Initiation of transcription and translation elongation at the HIV-1 LTR (Homo sapiens)

From WikiPathways

Revision as of 11:05, 22 July 2016 by MaintBot (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search


Following cellular activation or drug treatment, NFAT and NF-kB translocate to the nucleus and bind sites at the HIV-1 LTR. NFAT and NF-kB recruit p300/CBP to the LTR, resulting in acetylation of histone tails and transcriptional activation. In the case of NF-kB, proteosomal degradation of IkBa permits NF-kB translocation and displacement of the p50 homodimers. This is followed by Tat- dependent elongation in which Tat recruits the P-TEFb complex to TAR. Cdk9 phosphorylates the CTD of RNA Pol II, resulting in increased processivity. P-TEFb phosphorylates DSIF and NELF, resulting in removal of NELF from Pol II and converting DSIF into a positive elongation factor, thereby promoting productive elongation. Data nodes in blue represent HIV proteins.

Quality Tags

Ontology Terms



  1. Ruelas DS, Greene WC; ''An integrated overview of HIV-1 latency.''; Cell, 2013 PubMed


87386view11:05, 22 July 2016MaintBotadded missing graphids
82252view23:18, 16 September 2015Khanspersnew version
81816view06:09, 1 September 2015KhanspersModified description
81815view06:06, 1 September 2015KhanspersNew pathway

External references


View all...
NameTypeDatabase referenceComment
CBPGeneProductENSG00000005339 (Ensembl)
CDK9GeneProductENSG00000136807 (Ensembl)
CycT1GeneProductENSG00000129315 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
HDAC3GeneProductENSG00000171720 (Ensembl)
HDAC4GeneProductENSG00000068024 (Ensembl)
HDAC5GeneProductENSG00000108840 (Ensembl)
HDAC7GeneProductENSG00000061273 (Ensembl)
HDAC8GeneProduct55869 (Entrez Gene)
HDAC9GeneProductENSG00000048052 (Ensembl)
HEXIM1GeneProductENSG00000186834 (Ensembl)
HMBAMetaboliteHMDB41901 (HMDB)
IKBAGeneProductENSG00000100906 (Ensembl)
NELFAGeneProductENSG00000185049 (Ensembl)
NELFBGeneProductENSG00000188986 (Ensembl)
NELFCDGeneProductENSG00000101158 (Ensembl)
NELFEGeneProduct7936 (Entrez Gene)
NFATC1GeneProductENSG00000131196 (Ensembl)
NFATC2GeneProductENSG00000101096 (Ensembl)
NFATC3GeneProductENSG00000072736 (Ensembl)
NFATC4GeneProductENSG00000100968 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
ProstratinMetabolite399975 (Chemspider)
RELAGeneProductENSG00000173039 (Ensembl)
RNA Pol IIGeneProduct
SP1GeneProductENSG00000185591 (Ensembl)
SUPT4H1GeneProductENSG00000213246 (Ensembl)
SUPT5HGeneProductENSG00000196235 (Ensembl)
p300GeneProductENSG00000100393 (Ensembl)
p50GeneProductENSG00000109320 (Ensembl)

Annotated Interactions

No annotated interactions

Personal tools