Signaling by FGFR1 (Homo sapiens)

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IP3signalingpY177-BCR1-p-FGFR1mutant:GRB2:GAB2FGF10 PPP2R1A FGF8-1 GalNAc-T178-FGF23(25-251) p-8Y-FGFR1c p-8Y-FGFR1b p-S112,S115-SPRY2 p-S111,S120-SPRY2FGF10 p-8Y-FGFR1b FGF5-1 FGF22 p-8Y-FGFR1 N546K FGFR1 mutants withenhanced kinaseactivityUBB(153-228) PPP2CA GRB2-1 UBA52(1-76) FGF3 ATPKL-1 FGF10 UBC(229-304) GAB2 KL-1 FGF18 PD173074 KL-2 p-8Y-FGFR1b FGFR1 R576W FGF4 STAT3 FGF1 Ub:Y55/Y227-pSPRY2:CBLKL-2 p-8Y-FGFR1b FGF23(25-251) FGF6 RPS27A(1-76) FGF1 FGF4 FLRT3 FGF23(25-251) UBC(305-380) p-Y546,Y584-PTPN11 PPP2CA FGF23(25-251) p-8Y-FGFR1 K656E ActivatedoverexpressedFGFR1b homodimerKL-2 FGF8-1 CNTRL-FGFR1 fusion HSFGF8-1 GalNAc-T178-FGF23(25-251) HS UBC(77-152) FGF23(25-251) GalNAc-T178-FGF23(25-251) KL-1 FGF22 PIK3R1HS PIK3R1 FGF3 pY177-BCR-p-FGFR1 fusion FGF2(10-155) GRB2-1 FGF2(10-155) E3810 Brivanib KL-1 p-Y194,Y195,Y272-SHC1-3 FGF6 GRB2-1 FGF20 FGFRL1 Activated FGFR1chomodimerGDP FGF2(10-155) FGFR1c ATPFGFR1(22-763):TACC1(571-805) fusion FGF10 ATPFGF1 Brivanib alaninate p-Y55,Y227-SPRY2 p-8Y-FGFR1c FGF1 FGF8-1 pY177-BCR-p-FGFR1 fusion ATPKL-1 FGF20 FGF20 cytosolic FGFR1fusion mutantdimersp-Y-GAB2 MYO18A-FGFR1 fusion FGF6 FGFR1 N546K FGF3 FGF10 FGF22 FGF2(10-155) FGF17-1 FGF4 UBC(457-532) FGF9 UBC(1-76) FGFR1b homodimerp-6Y-FRS2 FGF2(10-155) GalNAc-T178-FGF23(25-251) ActivatedFGFR1:p-FRS2:GRB2:SOS1KL-2 FGF17-1 HS LRRFIP1-p-2Y-FGFR1 fusion p-4Y-PLCG1plasma membraneFGFR1 fusionsFGF6 UBC(229-304) FGF5-1 UBB(153-228) BRAF ATPFGF5-1 FGF3 FGF10 FGF22 FGF2(10-155) FGF8-1 HS FGF6 LRRFIP1-p-2Y-FGFR1 fusion CBL FGF3 GRB2:GAB1:PIK3R1PP2A(A:C):SPRY2GalNAc-T178-FGF23(25-251) SPRED2 FGF1 FGF10 UBC(381-456) RPS27A(1-76) FGF22 FGF5-1 BCR-p-FGFR1 fusion UBA52(1-76) FGF4 Midostaurin p-Y55,Y227-SPRY2 FGF2(10-155) p-Y371-CBL:GRB2FGF8-1 FGF8-1 FGF2(10-155) ZMYM2-p-2Y-FGFR1 fusion HS SU5402 p-STAT5A, p-STAT5BUBC(533-608) FGF4 FLRT1,2,3UBC(77-152) p-6Y-FRS2 TRIM24-FGFR1 fusion p-Y694-STAT5A PPP2CA FGF4 PLCG1p-6Y-FRS2 GRB2-1 FGF5-1 UBC(533-608) FGF10 FGF3 pY177-BCR-p-FGFR1fusion mutant dimerFGF23(25-251) FGF6 FGFR1 K656E Ub-(Y55/Y227)p-SPRY2p-8Y-FGFR1c FGF10 FGF17-1 FGF20 HS HSUBC(609-684) UBB(153-228) PIK3CAp-6Y FGFR1(22-763):TACC1(571-805) fusion GAB1 FGF20 MYO18A-FGFR1 fusion FGF5-1 UBC(457-532) SU5402 FGFR1bFGF5-1 p-8Y-FGFR1 P252T PPA2A(A:C):SPRY2FGF5-1 PIK3R1 FGF22 FGF20 PD173074 FGF22 FGF9 FGFR1 P252S ATPFGF20 SHC1-2 CPSF6-p-2Y-FGFR1 fusion LRRFIP1-FGFR1 fusion FGF1 SOS1 FGF9 FGF9 Plasma membraneFGFR1 fusion dimersFGF6 FGF22 FGF3 FGF8-1 GAB1 KL-1 p-5Y-FRS3 FGF5-1 FGFR1OP-p-FGFR1 fusion UBA52(1-76) FGFR1cADPActivatedFGFR1:p-FRS3GAB1 FGF6 FGF6 FGF4 FGF3 FGF10 FGFRL1-binding FGFsFGF3 FGF17-1 FGF10 FGF4 ADPFGF8-1 CPSF6-p-2Y-FGFR1 fusion FGF1 UBC(381-456) p-8Y-FGFR1b KL-1 UBC(153-228) PD173074 p-8Y-FGFR1c ZMYM2-FGFR1 fusion ADPKL-1 ATPUBC(381-456) ADPp-8Y-FGFR1c FGF2(10-155) SPRY2 FGF20 p-5Y-FRS3 FGF20 HS GRB2-1 FGF1 FGFR1c homodimerbound to FGFBCR-FGFR1 fusion FGF2(10-155) PD173074 KL-2 BCR-p-FGFR1 fusionmutant dimerPIK3CA UBC(609-684) KL-2 UBB(1-76) FGF22 FGFR1OP2-FGFR1 fusion SPRY2:B-RAFFGF2(10-155) CUX1-p-2Y-FGFR1 fusion FGF5-1 p-8T-FRS2 KL-2 GalNAc-T178-FGF23(25-251) ERLIN2(1-185):FGFR1(c.-88-822) fusion p-Y-GAB2 FGFR1c FGF23(25-251) FGF23(25-251) GRB2-1 p-6Y-FRS2 FGFR1c P252R FGF5-1 PPP2R1A FGF4 ActivatedFGFR1:p-FRSFGF8-1 FGF2(10-155) HSp-8Y-FGFR1c GRB2-1 FGF6 LRRFIP1-FGFR1 fusion FGF9 FGF10 p-8Y-FGFR1c FGF6 Tyrosine kinaseinhibitors ofoverexpressed FGFR1FGF1 PIK3R1 PTPN11 ActivatedFGFR1:p-FRS2FGF9 UBC(229-304) KL-2 GalNAc-T178-FGF23(25-251) FGF8-1 FGF4 p-FGFR1 mutantfusions:PI3Kp-Y55,Y227-SPRY2 GRB2-1 ActivatedoverexpressedFGFR1c homodimerp-8Y-FGFR1b KL-1 HRAS cytosolic p-FGFR1fusion mutantdimersFGF2(10-155) p-8Y-FGFR1b KL-1 p-S112,S121-SPRY2 FGF10 ATPFGF6 FGF20 FGF17-1 SU5402 UBC(533-608) UBC(609-684) UBC(1-76) ADPFGF5-1 FGF4 FGF8-1 HS FGF23 bound toKlotho and FGFR1cFGF6 FGF17-1 ADPGAB1 KL-2 FGF2(10-155) HS FGF22 FGF10 FGF5-1 ATPGalNAc-T178-FGF23(25-251) FGF5-1 UBC(381-456) PPP2R1A GRB2-1 KL-2 FGF22 PP2A(A:C):Y55/Y227-pSPRY2FGF6 FGF2(10-155) GalNAc-T178-FGF23(25-251) PPP2CB GalNAc-T178-FGF23(25-251) FGF6 FGF23(25-251) FGF22 FGF20 FGF17-1 UBB(153-228) Plasma membrane p-YFGFR1 fusion dimersKL-1 Dovitinib ActivatedFGFR1:p-8T-FRS2FGF17-1 UBC(457-532) p-8Y-FGFR1b FGF9 FGF5-1 Midostaurin FLRT1 UBC(533-608) p-8Y-FGFR1c FGF3 CPSF6-FGFR1 fusion KL-2 PPP2R1A FGF23(25-251) FGF4 HS GalNAc-T178-FGF23(25-251) HS UbPPA2A (A:C):Y55/Y227p-SPRY2:GRB2UBB(1-76) FGFR1 K656E HS KRAS FGF1 FGF1 FGF23(25-251) PI(3,4,5)P3FGFR1(22-763):TACC1(571-805) fusion FGF3 FGF8-1 CUX1-FGFR1 fusion p-FGFR1 fusionmutantdimers:PIK3R1KL-2 pY177-BCR-p-FGFR1 fusion ERLIN2(1-185):FGFR1(c.-88-822) fusion PLCG1 FGF2(10-155) ATPGRB2-1 ADPFGF23(25-251) PPP2CA FGF1 FGF6 ATPBRAF FGF9 BCR-FGFR1 fusion FGF23(25-251) FGFR1 fusion mutantdimers:TKIsRPS27A(1-76) KL-1 KL-1 FGF6 p-6Y-FRS2 FGF9 p-8Y- FGFR1 R576W FGFR1c UBB(1-76) PI(3,4,5)P3FGF20 GDPBCR-p-FGFR1 fusion p-S111,S120-SPRY2 GRB2-1 FGF9 RPS27A(1-76) FGF23(25-251) BRAFSTAT5A,STAT5BFGF9 SOS1 BCR-p-FGFR1 fusion ADPp-6Y-FRS2 UBC(153-228) Activated FGFR1mutant dimers withenhanced kinaseactivityFGF20 FGF23(25-251) PPP2CB ADPActivatedFGFR1:p-SHC1FGF9 KL-1 p-Y-GAB2 FRS2 FGF2(10-155) KL-1 KAL1:HSFGF23(25-251) PPP2CA FGF22 PPP2CB p-8Y-FGFR1b FGF20 FGF5-1 KL-2 PIK3R1 p-8Y-FGFR1c FGF1 ADPZMYM2-FGFR1 fusion GalNAc-T178-FGF23(25-251) UBC(305-380) p-8Y-FGFR1c pY177-BCR-p-FGFR1 fusion ActivatedFGFR1:p-FRS2:p-PTPN11FGF4 FGFR1b FGF4 UBA52(1-76) GRB2-1FGF20 FGF8-1 UBC(229-304) CNTRL-p-2Y-FGFR1 fusion FGFR1OP2-p-2Y-FGFR1 fusion p-6Y-FRS2 STAT1,3p-8Y-FGFR1b FGF17-1 FGFR1OP-FGFR1 fusion p-T,Y MAPK dimersFGF8-1 KL-2 p-Y239,Y240,Y317-SHC1-2 UBC(77-152) KL-1 SPRY2 GalNAc-T178-FGF23(25-251) FGF20 PPP2CB p-8Y-FGFR1b FGF4 UBB(77-152) FGF4 FGF9 KL-1 p-6Y-FRS2 SHC1-2 PIK3R1 PPA2A(A:C):S112/S115p-SPRY2FGF6 FGF9 ADPGRB2-1 FGF5-1 p-8Y-FGFR1b ATPBGJ398 FGF9 FGF9 TRIM24-FGFR1 fusion FGF1 FGFR1c homodimerE3810 p-T185,Y187-MAPK1 UBB(77-152) HS p-6Y-FRS2 FGF4 STAT5B FGF10 p-Y177-BCR-pY-FGFR1mutant:GRB2:p-GAB2:PIK3R1ATPActivated FGFR1P252X mutantsFGF3 FGFRL1-bindingFGFs:FGFRL1 dimerp-8Y-FGFR1b FGF3 p-8Y-FGFR1c FGF10 FGF17-1 FGF23(25-251) KL-2 FGF5-1 HS FGF8-1 FGF1 CUX1-p-2Y-FGFR1 fusion Activated FGFR1:FRS3UBC(1-76) FGFR1b FGF22 MYO18A-p-2Y-FGFR1 fusion GRB2-1 CNTRL-p-2Y-FGFR1 fusion FGF5-1 FGF22 FGF8-1 KL-1 ActivatedFGFR1:p-FRS2:GRB2:GAB1:PIK3R1FGF1 SPRED1/2 dimerFGF23(25-251) p-6Y-FRS2 FGF17-1 FGF9 KL-1 FGF22 HS LRRFIP1-p-2Y-FGFR1 fusion FGFR1b Y55/Y227-pSPRY2:CBLPIK3R1 MYO18A-FGFR1 fusion FGF17-1 UBB(77-152) KL-2 FGF4 FGF2(10-155) FGF4 GRB2-1 FGFR1OP2-p-2Y-FGFR1 fusion FGF9 FGF4 HS FGF1 ActivatedFGFR1:p-SHC1:GRB2:SOS1FGFR1b FGF9 FGF17-1 FGF3 UBC(153-228) p-T250,T255,T385,S437-MKNK1FGF3 FGF9 AZ 2171 FGF17-1 GRB2:GAB1Klotho bound toFGF23p-4Y-PLCG1 p-Y546,Y584-PTPN11 FGF5-1 GAB1 FGFR1OP-p-FGFR1 fusion FLRT2 cytosolic p-FGFR1fusion mutantdimersFGF20 UBA52(1-76) p-Y239,Y240,Y317-SHC1-2 FGFR1c p-Y371-CBL FGF5-1 p-Y546,Y584-PTPN11 FGF20 FGF6 FGF3 p-8Y-FGFR1b ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion FGFR1OP-p-FGFR1fusion mutant dimerFGF5-1 PPP2CB HS ADPUBC(457-532) FGF2(10-155) FGF10 GalNAc-T178-FGF23(25-251) HS FGF5-1 RAF/MAP kinasecascadeFGF2(10-155) BAG4(1-126):FGFR1(208-822) fusion ADPActivated FGFR1:FLRTFGF8-1 FGF5-1 FGF3 NRAS SRC-1FGF22 FGF17-1 GRB2-1 p-Y546,Y584-PTPN11 FGF17-1 FGFR1 P252T FGF10 KL-2 p-8Y-FGFR1 P252S FGF10 GRB2-1 GalNAc-T178-FGF23(25-251) FRS2UBC(77-152) FGF23(25-251) ActivatedFGFR1:p-FRS:p-PTPN11FGF17-1 FGF9 p-Y546,Y584-PTPN11 FGF6 Tyrosine kinaseinhibitors of FGFR1fusion mutantsFGF8-1 UBC(1-76) p-8Y-FGFR1b GRB2:GAB2BCR-p-FGFR1 fusion Dovitinib MYO18A-p-2Y-FGFR1 fusion NRAS FGF17-1 HS p-Y699-STAT5B FGF1 TRIM24-p-2Y-FGFR1 fusion FGF17-1 UBC(1-76) FGF6 SPRY2 p-8Y-FGFR1b p-8Y-FGFR1b FGF10 FGF1 BCR-p-FGFR1 fusion FGFR1c:KAL1ADPp-8Y-FGFR1c p-8Y-FGFR1c GRB2-1 PPP2CA HSFGFR1OP-p-FGFR1 fusion OverexpressedFGFR1:TKIsKL-2 SPRED1 activatedFGFR1:p-4Y-PLCG1activatedFGFR1:PLCG1FGF5-1 FGF3 FGF6 UbFGFR1 N546K ActivatedFGFR1:p-FRS:PTPN11pY177-BCR-p-FGFR1 fusion p-Y194,Y195,Y272-SHC1-3 GalNAc-T178-FGF23(25-251) FGF22 KAL1FGF9 HS ATPHS ZMYM2-p-2Y-FGFR1 fusion CUX1-p-2Y-FGFR1 fusion STAT1 p-Y701-STAT1 p-8Y-FGFR1b ActivatedFGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2FGF3 FGF23(25-251) p-8Y-FGFR1c PIK3R1 LRRFIP1-FGFR1 fusion CUX1-FGFR1 fusion GalNAc-T178-FGF23(25-251) ATPUBC(381-456) GAB1 p-8Y-FGFR1c P252R Activated FGFR1cbound toFGF23:KlothoFGF2(10-155) FGF1 FGFR1 P252S FGF2(10-155) FGF22 GalNAc-T178-FGF23(25-251) PIK3CA FGF8-1 AZD4547 FGF22 FGF6 KAL1 FGFRL1 dimerSPRED2 FGF17-1 FGFR1OP2-FGFR1 fusion KL-1 SHC1 p46,p52ADPUBC(609-684) HS p-8Y-FGFR1c FGF10 FGF5-1 SHC1-3 Overexpressed FGFR1homodimersTRIM24-p-2Y-FGFR1 fusion FGF20 FGF17-1 BAG4(1-126):p-8Y FGFR1(208-822) fusion FGF4 FGF23(25-251) FGF1 FRS3 ADPFGF9 ZMYM2-p-2Y-FGFR1 fusion UBC(609-684) p-Y55,Y227-SPRY2 FGF6 FGF9 p-8Y-FGFR1b GalNAc-T178-FGF23(25-251) CBLp-8Y-FGFR1c CBL FGF17-1 FGF6 FGF23(25-251) p-Y371-CBL CNTRL-p-2Y-FGFR1 fusion FGF17-1 FRS3Activated FGFR1p-5Y-FRS3 Activated FGFR1:SHC1FGF2(10-155) KL-1 FGF20 ATPFGF20 PIK3R1 FGF23(25-251) FGF1 FGF6 FGF2(10-155) cytosolic FGFR1fusion mutantsHS FGF8-1 FGF20 Dovitinib ATPHRAS FGF4 FGFR1OP-FGFR1 fusion HS FGFRL1 FGF2(10-155) PPP2CB HS UBB(77-152) SPRED1 FGFR1c P252R FGF20 FGF20 HS FGF1 CPSF6-FGFR1 fusion p-8Y-FGFR1b pY-STAT1,3FGF4 ADPFGF10 KAL1 FGF17-1 p-8Y-FGFR1c UBC(305-380) FGF8-1 ADPp-8Y-FGFR1c FGF4 p-8Y-FGFR1c KL-2 FGFR1c STAT5A FGF8-1 FGF17-1 PP2A (A:C)RPS27A(1-76) ActivatedFGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1FGF2(10-155) FGF17-1 FGF23(25-251) GTPp21 RAS:GDPFGF22 GAB2 ADPATPFGF22 p-8Y-FGFR1b KL-2 FGF1 p-8Y-FGFR1c ZMYM2-p-2Y-FGFR1 fusion FGF17-1 FGFR1OP-p-FGFR1 fusion S111/S120p-SPRY2:B-RAFFGF6 FGFRL1 PIP3 activates AKTsignalingKL-2 AZD4547 FGF3 Brivanib FGF10 HS GalNAc-T178-FGF23(25-251) KL-1 CPSF6-p-2Y-FGFR1 fusion pY177-BCR-pY-FGFR1mutant:GRB2:p-GAB1:PI3Kp-6Y-FRS2 FGF9 GRB2-1:SOS1FGF2(10-155) FGF3 FGF1 BAG4(1-126):FGFR1(208-822) fusion Activated FGFR1bhomodimerPPP2CA Ub-Activated FGFR1complex:Ub-p-FRS2SHC1-3 SOS1 FGF3 ADPFGF20 p-8Y-FGFR1c SU5402 p-8Y-FGFR1c UBC(77-152) FGF22 ActivatedFGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3KFGFR1b homodimerbound to FGFPI(3,4,5)P3 UBC(153-228) FGF18 FLRT2 FGF5-1 p-8Y-FGFR1c FGF9 FGFR1 P252X mutantsFGF4 KRAS FGF4 KL-1 FGFR1 mutant dimerswith enhancedkinase activityUBC(533-608) FGF8-1 p-8Y-FGFR1c FGF5-1 FGF2(10-155) ATPKL-1 FGF9 FGF4 GalNAc-T178-FGF23(25-251) FGF3 p-6Y-FRS2 PPP2CB HS p-5Y-FRS3 FGF10 ZMYM2-FGFR1 fusion FGF17-1 Dovitinib FGF4 PPP2R1A FGF22 FGF17-1 UBC(305-380) CUX1-p-2Y-FGFR1 fusion FGFR1b-binding FGFsFGF2(10-155) FGF22 FGF1 PIK3CA FGFR1c-binding FGFsHS FGF23(25-251) PI(4,5)P2FGF10 GalNAc-T178-FGF23(25-251) FGF22 FGF2(10-155) p-8Y-FGFR1b FGF2(10-155) p21 RAS:GTPFGF8-1 p-Y705-STAT3 FGF1 FGF4 GalNAc-T178-FGF23(25-251) GalNAc-T178-FGF23(25-251) ADPFGF8-1 Brivanib alaninate UBC(457-532) CUX1-FGFR1 fusion FGFRL1dimer:SPRED1/2dimerp-8Y-FGFR1b p-8Y-FGFR1b FGF1 PTPN11GalNAc-T178-FGF23(25-251) ActivatedFGFR1:p-FRS2:GRB2:GAB1:PI3KFGF22 FGF1 FGF3 FGF1 CNTRL-FGFR1 fusion FGF3 GalNAc-T178-FGF23(25-251) KL-2 KL-2 BCR-FGFR1 fusion UBC(305-380)