TNF signaling (Homo sapiens)

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6137, 7230, 49, 6634, 523, 12, 69, 7429, 464, 28, 3168614, 487, 577154, 63382, 16, 51, 59, 65941, 721426, 646327, 387641, 7218, 6213, 19, 24, 56, 57, 60...44, 5535145, 47, 7722, 31, 42cytosolCHUK:IKBKB:IKBKGBAG4 TNF(1-233) UbTNF(1-76) UBC(609-684) K63pUb-K377-RIP1 UBC(229-304) RNF31 TNF-alpha:TNFR1:DENN-SV,MADDRIPK1deubiquitinasesRIPK1 TRADD:TRAF2:RIP1:FADD:CASP8(1-479)ADPSPI-2 UBC(533-608) CHUK TRADD TAB3 TNF(77-233) TNF(77-233) TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4TRADD Activated IKKComplexTNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1RIPK1 TNF(1-233) TNF(1-76) trimerOTUD7B TRAF2XIAP IKBKG CASP8(1-479):UL36BIRC2 TAB1:TAB2,TAB3:TAK1BAG4IKBKB SMPD3 TRADD IKBKG TRADD TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:BIRC2/3:TAB1:TAK1:TAB2/3BIRC3 SHARPIN TAB2 BIRC2 CYLD TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3TNFRSF1A(22-455) TRAF2 TNFRSF1A(22-455) MADD SMPD3 IKKA:IKKB:NEMO:GNB2L1TNFRSF1A(22-455) SMPD2 K63pUb-K377-RIP1 SPPL2A TAB3 TNFRSF1A(22-455) TNF(77-233) UBC(381-456) viral serpinsXIAP TRADD SMPD2,3RBCK1 BIRC3 TNF(1-233) viral serpinsRNF31 UL36BIRC2,3,4TNF-alphatrimer:TNF-R1trimerTNF(1-233) BIRC3 CASP8(1-479) TNF(77-233) ADAM17 TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2IKBKG K63polyUbTRAF2 p-S418-CYLDTNF(77-233) TRAF2 LUBACTNFRSF1A(22-455) TNF(77-233) CRMA TAX1BP1 TNF-alpha trimer,soluble formOTULINSMPD2 CASP8(217-374) TRAF1K48polyUbTNFRSF1A(22-455) K63pUb-K377-RIP1 TRADD RIPK1(325-671) IKBKG TNFRSF1A(22-455) UBA52(1-76) TNF-alpha:TNFR1:NSMAF:GNB2L1TRAF2 TNF(77-233) TAB1 BIRC3 TNFAIP3 BIRC3 RIPK1-containg TNFR1signaling complexesTNFRSF1A(22-455) MAP3K7 TNFRSF1A(22-455) TNF-alpha:TNFR1TRADDBIRC2 TRAF1 SPPL2A,SPPL2BCYLDp-S177,S181-IKBKB TNF(1-233) DENN-SV,MADDTNF(77-233) FADDRNF31 TNFRSF1A(22-455) TRAF1(1-163)SHARPIN TNF(77-233) TNF(77-233) LUBAC:OTULINBIRC2 SHARPIN TAB2 IKBKB TRAF1 TNF(1-233) UBC(457-532) TRAF2 CASP8(1-479)Regulated NecrosisTNF(1-233) RPS27A(1-76) TAX1BP1:TNFAIP3TNF(1-233) RIPK1 RIPK1 USP4 DENN-SV MAP3K7 BIRC2 TNF(77-233) CASP8(385-479) BIRC3 RIPK1(1-324)GNB2L1 TRADD SHARPIN FLIP(S)SPI-2 TRAF2 TNF(77-233) UBC(1-76) active caspase-8TRADD CLIP3TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3TRAF2 GNB2L1 XIAP UL36 RIPK1 K48polyUb TRAF2 TNF(1-233) FADD TRADD TNFRSF1A:BAG4TRADD BIRC3 TRADD:TRAF2:RIP1:FADDUBB(77-152) TNFRSF1A(22-455) MADD XIAP TNFRSF1A(22-455) TRAF2 FADD XIAP USP2 RIPK1(325-671) Ligand-dependentcaspase activationTRAF2 TNF(77-233) TNF(1-233) RIPK1 TRAF2 CHUK TRAF2 TNFRSF1A(22-455) BIRC2 CASP8(385-479) CYLD p-S176,S180-IKKA TRADD TNFRSF1A(22-455) CHUK OTULIN TRAF2 TNF-alpha:TNFR1:NSMAF:GNB2L1:SMPD2,3XIAP TNF-alpha:TNFR1:NSMAFTRAF2 solubleTNF-alpha:TNFR1RBCK1 UBB(153-228) UBC(77-152) CRMA RNF31 TNF(1-233) RIPK1 UBC(305-380) CRMA TNF(77-233) TRADD BIRC3 TNF(1-233) CLIP3 TRAF2:TRADD:RIP1(325-671)TRADD TNF(1-233) trimerTNF(1-233) XIAP TRADD UBC(153-228) TRAF1(164-416)RBCK1 K63pUb-K377-RIP1 TNF(1-233) IKBKB TNFAIP3 TNFRSF1A(22-455) SPPL2B RIPK1TNF(1-34)K63pUb-K377-RIP1 TNFRSF1A(22-455) CASP8(217-374) CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3Zn2+ TNF(1-233) XIAP TNF(1-233) NSMAF USP21 TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMOBIRC2 TNF(52-76)NSMAF BIRC3 RBCK1 K48polyUb-RIPK1-containing TNFR1 complexesNSMAFTNFRSF1A(22-455) CASP8(1-479) K63pUb-K377-RIP1 TNF(1-233) TNF(77-233) activecaspase-8:viralCRMA/SPI-2NSMAF TRAF1 XIAP TNF(77-233) UBB(1-76) TNFRSF1A(22-455) XIAP ATPGNB2L1TNFRSF1A(22-455) TRAF2:TRADD:RIPK1BIRC2 SPI-2 GNB2L1 TRADD DENN-SV TNFAIP3 BIRC2 TAB1 TRAF2 TNF(1-233) TNF(77-233) TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBACTNF(77-233) CFLAR(1-480)BIRC2 BIRC3 ADAM17TAX1BP1 GNB2L176271040, 5330, 49, 66363623, 43, 727225581033, 50, 675414, 48714, 17, 20, 483539, 7054, 6315, 40, 538, 21, 32, 45, 7318101, 11