C-type lectin receptors (CLRs) (Homo sapiens)

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59, 601076, 90, 1059251, 9532, 4948, 976513, 4181, 1068263263, 6619, 85, 93247, 32, 566, 58, 10523, 4011, 374750, 7075, 94268, 455, 22, 53, 55, 679, 10, 7178, 8912916321, 86461614, 19, 101, 10331, 38, 39, 79, 9615, 17248, 976, 33, 43, 57, 765118, 9078, 8915, 69, 74, 80, 8330991, 1673436365185, 9351, 10825, 34, 74, 8454, 6120, 27, 47, 72, 88...70, 87, 9815, 64, 1004361cytosolendoplasmic reticulum lumencytosolnucleoplasmPPP3CB Ca2+GalNAc-MUC19(?-6254) RAF1 PYCARD GalNAc-MUC3A p-S176,S180-CHUK NFAT:CaN:CaMTAB3 GalNAc-MUC5AC GalNAc-MUC5B(26-5703) CLEC4D:FCER1G dimerGTP PPiPSMB5 MAP3K7 UBC(381-456) GalNAc-MUC15 Active NIK p52:RELBMAP3K141,3-beta-D-glucan RELA FCER1G TAB1 p-BCL10 MALT1 NRAS FCER1G SRC-1PAK2 GalNAc-MUC2 PPP3CA UBE2D1 TRAF6 GalNAc-MUCL1 PSMA7 CHUK CLEC6A NFKB2(1-900) CLEC10Ap-S276-RELA UBE2N p-6Y-SYK TAB1 CCL17,CCL22 mRNAITPR2 CLEC6A:FCER1Gdimer:alpha-mannanActive NIK ATPTAB2 PSMD10 UBB(153-228) RELB KRAS EP300 PSMB7 PSMB8 BCL10 oligomer PSMD3 PSMB10 RELB ATPProtein Kinase A, catalytic subunits ADPCD209 SYK CREBBP ATPPSMA5 PSMF1 K48-Ubp-T507,S645,S664-PRKCDNRAS PSMC2 AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerGalNAc-MUC17 PPP3CA pathogens:CLEC6A,CLEC4E:FCER1G dimerCa2+ ADPp-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomersp-S276-RELA:RELBGTP TDM PSMA1 CDC34 p-6Y-SYK pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2PSMC6 1,3-beta-D-glucan ActiveNIK:p-S176,180-IKKAdimerp-S32,36-IkB-alpha:NF-kB complexGalNAc-MUC13 CHUK:IKBKB:IKBKGPSMA5 TAB3 PSMC6 PSMC3 CLEC4D:FCER1Gdimer:TDMGTP alpha-mannan ATPRELB RELA pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYKUBC(153-228) PSMC5 NFKB1(1-433) PSMD2 ICAM2p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6PSME2 NFKBIA CASP8(385-479) KRAS SCF-beta-TRCPPSMB9 TDM MALT1 PSMD10 GalNAc-MUC4(29-2169) IP3 receptorhomotetramerRPS6KA5(MSK1/SAPK1):PKA catalytic subunitsFBXW11 NRAS CLEC4E PSMD11 TRAF6SKP1 GalNAc-MUC6(23-2392) Active NIK NFKB1:p-S276-RELAUb-200-UBB(153-228) HRAS 26S proteasomeCD209:ManLAMFCER1G PSMD14 Ub-656-UBC(609-684) TAB1 CARD9p-12S-NFATC1 I(1,4,5)P3FBXW11 Ub-200-UBC(153-228) Ca2+CLEC4E PPP3R1 PPP3R1 HRAS CREBBP, EP300PLCG2ITPR3 SYK UBE2N:UBE2V1PSMD4 UBE2N PLCG2 Ub-124-UBC(77-152) active p-T507,S645,S664-PRKCD H2OTn antigensTAB1:TAB2,TAB3:TAK1p-S177,S181-IKKB:IKKA:NEMOPSMA6 K63polyUb-TRAF6 oligomer RELBADPIL1B genePSMB7 ICAM3p-S338,Y340,Y341-RAF1 PSMD1 PAK1,2,3p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1NFKB1:p-S276,5AcK-RELA:p300/CBPManLAM NFKB1(1-433):RELAGalNAc-MUC21 CLEC7AUBB(77-152) PSMD13 p-S32,S36-NFKBIA ICAM3 RPS6KA5 UBE2D2,UBE2D1,(CDC34)PSMD6 SHFM1 p-S257-NFATC1 CLEC4C BTRC p-T507,S645,S664-PRKCD I(1,4,5)P3 GalNAc-MUC21 TDM EP300 PLCG2PPP3R1 Ub-504-UBC(457-532) CD209ATPalpha-mannan p-T231-CARD9 oligomer NFKB1(1-433) p21RAS:GTP:p-S338,Y340,Y341-RAF1p-T231-CARD9 oligomer AMPIL1B(117-269)RELA I(1,4,5)P3 Zn2+ ActiveNIK:p-176,S180-IKKAdimer:p-7S-p100:SCF-beta-TRCPGalNAc-MUC12 p-S177,S181-IKBKB HIV gp120,HCV gp E2CLEC6A PSMD8 CALM1RAF1GalNAc-MUC3B(?-901) ADPUb-48-RPS27A(1-76) UBE2N:UBE2V1CLEC6A:FCER1G dimerCLEC4E HRAS pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2GDP Ub-580-UBC(533-608) CASP8(217-374) GalNAc-MUC13 TDM,alpha-mannanUb-200-UBB(153-228) PI(3,4)P2 BCL10 oligomer ATPCLEC4A:HIV gp120,HCVgpE2ATPUBE2N:UBE2V1p-7S-p100 MALT1 oligomer PSMB2 PSMB1 alpha-mannan CLEC4E:FCER1Gdimer:TDM,alpha-mannanCARD9KRAS MALT1 oligomer CLEC4D p21 RAS:GDPAMPPSMD6 BCL10 oligomer p-S177,S181-IKKB:IKKA:pUb-NEMOTAB2 IKBKG TDMNFKB1(1-433) FYN p52:RELBp-S243-NFATC2 K48-UbCLEC4C:FCER1G dimerK63polyUb-TRAF6 oligomer PSMA8 PSMB6 CLEC10A:Tn antigensSHFM1 p-T231-CARD9oligomer:BCL10PSMC2 PSMD5 FCER1G Ub-428-UBC(381-456) alpha-mannan NFKB1(1-433) LYN GalNAc-MUC17 IKBKG ADPp-Y753,Y759-PLCG2CLEC4AMALT1PSMD5 FYN, LYNK48-polyUb-p-7S-p100:RELBCUL1 ITPR2 Active NIKHCV Genome polyprotein HCV Genome polyprotein PSMD4 PSMA4 CCL17 gene CLEC4D p-S276-RELA p-T231-CARD9oligomerADPFe3+ p-S276,5xAcK-RELA p52 BCL10 oligomer PSMD8 p-Y65,Y76-FCER1G PI(4,5)P2HRAS RELA PSMA7 CHUK p-S265-NFATC3 CCL22 gene I(1,4,5)P3alpha-mannan K63polyUbADPUBC(609-684) SYKPAK1 Fe3+ p-T231-CARD9 oligomer UBA3PSMC4 GalNAc-MUC1(24-1255) p-Y65,Y76-FCER1G K63polyUb-TRAF6 oligomer NFKB1(1-433) IKBKB BCL10 oligomer Ca2+ Ub-48-UBB(1-76) p-T231-CARD9 oligomer GalNAc-MUC4(29-2169) GTP Ca2+ATPPSMD9 CCL17 mRNA UBE2D2 TDM CALM1 CD209:ICAM3:Ca+2alpha-mannan CLEC4E PSME4 1,3-beta-D-glucan:p-Y15-CLEC7A:SYKNFKB1(1-433):RELAUb-504-UBC(457-532) PSMA3 p-S176,S180-CHUK alpha-mannanp-T231-CARD9 oligomer GalNAc-MUC2 RELA G76-NEDD8-C111-AcM-UBE2MUBC(229-304) MAP3K7 p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2CLEC7A ENV polyprotein ATPp-T231-CARD9:BCL10oligomersUb-200-UBC(153-228) TRAF6 oligomer TAB1 CCL22 mRNA p-S276-RELA p-T231-CARD9 oligomer PSME3 PSMD12 K63polyUbBCL10 oligomer HRAS UBA52(1-76) CLEC6A Ub-124-UBB(77-152) GalNAc-MUC5AC FCER1G TDM CLEC4E TAB2 ITPR2 ATPUb-580-UBC(533-608) K63polyUb-34,158-TAK1 PSMA4 K63polyUb-34,158-p-T178,184,187,S192-TAK1 1,3-beta-D-glucan:p-Y15-CLEC7API(3,4,5)P3 PDPK1 ATPp-T231-CARD9 oligomer K48PolyUb-K21,22-p-S32,S36-IkBA PSMB4 GDPPSMB5 Ca2+ UBE2V1 GalNAc-MUC12 Ca2+ MALT1 oligomer CLEC6A CLEC4E CD209 PPP3CA Ub-276-UBC(229-304) PSMD3 NFKB1:p-S276-RELA:p300/CBPAHCYL1 PSME2 MALT1 PPP3CB FCER1G Ub-48-UBA52(1-76) ATPActiveNIK:p-S176,180-IKKAdimer:p100:RELBIkB(alpha):NF-kBcomplexp-S243-NFATC2 p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1K63polyUbPSMB3 PYCARDIL1B(1-116)PSME4 K63polyUb-TRAF6 MALT1:activecaspase-8GalNAc-MUCL1 SKP1 DAGs p-T231-CARD9 oligomer GalNAc-MUC20 CLEC7A:1,3-beta-D-glucanPiADPp-T231-CARD9p21 RAS:GTP:RAF1MALT1 oligomer active caspase-8Ub-428-UBC(381-456) ManLAMNFKB1(1-433) PSMC4 p-Y753,Y759-PLCG2CHUK PSMF1 PSMB4 ENV polyprotein GalNAc-MUC19(?-6254) Fe3+ CD209 Zn2+ CLEC4C:FCER1Gdimer:HIV gp120,HCVgp E2PSMA2 p-Y15-CLEC7A CREBBP CALM1 alpha-mannan MALT1 oligomer Ca2+ Calcineurin (CaN)TDM ITPR3 p-T231-CARD9:BCL10oligomers:MALT1p100:RELBHCV Genome polyprotein ADPPSMB1 GalNAc-MUC1(24-1255) PSMB3 p-Y753,Y759-PLCG2 CLEC4E ITPR1 GalNAc-MUC7 CALM1:4xCa2+PSMD14 NRAS Calcineurin:Calmodulin (CaN:CaM)Ub-48-UBB(1-76) BTRC MALT1oligomers:activecaspase-8:ASCBCL10 oligomer p-Y15-CLEC7A p-Y65,Y76-FCER1G PSMD9 PSMA2 CLEC10A Ub-124-UBB(77-152) CLEC4E:FCER1G dimerNFAT:CaN:CaMTDM KRAS UBB(1-76) DAGsLYN RELB GalNAc-MUC15 CUL1 PSMA3 FCER1G CASP8(217-374) PSMD7 Ub-48-RPS27A(1-76) pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYKUBE2V1 PSMD7 BCL10 oligomer PSMC5 UBE2N Ub-TRAF6 trimerbound to CBMcomplexUb-48-UBA52(1-76) p-S176,S180-CHUK FYN UBC(457-532) Zn2+ CALM1 MALT1 oligomer PSMB8 PSMD2 ENV polyprotein FYN, LYNPPP3CA CLEC4E DAGs p-S276-RELA26S proteasomePPiActiveNIK:p-S176,180-IKKAdimer:p-7S-p100:RELBDAGs:activep-T507,S645,S664-PRKCDGalNAc-MUC6(23-2392) PSMB11 p-S265-NFATC3 ADPUb-48-UBC(1-76) p21RAS:GTP:p-S338-RAF1PSME1 Zn2+ Ubp-13S-NFATC3 K48-polyUb-p-7S-p100 alpha-mannan p-T231-CARD9 oligomer PAK3 TAB3 ATPp-T231-CARD9 oligomer p21 RAS:GTPUb-352-UBC(305-380) PSMC1 ITPR1 CLEC6A ITPR1 TAB3 KRAS ATPPPP3CB PSME1 NFKB1(1-433) NRAS PSMC3 p-Y65,Y76-FCER1G MALT1 PSME3 PPP3R1 ATPK63polyUb-TRAF6 oligomer TDM BCL10 FCER1G p-T231-CARD9:BCL10:MALT1:TRAF6 oligomersAc-CoAp-S257-NFATC1 CCL17,CCL22 genesADPIKKA dimerCLEC4A IL1B mRNAPSMB6 ADPPSMB2 UBC(1-76) UBC(533-608) FCER1G GTPITPR:I(1,4,5)P3tetramerUb-656-UBC(609-684) BCL10 oligomer MALT1 oligomer p-S552-CARD11 1,3-beta-D-glucan GalNAc-MUC7 PSMD1 RPS27A(1-76) Ub-48-UBC(1-76) 1,3-beta-D-glucanp-T231-CARD9:BCL10:MALT1 oligomersGalNAc-MUC3B(?-901) CD209:ICAM2PSMC1 CASP8(385-479) CHUK PSMA8 CLEC6A PSMD13 PhosphorylatedNFATC1,2,3Ub-352-UBC(305-380) p-S338-RAF1 NAD+ PSMA6 DAGs:p-T507,S645,S664-PRKCDSYKCALM1 UBC(77-152) GalNAc-MUC20 RELB p-S177,S181-IKBKB RELB ATPGalNAc-MUC3A GalNAc-MUC5B(26-5703) PSMB10 BCL10GalNAc-MUC16 PSMB9 CLEC4C PSMB11 NFKB2(1-900) ADPalpha-mannan p52 TAB2 IL1B(1-269)ITPR3 CLEC6A GalNAc-MUC16 p-14S-NFATC2 ADPNFKB1(1-433) H2OPPP3CB p-S176,S180-CHUK K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complexK63polyUb-NEMO PSMA1 RELB EP300 ICAM2 PSMD11 RELB CREBBP p-7S-p100 pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimerCASP8(385-479) CASP8(217-374) Ub-124-UBC(77-152) CLEC6A CoA-SHUBE2V1 TDM PSMD12 Fe3+ p-Y65,Y76-FCER1G p-6Y-SYK Ub-276-UBC(229-304) UBC(305-380) Active NIK 179452435, 1025229, 44, 6277427744, 287768524, 28