TCF dependent signaling in response to WNT (Homo sapiens)

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25, 34, 16422, 57, 109, 138, 139, 180...46, 108, 245168, 179, 190, 19215, 19, 27, 36, 73...28, 99181, 205, 229, 2377074, 80, 179, 237111107, 135, 156, 169, 19328, 9953, 166, 201, 2431141627, 70, 2024, 47, 51, 79, 81...112, 15220813, 21, 26, 32, 33, 56...31, 114, 1732493, 11, 23, 28-30, 37...28, 88, 144, 161, 2352081945, 9, 82, 97, 159...43, 194, 21810, 34, 39, 69, 83...53, 20195, 102, 118, 18820848, 58, 110, 153, 157...5362, 65, 113, 136, 170...7043, 194, 2181, 17, 50, 60, 76...42, 74, 83, 106, 123...2, 40, 57, 126, 143112, 15263, 80, 95, 102, 188...64, 103, 197189, 193, 2264, 15098, 116, 184, 2271948, 215, 25266, 2501111816, 28, 35, 49, 89...20154, 124107, 135, 156, 169, 193112, 114, 15228, 193, 19931, 61, 112, 114, 152...2892, 125, 129, 164, 171...133, 175, 185, 207, 22124924, 41, 44, 77, 87...18, 34, 75, 84, 105...12, 12420, 160, 244111160, 21021820124928, 134, 149, 228, 231early endosome lumenearly endosome lumennucleoplasmcytosolZNRF3 ATPHIST1H2BJ N4GlycoAsn-PalmS WNT3A CTBP1 RSPO:LGRN4GlycoAsn-PalmS WNT3A H3F3A PSMB1 HIST1H2AJ GSK3B APC SOX13 XAV939 DKK4 PPP2R5A APC Ub-121-HIST1H2BL UBB(77-152) KLHL12 UbAXIN1 CTBP1 APCUb-121-H2BFS RSPO4 RNF43 UBB(1-76) TCF7L2 HIST1H2AC PPP2R5D FZD5 TNKS p-T309,S474-AKT2 PPP2R5B ub-TLERSPO3 N4GlycoAsn-PalmS WNT8B TCF/LEF:CTNNB1:SOX4,SOX13,SOX17Ub-121-HIST1H2BJ Ub-RibC-AXIN:TNKS:RNF146UBC(533-608) H2AFJ SOX3 LEF1 NAMPSMC1 YWHAZ RUNX3:TCF7L2,(LEF1,TCF7L1)pp-DVL2 Ub-121-HIST1H2BO WNT:FZD:LRP5/6UBC(77-152) N4GlycoAsn-PalmS WNT5A(36-380) UBC(381-456) LRP6 LEO1 GSK3B 26S proteasomeCTNNB1 TLE2 N4GlycoAsn-PalmS WNT1 UBB(1-76) H2AFJ HIST1H2BM GSK3B TNKS pp-DVL1 ub-RNF43 LRP6 CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17UBC(609-684) pp-DVL1 BCL9 DVL3 UBA52(1-76) AXIN:TNKSUBC(305-380) CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexUbPPP2R1B Ub-TLE2 AMER1 TCF7 PSMA3 UBC(381-456) HIST1H2BK LRP6 HDAC1 UBC(153-228) TNKS1/2:XAV939TCF7L2 Ub-121-HIST1H2BM HIST1H2BB Ub-121-HIST1H2BL UBC(1-76) UBB(77-152) TCF7L1/TCF7L2/LEF1:CTNNB1:MYC geneLRP5 N4GlycoAsn-PalmS WNT5A(36-380) WIF1-binding WNTsPSMC4 TERT CDC73 CTNNB1 LGR5 HECW1SOX4 XAV939HIST1H2BH LEF1 PPP2R5C UBA52(1-76) KLHL12 EP300 Ub-121-HIST1H2BK DVLPIP5K1BUBC(153-228) LGR5 DKK1 N4GlycoAsn-PalmS WNT3A N4GlycoAsn-PalmS WNT3 pp-DVL1 Me3K5-HIST2H3A Ub-TLE1 LRP6 TLE3 TCF7 RSPO3 SMARCA4 Ub-TLE3 DKK2 CTNNB1Ub-TLE4 USP8RibC-AXIN:TNKS:RNF146TCF7L2 AXIN:SMURF2UBC(609-684) PPP2R5E GSK3B HIST1H2AC FZD8 TNKS2 H2BFS H2AFZ CUL3 PSMD14 CREBBP DACT1 TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5HIST3H3 TCF7L1 ub-AXIN1 TCF7L2 CXXC4HIST3H2BB SOX4 TCF7L2 DKK4 UBA52(1-76) N4GlycoAsn-PalmS WNT1 HIST3H3 ZNRF3 DKK4 UBB(1-76) Ub-121-HIST2H2BE RSPO3 FZD5 ub-AXIN:SMURF2UBC(1-76) LEO1TLE4 TCF7L2 PSMD11 SRY UBB(77-152) TCF7L1 N4GlycoAsn-PalmS WNT3A RibC-AXIN1 UBC(153-228) LGRATPKMT2DUBB(1-76) HIST1H2BC UBB(77-152) K63polyUb-APC RNF43 ADPTNKS2 SOX6 RSPO2 HIST2H2AC TCF7 RYK-binding WNTsLGR6 DVL1 GSK3B ZNRF3 DVL1UBB(153-228) H2AFJ UBC(229-304) SOX7 TCF7L1 PSMB8 TCF7L1 N4GlycoAsn-PalmS WNT3A FZD1 CSNK2A1 SOX9 DVL1 pp-DVL3 N4GlycoAsn-PalmS WNT8A AXIN2 gene HIST1H2BB PSMD3 RUNX3 UBB(77-152) RBX1 EP300 KAT5 GSK3B AdoHcyUBC(381-456) RSPO2 ub-DVL3 PSMD12 WNT3A:sFRPp-T308,S473-AKT1 ASH2LTCF7L2 DKK1 N4GlycoAsn-PalmS WNT3A AXIN1 DVL1:HECW1UBC(1-76) N4GlycoAsn-PalmS WNT8A Ub-121-HIST2H2BE pp-DVL3 RNF146 H2BFS p-4S,3T,T1479,S1490,T1493-LRP6 LEF1 PSME2 Ub-121-HIST1H2BK MYC gene pp-DVL3 HIST2H2AA3 FZD2 N4GlycoAsn-PalmS WNT3A HIST1H2BA CTNNB1 SFRP1 UBC(77-152) ub-TLE:XIAPRNF146GSK3BRBBP5PPP2R5B TCF7L2 Ub-RibC-AXIN2 PSMB10 ub-FZD4 UBC(153-228) SRY AXIN1 N4GlycoAsn-PalmS WNT1 Ub-121-HIST1H2BC LRP5 USP34ppDVL:PIP5K1BCTNNB1 CAV1 DVL2 DVL2 KRM1 pp-DVL1 UBC(229-304) SOX17 H2AFZ HIST2H3A YWHAZ SMURF2 FZD1 TCF7L1 HIST1H2AC SOX7 N4GlycoAsn-PalmS WNT3A GSK3B CTNNB1 RYK RSPOTRRAP UBC(1-76) PSMC2 HIST1H4 HIST1H2AD TCF4 gene:acetyl H4nucleosomeub-AXIN2 UBC(153-228) UBC(457-532) pp-DVL2 RibC-AXIN:TNKSYWHAZ CTNNB1 PSMD9 N4GlycoAsn-PalmS WNT5A(36-380) p-LRP6 PSMA7 FZD4 TNKS PPP2CB DVL2 TCF7 BCL9L RYKTCF/LEF:CTNNB1:BCL9:PYGORBX1 LRP6 BCL9 TCF/LEF:CTNNB1:AXIN2geneDVL3 WNT:FZD:LRP5/6:DVLLEF1 KMT2D FRAT1,2pp-DVL3 UBB(153-228) LGR4 GSK3B SOX4 CTNNB1 AMER1 TCF7L1 SOX13 RibC-AXIN2 RUVBL1 UBC(305-380) N4GlycoAsn-PalmS WNT3A PSMD7 pp-DVL3 Ub-121-HIST1H2BD TCF7L1 DVL3 LRP5 FRAT1 LGR6 TCF/LEF:CTNNB1:PAF1-like complexLEF1 H2AFB1 AXIN2 SOX4,SOX13,SOX17CTNNB1 pp-DVL2 SOX6 RSPO1 TLE1 ub-DVL1 CTNNB1 TCF7L2 TCF4 gene:nucleosomeATPSHFM1 HIST1H2AD PSMD2 PSMB3 PSMA2 LRP5 RPS27A(1-76) MEN1 TCF7L1 UBC(533-608) KLHL12 TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complexRPS27A(1-76) Ub-121-HIST1H2BD UBC(153-228) RUVBL1UBC(381-456) Me3K5-HIST3H3 GSK3B:AXIN1TCF7L2 CTNNB1 K63polyUb-APC RBX1 TCF7L1 PSMD8 pp-DVL3 RPS27A(1-76) CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexTCF7 HIST3H3 RSPO1 TLE tetramerHIST1H4 Ub-121-HIST1H2BC H2AFV K63polyUb-APCUb-121-HIST1H2BN HIST1H2BO SOX17 HECW1 TCF4 gene DVL1 PSMD10 HIST2H2AA3 NAD+LRP5 ZNRF3,RNF43PYGO2 RBBP5 ub-ZNRF3 pS20-CBY1 KRM2 H2AFX KRM2 WNT:FZD:LRP5/6:DVL:AXIN:GSK3BPYGO1 CXXC4 TCF7 CTNNBIP1:CTNNB1KRM1 H2AFX ATPAXIN1 DVL1 AdoMetPI4PHIST1H2BN TCF7L2 ADPAMER1UBB(77-152) TLE1 FZD2 PSMA6 PYGO2 CBY1 UBB(153-228) PSMA4 HIST2H2AC HIST1H2BA HIST1H2BD LEF1 PP2ARSPO1 canonical WNTsBTRCUb-121-HIST1H2BM RibC-AXIN1 UBC(533-608) UbHIST1H2AC CTNNB1 ASH2L XPO1:YWHAZ:p-S20-CBY1:CTNNB1PPP2CA BTRC XPO1:YWHAZ:p-S20-CBY1:CTNNB1DKK1 TCF7L1 CSNK1G2DVL3 TLE4 TCF/LEF:CTNNB1TCF7L1 YWHAZ:p-S20-CBY:CTNNB1PPP2R1A TLE4 YWHAZPPP2R5C UBC(1-76) Ub-121-H2BFS LEF1 FZD2 XPO1 PPP2R5A Ub-121-HIST1H2BH TLE3 pS20-CBY1:CTNNB1HIST1H2BJ H2AFZ CTNNB1 AXIN1 FZD1 UBC(77-152) RYK:WNTsTCF7 LGR4 UBC(77-152) RSPO4 FZD1 ub-DVL2 SOST UBC(77-152) WIF1HIST1H2BM pp-DVLUBC(381-456) RPS27A(1-76) Me3K5-H3F3A H2AFB1 pp-DVL1 SFRP2 CHD8LRP6 SOX4 CBY1:CTNNB1LRP6 PI(4,5)P2ub-FZD8 UBC(1-76) H2AFJ pS20-CBY1 Ub-TLE1 DVL:CUL3:KLHL12:RBX1CHD8 PSMA5 HIST1H2AD PSMB5 UBB(1-76) FZD2 TNKS2 SOST:LRP5/6CTNNB1:CHD8Degradation ofbeta-catenin by thedestruction complexCBY1CTNNB1 CCDC88CN4GlycoAsn-PalmS WNT8B ub-DVL1 AXIN2 FRAT1 PPP2R1B RPS27A(1-76) MYC gene: H2B K121ubnucleosomeLRP5 DVL2 CTNNB1 PPP2CA DKKLEF1 p-4S,3T,T1479,S1490,T1493-LRP6 N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6HIST1H2AB CoA-SHFRAT2 LEF1 N4GlycoAsn-PalmS WNT3 XIAP CTNNBIP1 LEF1 TCF7L2 PSMF1 Ubp-DVLUBB(1-76) PPP2R1B N4GlycoAsn-PalmS WNT3A N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43CTNNB1 CTNNBIP1UBB(153-228) CUL3:KLHL12:RBX1N4GlycoAsn-PalmS WNT8B SOX17 N4GlycoAsn-PalmS WNT8B pp-DVL2 HECW1 DVL2 KRM2 UBC(229-304) DKK2 BCL9CDC73WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3BLRP5 TCF7 UBC(533-608) RSPO:LGR:ub-ZNRF3,RNF43UBC(381-456) DACT1pS20-CBY1 N4GlycoAsn-PalmSWNT3ATCF/LEF:TLE:HDAC1KRM1/2UBC(457-532) LRP6 N4GlycoAsn-PalmS WNT9A Ub-RibC-AXIN1 PSME3 PSMD5 UBC(533-608) LRP6 TCF/LEF:CTNNB1:CBP/p300TCF4 gene HIST3H2BB UBC(609-684) H2AFV PYGO2 BCL9 AcK-HIST1H4 ADPHIST1H2BL XIAP UBC(305-380) Ub-121-HIST3H2BB SOSTLEF1 DVL1 PSMB6 DVL:CXXC4HIST2H2AA3 PPP2R5D PSMD4 HIST1H2AB BTRC HIST1H2BC PPP2CB RNF43 H2OLRP6 PSMC5 LGR4 XIAPTNKS2 DVL2:DACT1Ac-CoAN4GlycoAsn-PalmS WNT1 AXIN1 UBA52(1-76) TCF7L2 UBC(457-532) HIST1H2BN CTNNB1PPP2R5A PPP2R1A FZD1 TCF7L1 UBC(1-76) HIST1H2BH HIST1H2AJ Ub-121-HIST3H2BB H2OUBC(609-684) H2AFV HDAC1 ADPN4GlycoAsn-PalmS WNT8A UBC(77-152) SMURF2UBC(305-380) RNF146 PSMD6 p-DVL2 ADPSOX17 LRP5 p-T519,S524,S531-AXIN1 canonical FZDreceptorsAXIN2 N4GlycoAsn-PalmS WNT4 LRP5/6KAT5TLE2 LGR5 p-5S,5T-LRP5 TNKS2 AXIN1 TLE3 PPP2CB PSMC6 H2AFX PIP5K1B FRAT1,2:GSK3betaN4GlycoAsn-PalmS WNT5A(36-380) p-AKT1/2pp-DVL1 DVLsFRPH2AFZ UBC(77-152) CTBP1FZD2 RNF43 DKK2 Ub-TLE4 CUL3 Ub-TLE2 ADPHIST2H2AC N4GlycoAsn-PalmS WNT8B TCF7L2 WNT ligandbiogenesis andtraffickingDVL2LGR6 CTNNB1 UBC(457-532) N4GlycoAsn-PalmS WNT1 p-3S,2T-LRP5 PSMA1 SOX2 TCF/LEF:CTNNB1pp-DVL2 RSPO4 HIST1H3A p-DVL3 ZNRF3 FZD8 CSNK1A1 PSMC3 DVL2 PYGOWIF1 MYC gene:H2B K121ubH3K4me3 nucleosomeXPO1 Casein kinase IICTNNB1 PSMB11 UbHIST1H2AB UBC(457-532) UBC(153-228) XPO1PSMD13 N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6LEF1 WIF1:WNTPPP2R5C UBA52(1-76) UBC(381-456) p-S-DVL1 TNKS2 BCL9L LEF1 DVL1 CUL3 WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3BPSMB4 AXIN1 HIST2H2BE SFRP1 TCF/LEF:CTNNB1:APC:CTBP:BTRCTLE:XIAPTCF7L1 TNKS TLE1 TCF7 N4GlycoAsn-PalmS WNT1 H2AFB1 UBC(305-380) KRM:DKK:LRP5/6TCF7L1/TCF7L2/LEF1:CTNNB1UBC(609-684) TCF7 CSNK1A1FZD4 PPP2CA Ub-122-HIST1H2BA RSPO4 PSMB2 Ub-121-HIST1H2BO FZD5 PPP2R5B ub-FZD8 PPP2R1A N4GlycoAsn-PalmS WNT4 LRP5 p-2S,S1490,2T-LRP6 WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1Me3K5-HIST1H3A HIST1H2BD UBC(609-684) pp-DVL2 TCF7 N4GlycoAsn-PalmS WNT3A MYCN4GlycoAsn-PalmS WNT3A UBC(533-608) CTNNB1 RSPO1 CTNNB1 SMURF2 UBC(305-380) PPP2R5E pS20-CBY1 UbN4GlycoAsn-PalmS WNT3A SOX9 UBB(153-228) ub-FZD4 N4GlycoAsn-PalmS WNT8A PPP2R5D LGR6 UBC(457-532) UBC(229-304) PYGO1 RSPO2 UBC(609-684) UBA52(1-76) PSMA8 CTNNB1 FRAT2 LRP5 FZD6 MYC geneN4GlycoAsn-PalmS WNT1 CTNNB1 LEF1 WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1MEN1CSNK1A1 UBC(305-380) MYC gene Ub-121-HIST1H2BB CTNNB1 FZD6 TCF7L2 TCF7L1 UBC(229-304) UBB(1-76) HIST1H4 N4GlycoAsn-PalmS WNT8B N4GlycoAsn-PalmS WNT3A LRP6 PSME4 N4GlycoAsn-PalmS WNT3A HIST1H2BL FZD2 N4GlycoAsn-PalmS WNT9A CSNK1ELEF1 ub-FZD6 SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17DVL:CCDC88Cub-FZD6 BCL9L LGR5 PPP2R5E N4GlycoAsn-PalmS WNT1 ub-DVL:CUL3:KLHL12:RBX1CTNNB1 TLE1 CCDC88C AXINH2AFX H2AFB1 ATPLRP5 ub-DVL1:HECW1PYGO1 N4GlycoAsn-PalmS WNT3A CSNK2A2 KRM1 RSPO:LGR:ZNRF3,RNF43TRRAPub-FZD5 FZD5 LGR4 TCF7L1 MYC gene TCF/LEF:CTNNB1:SMARCA4:TERTPSMB7 HIST2H2AA3 RPS27A(1-76) Ub-121-HIST1H2BB ATPHDAC1SMARCA4HIST1H2AJ HIST1H2BO HIST1H2AB AXIN1 AXIN2 geneHIST2H2AC SFRP2 RibC-AXIN2 SOX3 UBA52(1-76) N4GlycoAsn-PalmS WNT8A HIST1H2AD TLE1:HDAC1Ub-122-HIST1H2BA TCF7 UBB(77-152) UBC(533-608) RSPO3 HIST2H2BE UBC(457-532) HIST1H2AJ H2AFV UBB(153-228) ub-FZD5 RSPO2 TERTTNKS PSMB9 CREBBP Ub-121-HIST1H2BJ TLE2 PSMD1 DVL3 GSK3B FZD1 UBB(153-228) CREBBP, EP300KRM:DKK:LRP5/6UBC(229-304) TNKS UBC(229-304) N4GlycoAsn-PalmS WNT8A N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43CAV1 Ub-121-HIST1H2BH HIST1H2BK PSME1 CTNNB1 UbUb-121-HIST1H2BN N4GlycoAsn-PalmS WNT3A AXIN1 RPS27A(1-76) APC:CTBP:CTNNB1:BTRCTNKS1/2SOX2 AXIN2Ub-TLE3 CSNK2B 28187, 2322081202412815, 712012271142011142087111419, 71, 117, 146, 154...14, 12020817420124523220116, 38, 45, 100, 101, 125...244