Oxidative Stress Induced Senescence (Homo sapiens)

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3, 5, 7, 9, 11...56, 722785901444, 68, 70, 12533, 8357, 66, 70, 12533, 80, 85, 993, 511, 37592712383, 111120571811944, 6810, 12, 48, 110, 13129, 44, 59801, 46, 65, 91, 10914, 492925, 74, 1004, 28, 64, 76, 96...123579, 637, 32, 36, 42, 53...69, 1241231233, 2311926, 39, 4590, 120nucleoplasmcytosolmitochondrial matrixUBC(457-532) HIST1H4 MAPKAPK3 Me3K-28-H3F3A p16-INK4a/p14-ARFmRNA: miR-24NonendonucleolyticRISCRNF2 p-T221,Y223-MAPK10 SUZ12ATPE2F3 E2F1 CDK4 p-T180,Y182-MAPK11 CBX8 H2AFZ UBC(229-304) CBX4 CDKN2AGene:H3K27Me3-Nucleosome:PRC1.4ADPADPp-T222,S272,T334-MAPKAPK2 p16-INK4a p-T180,Y182-MAPK14 HIST3H2BB RING1 MAP3K5TP53 p14-ARF mRNA KDM6B:Fe2+p16-INK4a p-T180,Y182-MAPK11 ADPATPRING1 Me3K-28-HIST2H3A MDM4 p14-ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53HIST1H2BO SUZ12 Gene ROSp-MAPK8/9/10p14-ARF p16-INK4A mRNAHIST1H2BC miR-24-2 EZH2 GeneCBX8 Oncogenic MAPKsignalingHIST1H2AD MINK1 Senescence-Associated Secretory Phenotype (SASP)EIF2C1 p14-ARFCDK6 p-S63,S73-JUN PHC2 MOV10 TFDP2 HIST1H2AJ PRC2 (EZH2) CoreHIST1H2AD SUZ12Gene:E2F1/2/3:DP1/2EIF2C4 2xHC-TXNMAP2K4CDKN2D EIF2C4 TNRC6A p-T325,T331,S362,S374-FOS p-2S-cJUN:p-2S,2T-cFOS:KDM6B GeneMDM4 phospho-MAPKp38:p-MAPKAPK3HIST1H2BK UBB(1-76) CDK4,CDK6CBX2 MOV10 p-T183,Y185-MAPK9 MAPKAPK2 p16-INK4A mRNA PHC2 HIST1H2BK RBBP7p-T325,T331,S362,S374-FOS TNRC6B IFNB1p-p38MAPK:p-MAPKAPK2/3p14-ARF mRNA EZH2 p-2S-cJUN:p-2S,2T-cFOSp-S166,S188-MDM2 CDKN2B HIST1H2BM DNA Damage/TelomereStress InducedSenescenceATPp16-INK4a/p14-ARFmRNAHIST2H2BE TNRC6C SCMH1-2 KDM6BHIST1H2BN ATPIntrinsic Pathwayfor ApoptosisHIST1H2BM E2F1 EED GeneMAP2K3 p-S,2T-MAPKAPK3 p-S37-TP53 p-T325,T331,S362,S374-FOSHIST1H2BA p-T,Y-MAPK8 HIST1H2BH CBX6 CDKN2A gene CDKN2D p-S207,T211-MAP2K6 EEDGene:E2F1/2/3:DP1/2RING1 TFDP1 HIST1H2BM HIST1H2BJ ATPSCMH1-2 RBBP4SUZ12 GeneTFDP1 p-T,Y MAPK dimersCDKN2B p14-ARF mRNAHIST3H2BB H2AFB1 p-MKK3/p-MKK6PHC1 TNIK gene MAP2K6 Me3K-28-HIST1H3A RPS27A(1-76) MAP3K5 SUCCAmiR-24-2 KDM6B Gene HIST2H2AC phospho-p38 MAPK:MAPKAPK2/3H2AFB1 MAPK8/9/10p-S257,T261-MAP2K4 p-MKK3/p-MKK6p-S166,S188-MDM2 CDKN2AGene:NucleosomeCDKN2A gene MINK1 gene PHC2 ATPCDK4,CDK6:INK4HIST1H2AB MINK1/TNIKCell CycleCheckpointsHIST2H2BE TP53 phospho-p38MAPK:p-T-182-MAPKAPK5E2F2 CDK6 ADPPHC3 H2AFV p-S271,T275-MAP2K7 ADPCDKN2AGene:H3K27Me3-NucleosomeSCMH1-2 PolyUb-TP53 HIST1H2BO H2AFJ p-T180,Y182-MAPK11 HIST1H2BB HIST1H2BH SUZ12 TXN miR-24-1 TNIK MAPK14 H2AFZ HIST1H2BJ CBX2 HIST2H2AA3 CDKN2C MAPKAPK5 MAPKAPK5 p-T180,Y182-MAPK11 ATPUBA52(1-76) H2AFB1 TFDP2 Me3K-28-HIST1H3A KDM6B GeneFe2+miR-24-1 HIST1H2BL UBC(1-76) ADPUBC(381-456) HIST3H2BB CBX2 Me3K-28-HIST2H3A E2F2 UBB(77-152) TNRC6B RBBP7 TFDP2 RBBP4 UbHIST1H2AJ TFDP1 p-S63,S73-JUNmiR-24NonendonucleolyticRISCKDM6B MAPK9 p-T185,Y187-MAPK1 CDKN2C ATPp16-INK4ap-T180,Y182-MAPK14 TP53 Fe2+ E2F1 EIF2C3 CBX6 H2AFV p-S189,T193-MAP2K3 HIST1H2BD HIST1H2AC HIST1H2BC p-PRC1.4 complexE2F2 UBC(533-608) ATPRNF2 HIST1H3A HIST1H2BB RNF2 p-T180,Y182-MAPK14 MDM4 MAP3K5:TXNHIST1H2BC MINK1/TNIK genesPolyUb-TP53 Tetramerp14-ARF p-S166,S188-MDM2dimer,p-S166,S188-MDM2:MDM4p-MAP2K4/p-MAP2K7UBC(153-228) E2F1 MAPKAPK2 UBC(609-684) TNRC6C p-S166,S188-MDM2 p-T183,Y185-MAPK9 HIST1H2BN p38 MAPK:MAPKAPK2/3PRC1.4p-S37-TP53 TetramerHIST1H2BK Oncogene InducedSenescenceEED Gene PHC3 BMI1 H2BFS MAPK11 HIST2H2AA3 CBX6 PHC1 HIST1H2BO MKK3/MKK6ADPATPH2AFX MDM4 HIST1H2BD E2F3 ADPMAPK8 EIF2C3 TFDP1,TFDP2:E2F1,E2F2,E2F3HIST1H2BA Me3K-28-H3F3A CBX4 TFDP2 p-T180,Y182-MAPK11 p-S189,T193-MAP2K3 EEDE2F3 MAPK14 p-T,Y-MAPK8 HIST2H3A HIST1H4 H2BFS HIST2H2AA3 HIST1H2BA p-S63,S73-JUN BMI1 HIST1H2BJ CBX4 p-T182-MAPKAPK5 phospho-p38 MAPK:MAPKAPK5p16-INK4A mRNA JUNAdoMetMAP4K4 gene Mitotic G1-G1/SphasesHIST2H2AC p-S-BMI1 H3F3A MAPKAPK3 H2AFZ p-S,2T-MAPKAPK3 TNRC6A ADPPHC1 HIST1H2AB HIST2H2BE MAPK11 CBX8 HIST2H2AC p38 MAPK:MAPKAPK5H2AFJ H2BFS HIST1H2BL 2OGHIST1H2BD p-MAPK8/9/10H2AFJ ADPTP53 TetramerEZH2 Gene HIST1H2BN UBB(153-228) p-T221,Y223-MAPK10 HIST1H2AC p-T202,Y204-MAPK3 E2F3 HIST1H2AD p-T180,Y182-MAPK14 CDK4 MAP4K4 CDKN2A gene HIST1H4 H2AFV UBC(77-152) TFDP1 HIST1H2BH ADPATPp14-ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4EZH2Gene:E2F1/2/3:DP1/2p-S166,S188-MDM2dimer,p-S166,S188-MDM2,MDM4:TP53FOSEED HIST1H2AJ HIST1H2BB UBC(305-380) AdoHcyp-S166,S188-MDM2 EIF2C1 p-S257,T261-MAP2K4PHC3 CDKN2A geneINK4p-S207,T211-MAP2K6 H2AFX p-T180,Y182-MAPK14 H2AFX E2F2 HIST1H2AC HIST1H2BL HIST1H2AB EZH2MAPK10 34, 43, 51, 105, 117...13, 22, 30, 41, 50...90, 1204, 17, 35, 38, 47...21, 104, 106, 1074957, 66, 70, 12516, 101, 1292758, 77, 1021238, 18, 31, 112, 121662, 6, 15, 19, 20, 24...44, 68291239966