Signaling by FGFR3 (Homo sapiens)

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70, 93, 97, 107, 128...37, 50, 11717, 1211081061038, 18, 65, 66, 1111032, 19, 67, 99, 114...1, 79, 13432, 37, 40, 50, 1343, 98, 12429, 5946, 63, 71, 14740, 12840, 79, 96, 1175, 39, 55, 78, 132...14, 54, 64, 7643, 80, 129, 1382624, 36, 41, 45, 67...14, 54, 64, 7650, 1291, 42, 79, 13440, 1286013, 23, 1352, 62, 67, 99, 112...3, 75, 12733, 125, 12786, 106117, 11892, 12221, 42, 79, 13424, 30, 36, 41, 45...98, 1083, 7547, 12512313, 51, 102, 1356061, 14061, 1402611140, 50, 117, 11823, 96, 11813748, 117, 13852, 1066, 11, 62, 72, 91...17, 25, 31, 49, 57...5, 39, 56, 74, 78...40, 128cytosolGolgi lumencytosolp-6Y-FRS2 UBC(457-532) HS ATPFGF1 p-6Y-FRS2 p-4Y-PLCG1FGFR3 K650T UBC(1-76) FGF17-1 FGF1 p-6Y-FGFR3b p-6Y-FGFR3 S371C FGFR3(23-793)-TACC3(143-838) fusion FGFR3 cysteine mutant dimers p-6Y-FRS2 FGF17-1 p-Y546,Y584-PTPN11 FGF9 HS FGF5-1 FGFR3 K650M PPP2CB p-Y55,Y227-SPRY2 FGF2(10-155) FGF5-1 HS FGF4 p-6Y-FGFR3 G380R PLCG1 FGF18 FGF17-1 BRAFUBC(153-228) PPP2CA FGF4 PP2A (A:C)UBB(1-76) PPA2A(A:C):SPRY2p21 RAS:GTPp-5Y-FRS3 FGF20 FGF1 RPS27A(1-76) FGF17-1 PIK3CAp-6Y-FGFR3c PPP2CA FGF20 UBC(609-684) FGFR3 mutantdimers:TKIsFGF5-1 PIK3CA ActivatedFGFR3:p-FRS3RPS27A(1-76) FGFR3(23-758)-TACC3(549-838) fusion FGF2(10-155) p-6Y-FGFR3b FGF9 FGF2(10-155) FGF5-1 FGF16 UBC(381-456) FGF17-1 FGF1 PPP2CB GRB2-1Activated FGFR3:SHC1GalNAc-T178-FGF23(25-251) FGF16 FGF9 FGF2(10-155) FGFR3c homodimerbound to FGFPPP2CB GalNAc-T178-FGF23(25-251) FGF1 SRC-1KRAS FGF5-1 GRB2-1 p-5Y-FRS3 FGF18 FGF2(10-155) GalNAc-T178-FGF23(25-251) FGF18 FGF5-1 Ub:Y55/Y227-pSPRY2:CBLFGFR3(23-760)-TACC3(612-838) fusion FGF18 GalNAc-T178-FGF23(25-251)FGF5-1 FGF2(10-155) GalNAc-T178-FGF23(25-251) HS UBC(457-532) FGF17-1 PI(3,4,5)P3UBC(229-304) FGF17-1 FGF8-1 FGF1 ATPFGF18 FGF9 SPRY2 p-6Y-FGFR3c Tyrosine kinaseinhibitors of FGFR3mutantsFGFR3 G380R FGF2(10-155) p-4Y FGFR3(23-760)-TACC3(612-838) fusion p-T185,Y187-MAPK1 FGF18 FGF4 FGF16 HRAS FGF16 GRB2-1 Masitinib FGF16 NRAS p-6Y-FGFR3c GTP FGF4 FGFR3 R248C UBC(229-304) FGF18 FGF17-1 FGF2(10-155) p21 RAS:GDPFGF8-1 p-6Y-FGFR3b FGF9 FGFR3 K650E p-T250,T255,T385,S437-MKNK1FGF4 GRB2-1 FGF20 p-6Y-FGFR3b ADPp-S111,S120-SPRY2 FGFR3 Y373C FGF1 p-Y371-CBL:GRB2FGF5-1 p-6Y-FGFR3b p-6Y-FRS2 FGFR3 Y373C p-Y371-CBL p-6Y-FGFR3c FGF1 p-4Y FGFR3(23-793)-TACC3(143-838) fusion FGF9 FGF17-1 Ub-Activated FGFR3complex:Ub-p-FRS2GalNAc-T178-FGF23(25-251) p-Y55,Y227-SPRY2 FGF18 p-6Y-FGFR3 G380R FGFR3c P250Rp-6Y-FGFR3b p-6Y-FGFR3 Y373C FGF2(10-155) p-Y55,Y227-SPRY2 p-Y194,Y195,Y272-SHC1-3 FGF1 ATPp-6Y-FGFR3b p-6Y-FGFR3c GRB2-1 FGFR3(23-760)-TACC3(647-838) fusion UBC(381-456) FGF5-1 UBC(609-684) GAB1 FGF18 p-6Y-FRS2 FGF18 ATPFGF20 UBC(533-608) FGF4 ActivatedFGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2p-6Y-FGFR3 K650Q FGFR3 point mutant dimers with enhanced kinase activity E3810 FGF20 FGF17-1 FGF16 FGF17-1 FGFR3 A391E FGF2(10-155) ADPMidostaurin FGF5-1 p-6Y-FGFR3b PI(3,4,5)P3 UBC(153-228) FGF1 FGF8-1 HS BRAF p-6Y-FRS2 PI(4,5)P2FGF4 activatedFGFR3:PLCG1ADPFRS3FGF8-1 UBA52(1-76) GRB2-1 FGFR3(23-760)-TACC3(612-838) fusion FGFR3 G370C FGF18 p-6Y-FRS2 p-6Y-FGFR3 K650T HS ActivatedFGFR3:p-8T-FRS2GRB2-1 Activated FGFR3FGF9 UBC(305-380) UBC(533-608) BGJ398 GRB2:GAB1FGF2(10-155) HS FGFR3 point mutantswith enhancedkinase activityFGF20 GalNAc-T178-FGF23(25-251) FGF5-1 p-6Y-FGFR3c FGF2(10-155) p-T,Y MAPK dimersHS HS p-Y546,Y584-PTPN11 FGF23(25-251)FGF20 HRAS E7080 UbPIK3R1 UBC(1-76) DAG and IP3signalingUBA52(1-76) FGFR3 795fs*139 FGF1 p-T202,Y204-MAPK3 FGF2(10-155) SPRY2 FGF16 HS FGF9 SU5402 p-6Y-FGFR3c PIK3R1 UDP-GalNAcFGF4 p-6Y-FRS2 FGF8-1 FGF9 FGF20 FGF5-1 FGF1 FGF1 FGF1 FGFR3 S371C FGF2(10-155) HS GAB1 FGF5-1 UBA52(1-76) GalNAc-T178-FGF23(25-251) p-6Y-FGFR3b UBC(153-228) FGF4 FGF18 AZD4547 HSFGF17-1 FGF17-1 HS p6Y-FGFR3c P250R FGFR3 S371C ADPGalNAc-T178-FGF23(25-251) FGFR3 cysteinemutant dimersUBB(77-152) FGFR3 FGF16 ActivatedFGFR3:pY-SHC1:GRB2:SOS1FGF20 FGF8-1 GRB2-1 p-6Y-FGFR3b G697C p-6Y-FGFR3b FGF20 FGF1 FGF5-1 p-6Y-FGFR3c GRB2-1 FGF2(10-155) FGF1 FGF20 FGF5-1 PPP2CA GRB2-1 p-Y546,Y584-PTPN11 FGFR3 fusionsFGF18 SHC1-2 FGF4 GAB1 FGF1 FGF20 p-6Y-FGFR3b GRB2-1 FGF8-1 FGF1 GalNAc-T178-FGF23(25-251) FGF4 UBC(1-76) GRB2-1 FGF8-1 ATPUBC(77-152) FRS3 FGFR3 K650M Activated FGFR3:FRS2FGF4 FGF8-1 PIK3R1 FGF9 ADPActivatedFGFR3:p-FRS2:GRB2:GAB1:PIK3R1FGF4 BGJ398 PIK3R1 FGFR3 G382D p-6Y-FGFR3 G370C PI(3,4,5)P3p-6Y-FGFR3c ActivatedFGFR3:p-FRS2FGF8-1 FGF8-1 FGFR3b G697C FGF17-1 FGF20 FGF16 Y55/Y227-pSPRY2:CBLPPP2CB FGF17-1 FGFR3 K650N FGFR3c P250R FGF1 FGF2(10-155) UBC(609-684) GAB1 UBC(457-532) p-6Y-FRS2 FGF1 HS FGF9 ATPFGFR3 G380R FGF18 GalNAc-T178-FGF23(25-251) GalNAc-T178-FGF23(25-251) PPP2R1A FGFR3 mutant dimersFGF17-1 FGFR3c P250R p-6Y-FRS2 FGFR3c P250R mutantdimer bound to FGFFGF18 UBC(77-152) ADPUBC(533-608) p-4Y FGFR3(23-758)-TACC3(649-838) fusion p-Y194,Y195,Y272-SHC1-3 FGF9 FGFR3 G380R p-6Y-FGFR3 K650E ActivatedFGFR3:p-FRS2:p-PTPN11p-Y FGFR3 fusiondimersGalNAc-T178-FGF23(25-251) HSFGF9 FGF5-1 FGFR3c P250R FGF9 PPP2CA ActivatedFGFR3:p-FRS:p-PTPN11FGFR3b FGF9 ADPp-6Y-FGFR3c SOS1 UBC(229-304) FGFR3b homodimerbound to FGFFGF16 Activated FGFR3bhomodimerFGFR3c-binding FGFsPLCG1p-6Y-FGFR3c UBA52(1-76) UBB(77-152) PPP2CA FGF1 GalNAc-T178-FGF23(25-251) FGFR3 A391E ATPFGF1 FGF16 FGFR3 (4;14)translocationmutant dimersGAB1 UBC(305-380) FGFR3 Y373C FGF4 p-Y55,Y227-SPRY2 E3810 FGF18 GRB2-1:SOS1GalNAc-T178-FGF23(25-251) p-5Y-FRS3 p-Y546,Y584-PTPN11 FGF9 UBB(153-228) GalNAc-T178-FGF23(25-251) UBB(77-152) p-6Y-FGFR3 R248C PPP2CB FGF9 FGFR3 K650T FGF8-1 FGFR3 PIK3R1 GalNAc-T178-FGF23(25-251) p-6Y-FGFR3 K650E FGF17-1 FGFR3 K650Q RAF/MAP kinasecascadeATPPP2A(A:C):Y55/Y227-pSPRY2FGF9 FGFR3 K650E p-6Y-FRS2 UBC(381-456) FGF18 FGFR3 R248C FGF8-1 FGF2(10-155) E7080 FGF17-1 UBC(609-684) UBC(457-532) p-Y239,Y240,Y317-SHC1-2 FGF5-1 p-6Y-FGFR3c FGFR3 K650N FGF9 GALNT3UBC(77-152) HS FGF4 FGF16 ADPGalNAc-T178-FGF23(25-251) FGF17-1 FGFR3 G382D FGF16 FGFR3 K650E UBC(153-228) FGF2(10-155) FGFR3b-binding FGFsFGFR3 R248C FGF5-1 UBC(533-608) p-6Y-FGFR3 G382D NRAS FGF18 GalNAc-T178-FGF23(25-251) FGF8-1 activatedFGFR3:p-4Y-PLCG1FGF8-1 FGF1 FGF5-1 UBB(1-76) p-S112,S115-SPRY2 UBC(77-152) FGFR3b S249C ATPp-8T-FRS2 PPP2CA FGF17-1 FGF16 GalNAc-T178-FGF23(25-251) PP2A(A:C):S112/S121-pSPRY2FGFR3(23-760)-BAIAP2L1(18-522) fusion HS FGF17-1 FGFR3 point mutant dimers with enhanced kinase activity GalNAc-T178-FGF23(25-251) FGF18 GalNAc-T178-FGF23(25-251) FGF9 ATPKRAS FGF5-1 FGF17-1 FGF18 FGF16 PiSHC1 p46,p52FGF2(10-155) p-6Y-FGFR3b FGF1 SHC1-2 FGF1 FGF2(10-155) PD173074 SHC1-3 p-6Y-FGFR3c FGF2(10-155) p-4Y FGFR3(23-760)-TACC3(647-838) fusion FGF9 FGF8-1 p-Y239,Y240,Y317-SHC1-2 HS FGF1 p-6Y-FGFR3b UBB(153-228) p-6Y-FGFR3 A391E FGF18 FGF9 UBC(533-608) FGF1 FGF20 FGF18 ATPATPFGFR3(23-758)-TACC3(649-838) fusion UBB(153-228) FGF4 FGF9 PD173074 UBC(77-152) FGF18 S111/S120p-SPRY2:B-RAFFGF1 UBB(1-76) RPS27A(1-76) UBC(153-228) FGF16 HS FGF9 SOS1 FGF16 UBB(153-228) FGF8-1 FGF4 ActivatedFGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1FGFR3 cysteine mutant dimers FGFR3 G382D FGF2(10-155) FGF8-1 FGF17-1 PPP2R1A FGF8-1 UBB(153-228) FGF20 FGF8-1 HS UBB(1-76) PPP2R1A FGFR3 K650E FGF4 AZD4547 p-6Y-FGFR3c FGF18 CBLRPS27A(1-76) HS p-5Y-FRS3 Dovitinib UBC(1-76) PPA2A(A:C):S112/S115p-SPRY2FGFR3 G370C ADPPPP2CB SPRY2 FGFR3b S249C FGF17-1 GalNAc-T178-FGF23(25-251) ADPFGF20 FGF1 HS p-6Y-FGFR3 Y373C FGF8-1 ActivatedFGFR3:p-FRS2:GRB2:GAB1:PI3Kp-6Y-FGFR3c Ub-(Y55/Y227)p-SPRY2p-6Y-FGFR3c p-6Y-FGFR3b FGF20 UBB(77-152) UBA52(1-76) FGF17-1 FGFR3 (4;14) translocation mutant dimers FGF1 FGF16 p-S112,S121-SPRY2 FGF8-1 FGFR3 fusion dimersp-6Y-FGFR3b HS Activated FGFR3cP250R mutantPIP3 activates AKTsignalingFGF5-1 FGFR3 point mutantdimers withenhanced kinaseactivityFGF9 FGF16 PPP2R1A FGF5-1 p-6Y-FGFR3b FGF20 RPS27A(1-76) FGF16 FGF2(10-155) GalNAc-T178-FGF23(25-251) FGF4 FGF4 ATPFGFR3(23-760)-TACC3(647-838) fusion Midostaurin GDPGDP FGF18 FGFR3 cysteinemutantsActivatedFGFR3:p-FRSFGF20 GalNAc-T178-FGF23(25-251)ATPp-6Y-FGFR3c p-6Y-FGFR3b FGF2(10-155) FGF8-1 FGF16 FGF2(10-155) ATPp-6Y-FGFR3b FGF4 FGFR3bFGF18 FGFR3(23-760)-BAIAP2L1(18-522) fusion FGF17-1 UBC(381-456) FGF16 FGF9 FGF16 FGF9 p-6Y-FGFR3c FGFR3 G380R HS FGF2(10-155) UBC(1-76) UBC(229-304) p-6Y-FGFR3c FGF5-1 Activated FGFR3:FRS3pY-FGFR3 Activated FGFR3mutants withenhanced kinaseactivityFGF4 p-Y371-CBL FGFR3(23-758)-TACC3(649-838) fusion FGF20 FGF20 PPP2CA p-6Y-FGFR3c FGFR3 795fs*139 GalNAc-T178-FGF23(25-251) ActivatedFGFR3:p-FRS:GRB2:SOS1p-S111,S120-SPRY2FGF9 ADPFGF8-1 Masitinib FGF8-1 FRS2 FGF4 p-6Y-FGFR3b FGF16 p-5Y-FRS3 p-6Y-FGFR3 G382D FGF4 PTPN11 FGFR3 (4;14)translocationmutantsFGF20 UBB(77-152) FGF5-1 ActivatedFGFR3:pY-SHC1PPP2R1A FGF16 PP2A(A:C):SPRY2GRB2-1 FRS2FGF17-1 PPP2R1A ADPFGFR3(23-793)-TACC3(143-838) fusion FGF9 FGF2(10-155) FGF5-1 FGF1 p-6Y-FGFR3b S249C mutant FGF8-1 HS p-6Y-FGFR3c PIK3R1FGF17-1 FGFR3 Y373C p-Y55,Y227-SPRY2 UDPFGF9 FGF20 FGFR3c FGF17-1 SHC1-3 FGFR3b G697C FGFR3cUBB(1-76) FGF20 FGF20 CBL GalNAc-T178-FGF23(25-251) SOS1 FGF5-1 FGF4 SU5402 FGF2(10-155) ADPHS FGF18 FGFR3 K650Q GRB2:GAB1:PIK3R1p-6Y-FGFR3c p-Y371-CBL FGFR3 R248C GalNAc-T178-FGF23(25-251) FGF20 Activated FGFR3t(4;14)translocationmutantsFGFR3 G382D FGF20 FGF4 HS p-6Y-FGFR3b FGF8-1 FGF16 FGF8-1 FGF18 FGFR3(23-758)-TACC3(549-838) fusion FGFR3 (4;14) translocation mutant dimers ActivatedFGFR3:p-FRS:PTPN11p-6Y-FGFR3 K650M Activated FGFR3cysteine mutantsFGF17-1 p-6Y-FGFR3 R248C PPP2CB FGF20 FGF8-1 GalNAc-T178-FGF23(25-251) HS FGF8-1 Activated FGFR3chomodimerUBC(305-380) FGF20 PPA2A (A:C):Y55/Y227p-SPRY2:GRB2PIK3CA p-Y546,Y584-PTPN11 GRB2-1 p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion ADPFGF18 FGF5-1 FGF9 UBC(229-304) FGF8-1 FGF18 p-6Y-FGFR3b FGF2(10-155) FGF20 FGF5-1 UBC(305-380) p-6Y-FRS2 FGF18 UBC(305-380) UBC(457-532) FGF20 Dovitinib HS FGF17-1 p-6Y-FGFR3b HS UBC(381-456) FGF17-1 FGF4 HS p-4Y-PLCG1 FGF1 FGF4 UBC(609-684) FGF18 FGF20 BRAF GAB1 p-Y546,Y584-PTPN11 FGF16 FGF16 GalNAc-T178-FGF23(25-251) FGF5-1 FGF8-1 CBL SPRY2:B-RAFFGF9 p-4Y FGFR3(23-758)-TACC3(549-838) fusion FGF4 p-6Y-FGFR3 K650N PTPN11p-6Y-FGFR3c ActivatedFGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3KUbp-6Y-FGFR3b p-6Y-FGFR3 795fs*139 FGF16 GalNAc-T178-FGF23(25-251) PPP2R1A HS ADPGTP24, 41, 1099539, 74, 14890169, 15, 25, 116741119, 15, 25, 11636, 90, 10939, 132736, 90, 1099938382, 10, 15, 24, 41...10, 24, 67, 10941, 1096, 11, 72, 91, 11215, 25, 31, 105, 110...19, 94, 1151069915, 25, 31, 105, 110...67, 8215, 25, 31, 105, 110...31, 346, 28, 53, 14239, 13239, 13236, 84, 1096, 28, 53, 14241, 14936, 84, 10939, 13224, 4119, 94, 11539, 13219, 94, 11510639, 1321264, 12, 35, 44, 68...10639, 74, 14841, 14920, 91, 15139, 13239, 1321084524, 41, 10914839, 74, 14827, 58, 10939, 13239, 13214810, 24, 4136, 84, 10941, 149952, 10, 15, 24, 41...10667, 8234, 94, 11536, 99, 10922, 12034, 94, 11531, 3439, 1322, 10, 15, 24, 41...67, 82457427, 58, 1091112, 10, 15, 24, 41...8836, 99, 10927, 58, 10910, 24, 67, 10936, 99, 10939, 13224, 41, 10919, 94, 11510, 24, 4115, 24, 41, 99, 10015, 24, 41, 99, 1001620, 91, 15136, 99, 10911122, 1207411136, 84, 109712915, 25, 31, 105, 110...148