NOTCH1 regulation of human endothelial cell calcification (Homo sapiens)

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1Valve endotheliumFlow / Shear stressInterstitial CellExtracellular MatrixSAT1ALPLFGFR3VEGFPAR1GJA5CALUITGA1NOTCH1MGPSOX6Secreted proteinsPLATCalcificationPTHrPDLL1DLL3DLL4JAG1JAG2


Model of NOTCH1 regulation of human endothelial cell calcification.

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Ontology Terms



  1. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D; ''NOTCH1 regulates matrix gla protein and calcificationgene networks in human valve endothelium.''; J Mol Cell Cardiol, 2015 PubMed Europe PMC


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87953view13:07, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
87385view11:05, 22 July 2016MaintBotadded missing graphids
82217view20:45, 15 September 2015Khanspersupdates
81814view06:06, 1 September 2015KhanspersModified description
81813view06:04, 1 September 2015KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ALPLGeneProductENSG00000162551 (Ensembl)
CALUGeneProductENSG00000128595 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
GJA5GeneProduct2702 (Entrez Gene)
ITGA1GeneProductENSG00000213949 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
MGPProteinENSG00000111341 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PAR1GeneProductENSG00000198121 (Ensembl)
PLATProteinENSG00000104368 (Ensembl)
PTHrPProteinENSG00000104368 (Ensembl)
SAT1GeneProductENSG00000130066 (Ensembl)
SOX6GeneProductENSG00000110693 (Ensembl)
VEGFGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

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