Resolution of Abasic Sites (AP sites) (Homo sapiens)

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1, 2, 9, 17, 18, 30...3, 17, 438, 12, 17, 471239551830, 402, 17, 29, 597, 31, 623714, 19, 41, 43, 46...6, 18, 36, 522410, 14, 274, 21, 35, 613, 17, 43, 6530, 40, 581, 12, 13, 20, 514430, 4030, 40, 585337, 4917, 18, 451843, 5022, 38, 685, 12, 17, 53, 5428, 34, 42, 48, 67...5730, 4017, 453712, 17, 475, 17, 6330, 401, 12, 20, 5611, 15, 306, 16, 25, 5530, 4030, 403732, 55cytosolmitochondrial matrixnucleoplasmPOLB RPA1 POLB LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNAPAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNANEIL1 LIG3:XRCC1:POLB:dsDNAPOLD3 NEIL1,NEIL2MPG APEX1 PPiRFC1 POLE4 XRCC1 POLD4 POLE3 RFC5 NEIL1 POLB:SSB-gap-dsDNARPA3 POLE POLD2 POLB dsDNA NEIL2 SSB-dsDNA POLE MBD4ADPRHL2RFC3 APEX1 FEN1SMUG1:AP-dsDNARFC3 LIG1:POLB:dsDNAFEN1 POLE3 APEX1 AP-dsDNA POLD1 SMUG1 RFC5 OGG1 LIG3 NAMRFC1 LIG3:XRCC1SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA APEX1 SSB(5'-ddRP)-dsDNA POLD3 APEX1:SSB(5'-ddRP)-dsDNAPOLB APEX1 APEX1 OGG1:AP-dsDNAXRCC1 RFC4 RFC1 TDG:AP-dsDNAPOLE4 SUGPPARP1 OGG1PCNA LIG3 LIG3 PCNA RFC2 PARP2 RFC2 POLB LIG1:POLB:SSB(3'poly-dNMP)-dsDNAXRCC1 AP-dsDNA POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNAPOLBPCNA PAR-PARP1,PAR-PARP2dimersRFC3 LIG1LIG3 POLD3 SSB(3'Pi-5'dRP)-dsDNA POLB AP-dsDNA POLE4 RFC5 NEIL2 TDG NTHL1RPA3 RFC5 LIG3 RPA1 RPA3 POLE4 UNG-1 POLB LIG3 PCNA POLD4 POLE4 TDGLIG1 POLE4 PPidsDNA NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNANEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNASSB(3'dNMP-displaced 5'ddRP)-dsDNA FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAMBD4:CpG(AP)-dsDNASSB-gap-dsDNA Base-ExcisionRepair, AP SiteFormationLIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNAPOLB APEX1RPA3 POLB POLB RFC1 SSB(3'poly-dNMP)-dsDNA PNKP POLD3 SSB(3'Pi)-gap-dsDNA NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNAAPEX1 NEIL1 PARGPOLE2 RFC1 SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA SSB(3'poly-dNMP)-dsDNA SSB(3'poly-dNMP)-dsDNA PARP1 poly(ADP-ribose)dsDNA POLB RFC4 POLB:APEX1:SSB(5'ddRP)-dsDNASSB-gap-dsDNA MUTYH-3 POLE3 NEIL1,NEIL2POLE SSB(3'dNMP-displaced 5'ddRP)-dsDNA MUTYH:AP-dsDNAPPiPiPOLE3 PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAH2ONEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNAPOLB SSB(3'dNMP-displaced 5'ddRP)-dsDNA RFC2 POLE RPA3 POLE MPGMUTYHPOLE2 APEX1FEN1 APEX1dNTPRPA2 AP-dsDNA PAR-PARP2 LIG3 SSB-dsDNA RFC5 POLD4 NTHL1 SSB(3'poly-dNMP)-dsDNA POLD2 POLB POLBPCNA:POLD,POLE:RPA:RFCXRCC1 NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNAPARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNAAPEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNARFC2 NEIL1 POLD4 POLB RPA2 POLB:APEX1:SSB(AP->5'-dRP)-dsDNARFC4 MUTYH-6 PAR-PARP1 XRCC1 POLD1 MBD4 MPG:AP-dsDNAAPEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNASSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA SMUG1XRCC1 AP-dsDNA POLE2 RFC1 RPA2 POLB PNKPRPA1 NAD+LIG3 POLD2 SSB-gap-dsDNA SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA NEIL1 PARP1,PARP2 dimersPOLE2 PCNA LIG3:XRCC1POLE3 RFC4 APEX1:AP-dsDNAAPEX1 dsDNARFC5 PARP2 PNKP POLD1 APEX1 POLD1 AP-dsDNA AP-dsDNA XRCC1 PARP1 FEN1RFC2 NEIL2 APEX1PAR-PARP1 APEX1 POLD3 POLB:SSB(3'poly-dNMP)-dsDNAFEN1 RFC4 RFC2 LIG3 NEIL2 POLD4 NEIL1,NEIL2:AP-dsDNAPOLE POLB AP-dsDNA ADP-D-riboseH2OPOLE2 NEIL2 NEIL1 PCNA PNKP NEIL2 LIG1 AP-dsDNA RPA2 NTHL1:AP-dsDNASSB(3'Pi)-gap-dsDNA PNKPRPA3 SSB(AP->5'-dRP)-dsDNA FEN1 POLD2 LIG3:XRCC1:POLB:SSB-gap-dsDNAAP-dsDNA NEIL2 XRCC1 LIG1 POLD3 POLD1 MUTYH-6 RPA1 ADP-riboseAPEX1:SSB(AP->5'-dRP)-dsDNA5'ddRP-FLAP-ssDNANEIL2 FEN1 dNTPMUTYH-3 NEIL1 POLB POLE3 SSB(AP->5'-dRP)-dsDNA PARP2 SSB(3'Pi-5'dRP)-dsDNA APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNANEIL1 PAR-PARP2 UNG-1:AP-dsDNAXRCC1 LIG3:XRCC1:POLB:SSB-dsDNAPOLD1 dsDNA RFC3 UNG-1LIG1 POLB NEIL1 POLB H2ORFC3 POLB POLBNEIL2 NEIL1 POLD2 NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNAPOLBdNTPPNKP POLE2 RPA2 RFC4 POLD2 RPA1 POLD4 SSB(5'-ddRP)-dsDNA RPA2 FEN1 NEIL2 APEX1 NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNARPA1 RFC3 3030, 403043434330, 40, 583730, 4013, 514330, 403330, 4030, 40, 585323, 26334337


Description

Resolution of AP sites can occur through the single nucleotide replacement pathway or through the multiple nucleotide patch replacement pathway, also known as the long-patch base excision repair (BER). Except for the APEX1-independent resolution of AP sites via single nucleotide base excision repair mediated by NEIL1 or NEIL2 (Wiederhold et al. 2004, Das et al. 2006), single nucleotide and multiple-nucleotide patch replacement pathways are both initiated by APEX1-mediated displacement of DNA glycosylases and cleavage of the damaged DNA strand by APEX1 immediately 5' to the AP site (Wilson et al. 1995, Bennett et al. 1997, Masuda et al. 1998). The BER proceeds via the single nucleotide replacement when the AP (apurinic/apyrimidinic) deoxyribose residue at the 5' end of the APEX1-created single strand break (SSB) (5'dRP) can be removed by the 5'-exonuclease activity of DNA polymerase beta (POLB) (Bennett et al. 1997). POLB fills the created single nucleotide gap by adding a nucleotide complementary to the undamaged DNA strand to the 3' end of the SSB. The SSB is subsequently ligated by DNA ligase III (LIG3) which, in complex with XRCC1, is recruited to the BER site by an XRCC1-mediated interaction with POLB (Kubota et al. 1996). BER proceeds via the multiple-nucleotide patch replacement pathway when the AP residue at the 5' end of the APEX1-created SSB undergoes oxidation-related damage (5'ddRP) and cannot be cleaved by POLB (Klungland and Lindahl 1997). Long-patch BER can be completed by POLB-mediated DNA strand displacement synthesis in the presence of PARP1 or PARP2, FEN1 and DNA ligase I (LIG1) (Prasad et al. 2001). When the PCNA-containing replication complex is available, as is the case with cells in S-phase of the cell cycle, DNA strand displacement synthesis is catalyzed by DNA polymerase delta (POLD) or DNA polymerase epsilon (POLE) complexes, in the presence of PCNA, RPA, RFC, APEX1, FEN1 and LIG1 (Klungland and Lindahl 1997, Dianova et al. 2001). It is likely that the 9-1-1 repair complex composed of HUS1, RAD1 and RAD9 interacts with and coordinates components of BER, but the exact mechanism and timing have not been elucidated (Wang et al. 2004, Smirnova et al. 2005, Guan et al. 2007, Balakrishnan et al. 2009). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 73933
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Matthews, Lisa

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
101292view11:17, 1 November 2018ReactomeTeamreactome version 66
100829view20:48, 31 October 2018ReactomeTeamreactome version 65
100370view19:23, 31 October 2018ReactomeTeamreactome version 64
99917view16:07, 31 October 2018ReactomeTeamreactome version 63
99472view14:39, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99126view12:40, 31 October 2018ReactomeTeamreactome version 62
93935view13:46, 16 August 2017ReactomeTeamreactome version 61
93522view11:25, 9 August 2017ReactomeTeamreactome version 61
89075view15:50, 21 August 2016EgonwOntology Term : 'regulatory pathway' added !
86621view09:22, 11 July 2016ReactomeTeamreactome version 56
83320view10:46, 18 November 2015ReactomeTeamVersion54
81469view13:00, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
5'ddRP-FLAP-ssDNAR-HSA-5651774 (Reactome)
ADP-D-riboseMetaboliteCHEBI:16960 (ChEBI)
ADP-riboseMetaboliteCHEBI:57967 (ChEBI)
ADPRHL2ProteinQ9NX46 (Uniprot-TrEMBL)
AP-dsDNA R-HSA-110187 (Reactome)
APEX1 ProteinP27695 (Uniprot-TrEMBL)
APEX1:AP-dsDNAComplexR-HSA-110332 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNAComplexR-HSA-110407 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNAComplexR-HSA-5651812 (Reactome)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNAComplexR-HSA-5651804 (Reactome)
APEX1:SSB(5'-ddRP)-dsDNAComplexR-HSA-5649859 (Reactome)
APEX1:SSB(AP->5'-dRP)-dsDNAComplexR-HSA-110334 (Reactome)
APEX1ProteinP27695 (Uniprot-TrEMBL)
Base-Excision

Repair, AP Site

Formation
PathwayR-HSA-73929 (Reactome) Base excision repair is initiated by DNA glycosylases that hydrolytically cleave the base-deoxyribose glycosyl bond of a damaged nucleotide residue, releasing the damaged base (Lindahl and Wood 1999, Sokhansanj et al. 2002).
FEN1 ProteinP39748 (Uniprot-TrEMBL)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAComplexR-HSA-5651754 (Reactome)
FEN1ProteinP39748 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
LIG1 ProteinP18858 (Uniprot-TrEMBL)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNAComplexR-HSA-5651808 (Reactome)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNAComplexR-HSA-5651810 (Reactome)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNAComplexR-HSA-5651769 (Reactome)
LIG1:POLB:dsDNAComplexR-HSA-5651790 (Reactome)
LIG1ProteinP18858 (Uniprot-TrEMBL)
LIG3 ProteinP49916 (Uniprot-TrEMBL)
LIG3:XRCC1:POLB:SSB-dsDNAComplexR-HSA-110341 (Reactome)
LIG3:XRCC1:POLB:SSB-gap-dsDNAComplexR-HSA-110339 (Reactome)
LIG3:XRCC1:POLB:dsDNAComplexR-HSA-110343 (Reactome)
LIG3:XRCC1ComplexR-HSA-110338 (Reactome)
MBD4 ProteinO95243 (Uniprot-TrEMBL)
MBD4:CpG(AP)-dsDNAComplexR-HSA-110194 (Reactome)
MBD4ProteinO95243 (Uniprot-TrEMBL)
MPG ProteinP29372 (Uniprot-TrEMBL)
MPG:AP-dsDNAComplexR-HSA-110207 (Reactome)
MPGProteinP29372 (Uniprot-TrEMBL)
MUTYH-3 ProteinQ9UIF7-3 (Uniprot-TrEMBL) This isoform of MUTYH uses exon 1-alpha and the exon 3 splice donor site variant-3. This is one of the most abundant MUTYH transcripts, while the transcripts that corresponds to the canonical UniProt sequence and to the longest NCBI transcript of MUTYH are rare or not present (Plotz et al. 2012).
MUTYH-6 ProteinQ9UIF7-6 (Uniprot-TrEMBL)
MUTYH:AP-dsDNAComplexR-HSA-110200 (Reactome)
MUTYHComplexR-HSA-9606670 (Reactome)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NAMMetaboliteCHEBI:17154 (ChEBI)
NEIL1 ProteinQ96FI4 (Uniprot-TrEMBL)
NEIL1,NEIL2:AP-dsDNAComplexR-HSA-5649693 (Reactome)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNAComplexR-HSA-5649729 (Reactome)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNAComplexR-HSA-5649733 (Reactome)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNAComplexR-HSA-5649722 (Reactome)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNAComplexR-HSA-5649816 (Reactome)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNAComplexR-HSA-5649730 (Reactome)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNAComplexR-HSA-5649706 (Reactome)
NEIL1,NEIL2ComplexR-HSA-5649697 (Reactome)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNAComplexR-HSA-5649715 (Reactome)
NEIL2 ProteinQ969S2 (Uniprot-TrEMBL)
NTHL1 ProteinP78549 (Uniprot-TrEMBL)
NTHL1:AP-dsDNAComplexR-HSA-110193 (Reactome)
NTHL1ProteinP78549 (Uniprot-TrEMBL)
OGG1 ProteinO15527 (Uniprot-TrEMBL)
OGG1:AP-dsDNAComplexR-HSA-110195 (Reactome)
OGG1ProteinO15527 (Uniprot-TrEMBL)
PAR-PARP1 ProteinP09874 (Uniprot-TrEMBL)
PAR-PARP1,PAR-PARP2 dimersComplexR-HSA-5651709 (Reactome)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAComplexR-HSA-5651725 (Reactome)
PAR-PARP2 ProteinQ9UGN5 (Uniprot-TrEMBL)
PARGProteinQ86W56 (Uniprot-TrEMBL)
PARP1 ProteinP09874 (Uniprot-TrEMBL)
PARP1,PARP2 dimersComplexR-HSA-5649884 (Reactome)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNAComplexR-HSA-5649866 (Reactome)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAComplexR-HSA-5649888 (Reactome)
PARP2 ProteinQ9UGN5 (Uniprot-TrEMBL)
PCNA ProteinP12004 (Uniprot-TrEMBL)
PCNA:POLD,POLE:RPA:RFCComplexR-HSA-5651799 (Reactome)
PNKP ProteinQ96T60 (Uniprot-TrEMBL)
PNKPProteinQ96T60 (Uniprot-TrEMBL)
POLB ProteinP06746 (Uniprot-TrEMBL)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNAComplexR-HSA-5649885 (Reactome)
POLB:APEX1:SSB(5'ddRP)-dsDNAComplexR-HSA-5649858 (Reactome)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNAComplexR-HSA-110335 (Reactome)
POLB:SSB(3'poly-dNMP)-dsDNAComplexR-HSA-5651778 (Reactome)
POLB:SSB-gap-dsDNAComplexR-HSA-110337 (Reactome)
POLBProteinP06746 (Uniprot-TrEMBL)
POLD1 ProteinP28340 (Uniprot-TrEMBL)
POLD2 ProteinP49005 (Uniprot-TrEMBL)
POLD3 ProteinQ15054 (Uniprot-TrEMBL)
POLD4 ProteinQ9HCU8 (Uniprot-TrEMBL)
POLE ProteinQ07864 (Uniprot-TrEMBL)
POLE2 ProteinP56282 (Uniprot-TrEMBL)
POLE3 ProteinQ9NRF9 (Uniprot-TrEMBL)
POLE4 ProteinQ9NR33 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PiMetaboliteCHEBI:18367 (ChEBI)
RFC1 ProteinP35251 (Uniprot-TrEMBL)
RFC2 ProteinP35250 (Uniprot-TrEMBL)
RFC3 ProteinP40938 (Uniprot-TrEMBL)
RFC4 ProteinP35249 (Uniprot-TrEMBL)
RFC5 ProteinP40937 (Uniprot-TrEMBL)
RPA1 ProteinP27694 (Uniprot-TrEMBL)
RPA2 ProteinP15927 (Uniprot-TrEMBL)
RPA3 ProteinP35244 (Uniprot-TrEMBL)
SMUG1 ProteinQ53HV7 (Uniprot-TrEMBL)
SMUG1:AP-dsDNAComplexR-HSA-5649542 (Reactome)
SMUG1ProteinQ53HV7 (Uniprot-TrEMBL)
SSB(3'Pi)-gap-dsDNA R-HSA-5649821 (Reactome)
SSB(3'Pi-5'dRP)-dsDNA R-HSA-5649718 (Reactome)
SSB(3'dNMP-displaced 5'ddRP)-dsDNA R-HSA-5649881 (Reactome)
SSB(3'poly-dNMP)-dsDNA R-HSA-5651764 (Reactome)
SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA R-HSA-5649865 (Reactome)
SSB(5'-ddRP)-dsDNA R-HSA-5649861 (Reactome)
SSB(AP->5'-dRP)-dsDNA R-HSA-110333 (Reactome)
SSB-dsDNA R-HSA-110340 (Reactome)
SSB-gap-dsDNA R-HSA-110336 (Reactome)
SUGPMetaboliteCHEBI:33447 (ChEBI)
TDG ProteinQ13569 (Uniprot-TrEMBL)
TDG:AP-dsDNAComplexR-HSA-110191 (Reactome)
TDGProteinQ13569 (Uniprot-TrEMBL)
UNG-1 ProteinP13051-1 (Uniprot-TrEMBL)
UNG-1:AP-dsDNAComplexR-HSA-110188 (Reactome)
UNG-1ProteinP13051-1 (Uniprot-TrEMBL)
XRCC1 ProteinP18887 (Uniprot-TrEMBL)
dNTPMetaboliteCHEBI:16516 (ChEBI)
dsDNA R-HSA-5649637 (Reactome)
dsDNAR-HSA-5649637 (Reactome)
poly(ADP-ribose)R-ALL-8952909 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
5'ddRP-FLAP-ssDNAArrowR-HSA-110363 (Reactome)
5'ddRP-FLAP-ssDNAArrowR-HSA-5651782 (Reactome)
ADP-D-riboseArrowR-HSA-5651828 (Reactome)
ADP-riboseArrowR-HSA-8952903 (Reactome)
ADPRHL2mim-catalysisR-HSA-8952903 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110349 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110350 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110351 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110352 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110353 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110354 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110355 (Reactome)
APEX1:AP-dsDNAArrowR-HSA-110356 (Reactome)
APEX1:AP-dsDNAR-HSA-110359 (Reactome)
APEX1:AP-dsDNAmim-catalysisR-HSA-110359 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNAArrowR-HSA-110364 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNAR-HSA-110368 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNAmim-catalysisR-HSA-110368 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNAArrowR-HSA-110368 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNAR-HSA-110363 (Reactome)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNAmim-catalysisR-HSA-110363 (Reactome)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNAArrowR-HSA-110363 (Reactome)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNAR-HSA-110371 (Reactome)
APEX1:SSB(5'-ddRP)-dsDNAArrowR-HSA-5649856 (Reactome)
APEX1:SSB(5'-ddRP)-dsDNAR-HSA-5649854 (Reactome)
APEX1:SSB(AP->5'-dRP)-dsDNAArrowR-HSA-110359 (Reactome)
APEX1:SSB(AP->5'-dRP)-dsDNAR-HSA-110360 (Reactome)
APEX1:SSB(AP->5'-dRP)-dsDNAR-HSA-5649856 (Reactome)
APEX1ArrowR-HSA-110375 (Reactome)
APEX1ArrowR-HSA-5649873 (Reactome)
APEX1ArrowR-HSA-5651809 (Reactome)
APEX1R-HSA-110349 (Reactome)
APEX1R-HSA-110350 (Reactome)
APEX1R-HSA-110351 (Reactome)
APEX1R-HSA-110352 (Reactome)
APEX1R-HSA-110353 (Reactome)
APEX1R-HSA-110354 (Reactome)
APEX1R-HSA-110355 (Reactome)
APEX1R-HSA-110356 (Reactome)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAArrowR-HSA-5651739 (Reactome)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAR-HSA-5651782 (Reactome)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAmim-catalysisR-HSA-5651782 (Reactome)
FEN1ArrowR-HSA-110363 (Reactome)
FEN1ArrowR-HSA-5651782 (Reactome)
FEN1R-HSA-110364 (Reactome)
FEN1R-HSA-5649873 (Reactome)
H2OR-HSA-5649705 (Reactome)
H2OR-HSA-5651828 (Reactome)
H2OR-HSA-8952903 (Reactome)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNAArrowR-HSA-110371 (Reactome)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNAR-HSA-5651805 (Reactome)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNAmim-catalysisR-HSA-5651805 (Reactome)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNAArrowR-HSA-5651805 (Reactome)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNAR-HSA-5651809 (Reactome)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNAArrowR-HSA-5651773 (Reactome)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNAR-HSA-5651789 (Reactome)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNAmim-catalysisR-HSA-5651789 (Reactome)
LIG1:POLB:dsDNAArrowR-HSA-5651789 (Reactome)
LIG1:POLB:dsDNAR-HSA-5651792 (Reactome)
LIG1ArrowR-HSA-5651792 (Reactome)
LIG1ArrowR-HSA-5651809 (Reactome)
LIG1R-HSA-110371 (Reactome)
LIG1R-HSA-5651773 (Reactome)
LIG3:XRCC1:POLB:SSB-dsDNAArrowR-HSA-73932 (Reactome)
LIG3:XRCC1:POLB:SSB-dsDNAR-HSA-73931 (Reactome)
LIG3:XRCC1:POLB:SSB-dsDNAmim-catalysisR-HSA-73931 (Reactome)
LIG3:XRCC1:POLB:SSB-gap-dsDNAArrowR-HSA-110376 (Reactome)
LIG3:XRCC1:POLB:SSB-gap-dsDNAR-HSA-73932 (Reactome)
LIG3:XRCC1:POLB:SSB-gap-dsDNAmim-catalysisR-HSA-73932 (Reactome)
LIG3:XRCC1:POLB:dsDNAArrowR-HSA-73931 (Reactome)