Ac-K3016-ATM HIST1H2BK DNA double-strand break ends H2AFX HIST1H2BB RAD50 HIST1H2BC DNA double-strand break ends Zn2+ p-T4827-HERC2 BAP1 p-S102-WHSC1 Ac-CoAUBE2V2 HIST1H2BO HIST1H2BH HIST2H2BE HIST3H3 HIST1H2BL p-T4827,SUMO1-HERC2 H2BFS RAD50 p-S343-NBN HIST1H2BD HIST1H2BA p-S343-NBN HIST1H2BA p-S1981,Ac-K3016-ATM RNF8 BRCA1 Me2K21-HIST1H4 p-S343-NBN p-S343-NBN HIST1H2BH HIST1H2BC HIST1H2BH KAT5 HIST1H2BH HIST1H2BJ HIST1H2BC HIST1H2BM p-T68-CHEK2 BRE p-S1981,Ac-K3016-ATM RNF168 Zn2+ DNA double-strand break ends HIST1H2BM Zn2+ DNA double-strand break ends MRE11A HIST1H2BD DNADSBs:MRN:Ac-K3016-ATM dimer:KAT5K48PolyUb-KDM4A RNF8 H2BFS HIST1H2BD p-S140-H2AFX K63PolyUb-K14,K16,p-S140-H2AFX p-S1981,Ac-K3016-ATM HIST1H2BD ATPHIST3H2BB HIST1H2BM p-S102-WHSC1 DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4HERC2 RAD50 HIST3H3 UBE2V2 MRE11A Me2K21-HIST1H4 ADPHIST3H2BB HIST1H2BJ dsDNAUBE2N HIST2H2BE ABL1KAT5 DNA double-strand break ends p-EYA1-4HIST1H2BO p-S1981,Ac-K3016-ATM HIST1H2BN p-EYA4 HIST2H2BE DSB inducing agentsRNF168 gamma-ray DNADSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5p-T,Y-MAPK8 BABAM1 proton HIST1H2BB MRE11A HIST1H4 ADPHERC2-SUMO1 DNA double-strand break ends p-S1981,Ac-K3016-ATM HIST1H2BO RAD50 HIST1H2BJ p-S102-WHSC1 DNA DSBs:MRNUBE2N HIST1H2BB Zn2+ DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-NucleosomeUBB(77-152) HIST1H2BL HIST1H2BC DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1p-S140-H2AFX HIST1H2BC BABAM1 HIST2H2BE HIST3H3 HIST1H2BB p-S140-H2AFX KAT5 HIST1H2BM UIMC1HERC2-SUMO1 ATPHERC2-SUMO1 H2BFS PIAS4 HIST1H2BM MRE11A MRE11A ADPRNF8 DNA double-strand break ends HIST3H3 HIST1H2BB TP53 BREHIST2H2BE HIST1H2BH HIST3H3 KDM4A KAT5 p-Y143-H2AFX p-EYA1 p-S1981,Ac-K3016-ATM HIST1H2BL HIST3H3 p-5T-MDC1 HIST1H2BJ HIST1H2BD p-S1981,Ac-K3016-ATM HIST1H2BD KAT5 HIST1H2BN p-S140-H2AFX p-Y143-H2AFX KAT5 p-S343-NBN p-T68-CHEK2 dimerHIST1H2BO HIST3H2BB HIST1H2BC HIST1H2BJ HIST1H2BK HIST1H2BO PiHIST2H2BE UBA52(1-76) H2BFS HIST2H2BE Me2K21-HIST1H4 HIST1H2BL H2BFS p-S343-NBN BARD1p-5T-MDC1 MRE11A HIST1H2BD Zn2+ ATPNBN p-S1981,Ac-K3016-ATM KDM4B Me2K21-HIST1H4 p-S102-WHSC1 MRE11A BARD1 EYA2 HIST1H2BH Zn2+ KAT5 p-S343-NBN HIST1H2BJ NBN PIAS4 HIST2H2BE HIST1H2BN HIST1H2BA BRCC3 HIST1H2BC HIST1H2BN HIST3H2BB HIST1H2BO p-T4827,SUMO1-HERC2 DNA double-strand break ends PIAS4 HIST1H2BK p-S456-ABL1p-S1981,Ac-K3016-ATM H2OHIST1H2BD HERC2-SUMO1 RAD50 p-S140-H2AFX DNA double-strand break ends BRE p-T4827,SUMO1-HERC2 HIST1H2BN ATPBRCA1:BARD1DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1H2BFS ADPHIST1H2BA RAD50 HIST3H2BB KPNA2 p-S1387,S1423,S1524,S1547-BRCA1 TP53 TetramerDNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175AHIST1H2BD DNA double-strand break ends HIST1H4 HERC2-SUMO1 HIST2H2BE HERC2-SUMO1 KAT5 HIST1H2BO MDC1 p-S343-NBN HIST1H2BK p-S140-H2AFX HIST1H2BO UIMC1 HIST1H2BA KAT5 HIST1H2BM HIST2H2BE RAD50 HIST1H4 HIST1H2BB KAT5 HIST1H2BM UBE2V2 RAD50 HIST1H2BN Zn2+ DNA double-strand break ends DNA double-strand break ends H2Op-S102-WHSC1 HIST1H2BL RAD50:MRE11Ap-S140-H2AFX Me2K21-HIST1H4 HIST1H2BL H2BFS DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4HIST1H2BN KAT5 p-5T-MDC1 KDM4A HIST1H2BM K63PolyUb-K14,K16,p-S140-H2AFX HIST3H2BB HIST1H2BJ p-S1981,Ac-K3016-ATM HIST1H2BL p-S406-FAM175A DNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+HIST1H2BB DNA double-strand break ends RNF8 HIST3H3 MRE11A HIST1H2BL HDR throughHomologousRecombination (HRR)or Single StrandAnnealing (SSA)HIST1H2BD Zn2+ p-S102-WHSC1 HIST1H2BK MRE11A HDR through MMEJ(alt-NHEJ)ATPHIST1H2BK K48PolyUb-KDM4B HIST3H2BB MRE11Ap-S140-H2AFX HIST1H2BJ BAZ1B HIST1H2BC HIST1H2BK HIST3H2BB Zn2+ p-T4827,SUMO1-HERC2 p-S343-NBN HIST1H2BH p-T4827,SUMO1-HERC2 HIST1H2BD HIST1H2BA 498, 10018181818991871751834983434100181898, 10077181061818621, 24, 30, 51, 52, 55...79, 1061818981898277, 9, 11, 12, 22...116116346518101, 119