TCF dependent signaling in response to WNT (Homo sapiens)

From WikiPathways

Jump to: navigation, search
33, 36, 12610, 27, 66, 88, 98...11, 33, 87, 95, 125...510220, 40, 76, 146, 14923, 35, 78, 104, 12827, 88, 14520344, 73, 87, 90, 137...20470, 75, 139, 142, 166...18127, 61, 122, 167, 20827, 30, 109, 218, 24084, 87, 95, 137113, 205271535, 123, 21733, 43, 55, 90, 96...51, 39, 45, 124, 150...13, 136, 18353, 81, 110, 130, 132...12, 19, 116, 180, 189...20654, 77158, 20120480, 101, 170, 22112, 19, 20621, 51, 81181108, 186, 2419, 31, 56, 68, 97...48, 84, 89, 23364, 127, 17487, 105, 153, 2364, 50, 82, 86, 111...12, 1954, 19224, 46, 79, 83, 93...99, 112, 135, 1812258110220420318, 25, 26, 55, 72...218112, 1921, 51, 8152, 88, 138, 159, 185140, 189, 20627, 16429, 44, 73, 903, 8, 28, 33, 36...36, 47, 91, 107, 131...10227, 1642, 17, 27, 58, 62...15, 108135, 18152, 88, 138, 159, 18513563, 88, 2516, 37, 38, 49, 59...118, 120, 17720322, 32, 76, 92, 144...cytosolearly endosome lumennucleoplasmearly endosome lumenSOX4 FZD4 ub-FZD6 UBA52(1-76) Ub-TLE3 RibC-AXIN1 SOX2 DVL3 MYC gene: H2B K121ubnucleosomeCTNNB1 TCF/LEF:CTNNB1:APC:CTBP:BTRCN4GlycoAsn-PalmS WNT5A(36-380) Ub-TLE4 BCL9 RSPO1 H2AFZ USP34LGR6 p-3S,2T-LRP5 FZD5 AdoHcyPSMC5 ADPH2AFB1 AXIN1 DKK2 UBC(533-608) CHD8 NAD+LGR5 HIST1H4 UBC(609-684) HIST2H2AC H2AFJ N4GlycoAsn-PalmS WNT3A PPP2R5B ZNRF3 Ub-122-HIST1H2BA TCF7L2 SOX6 PSME2 MYC geneCTNNBIP1UBB(1-76) TCF/LEF:CTNNB1:AXIN2geneUBC(1-76) BTRCpp-DVL2 UBA52(1-76) FZD4 UBB(77-152) FZD2 UBB(77-152) LGR5 p-S-DVL1 Ub-121-H2BFS TLE4 XIAP pp-DVL1 p-T309,S474-AKT2 KLHL12 TCF7L2 TCF7L2 CTNNB1 TNKS LRP5 PSMB11 SOX7 YWHAZ UBC(609-684) RPS27A(1-76) TCF7 UBC(533-608) TLE2 CSNK1EUBC(609-684) N4GlycoAsn-PalmS WNT8A p-4S,3T,T1479,S1490,T1493-LRP6 RibC-AXIN2 APC TCF7 LEF1 CDC73 UBA52(1-76) pp-DVL1 UBB(1-76) PSMA5 UBB(1-76) DVL:CUL3:KLHL12:RBX1UBC(381-456) TCF/LEF:CTNNB1Degradation ofbeta-catenin by thedestruction complexUBB(1-76) N4GlycoAsn-PalmS WNT3A ZNRF3,RNF43KRM1 WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1TLE1:HDAC1UBC(457-532) SMURF2TLE tetramerTCF7L1 HIST1H2BA UBB(77-152) UBB(1-76) HIST1H2AD TCF7L1 GSK3BTNKS pp-DVL2 ub-FZD8 HIST1H2AC UBC(153-228) K63polyUb-APCPPP2CB LRP5 LEF1 RSPO2 PSMB7 ub-AXIN1 HIST2H2BE HIST1H2BB canonical FZDreceptorspS20-CBY1:CTNNB1UBC(1-76) PIP5K1B UBC(229-304) ATPUBC(153-228) PPP2R5A CTNNB1 KMT2DLEF1 TLE4 UBB(153-228) UBC(1-76) CTNNB1 TLE4 CTNNB1 H2BFS TCF7 PYGO1 TCF/LEF:CTNNB1:SOX4,SOX13,SOX17PYGO1 BCL9N4GlycoAsn-PalmS WNT8A FZD8 FZD1 TLE3 HIST2H2AC DVL3 AXIN1 DVL:CCDC88CLRP6 Ub-121-HIST1H2BD N4GlycoAsn-PalmS WNT8B CTBP1 DVL1 FZD1 CXXC4HIST3H2BB TCF7L2 Ub-121-HIST1H2BN TCF/LEF:TLE:HDAC1AXIN2 UBA52(1-76) SOX4 DVL3 LRP6 CSNK1A1 DVL1 CSNK2A1 LGR6 N4GlycoAsn-PalmS WNT4 KLHL12 ub-RNF43 TNKS2 PSME3 MYC gene:H2B K121ubH3K4me3 nucleosomeDACT1 Ub-121-HIST1H2BJ PSMB10 XPO1:YWHAZ:p-S20-CBY1:CTNNB1LEO1RNF146FZD6 RNF146 KAT5HIST3H3 FRAT2 pp-DVL2 CTBP1 Me3K5-H3F3A p-DVLAXIN1 YWHAZ TCF7 PSMC2 PSMB8 Me3K5-HIST1H3A WNT:FZD:LRP5/6:DVLUBC(153-228) UBC(153-228) UBC(457-532) PPP2R5D UbBCL9L TCF7L2 CTNNB1 HIST1H2BN 26S proteasomeRSPO1 Ub-121-HIST3H2BB LEF1 ADPPSMC6 PSMD8 LRP5 SMURF2 DKK2 AXINHIST1H2AJ AXIN1 HIST1H2AC FZD1 UBC(457-532) DVL2 N4GlycoAsn-PalmS WNT3A RUVBL1 PPP2R1B RSPO1 AXIN2TCF7L2 UBC(609-684) Ac-CoAHIST1H2AD CTNNB1 CBY1:CTNNB1UBC(229-304) Ubub-DVL2 RPS27A(1-76) CREBBP TLE2 MEN1HIST1H2BO pp-DVL2 TERTub-FZD4 CREBBP, EP300UBC(305-380) APCRPS27A(1-76) LGR5 RNF43 TCF7L1 TERT N4GlycoAsn-PalmS WNT3A RUNX3:TCF7L2,(LEF1,TCF7L1)PPP2R5C CBY1AXIN1 AXIN:TNKSPI(4,5)P2TNKS2 ATPHIST1H2AC UBC(457-532) TCF/LEF:CTNNB1:CBP/p300UBC(533-608) CAV1 DVL1 RSPO4 ub-AXIN2 PYGO2 Me3K5-HIST3H3 N4GlycoAsn-PalmS WNT1 GSK3B DVLADPTCF7 ASH2LKRM1/2FRAT1,2:GSK3betaN4GlycoAsn-PalmS WNT8B PI4PN4GlycoAsn-PalmS WNT3A HIST1H2AB LRP6 ub-DVL1:HECW1H2AFX CTNNB1 WNT ligandbiogenesis andtraffickingN4GlycoAsn-PalmS WNT8B ub-FZD6 PSMD7 Ub-121-HIST1H2BL HECW1Ub-121-HIST1H2BO UBC(381-456) Me3K5-HIST2H3A PSMA7 UbCCDC88CCXXC4 WNT:FZD:LRP5/6:DVL:AXIN:GSK3BN4GlycoAsn-PalmS WNT1 ADPpp-DVL3 FZD1 Ub-121-HIST1H2BK UBC(457-532) H2AFX N4GlycoAsn-PalmSWNT3ARSPO4 H2AFV DKK1 LGRUBB(153-228) SOX6 UBB(77-152) p-S33,S37,T41,S45 CTNNB1 SMARCA4 LRP6 PSMB2 YWHAZ TCF7L1 SOX17 DKKHIST1H4 SOX3 PPP2R5C Ub-121-HIST1H2BC LEF1 UBC(153-228) SOX2 PSMA3 HIST1H2BM FZD2 LRP6 HIST2H2AA3 UBC(1-76) TCF/LEF:CTNNB1:BCL9:PYGOUb-TLE1 KRM:DKK:LRP5/6ZNRF3 RNF43 Ub-122-HIST1H2BA AXIN2 N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43ATPRSPO2 DVLp-S33,S37,T41,S45CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complexLEF1 HIST1H2BH H2AFB1 AXIN1 H2AFJ TCF7 RYKWIF1-binding WNTsN4GlycoAsn-PalmS WNT9A HIST1H2AJ GSK3B RSPOH2AFV UBC(305-380) Ub-TLE1 UbUBC(1-76) CBY1 DVL2 PSMA8 LEF1 TCF7L1/TCF7L2/LEF1:CTNNB1TLE1 TNKS2 N4GlycoAsn-PalmS WNT9A TCF7L1 ub-DVL3 RPS27A(1-76) PPP2CA PPP2R5C HIST1H2BK FZD1 N4GlycoAsn-PalmS WNT5A(36-380) PPP2R1A SFRP1 LEF1 UBC(457-532) UBC(457-532) FZD8 WNT3A:sFRPUBC(77-152) LRP5 UBC(77-152) RUVBL1XPO1AXIN2 gene CSNK2B H2OAPC:CTBP:CTNNB1:BTRCHIST1H2BJ Ub-121-HIST1H2BL Ub-121-HIST1H2BB UBC(229-304) TNKS2 HIST1H2AB SOST PPP2R5E LEF1 TCF7L2 RSPO2 RNF146 pS20-CBY1 CoA-SHTCF7 UBC(305-380) HIST1H2BD N4GlycoAsn-PalmS WNT3A H2AFX ASH2L AcK-HIST1H4 PYGO2 PPP2R5B NAMUBC(305-380) RSPO4 Ub-121-HIST1H2BC N4GlycoAsn-PalmS WNT5A(36-380) TNKS N4GlycoAsn-PalmS WNT3A p-LRP6 DVL2 DKK4 N4GlycoAsn-PalmS WNT1 PPP2R5A HIST3H2BB SMURF2 UBC(77-152) EP300 SFRP2 TLE1 DVL1 N4GlycoAsn-PalmS WNT1 TCF7L1 Ub-121-HIST1H2BH UBC(153-228) N4GlycoAsn-PalmS WNT3A EP300 Ub-RibC-AXIN2 p-DVL3 RBX1 HIST1H2AD PSMB5 PSMA2 KRM:DKK:LRP5/6HIST1H2BM RSPO:LGRHIST1H2BA PSMD3 UBC(381-456) pp-DVL3 RSPO4 HIST3H3 MYC gene pp-DVLUb-TLE3 H2AFB1 PSME1 CUL3 UbUBC(381-456) UBB(153-228) RibC-AXIN1 HIST1H2BL ub-TLE:XIAPTLE1 Ub-121-HIST1H2BN CTNNB1 ATPUbTCF4 gene:acetyl H4nucleosomePPP2R1A YWHAZ:p-S20-CBY:CTNNB1PYGO1 SMARCA4DVL2 RPS27A(1-76) H2AFZ FZD2 PSMB6 Ub-TLE4 FZD5 BCL9 DKK1 ADPH2AFV PSMD5 SOX13 p-4S,3T,T1479,S1490,T1493-LRP6 AXIN1 PYGOPPP2CB ub-DVL1 LRP6 RSPO3 pS20-CBY1 BCL9L HIST1H2AB FRAT1 PSMD10 Ub-TLE2 USP8UBB(77-152) RSPO3 GSK3B N4GlycoAsn-PalmS WNT8A N4GlycoAsn-PalmS WNT3A MYC gene p-T308,S473-AKT1 UBC(77-152) N4GlycoAsn-PalmS WNT8A TCF7 KRM1 BCL9 LRP5 PSMD2 DVL2 TCF/LEF:CTNNB1:SMARCA4:TERTCCDC88C N4GlycoAsn-PalmS WNT8B N4GlycoAsn-PalmS WNT3A HIST1H2BH CUL3:KLHL12:RBX1Ub-121-HIST1H2BO pp-DVL1 CTNNB1 N4GlycoAsn-PalmS WNT8A SOX4 AXIN2 N4GlycoAsn-PalmS WNT3A XIAP pp-DVL3 CTNNB1:CHD8N4GlycoAsn-PalmS WNT3 CTNNBIP1:CTNNB1LEF1 SOX13 CUL3 TCF7L1 N4GlycoAsn-PalmS WNT1 ub-FZD5 PPP2R5A N4GlycoAsn-PalmS WNT3A p-2S,S1490,2T-LRP6 TCF4 gene TNKS2 TCF7L1 LRP6 DVL1 SOX7 TLE2 AdoMetub-AXIN:SMURF2UBC(305-380) CTNNB1 LRP6 ATPUBC(533-608) DVL1SOX9 HIST2H2BE N4GlycoAsn-PalmS WNT3A PPP2CB WIF1 H3F3A GSK3B:AXIN1pS20-CBY1 HIST1H2BK RPS27A(1-76) HIST1H2BC CTNNB1 LRP5 ppDVL:PIP5K1Bub-FZD8 AXIN1 HIST1H2BD WNT:FZD:LRP5/6PP2ARibC-AXIN:TNKSPIP5K1BPSMD1 ub-FZD4 N4GlycoAsn-PalmS WNT3A TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5TNKS Ub-RibC-AXIN:TNKS:RNF146SFRP1 UBC(77-152) UBC(381-456) RSPO:LGR:ub-ZNRF3,RNF43FRAT1 LRP6 HIST1H2BJ TCF7L2 TLE:XIAPpp-DVL3 CTNNB1 N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6HIST1H4 TNKS1/2:XAV939CTNNB1 pS20-CBY1 KRM2 Ub-TLE2 TCF7L1 canonical WNTsSOX4,SOX13,SOX17CTNNB1 Ub-121-HIST1H2BH TCF7 TCF7L2 PYGO2 FZD2 FRAT2 WIF1UBC(1-76) WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1N4GlycoAsn-PalmS WNT8B RNF43 TLE1 ub-DVL1 RBX1 CTNNB1 LRP5 p-ub-APC HIST1H2AJ UBC(533-608) CTNNB1 FRAT1,2RBBP5 PPP2CA UBB(1-76) KRM2 Ub-121-HIST1H2BD TLE3 XIAPH2AFZ pp-DVL1 PSMA1 TRRAP LRP6 UBB(77-152) SRY UBC(609-684) CSNK1G2XAV939PSMF1 GSK3B TCF7L2 HIST1H2BB CDC73DVL1 PPP2R5E PSMA6 H2BFS TCF7L1 sFRPPSMA4 p-T519,S524,S531-AXIN1 ADPRibC-AXIN:TNKS:RNF146RSPO1 PSMD11 UBB(153-228) RBX1 PSMC1 p-5S,5T-LRP5 CAV1 UBC(229-304) PPP2R5B N4GlycoAsn-PalmS WNT1 CTNNB1 UBC(305-380) HIST1H2BC pp-DVL1 HIST2H2AC FZD1 KRM2 RSPO2 HIST1H2BO UBC(229-304) SOSTUb-121-HIST1H2BM TCF7L2 PSME4 pp-DVL3 DVL:CXXC4PPP2R5D LGR4 PSMB3 HIST1H2AB TCF4 gene:nucleosomeTCF/LEF:CTNNB1:PAF1-like complexUBC(533-608) HIST1H2BL LEF1 HIST2H2AA3 DVL2CUL3 HIST1H3A UBB(77-152) TCF7L1 LRP5/6LRP6 Casein kinase IIRNF43 UBC(609-684) UBB(153-228) CTNNB1CSNK2A2 MYCUbSOX9 XPO1 DKK2 TCF7L2 FZD2 CTNNB1GSK3B UBA52(1-76) KAT5 LGR4 LRP5 HIST2H3A AMER1 HIST2H2AC CTNNB1 SOST:LRP5/6RSPO3 GSK3B HIST2H2AA3 RYK LEF1 N4GlycoAsn-PalmS WNT3A TNKS K63polyUb-APC LEO1 Ub-121-H2BFS p-DVL2 N4GlycoAsn-PalmS WNT3A GSK3B TNKS1/2TCF7L2 LRP5 SOX4 PPP2R1B DVL3 SRY YWHAZCSNK1A1 pp-DVL2 HECW1 UBC(153-228) DVL1:HECW1PSMD4 TCF7L1 SFRP2 HIST1H2AD SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17DKK4 PPP2CA RSPO3 CTBP1BTRC CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17TCF7L1/TCF7L2/LEF1:CTNNB1:MYC geneUBC(77-152) ub-DVL:CUL3:KLHL12:RBX1FZD5 LGR4 Ub-121-HIST1H2BB HDAC1RBBP5LGR6 SOX17 GSK3B SOX17 UBC(305-380) TLE3 Ub-121-HIST1H2BJ N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43H2AFZ DKK4 ub-FZD5 p-AKT1/2WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3BPSMD12 PSMB1 HIST3H3 H2AFV H2AFJ BCL9L TCF7 N4GlycoAsn-PalmS WNT1 TCF7L1 DVL2:DACT1N4GlycoAsn-PalmS WNT8B N4GlycoAsn-PalmS WNT3 HDAC1 AXIN2 geneATPPSMB9 DVL3 HECW1 WIF1:WNTUBC(1-76) TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complexBTRC LGR6 SHFM1 ZNRF3 LGR5 pp-DVL3 TNKS2 PSMC4 UBA52(1-76) UBC(229-304) WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3BUb-RibC-AXIN1 PSMD6 CTNNB1 FZD2 Ub-121-HIST1H2BM LRP5 RUNX3 Ub-121-HIST2H2BE TCF7L1 LEF1 H2AFB1 pp-DVL2 PSMD9 KLHL12 UBC(229-304) TCF7L2 TCF7 PPP2R1A Ub-121-HIST3H2BB CTNNB1 TNKS CTNNBIP1 ub-ZNRF3 H2OFZD6 pp-DVL1 H2AFX HIST1H2AC KRM1 UBC(609-684) MYC gene RSPO:LGR:ZNRF3,RNF43PSMD14 ZNRF3 CTNNB1 XPO1:YWHAZ:p-S20-CBY1:CTNNB1CREBBP DACT1CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexGSK3B Ub-121-HIST1H2BK UBB(1-76) Ub-121-HIST2H2BE TCF7 H2AFJ TRRAPPSMD13 KMT2D TCF7L2 AXIN1 UBC(381-456) CHD8TCF/LEF:CTNNB1HDAC1 CTNNB1 UBC(533-608) TCF4 gene AMER1DKK1 N4GlycoAsn-PalmS WNT5A(36-380) SOX17 UBC(381-456) TCF7L1 FZD5 CSNK1A1RYK:WNTsLGR4 PPP2R5D UBB(153-228) N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6HIST1H2AJ LEF1 HIST1H2BN PSMB4 LEF1 AXIN1 PPP2R1B PSMC3 N4GlycoAsn-PalmS WNT4 UBB(153-228) UBC(77-152) XPO1 ub-TLEAXIN:SMURF2MEN1 DVL2 AMER1 RYK-binding WNTsAPC RibC-AXIN2 UBA52(1-76) N4GlycoAsn-PalmS WNT1 PPP2R5E LRP5 SOX3 HIST2H2AA3 N4GlycoAsn-PalmS WNT8A RPS27A(1-76) N4GlycoAsn-PalmS WNT3A 14471141022067, 57188181181181102181206771, 114186221148, 18816, 33, 34, 60, 85...10213279, 31, 119, 172, 188...20627