Signaling by FGFR2 (Homo sapiens)

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1, 4, 21, 32, 67...6, 10, 39, 53, 9354, 100, 104, 15614, 31, 50, 6512, 44, 58, 59, 84...33, 42, 71, 92, 9414, 50, 122, 136, 1399, 13, 56, 62, 66...588647, 49, 70, 14348, 9016, 17, 40, 82106, 133, 15310, 87, 1518122, 34, 60, 1227, 5255, 65, 14450, 11358, 5913588, 98, 105, 11260, 61, 12231, 69, 10347, 14313734, 60, 61, 12212, 44, 58, 59, 84...13531, 6514, 60, 65, 10327, 111, 121, 15778, 9676, 1068169, 100, 15616, 17, 40, 829, 12, 57-59, 62...37, 7710814, 677, 11, 23, 52, 101...137206, 10, 39, 53, 9363, 131, 1332, 12, 18, 25, 29...7614, 6751, 55, 113, 12350, 65, 13685, 1082, 12, 18, 29, 36...9687, 1511371373, 26, 28, 30, 48...115, 14063, 107, 140131, 133129108, 11826, 48, 72, 90, 117...15, 33, 41, 42, 71...14, 67cytosolnucleoplasmPPP2R1A KRAS UBB(1-76) ATPActivated FGFR2b homodimer bound to FGF p-8Y-FGFR2c A314D p-T202,Y204-MAPK3 Activated FGFR2chomodimer bound toFGFp-8Y-FGFR2b P253R Activated FGFR2c homodimer bound to FGF p-8Y-FGFR2b P253R POLR2I FGFR2c homodimerbound to FGFHNRNPH1 p-6Y-FRS2 FRS3FGF10 FGF22 PLCG1GTF2F2 Activated FGFR2mutants withenhanced kinaseactivityUBB(1-76) FGFR2 N549K p-8Y-FGFR2c A314S UBB(77-152) FGF10 p-5Y-FRS3 FGF1 UBC(533-608) FGFR2 fusionsSPRY2:B-RAFFGFR2b short ATPPI(3,4,5)P3 FGFR2b S373C FGFR2 FGFR2bTyrosine kinaseinhibitors of FGFR2mutantsSU5402 UBC(153-228) POLR2F FGF9 FGF9 ATPPPA2A(A:C):S112/S115p-SPRY2p-8Y-FGFR2 K660M UBA52(1-76) p-8Y-FGFR2c A314D HS Activated FGFR2 ligand-independent mutants p-8Y-FGFR2c S372C GRB2-1 p-8Y-FGFR2 N549H NRAS UBB(153-228) Pazopanib ActivatedFGFR2:p-FRS2:GRB2:GAB1:PI3KFGFR2c S372C p-Y546,Y584-PTPN11 p21 RAS:GTPPLCG1 POLR2G p-Y FGFR2 fusion dimers FGFR2b-binding FGFs RPS27A(1-76) ActivatedFGFR2:pY-SHC1Activatedoverexpressed FGFR2dimersActivated FGFR2b homodimer bound to FGF ESRP1ActivatedFGFR2:p-FRS:GRB2:SOS1UBC(381-456) FGF4 FGFR2b Y376C FGFR2b mutants withenhanced ligandbindingPPP2CB p-8Y-FGFR2c W290G p-Y55,Y227-SPRY2 UBB(77-152) p-8Y-FGFR2b S252W p-8Y-FGFR2b S252W E3810 FGF2,7,10,22FGF5-1 GalNAc-T178-FGF23(25-251) POLR2K GAB1 FGFR2 L764fs*4 HS UBC(1-76) GTF2F1 p-8Y-FGFR2 S267P FGFR2c S252W POLR2D p-6Y-FRS2 Activated FGFR2b homodimer bound to FGF Activated FGFR2c homodimer bound to FGF Activated FGFR2b homodimer bound to FGF p-Y55,Y227-SPRY2 NCBP1 FGFR2c A315S GAB1 UBC(1-76) HS PIK3CA FGFR2c A315T UBC(381-456) FGF7 GRB2:GAB1GP369 PI(4,5)P2FGFR2(22-767)-AHCYL1(108-530) fusion POLR2I FGFBP3 FGFR2c NCBP2 FGF3 HRAS FGFR2 mutant dimers with enhanced kinase activity FGF5-1 Activated FGFR2b homodimer bound to FGF BRAF ADPSPRY2 p-Y55,Y227-SPRY2 FGF10 FGF17-1 UBC(533-608) FGFR2bmutant-bindingFGFs:FP-1039FGF6 ATPE7080 ADPPPP2R1A UBC(229-304) POLR2B p-Y FGFR2 fusiondimersActivated FGFR2c homodimer bound to FGF p-Y371-CBL Activated FGFR2b homodimer bound to FGF GTP FGF22 Activated overexpressed FGFR2 dimers PP2A (A:C)Activated FGFR2c homodimer bound to FGF POLR2I Activated FGFR2b homodimer bound to FGF HS FGF1 FGFR2 K660E POLR2H FRS2 Activated FGFR2b homodimer bound to FGF FGFR2 ligand-independent mutant dimers ActivatedFGFR2:p-FRS2:GRB2:GAB1:PIK3R1HS NCBP2 UBB(153-228) FGFR2b mutant dimerswith enhancedligand-bindingbound to FGFsFGFR2c A315S Activated FGFR2b homodimer bound to FGF RPS27A(1-76) UBC(305-380) UBC(305-380) UBC(609-684) FGFR2c A314D SHC1-2 FGFR2 K660M UBC(77-152) FGFR2c W290G FGFR2c Y375C S111/S120p-SPRY2:B-RAFp-T,Y MAPK dimersActivated FGFR2:SHC1UBC(457-532) RBFOX2 p-S112,S115-SPRY2 ADPp-8Y-FGFR2c A315S mutant FGF1,2Activated FGFR2:FRS3Activated FGFR2mutants:p-4Y-PLCG1p-8Y-FGFR2c A314D FGFR2ligand-independentmutantsUb:Y55/Y227-pSPRY2:CBLFGF6 UBC(609-684) PIK3R1 FGFR2c P253R p-6Y FGFR2 (22-767)-CCAR(51-923) fusion POLR2A FGF2(10-155) p-Y371-CBL:GRB2GTF2F2 p-6Y-FRS2 FGFR2b-binding FGFs Pazopanib PIK3R1PPP2CB p-6Y FGFR2(22-768)-BICC1(80-974) fusion PPP2CB FGF7 PPP2CB UBC(1-76) ActivatedFGFR2:pY-SHC1:GRB2:SOS1FGF9 SPRY2 FGF10 p-4Y-PLCG1FGFR2c A314D FGF5-1 Activated FGFR2b homodimer bound to FGF UBC(381-456) POLR2G UBC(229-304) FGF7 FGF22 KRAS FGF10 Activated FGFR2bmutants withenhanced ligandbindingUBC(229-304) ActivatedFGFR2:p-FRS:p-PTPN11TIAL1 Activated FGFR2b homodimer bound to FGF FGF2(10-155) FGF16 FP-1039FGF2(10-155) HS UBC(77-152) p-Y546,Y584-PTPN11 Ubp-8Y-FGFR2c P253R p-8Y-FGFR2c A315T PPP2CA ATPPOLR2H FGF1 HNRNPH1 activatedFGFR2:PLCG1FGFR2 point mutantdimersPOLR2A NRAS FGFR2b, FGFR2cactivatedFGFR2:p-4Y-PLCG1Activated FGFR2b homodimer bound to FGF BRAF Activated FGFR2c homodimer bound to FGF FGF22 FGFR2(22-768)-BICC1(80-974) fusion POLR2G Activated FGFR2b homodimer bound to FGF ADPp-8Y-FGFR2-3 FGF8-1 Activated FGFR2cmutants withenhancedligand-bindingFGFR2b short PP2A(A:C):Y55/Y227-pSPRY2Overexpressed FGFR2homodimersFGF4 GRB2-1PiFGFR2c P253R p-8Y-FGFR2c A314S ATPActivated FGFR2c homodimer bound to FGF UBC(153-228) FGF8-1 GalNAc-T178-FGF23(25-251) NCBP1 Activated FGFR2c homodimer bound to FGF FGFR2b-binding FGFs PIK3R1 FGF2(10-155) ATPUBA52(1-76) UBC(609-684) GAB1 FGFR2c mutantbinding FGFsFGFBP2 PPP2CB PIK3R1 UBC(457-532) FGFR2b P253R p-8Y-FGFR2c A314D OverexpressedFGFR2:TKIsActivated FGFR2 mutants with enhanced kinase activity SU5402 FGF6 p-6Y FGFR2(22-767)-AHCYL1(108-530) fusion p-8Y-FGFR2b S252W FGFR2c-binding FGFs NCBP1 SRC-1UBC(305-380) p-8Y-FGFR2c P253R SHC1-2,SHC1-3GRB2-1 Activated FGFR2c homodimer bound to FGF FGF7 p-Y371-CBL UBC(533-608) PPA2A(A:C):SPRY2POLR2L HS p-8Y-FGFR2b S373C FGF6 FGF10 p-S112,S121-SPRY2 capped, methylated FGFR2 nascent transcript FGF1 p-6Y-FRS2 HNRNPF UBA52(1-76) Activated overexpressed FGFR2 dimers FGFR2c A314S ADPp-6Y-FRS2 FGFR2b P253R p-Y239,Y240,Y317-SHC1-2 FGF17-1 ActivatedFGFR2:p-FRSUBC(77-152) Activated FGFR2 ligand-independent mutants FGFR2b-binding FGFs FGFR2c A314S RBFOX2 FGFR2 S267P FGF6 FGFR2ligand-independentmutant dimersUBC(609-684) FGFR2b-binding FGFs FGFR2 IIIb-specificsplicing complexFGFR2c P253R FRS3 HS FGFR2(22-767)-AFF3(292-1226) fusion E3810 ESRP2 CBLGRB2-1 POLR2D FGF20 ActivatedFGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2POLR2E UBC(305-380) p-4Y-PLCG1 DAG and IP3signalingPPP2R1A FGFR2c-binding FGFs PPP2CA PI(3,4,5)P3 FGF3 BRAFADPFGFR2 K660E ADPActivatedFGFR2:p-FRS2p-8Y-FGFR2 N549K ADPFGF10 p-6Y FGFR2(22-767)-AFF3(292-1226) fusion p-Y194,Y195,Y272-SHC1-3 FGF9 FGF18 FGFR2b mature mRNAFGFR2c S252W FGF2(10-155) p-8T-FRS2 FGFR2 IIIc-specificsplicing complexFGFR2(2-822)-CIT(927-2027) fusion HRAS FGFR2c A315S UBC(77-152) FGF7 ATPTIA1/TIAL1FGF10 ADPActivated FGFR2ligand-independentmutantsFGF9 p-Y194,Y195,Y272-SHC1-3 GalNAc-T178-FGF23(25-251) UBC(457-532) PPP2CA FGFR2IIIaTM:FGF1,2:FGFR2b,FGFR2cp-S111,S120-SPRY2PIK3CAUBC(153-228) HNRNPF FGF6 FGF7 PI(3,4,5)P3p-8Y-FGFR2 K660E FGFR2 W290C Activated FGFR2b homodimer bound to FGF PP2A(A:C):SPRY2PLCG1 ADPActivated FGFR2mutantsp-6Y FGFR2(22-767)-CCDC6(102-474) fusion GRB2-1 capped, methylated FGFR2 nascent transcript p-8Y-FGFR2c Y375C UBC(381-456) FGF16 ATPUBC(457-532) POLR2F GAB1 ADPActivated FGFR2b homodimer bound to FGF UBB(153-228) FGFR2c S252W Ub-Activated FGFR2complex:Ub-p-FRS2ATPFGFR2 fusion dimersFGFR2b S252W FGFR2 IIIa TM PPP2CA Activated FGFR2:FRS2POLR2B FGFR2c Y375C UBC(381-456) Activated FGFR2c homodimer bound to FGF HNRNPMFGFR2b P253R BGJ398 FP-1039 HS Activated FGFR2c homodimer bound to FGF FGFR2 mutant dimers with enhanced kinase activity p-8Y-FGFR2b S376C GDP UBC(229-304) Activated FGFR2Tyrosine kinaseinhibitors ofoverexpressed FGFR2FGF2(10-155) FGFR2(22-767)-CCAR(51-923) fusion capped, methylatedpre-FGFR2 mRNA:CBCcomplexFGFR2c A315T UBC(533-608) UbFGFR2 N549H POLR2L Activated FGFR2c homodimer bound to FGF FGF7 SOS1 p-T185,Y187-MAPK1 FGF20 PD173074 GRB2-1 FGFR2b C3 variant TIA1 FGFR2cFGF6 PTBP1FGF10 PPP2R1A FGFR2b S252W p-Y FGFR2 fusion dimers FGFR2c-binding FGFs FGFR2c P253R p-8Y-FGFR2-5 UBC(229-304) HS p-8Y-FGFR2c S252W FGF16 p-6Y FGFR2(22-767)-OFD1(38-1012) fusion Activated FGFR2c homodimer bound to FGF PPP2CB FGF1 p-6Y-FRS2 FGFR2 HSUBA52(1-76) POLR2C FGF7 p-8Y-FGFR2c long RPS27A(1-76) Activated FGFR2c homodimer bound to FGF GP369p-S111,S120-SPRY2 p-8Y-FGFR2 W290C p-5Y-FRS3 PP2A(A:C):S112/S121-pSPRY2UBC(457-532) ActivatedFGFR2:p-FRS2:p-PTPN11FGF18 UBC(609-684) HS p-8Y-FGFR2c P253R FGFR2c-binding FGFs FGF9 p-8Y-FGFR2 K660N SHC1-3 FGFR2b homodimerbound to FGFp-5Y-FRS3 UBC(1-76) FGFR2(22-767)-CCDC6(102-474) fusion NCBP2 p-6Y-FRS2 FGFR2b S252W ADPPTPN11 Activated FGFR2b homodimer bound to FGF FGFR2c mature mRNAFGFR2 K660N GTF2F1 ActivatedFGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1p-8Y-FGFR2c A315S mutant Activated FGFR2b homodimer bound to FGF Activated FGFR2c homodimer bound to FGF FRS2Activated FGFR2mutants:PLCG1Ub-(Y55/Y227)p-SPRY2POLR2L FGFR2b C3 variant p-Y55,Y227-SPRY2 FGFR2 K660N SHC1-3 POLR2E Y55/Y227-pSPRY2:CBLHS UBB(1-76) UBC(305-380) p-Y FGFR2 fusion dimers p-6Y FGFR2(2-822)-CIT(927-2027) fusion FGF1 PTPN11FGF10 p-8Y-FGFR2b S252W Activated FGFR2c homodimer bound to FGF FGFR2b FGFBP1 FGFR2(22-767)-CCDC6(102-474) fusion p-8Y-FGFR2c A315T FGF2(10-155) FGF9 FGFBP:FGFGTF2F1 FGFR2c long p-6Y-FRS2 HNRNPA1 FGF7 FGF2(10-155) Activated FGFR2c homodimer bound to FGF capped, methylated FGFR2 nascent transcript CBL FGFR2 Activated FGFR2 ligand-independent mutants FGFR2b Y376C FGFR2b-binding FGFs FGFR2c-binding FGFs ATPFGFR2 N549H GDPUBB(153-228) FGF22 FGFR2(22-768)-BICC1(80-974) fusion FGF10 PPP2CA FGF17-1 p-Y546,Y584-PTPN11 p-5Y-FRS3 SOS1 RPS27A(1-76) Activated overexpressed FGFR2 dimers TIA1 FGFR2b C3 variant ATPp-8Y-FGFR2b P253R FGFR2 mutant dimerswith enhancedkinase activityFGFR2bmutant-binding FGFsFGFR2c W290G FGFR2(22-767)-AFF3(292-1226) fusion POLR2K FGF20 GRB2-1:SOS1GRB2-1 GAB1 FGFR2(2-822)-CIT(927-2027) fusion p-8Y-FGFR2c A315T p-8Y-FGFR2c A314S FGFR2c-binding FGFs RAF/MAP kinasecascadeActivated FGFR2c homodimer bound to FGF PIK3R1 FGFR2 K660M p-6Y-FRS2 p-5Y-FRS3 p-T250,T255,T385,S437-MKNK1FGFR2c short UBB(77-152) ADPBGJ398 FGF1 Activated FGFR2c homodimer bound to FGF UBB(1-76) RPS27A(1-76) PPA2A (A:C):Y55/Y227p-SPRY2:GRB2p-8Y-FGFR2c S252W ADPFGFR2 IIIa TMUBB(1-76) FGFR2(22-767)-AHCYL1(108-530) fusion ATPFGFR2b-binding FGFs FGFBP1 FGFR2(22-767)-OFD1(38-1012) fusion FGF6 p-6Y-FRS2 p-8Y-FGFR2c A315S mutant FGF9 FGF9 UBB(153-228) p-6Y FGFR2(22-767)-CASP7(1-303) fusion FGF2(10-155) FGF2(10-155) ActivatedFGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3Kp-Y371-CBL POLR2J AZD4547 FGFR2c A315S p-8Y-FGFR2b P253R FGFR2c A314D FGF9 CBL UBB(77-152) Phosphorylated Fibroblast growth factor receptor 2b short POLR2J POLR2D FGFR2(22-767)-OFD1(38-1012) fusion FGFR2b P253R GTF2F2 HSFGF6 UBB(77-152) FGF7 GRB2:GAB1:PIK3R1POLR2H UBC(153-228) FGFR2b long FGFR2c-binding FGFs PD173074 ADPFGFR2 L764fs*4 Activated FGFR2b homodimer bound to FGF p-8Y-FGFR2c A315S mutant ATPSHC1-2 p-Y546,Y584-PTPN11 PI(3,4,5)P3FGFBP2 ADPGRB2-1 FGF7 FGF2(10-155) FGF9 FGFR2c A314S PPP2R1A FGF2(10-155) FGF18 FGFR2b C3 variant PIK3R1 ActivatedFGFR2:p-8T-FRS2FGFR2 mutants withenhanced kinaseactivityPOLR2F POLR2A Activated FGFR2 mutants with enhanced kinase activity ESRP1 POLR2K HSp-Y239,Y240,Y317-SHC1-2 FGFR2c-binding FGFsp-8Y-FGFR2c S252W PPP2CA HS GRB2-1 PPP2R1A ATPFGF2(10-155) FGFR2 S267P FGF10 ActivatedFGFR2:p-FRS:PTPN11FGFR2 ligand-independent mutant dimers FGFR2(22-767)-CASP7(1-303) fusion p-6Y-FRS2 FGFR2b long GTPp-Y546,Y584-PTPN11 Overexpressed FGFR2UBC(153-228) POLR2J FGFR2b S373C FGF2(10-155) PIP3 activates AKTsignalingFGF8-1 hnRNPH1:hnPNPF:RBFOX2Activated FGFR2b homodimer bound to FGF ATPFGF10 FGF6 FGFR2b-binding FGFs FGFR2b POLR2E UBC(533-608) p-Y55,Y227-SPRY2 FGFR2 N549K Activated FGFR2c homodimer bound to FGF GRB2-1 FGF9 PPP2R1A FGFBP3 FGFR2 p-8Y-FGFR2c S252W FGFR2c S252W FGFR2b-binding FGFsFGF3 FGFR2c A314S Activated FGFR2c homodimer bound to FGF GRB2-1 FGF6 FGFR2c A314D FGFR2c long ESRP2p-8Y-FGFR2c A314S TIAL1 GRB2-1 p-6Y-FGFR2b C3 variant HS PTBP1 UBC(77-152) Activated FGFR2 mutants with enhanced kinase activity AZD4547 POLR2C Activated FGFR2c homodimer bound to FGF FGF2(10-155) FGF1 FGFR2c SOS1 SPRY2 FGFR2c mutant dimerswith enhancedligand-bindingbound to FGFsp-6Y-FRS2 FGFR2b S252W Overexpressed FGFR2homodimers:GP369FGFBPActivated FGFR2b homodimer bound to FGF FGFR2c mutants withenhanced ligandbindingFGFR2b-binding FGFs FGFR2 point mutantdimers:TKIsUBA52(1-76) HNRNPA1PIK3CA phosphorylated FGFR2 L764fs*4 FGFR2c A315T FGF2(10-155) GAB1 FGF6 p-Y546,Y584-PTPN11 FGFR2(22-767)-CASP7(1-303) fusion PPP2CA FGFR2c-binding FGFs p-8Y-FGFR2c A315T Activated FGFR2c homodimer bound to FGF POLR2B ADPFGFR2c short p-4Y-PLCG1 FGFR2(22-767)-CCAR(51-923) fusion FGF4 GRB2-1 POLR2C HNRNPM p21 RAS:GDPFGFR2c S372C FGFR2c A315T p-8Y-FGFR2 FGF7 Activated FGFR2b homodimer bound to FGF PPP2CB ATPE7080 Activated FGFR2bhomodimer bound toFGFGRB2-1 p-8Y-FGFR2c P253R Activated FGFR2b homodimer bound to FGF FGFR2 W290C UBC(1-76) FGF7 ActivatedFGFR2:p-FRS37229, 35, 59, 8312116, 15110829, 35, 59, 83598238, 792444, 59, 9729, 35, 59, 834426, 72, 11712, 59, 78, 83174429, 35, 59, 8312, 59, 8329, 35, 595926, 72, 11729, 35, 594029, 35, 59121229, 35, 59, 838673, 8172116, 15129, 35, 59, 83404012, 1471238, 7929, 35, 598, 64, 68, 80, 95...29, 35, 5946116, 15129, 35, 59, 835917402, 7929, 35, 5986487429, 35, 59404010838, 79409129, 35, 5929, 35, 5974404057, 12412626, 72116, 15182761229, 35, 59, 83825, 9, 458640, 82594629, 35, 59, 8326, 72, 117404626, 72, 11712, 147754017444029, 35, 59, 8310812, 15229, 35, 59, 8357, 124116, 151116, 15129, 35, 59, 8319126724029, 35, 59, 8310859469140, 82597412, 58, 59, 8938, 79116, 1512429, 35, 5912, 15229, 35, 59116, 15144, 59, 9729, 35, 5912, 7872744029, 35, 59, 8329, 35, 5929, 35, 5958, 132, 141, 1549759113116, 1515912, 58, 59, 8943, 59, 114, 12712, 7829, 35, 5912, 59, 8329, 35, 595, 9, 454057, 12458, 132, 141, 154116, 151124029, 35, 59, 8329, 35, 59, 8326, 48, 9043, 59, 114, 12729, 35, 59