Signaling by FGFR3 (Homo sapiens)

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32, 48, 64, 79, 83...15, 68, 84, 116, 125...2829, 87, 8810076, 92, 103, 11466, 105, 1239, 50, 69, 865516, 19, 22, 24, 37...947411, 16, 21, 23, 42...1222, 26, 36, 11941, 12317, 18, 4017, 71, 1055, 7, 31, 65, 78...10, 1347534, 76, 92, 10323, 5612, 13, 29, 6718, 5547, 13967, 11230, 43, 110, 12079, 14012, 13, 5779, 14034, 92, 1032813, 43, 11713, 67, 88, 9212, 57, 61, 67, 10313435, 53, 75, 109, 129115, 13467, 11267, 1127, 31, 59, 65, 70...15, 25, 51, 68, 81...2, 36, 8717, 7113, 299, 50, 69, 8614, 49, 111, 12612277, 9031, 52, 59, 70, 80...19, 24, 37, 58, 59, 7210012, 110cytosolcytosolGolgi lumenUBA52(1-76) FGF1 FGFR3 K650E PIK3CA FGF8-1 ATPFGFR3 K650T FGF1 BRAF p-5Y-FRS3 p-6Y-FGFR3b p21 RAS:GDPGalNAc-T178-FGF23(25-251) p-6Y-FGFR3 Y373C FGF5-1 FGF17-1 FGF20 GalNAc-T178-FGF23(25-251) FGF17-1 FGFR3 Y373C FGF4 FGF20 p-6Y-FGFR3c UBC(609-684) p-4Y FGFR3(23-758)-TACC3(549-838) fusion PIK3R1 FGF8-1 FGF2(10-155) FGF18 KRAS FGF2(10-155) GRB2-1 FGFR3(23-760)-TACC3(647-838) fusion FGF17-1 FGF17-1 Activated FGFR3:SHC1FGF1 p-Y FGFR3 fusiondimersFGF5-1 p-8T-FRS2 SPRY2 HS p-6Y-FGFR3c FGF17-1 p-6Y-FGFR3 K650N FGF18 GAB1 GRB2-1 FGFR3 cysteinemutantsp-6Y-FGFR3b UBC(229-304) UBB(77-152) p-6Y-FRS2 FGFR3(23-758)-TACC3(649-838) fusion HS FGF8-1 FGF16 FGF20 FGFR3 S371C GRB2-1 GalNAc-T178-FGF23(25-251) SOS1 PPA2A(A:C):SPRY2FGF9 p-6Y-FGFR3c p-6Y-FRS2 FGF9 FGF9 p-6Y-FGFR3 K650Q GalNAc-T178-FGF23(25-251) FGF2(10-155) FGF17-1 UBC(457-532) FGF4 UBB(77-152) FGF8-1 UBC(1-76) p-6Y-FRS2 FGF5-1 p-4Y FGFR3(23-758)-TACC3(649-838) fusion UBB(153-228) Ub-Activated FGFR3complex:Ub-p-FRS2FGF18 ADPFGF2(10-155) SOS1 UBC(153-228) ATPFGF8-1 p-6Y-FGFR3b FGF18 UBC(457-532) UBC(609-684) UBB(1-76) FGFR3(23-760)-BAIAP2L1(18-522) fusion ActivatedFGFR3:p-FRS:p-PTPN11GalNAc-T178-FGF23(25-251) FGF20 p-6Y-FGFR3b FGF20 FGFR3 G370C PP2A (A:C)HS FGFR3 mutant dimersFGF2(10-155) GalNAc-T178-FGF23(25-251) FGF16 FGF1 p-Y546,Y584-PTPN11 FGF5-1 FGF1 GalNAc-T178-FGF23(25-251) FGFR3 (4;14) translocation mutant dimers ActivatedFGFR3:pY-SHC1:GRB2:SOS1HS p-6Y-FGFR3c FGF4 SPRY2 ActivatedFGFR3:p-FRS2PPP2CB FGF20 RPS27A(1-76) FGF8-1 p-6Y-FGFR3 R248C UBC(533-608) FGF5-1 GalNAc-T178-FGF23(25-251) UBB(1-76) p-6Y-FGFR3c FGF8-1 PPP2CB p-6Y-FGFR3 K650M UBA52(1-76) FGF8-1 ATPFGFR3 Y373C p-6Y-FGFR3b G697C UBC(77-152) UBC(609-684) FGF5-1 FGF1 FGF4 FGFR3c homodimerbound to FGFPPP2CB p-Y55,Y227-SPRY2 UBC(533-608) GAB1 p-Y371-CBL:GRB2UDP-GalNAcFGFR3 A391E FGF4 FGF4 FGF2(10-155) FGF16 PPP2R1A FGF9 FGF18 HS p-5Y-FRS3 ATPFGF9 Activated FGFR3cysteine mutantsFGF5-1 FGF18 UBC(457-532) GTP ActivatedFGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3KFGFR3b-binding FGFsHS FGF18 FGF5-1 UBC(381-456) FGF20 FGF2(10-155) Activated FGFR3:FRS3FGF2(10-155) GRB2-1FGF16 FGF18 SPRY2 ADPFGF16 FGF9 GRB2:GAB1p-6Y-FGFR3 R248C GalNAc-T178-FGF23(25-251) BGJ398 FGF5-1 FGFR3 Y373C PP2A(A:C):S112/S121-pSPRY2FGFR3 S371C UBC(305-380) FGF17-1 FGF1 FGFR3(23-793)-TACC3(143-838) fusion FGFR3(23-758)-TACC3(549-838) fusion FGFR3 cysteinemutant dimersUBC(77-152) FGFR3b UBB(153-228) ADPGalNAc-T178-FGF23(25-251) FGF20 FGF9 Activated FGFR3:FRS2GalNAc-T178-FGF23(25-251) PPP2R1A FGFR3 K650Q HS ADPp-6Y-FGFR3b UBC(381-456) UBC(153-228) p-T185,Y187-MAPK1 FGF1 Ub:Y55/Y227-pSPRY2:CBLFGF1 FGF20 FGFR3 fusion dimersHS FGF2(10-155) PPP2CB FGFR3b G697C p-6Y-FGFR3c p-6Y-FGFR3c activatedFGFR3:PLCG1FGF2(10-155) FGF17-1 FGF8-1 p-6Y-FGFR3c p-6Y-FGFR3b UBB(77-152) p-6Y-FGFR3c pY-FGFR3 FGF4 FGF17-1 UBC(305-380) FGF9 UBC(381-456) FGF1 FGFR3 cysteine mutant dimers PPP2CA FGF9 FGF16 p-4Y-PLCG1 FGFR3 mutantdimers:TKIsFGFR3 G370C FGF20 FGFR3 G382D PLCG1 FGF18 p-6Y-FGFR3b FGF1 FGF5-1 PI(4,5)P2ATPFGF16 FGF8-1 FGF5-1 FGF8-1 p-S111,S120-SPRY2CBL FGF9 FGFR3 G382D PPP2CA FGF8-1 FGFR3(23-760)-BAIAP2L1(18-522) fusion FGFR3 R248C UBB(153-228) FGFR3 R248C FGF2(10-155) FGF5-1 FGFR3 fusionsp-6Y-FGFR3b FGF8-1 FGFR3c P250RFGFR3(23-793)-TACC3(143-838) fusion ActivatedFGFR3:p-FRSFGF2(10-155) FGF20 p-6Y-FGFR3 G382D FGF8-1 p-6Y-FRS2 FGF8-1 FGF16 FGF4 NRAS FGFR3 K650N HS PI(3,4,5)P3 Activated FGFR3chomodimerPPP2R1A GalNAc-T178-FGF23(25-251) FGFR3(23-760)-TACC3(612-838) fusion HS FGF20 FGFR3c P250R ActivatedFGFR3:p-FRS2:GRB2:GAB1:PI3KFGFR3c P250R p-6Y-FGFR3 S371C UBB(1-76) FGF8-1 FGF17-1 ActivatedFGFR3:p-FRS:GRB2:SOS1FGF20 ActivatedFGFR3:p-FRS:PTPN11CBL PPP2CA FGF16 ADPFGF16 UBC(457-532) p-6Y-FGFR3 G382D Activated FGFR3bhomodimerPPP2CB FGF2(10-155) FGF17-1 ADPADPFGFR3 cysteine mutant dimers UBA52(1-76) FGFR3 R248C FGF1 PIK3CA FGF9 FGFR3c P250R FGF1 FGF4 FGF18 p-6Y-FGFR3c FGF2(10-155) FGF17-1 p-Y194,Y195,Y272-SHC1-3 FGF1 FGF9 FGF9 ActivatedFGFR3:p-FRS3FGF1 p-6Y-FGFR3 K650T FGF16 FGF4 FGF20 p-6Y-FGFR3 A391E FGF1 ActivatedFGFR3:p-FRS2:GRB2:GAB1:PIK3R1PPP2CB PTPN11 FGF4 FGF17-1 FGF5-1 FGF8-1 FGF1 SHC1-3 p-6Y-FGFR3 795fs*139 FGFR3cp-6Y-FGFR3b UBB(153-228) FGF20 PPP2R1A FGF5-1 FGF9 FGF4 RAF/MAP kinasecascadeFGFR3(23-760)-TACC3(647-838) fusion p-Y371-CBL FGFR3 K650T p-4Y FGFR3(23-760)-TACC3(612-838) fusion UBC(229-304) FGF16 PIK3R1FGFR3 K650E UBB(153-228) p-6Y-FGFR3c UBC(305-380) UbGRB2-1 FGFR3 G380R GRB2-1 FGF16 ADPGRB2-1 FGF2(10-155) FGF4 activatedFGFR3:p-4Y-PLCG1PP2A(A:C):SPRY2FGF9 p-Y546,Y584-PTPN11 FGFR3 G382D p-T,Y MAPK dimersUBC(609-684) KRAS p-6Y-FGFR3 G380R FGFR3 795fs*139 HS p-5Y-FRS3 GalNAc-T178-FGF23(25-251) FGFR3(23-760)-TACC3(612-838) fusion GDP FGF4 UDPp-6Y-FGFR3c FGF8-1 DAG and IP3signalingFGF5-1 FGF20 SPRY2:B-RAFPPP2CB PI(3,4,5)P3UBC(457-532) p-6Y-FRS2 PP2A(A:C):Y55/Y227-pSPRY2PPP2R1A UBC(77-152) UBC(1-76) FGF20 ActivatedFGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1FGF8-1 p-6Y-FGFR3c FGF20 FGFR3 G380R FGF1 GalNAc-T178-FGF23(25-251) p-6Y-FRS2 FGF17-1 GalNAc-T178-FGF23(25-251) FGF4 FGFR3 R248C FGF5-1 FGF1 SHC1-2,SHC1-3FGF2(10-155) p-6Y-FGFR3b p-6Y-FGFR3b FGFR3 795fs*139 FGF1 p-T250,T255,T385,S437-MKNK1p6Y-FGFR3c P250R FGF17-1 FGF17-1 ADPp-Y546,Y584-PTPN11 p-S111,S120-SPRY2 GAB1 FGF20 FGFR3 point mutantswith enhancedkinase activityFGFR3 G380R FGFR3 G382D GRB2-1 BGJ398 FGF8-1 FGF1 FGF20 FGFR3b S249C GRB2-1 p-Y55,Y227-SPRY2 FGF17-1 FGF9 FGF18 FGF2(10-155) FGF16 FGF18 FGF1 FGFR3 point mutant dimers with enhanced kinase activity UBC(77-152) FGF20 p-Y371-CBL HS p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion p-6Y-FRS2 UBC(305-380) FGF4 FGF1 FGF5-1 Y55/Y227-pSPRY2:CBLFGF2(10-155) GAB1 FGF17-1 FGF1 FGF8-1 p-6Y-FGFR3b FGFR3b homodimerbound to FGFBRAFFGF1 PPP2CA p-6Y-FGFR3c FGF4 FGF17-1 ATPp-6Y-FRS2 GalNAc-T178-FGF23(25-251) FGF18 ADPFGF9 FGF5-1 PPA2A (A:C):Y55/Y227p-SPRY2:GRB2p-5Y-FRS3 UBB(1-76) GRB2-1:SOS1FGF5-1 FGFR3 A391E FGFR3b G697C FGF20 p-6Y-FGFR3c FGF18 p-Y239,Y240,Y317-SHC1-2 p-6Y-FGFR3c p-Y239,Y240,Y317-SHC1-2 UBC(381-456) GDPFGF9 FGF18 FGF18 UBB(77-152) GalNAc-T178-FGF23(25-251) FGF9 UBC(229-304) UBC(1-76) RPS27A(1-76) p-4Y-PLCG1p-6Y-FGFR3 G370C p-Y55,Y227-SPRY2 HS FGF16 FGFR3b S249C PPP2CA FGF16 FGF20 GalNAc-T178-FGF23(25-251)ADPp-6Y-FGFR3c FGF8-1 FGF17-1 FGF5-1 p-Y546,Y584-PTPN11 HS FGF18 FGF16 UBC(609-684) p-6Y-FGFR3b ActivatedFGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2FGF2(10-155) FGF9 p-Y546,Y584-PTPN11 Activated FGFR3p-S112,S121-SPRY2 p-6Y-FGFR3c ATPp-Y371-CBL p-4Y FGFR3(23-793)-TACC3(143-838) fusion p-6Y-FGFR3b UBC(153-228) FGF20 FGF1 FGF18 ATPFGF23(25-251)FGF16 UBC(1-76) FGF16 SHC1-2 FGF18 FGF5-1 FRS2 FGF4 HS FGFR3 FGF20 BRAF GRB2:GAB1:PIK3R1AZD4547 FGF2(10-155) GalNAc-T178-FGF23(25-251) FGF16 FGF5-1 p-6Y-FGFR3b HS PIK3R1 p-6Y-FRS2 UBC(153-228) FGF2(10-155) FGF16 FGF5-1 FGF16 FGF4 ActivatedFGFR3:p-FRS2:p-PTPN11FGF2(10-155) FGF18 FGFR3c FGFR3c P250R mutantdimer bound to FGFFGF18 FGFR3 point mutantdimers withenhanced kinaseactivityFGF18 p-6Y-FGFR3c FGF9 FGF8-1 HS FGFR3 K650N GalNAc-T178-FGF23(25-251) FGF4 FGF4 FGF8-1 FGF20 FGF17-1 ActivatedFGFR3:pY-SHC1FGF17-1 FGFR3 G380R p-S112,S115-SPRY2 FGF4 GRB2-1 p-6Y-FRS2 SHC1-2 PIK3R1 FGFR3 point mutant dimers with enhanced kinase activity HRAS ATPSOS1 FGF18 FRS3FGF9 UBC(229-304) GalNAc-T178-FGF23(25-251) PiFGF4 ATPp-6Y-FGFR3b FGF17-1 FGFR3bRPS27A(1-76) FRS3 S111/S120p-SPRY2:B-RAFUBA52(1-76) FGF16 HS FGFR3 K650E FGF17-1 FGF2(10-155) p-Y55,Y227-SPRY2 p-5Y-FRS3 UBC(1-76) HS PPA2A(A:C):S112/S115p-SPRY2UBC(305-380) FGF5-1 HS p-6Y-FGFR3b FGF9 GALNT3ADPHRAS FGF18 p-6Y-FGFR3 Y373C FGFR3 Y373C PPP2CA FGF18 HS p-6Y-FGFR3b ATPFGF2(10-155) SRC-1FGFR3 (4;14)translocationmutant dimersFGF4 ADPUBC(77-152) FGF1 Activated FGFR3mutants withenhanced kinaseactivityADPFGF8-1 UBB(77-152) FGF20 UBC(229-304) p-Y546,Y584-PTPN11 RPS27A(1-76) p-6Y-FGFR3b GRB2-1 HS FGF4 FGF1 FGF17-1 FGFR3 K650M HS FGF8-1 RPS27A(1-76) p-6Y-FGFR3b FGF18 FGFR3(23-758)-TACC3(549-838) fusion FGF9 SHC1-3 p-6Y-FGFR3b FGF2(10-155) FGF16 p-Y55,Y227-SPRY2 FGFR3 K650E FGF5-1 FGF4 GalNAc-T178-FGF23(25-251) HS PIP3 activates AKTsignalingATPGRB2-1 FGF5-1 FGF4 GalNAc-T178-FGF23(25-251) p-6Y-FGFR3c FGF9 GAB1 FGF17-1 p-6Y-FGFR3b FGF16 p-6Y-FGFR3c FGFR3 FGF17-1 p-6Y-FGFR3c FGF9 HS p-6Y-FGFR3b S249C mutant Tyrosine kinaseinhibitors of FGFR3mutantsFGF2(10-155) ATPp21 RAS:GTPPI(3,4,5)P3FGF18 FGF16 FGF2(10-155) UBC(381-456) FGF17-1 FGF17-1 HS FGF8-1 HSp-6Y-FGFR3 K650E PIK3R1 FGFR3c-binding FGFsGTPFGF8-1 FGF5-1 PIK3R1 FGFR3 K650M ActivatedFGFR3:p-8T-FRS2UBC(533-608) FGF9 PTPN11GalNAc-T178-FGF23(25-251) FGF5-1 FGF20 UBB(1-76) FGFR3 K650Q NRAS FGF8-1 FGF18 FGF9 FGF20 HS FGF1 FGF17-1 FGF1 FGF18 GalNAc-T178-FGF23(25-251) p-6Y-FGFR3c FGF8-1 FGFR3 (4;14) translocation mutant dimers HSFGF2(10-155) UBA52(1-76) p-T202,Y204-MAPK3 Activated FGFR3cP250R mutantHS FGF17-1 HS FGF16 UbFGFR3 (4;14)translocationmutantsGalNAc-T178-FGF23(25-251) HS GalNAc-T178-FGF23(25-251) Activated FGFR3t(4;14)translocationmutantsFGF8-1 p-6Y-FRS2 PPP2R1A FGF5-1 FGFR3(23-758)-TACC3(649-838) fusion ATPFGF18 ATPFGF17-1 FGF8-1 UBC(153-228) FGF9 AZD4547 PPP2R1A FGF9 FRS2p-6Y-FGFR3 K650E ADPFGF18 GRB2-1 PIK3CAGalNAc-T178-FGF23(25-251)GalNAc-T178-FGF23(25-251) p-4Y FGFR3(23-760)-TACC3(647-838) fusion p-6Y-FRS2 GRB2-1 FGF9 p-6Y-FGFR3 G380R Ub-(Y55/Y227)p-SPRY2GalNAc-T178-FGF23(25-251) PPP2CA FGF20 FGF4 FGF2(10-155) FGF20 FGF1 PLCG1UBC(533-608) GalNAc-T178-FGF23(25-251) CBLGAB1 FGF1 p-Y194,Y195,Y272-SHC1-3 FGF18 UBC(533-608) FGF16 FGF16 FGF4 p-6Y-FGFR3b FGF9 FGF20 24, 70, 10642, 80, 1388111, 9524, 39, 1061, 8, 20, 27, 38...6, 11, 21, 42, 85...754, 6, 46, 58, 59, 70...15, 841945, 58224, 59, 72, 1066, 46, 58, 70, 72134814, 6, 46, 58, 59, 70...58, 10624, 39, 1065515, 841960, 106, 14124, 70, 1063, 6, 21, 1134, 6, 46, 58, 59, 70...15, 84914, 59, 72, 10613442, 95, 1384, 58, 7215, 81, 918215, 8424, 70, 1067524, 39, 1067058, 72, 10645, 586, 11, 21, 42, 85...54122, 13615, 8415, 8445, 5833, 599142, 95, 13860, 106, 14160, 106, 14158, 7224, 39, 10633, 5915, 8411, 9515, 81, 914, 6, 46, 58, 59, 70...58, 72, 10613422, 24, 10658, 72, 10675916, 46, 58, 70, 721347515, 8415, 8442, 80, 13815, 8411065, 78, 104, 124, 12822, 24, 1067015, 8442, 80, 13833, 598115, 81, 916, 11, 21, 42, 85...15, 844, 58, 7224, 70, 1063, 6, 21, 1136, 11, 21, 42, 85...42, 80, 138